착화제와 유기산이 Wistar rat체내의 Sr 분포에 미치는 영향

이기호,이제호,박상윤,이승훈,유용운,윤택구 대한방사선 방어학회 1990 방사선방어학회지 Vol.15 No.2

Wistar rat에 85SrCl2를 꼬리 정맥에 주사하여 체내 기관과 혈액 내 분포, 잔존율을 조사하였고 착화제와 유기산을 투여하여 혈장 단백질에 결합하는 Sr양의 변화를 측정하였다. 혈액내에서 Sr은 혈장에 60%, 세포에 40%부착되어 이동하였다. 혈장에 존재하는 Sr중 약 50%정도는 혈장 단백질과 결합한 상태였고, 세표에는 세포 표면에 가볍게 부착되어 있었다. Erythrocyte나 granulocyte보다 lymphocyte에 많은 양의 Sr이 부착되어 있었다. 투여후 초기 1시간 이내에 혈액 내에서 급격히 감소하여 뼈에 침착되었다. 이때 각 기관에서도 Sr의 잔존율은 24시간 이내에 크게 감소하였고, 뼈로 침착된 Sr은 24시간 이후에 서서히 감소하였다. 착화제 EDTA, EGTA 및 DTPA를 투여한 경우, 혈장 단백질에 결합하는 Sr의 양은 대조군의 57%에서 27-33%로 감소하였으며 citrate 및 oxalate의 투여시는 이값이 19%와 40%로 각각 감소하였다. 85SrCl2 was injected to the tail vein of Wistar rats and investigated its distribution and clearance in the tissues and blood. We also measured the changes in Sr binding to the blood plasma protein by administrating chelating agents and organic acids. For the blood, 60% of the Sr occurred in the plasma and 40% on the cell membrane. Fifty percent of Sr in the blood plasma was bound to plasma protein. Sr on the cell membrane seemed to be bound loosely. The binding in the lymphocyte was higher than in the erythrocyte and granulocyte. Within one hour Sr was quickly disappeared from the blood stream, to be accumulated in the bone. Twenty four hours after the injection, Sr decreased rapidly in the organs of soft tissue, but slowly in the bone. The binding of Sr to plasma protien decreased from 57% of the control to 27-33% in the group treated with chelating agents. EDTA. EGTA and DTPA and to 19% and 40% in the groups treated with organic acids, citrate and oxalate, respectively.

복어중독에 의한 가사 상태에서 소생한 1예

송승찬,신진호,강석우,박경남,최호순,박근태,문희식,기춘석,이성희,윤병철,노우균,조균석,이민호 大韓應急醫學會 1998 대한응급의학회지 Vol.9 No.3

Tetrodotoxin is a neurotoxin produced by about 90 species of puffer fish and causes paralysis of central nervous system and peripheral nerves by blocking the movement of all monovalent cation. Ingestion of tetrodotoxin produces clinical manifestations such as paresthesias(within 10-45 min), vomiting, lightheadedness, salivation, muscle twitching, dysphagia, difficulty in speaking, convulsion and death that expressed by cardiopulmonary arrest with loss of brain stem reflex sometimes. Tetrodotoxin prevents or delays ischemia induced neuronal death by way of following 3 mechanisms. Firstly, it reduces the energy demand of the brain tissues. Secondly, it delays or even prevents anoxic depolarization. Finally, it deminishes ischemia induced cell swelling and cerebral edema. We report a case of puffer fish poisoning which presented with cardiopulmonary arrest and loss of brain stem reflex, but completely recovered by aggressive cardiopulmonary resuscitation.

