Dynamics of Nonlinear System Based on a CMOS Array Circuit with Quantized Internal States

Jun Qi Zhu,Katsufusa Shono 대한전자공학회 1994 대한전자공학회 세미나 Vol.1994 No.-

Limonoids from the roots of Trichilia sinensis and their cytotoxicities

Zhu-Nian Wang,Wen-Li Mei,Hui-Qin Chen,Jun Wang,Zhu-Nian Wang,Hao Fu Dai 대한약학회 2018 Archives of Pharmacal Research Vol.41 No.12

Six new compounds (1–4, 8, 10), along with six known limonoids (5–7, 9, 11, 12), were isolated from the roots of Trichilia sinensis. Their structures were elucidated on the basis of extensive spectroscopic methods including 1H NMR, 13C NMR, DEPT, HSQC, HMBC, 1H–1H COSY and ROESY experiments, as well as by comparison with the literature. All the compounds were evaluated for cytotoxicities against K562, SGC-7901 and BEL-7402 cell lines. Compounds 2, 7, 10, 11, and 12 showed weak inhibitory activity to the selected cell lines.

Efficacy and safety of olmesartan medoxomil/amlodipine fixed-dose combination for hypertensive patients uncontrolled with monotherapy

Jun-Ren Zhu,Shu-Yang Zhang,Ping-Jin Gao 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.12

This study aimed to evaluate the efficacy andsafety of olmesartan medoxomil (OM)/amlodipine (AML)20/5 mg fixed-dose combination tablet in Chinese mild tomoderately hypertensive patients with inadequate bloodpressure (BP) control on monotherapy. Two multicenter,randomized, double-blind, double-dummy, active-controlled,parallel group clinical trials were conducted. Afterscreening and a 2-week placebo run-in period, patients with95 mmHg B seated diastolic blood pressure (SeDBP) \110 mmHg received monotherapy with OM 20 mg (inStudy 1) or AML 5 mg (in Study 2), once daily for4 weeks. Patients with 90 mmHg B mean SeDBP \110 mmHg at the end of the monotherapy period wererandomized to receive OM/AML 20/5 mg treatment orcontinue with the monotherapy, once daily for 8 weeks. OM/AML (20/5 mg) treatment significantly lowered bothsystolic and diastolic BP at 4 and 8 weeks compared to40 mg olmesartan or 5 mg AML. The incidence of drugrelatedadverse effects did not differ significantly betweenthe groups. OM/AML 20/5 mg was superior to OM 40 mgor AML 5 mg monotherapy in lowering BP in Chinesemild to moderately hypertensive patients with inadequateBP control on monotherapy. No new or unexpected safetyissues were identified with OM/AML combination therapycompared to monotherapy.

Identification of ssDNA Aptamers Specific for Anti-neuroexcitation Peptide III and Molecular Modeling Studies: Insights into Structural Interactions

Jun Zhu,Jian Wang,Zhen-Cheng Su,Qin Li,Mao-Sheng Cheng,Jing-Hai Zhang 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.9

Twelve ssDNA aptamers specific for a novel recombinant anti-neuroexcitation peptide (ANEPIII) were identified using the SELEX method from a 79-nucleotide ssDNA pool to purify ANEPIII in a more efficient way. To further understand the binding modes between ssDNA and ANEPIII, fully flexible dinucleotides were docked onto the homology-modeled ANEPIII structure. AutoDocking identified favorable binding sites on ANEPIII for nucleotides, which was valuable for designing more potent ligands.

A Novel Intermediate Estimator Based Secure Consensus Control for Multi-agent Systems with Application to Networked Multi-axis Motion Synchronization

Jun-Wei Zhu,Chao-Yang Liang,De-Feng He,Xin Wang 제어·로봇·시스템학회 2021 International Journal of Control, Automation, and Vol.19 No.4

This paper studies the secure consensus control problem of multi-agent systems under DoS attacks onthe sensor, the actuator, and the communication topology. A resilient intermediate estimator based attack tolerantcontrol strategy is proposed. By fully exploiting the hardware redundancies, both of the estimators and the controlprotocols can be reconstructed online according to different DoS attack scenarios. Finally, the experiment results ofthe networked multi-axis motion control system are given to verify the effectiveness of the proposed method.

Fault-tolerant Control for Linear System Under Sensor Saturation Constraint

Jun-Wei Zhu,Qiao-Qian Zhou,Jianming Xu,Jian-Wei Dong 제어·로봇·시스템학회 2021 International Journal of Control, Automation, and Vol.19 No.1

An observer-based fault-tolerant control method is proposed for a linear system with sensor saturationconstraint. Considering the linear system with simultaneous actuator faults and sensor faults, the sensor saturation would bring the output measurement error of the system, which would result in the estimation performancedegradation. Firstly, the intermediate estimator is modified to estimate the system states and fault signals at thesimultaneous time, and the fault-tolerant controller is designed based on the estimation to compensate the effectof actuator faults effectively. Through Lyapunov stability analysis, the sufficient conditions are obtained to ensurethe states of closed-loop system to be uniformly ultimately bounded. The effect of sensor saturation error can besuppressed by adjusting some specified parameters directly without introducing any performance index. Finally, theeffectiveness and superiority of the proposed method are verified by a simulation example