사적 측면에서 본 신체활동의 의미의 변화

이유복 / 류기호 공주교육대학교 초등연구원 1980 公州敎大論叢 Vol.16 No.-

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동물체모 및 장기 중 카드뮴의 방사화 분석

이기호,유용운 대한방사선 방어학회 1990 방사선방어학회지 Vol.15 No.2

백서의 장기 내 카드뮴의 축적분포를 중성자 조사에 의한 방사분석법으로 조사하였다. CdCl2를 1주일에 10mg /kg씩 급식되도록 매일 물병으로 투여하였으며 1주, 2주, 3주, 1개월, 2개월 및 3개월 기간동안 장기 복용케한 후 주요장기 및 체모를 시료로 하여 방사화 분석을 수행하여 아래와 같은 결론을 얻었다. 1) 115Cd을 방사추적자로 사용하여 24시간 경과 후 체내 카드뮴의 분포를 조사한 결과 혈액에 0.03%신장에 2.99% 간장에 3.50%를 나태내었다. 2) Cd은 혈액을 통해 신속히 순환되어 신장을 통하여 백설되나 간장과 체모에도 축적되는 결과를 나타냈다. 3) CdCl2를 급식케 한 실험군의 주요 장기별 Cd함량을 측정 비교한 결과를 이용하여 간장 내 Cd의 축적을 체모 내 Cd함량으로부터 진단 하는 지표로 사용이 가능케 되었다. Rats were ingested in drinking water 600mg/L of cadmium chloride solution during 3 months, then the distribution of Cd in major organs and hair were determined by neutron activation analysis. The results were as followings. 1. After administration for 24 hours'using 115cmCd as tracer, the distribution of blood was 0.03%, kidney 2.99% and liver 3.50% to determine with whole body counter. 2. Cd metal was rapidly excreted with kidney through blood and their accumulation appeared in liver and hair. 3. The comparative data to determine using neutron activation analysis, the content of cadmium of major organs in rats ingested of CdCl2 during 3 month were shown to increase significantly both hair and liver. Above facts, hair samples were able to use as the diagnostic index to evaluate the accumulation of cadmium in liver.

중심 정맥 삽관법에 의한 동정맥루: 증례 및 문헌 고찰

이 근,원형섭,양기창,박철완,김상일,정호성,이종호 대한응급의학회 1995 대한응급의학회지 Vol.6 No.1

A 36-year old woman with end stage renal failure and hypertension was transferred from a university hospital to our emergency department due to a enlarging right cervical mass associated with a palpable thrill and a bruit. Over a 2 month period, she required hemodialysis for severe azotemia at a university hospital in Seoul. 3 days after a difficult attempt at a internal jugular cannulation, she developed a progressive swelling in the right lower cervical area. An arch and primary branch arteriogram revealed a arteriovenous fistula between right innominate artery and internal jugular vein with a large intervening pseudoaneurysm. She underwent vascular surgery within 1 week of injury and subsequent postoperative angiogram showed complete resolution of the fistula. This rare condition is reported with a review of the literature.

HIV 감염 환자에서 발생한 편평 콘딜롬 1예

이해웅,오상현,장성은,최지호,문기찬,고재경 대한피부과학회 2006 大韓皮膚科學會誌 Vol.44 No.4

후처리를 통한 규칙집합의 축소

이기철,이준호 弘益大學校 科學技術硏究所 1998 科學技術硏究論文集 Vol.9 No.1

In the past decade, knowledge extraction from raw data has been extensively studied. Especially, decision tree based methods and neural network based methods have been shown to be effective with their own merits and demerits. In our lab, a novel approach based on simultaneous expansion of attributes using the expansion method of Espresso has been studied. In this paper, post pruning methods are studied and suggested to improve the rules derived before, and its usefulness has been shown by extensive comparative experiments. We rely on coding cost based schemes, and this result was used to extend the already developed system el to improve the rule set quality.

프랙탈 분석을 이용한 치근단병소 치유과정의 골 변화

이지민,박혁,정호걸,김기덕,박창서 대한구강악안면방사선학회 2005 Imaging Science in Dentistry Vol.35 No.2

Purpose : To investigate the change of bone healing process after endodontic treatment of the tooth with an apical lesion by fractal analysis. Materials and Methods : Radiographic images of 35 teeth from 33 patients taken on first diagnosis, 6 months, and 1 year after endodontic treatment were selected. Radiographic images were taken by JUPITER Computerized Dental X-ray System. Fractal dimensions were calculated three times at each area by Scion Image PC program. Rectangular region of interest (30×30) were selected at apical lesion and normal apex of each image. Results : The fractal dimension at apical lesion of first diagnosis (L_(0)) is 0.940±0.361 and that of normal area (N_(0)) is 1.186±0.727 (p<0.05). Fractal dimension at apical lesion of 6 months after endodontic treatment (L₂) is 1.076± 0.069 and that of normal area (N₁) is 1.192±0.055 (p<0.05). Fractal dimension at apical lesion of 1 year after endodontic treatment (L₂) is 1.163±0.074 and that of normal area (N₂) is 1.225 0.079 (p<0.05). After endodontic treatment, the fractal dimensions at each apical lesions depending on time showed statistically significant difference. And there are statistically significant different between normal area and apical lesion on first diagnosis, 6 months after, 1 year after. But the differences were grow smaller as time flows. Conclusion : The evaluation of the prognosis after the endodontic treatment of the apical lesion was estimated by bone regeneration in apical region. Fractal analysis was attempted to overcome the limit of subjective reading, and as a result the change of the bone during the healing process was able to be detected objectively and quantitatively.

Prospidin이 Mouse의 간장에 미치는 영향

이규식,정호삼,이민형,백두진,기춘석 한양대학교 의과대학 1986 한양의대 학술지 Vol.6 No.1

Prospidin, a new alkylating agent, has antimitotic and anticancer effect. Incubation with prospidin increases the stability of DNA and suppresses the incorporation of uridine into RNA by 15-20 percent. Prospidin is cytostatic for suspension culture and cells are blocked in G₂ phase of the cell cycle. The authors have demonstrated the effect of prospidin on the liver of mice histologically and histochemically and observed the cellular changes, loss of pyroninophilic granules and accumulation of fat in the hepatic parenchymal cells. Sixty-five healthy mice of ICR strain, average weight being 20g, were divided into two groups; control and prospidin-treated groups. All experimental animals were administered foo and water ad libitum. Animals of the prospidin-treated groups were administered prospidine 500mg per kg of body weight intraperitoneally fter dilution in the water for injection. Animals of the control group were administered only water for injection. Prospidin treated animals were sacrificed at intervals of 6, 12, 24, 36 and 48 hours after administration of prospidin. Histological preparations were made by way of hematoxylin and eosin stain for the cellular changes, methyl green-pyronin stain for pyroninophilic granules and oil red O stain for fat accumulation in the mouse liver. The results obtained are as follows. 1. Cellular swelling associated with vesicular formation were observed in the hepatic parenchymal cells of entire hepatic lobule at 24 and 36 hours after administration of prospidin. 2. A marked reduction of the pyroninophilic granules were observed in the hepatocyte of he whole hepatic lobule at 24, 36 and 48 hours following drug administration. 3. Fat deposits in the hepatic lobule were seen at 36 hours after administration of prospidin. It is suggested that prospidin acts as a cytotoxic agent and causes cellular swelling with vesicular formation, loss of pyroninophilic granules, and fat accumulation in the parenchymal cells of the liver.

L_iF 紛末의 Exo-emission Parameter

李春鎬,李起芳 全北大學校 基礎科學硏究所 1978 基礎科學 Vol.1 No.1

We make use of a method for calculating the thermoluminescence(or T.L) parameters to deduce the activation energy and the frequency factor of Lif crystal powder from TSEE glow curve on the assumption that the second-order kinetics of TL is closely related to the exoemision of trapped electron. The activation energy, also, has been calculated by the method of Kelly and Laubitz for the calculation of the activation energy from two points of the glow peaks. The deduced values of the activation evergy and the frequency factor of LiF pawder at peak temperatures 120℃ and 225℃ are 1.34±0.12ev, 1.65±0.01ev, and 4.2×10 exp (-18) sec and 6.3×10 exp (-16). According to the result of the study, we may conclude that the exo-emission of LiF powder follows the second-order kinetics of thermoluminescence.