“(是)……的”句中“的”与宾语的位置关系 --以“S(是)AVO的”和“S(是)AV的O”句式为主

Zhu-jun Lian 한국중국언어학회 2022 중국언어연구 Vol.- No.98

“(是)……的”焦点句中宾语可以放在“的”之前,也可以放在“的”之后,我们将前者称为“VO的”句式,后者为“V的O”句式。本文通过语料库考察了以下三种情况:(1)采用“VO的”句式、不采用“V的O”句式的情况,(2)采用“V的O”句式、不采用“VO的”句式的情况,(3)两种句式都可采用的情况。 通过考察我们详细列出了属于(1)和(2)两种情况的语义和句法条件,发现”V的O“句式比”VO的“句式具有更强的构式义,能够把进入其中的不符合条件的V和O强制解读为符合条件的成分。 对于第(3)种情况,本文证实并分析了以下三种倾向性:(A)当“VO”为动宾式离合词时,人们倾向于采用“V的O”句式,(B)当宾语为代词时,人们倾向于采用“VO的”句式,(C)当动词后同时出现结果补语和宾语时,人们倾向于采用“VO的”句式,不管宾语是特指性成分还是泛指性成分。此外,我们还发现话者的态度也会影响到选择哪种句式。当话者对言及的事件十分在意时,往往会采用“VO的”句式,而当话者要客观陈述某个事件或对某个事件不太在意时,则往往采用“V的O”句式。因为存在这种区别,这两种句式在对话语体中会带来不同的语用效果:采用“VO的”句式可以让话者的言语带上某种比较强烈的感情,而采用“V的O”句式则会拉开话者与听者的距离,使话者听起来显得冷淡、冷漠。

Clinicopathological characteristics, treatment and outcomes in uterine carcinosarcoma and grade 3 endometrial cancer patients: a comparative study

Jun Zhu,Hao Wen,Rui Bi,Xiaohua Wu 대한부인종양학회 2016 Journal of Gynecologic Oncology Vol.27 No.2

Objective: Uterine carcinosarcoma (UCS) shared the same staging system with endometrial carcinoma in the International Federation of Gynecology and Obstetrics 2009. The aim of the present study was to compare the clinicopathological and prognostic characteristics between UCS and grade 3 endometrioid endometrial carcinoma (G3EC). Methods: A retrospective analysis of 60 UCS and 115 G3EC patients with initial treatment at the Department of Gynecology in the Fudan University Shanghai Cancer Center between February 2006 and August 2013. Chi-square analysis was used to compare differences between variables. Prognostic factors were determined using univariate/multivariate analysis, and the survival rates were assessed using the Kaplan-Meier method. The Cox regression model was used to assess the independent prognostic factor. Results: UCS had significantly worse overall survival (OS) compared with G3EC. Carcinosarcoma subtype was an independent factor (hazard ratio [HR], 2.4; 95% confidence interval [CI], 1.0 to 5.8; p=0.039), stratified based on stage. Compared with G3EC, UCS patients had a greater incidence of ascites fluid (55.0% vs. 15.7%, p<0.001) and adnexal involvement (20.0% vs. 8.7%, p=0.048) and larger median tumor volume (4.6 cm vs. 4.0 cm, p=0.046). Subgroup analysis of the prognostic factors revealed that UCS patients exhibited worse OS than G3EC patients in such specific subgroups as patients at younger ages, with postmenopausal status, without ascites fluid, with early stage diseases, without vagina invasion, without lymph node metastases and receiving adjuvant chemo/radiotherapy. Adjuvant radiotherapy with chemotherapy was predictive of better survival in UCS patients compared with chemotherapy or radiotherapy alone (5-year OS, 71.0% vs. 35.8%, p=0.028). Multivariate Cox regression revealed that tumor mesenchymal component (HR, 4.6; 95% CI, 1.4 to 15.8; p=0.014) was an independent prognostic factor for UCS, whereas advanced stages (HR, 5.9; 95% CI, 1.0 to 33.9; p=0.046) and ascites fluid (HR, 5.1; 95% CI, 1.1 to 22.7; p=0.032) were independently correlated with poor prognosis for G3EC patients. Conclusion: The distinctions in both clinicopathological and prognostic characteristics between UCS and G3EC suggest that this subtype should be treated separately from high-risk epithelial endometrial carcinoma.

The Design of Fingerprint Identification System based on Improved Binarization Algorithm

Zhu Heng-jun,Guo Ying,Zhang nan-nan,Liang Hong 보안공학연구지원센터 2014 International Journal of Security and Its Applicat Vol.8 No.6

An eigenspace projection clustering method for structural damage detection

Zhu, Jun-Hua,Yu, Ling,Yu, Li-Li Techno-Press 2012 Structural Engineering and Mechanics, An Int'l Jou Vol.44 No.2

An eigenspace projection clustering method is proposed for structural damage detection by combining projection algorithm and fuzzy clustering technique. The integrated procedure includes data selection, data normalization, projection, damage feature extraction, and clustering algorithm to structural damage assessment. The frequency response functions (FRFs) of the healthy and the damaged structure are used as initial data, median values of the projections are considered as damage features, and the fuzzy c-means (FCM) algorithm are used to categorize these features. The performance of the proposed method has been validated using a three-story frame structure built and tested by Los Alamos National Laboratory, USA. Two projection algorithms, namely principal component analysis (PCA) and kernel principal component analysis (KPCA), are compared for better extraction of damage features, further six kinds of distances adopted in FCM process are studied and discussed. The illustrated results reveal that the distance selection depends on the distribution of features. For the optimal choice of projections, it is recommended that the Cosine distance is used for the PCA while the Seuclidean distance and the Cityblock distance suitably used for the KPCA. The PCA method is recommended when a large amount of data need to be processed due to its higher correct decisions and less computational costs.