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간세포암의 고주파 열치료 후 천자침 경로를 통한 전이 1례
조영완,박석주,진한영,김준영,이재익,강명주,박정하,윤정희,박성재,지삼룡,이연재,이상혁,설상영 인제대학교 2006 仁濟醫學 Vol.27 No.-
Radiofrequency ablation(RFA), as a form of minimally invasive therapy for hepatocellular carcinoma, has become an important treatment modality. Because of limitation of surgery, RFA has become standard therapy for hepatocellular carcinoma in some situations. But there are some complications of RFA such as bleeding, infection, hematoma, adjacent organ thermal damage including intestinal perforation, needle track seeding, and so on. There are few reports in the literature that systematically evaluate the incidence of needle tract seeding and its associated risk factors. And only 2 cases of needle tract seeding of hepatocellular carcinoma after RFA were reported in Korea. We report a case of needle tract seeding of hepatocellular carcinoma after RFA.
학동기 이후의 성장 주기별 신장 및 체중 증가율에 관한 연구
신상만,박경배,박준수,김창휘 순천향의학연구소 1996 Journal of Soonchunhyang Medical Science Vol.2 No.2
This study was carried out to know the growth rate of height and weight in Korean children which was conducted on semi-longitudinal research method. For this study, health records of the sample group that carry information for the period from their first grade of elementary school to the third grade of high school were used, 120 males and 120 females who became third grade of high school in 1994 were selected at random from each of the four cities; Seoul, Chonan, Kumi and Eumsung. Among 917 candidates, 460 males and 457 females born between March 1976 and December 1976 were finally selected as a sample for the purpose of this research. The results are as follows; 1. Measurement of the physique Both male and female samples showed constant growth in height and weight. Male grew from the range of 115.8±4.8㎝ at the age of 6 to 171.5±5.6㎝ at 17 while females grew from the range of 114.6±4.7㎝ to 158.9±5.1㎝. The Weight of males rose from the range of 19.9±2.5Kg at the age of 6 to 62.5 ±8.1Kg at 17 while that of females increased from the range of 19.3±2.4Kg to 54.1±6.9Kg. 2. Growth and Nutritional Indices The study revealed that relative weight of the sample group increased as they grew older. The Kaup index also showed an increase in line with the advancement in their ages, and exceeded 2.0 at the age of 15 for males and at the age of 14 for females. The Rohrer index, on the other hand, showed a declining trend for the first several years but began to increase at the age of 13 for males and at the age of 11 for females. 3. Comparative analysis with similar regardless that were performed using sample groups born in 1965 and 1970 revealed the followings; ① Height - The average height of male samples(born in 1976) under this survey was bigger than that of male samples born in 1965 in their respective age from 6 to 17. - The average height of male samples born in 1970 was bigger than that of male samples born in 1970 from 6 to 14 but showed no difference after 15. - Female samples born in 1976 showed height that was bigger than the other sample groups born in 1965 and 1970 in their respective age from 6 to 17. ② Weight Both male and female samples under this survey weighed more than their counterpart sample groups born in 1965 and 1970 in their respective age. 4. The Maximum Growth Age was 12.3 for males and 10.4 for females. Males grew 5.92±2.77㎝ a year on an average when they were 12 and 13 years old while females grew 5.93±2.69㎝ when they were 11 and 12 years old. In conclusion, the study revealed that like in other countries males and females experienced the second growth spurt during their adolescence and relatively slow growth thereafter. Unlike height which showed constant growth, weight varied; there were incidences where females even experienced weight loss after years of diminishing growth rate in the wake of the adolescence.
Park, Joon Ha,Park, Chan Woo,Ahn, Ji Hyeon,Choi, Soo Young,Shin, Myoung Cheol,Cho, Jun Hwi,Lee, Tae-Kyeong,Kim, In Hye,Cho, Jeong Hwi,Lee, Jae-Chul,Kim, Yang Hee,Kim, Young-Myeong,Kim, Jong-Dai,Tae, H Elsevier 2017 Chemico-biological interactions Vol.278 No.-
<P><B>Abstract</B></P> <P>Hydroquinone (HQ), a major metabolite of benzene, exists in many plant-derived food and products. Although many studies have addressed biological properties of HQ including the regulation of immune responses and antioxidant activity, neuroprotective effects of HQ following ischemic insults have not yet been considered. Therefore, in this study, we examined neuroprotective effects of HQ against ischemic damage in the gerbil hippocampal cornu ammonis 1 (CA1) region following 5 min of transient cerebral ischemia. We found that pre- and post-treatments with 50 and 100 mg/kg of HQ protected CA1 pyramidal neurons from ischemic insult. Especially, pre- and post-treatments with 100 mg/kg of HQ showed strong neuroprotective effects against ischemic damage. In addition, pre- and post-treatments with 100 mg/kg of HQ significantly attenuated activations of astrocytes and microglia in the ischemic CA1 region compared to the vehicle-treated-ischemia-operated group. Briefly, these results show that pre- and post-treatments with HQ can protect neurons from transient cerebral ischemia and strongly attenuate ischemia-induced glial activation in the hippocampal CA1 region, and indicate that HQ can be used for both prevention and therapy of ischemic injury.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Low dose of hydroquinone (HQ), a tumorigenesis-inducing factor, does not show neuronal damage. </LI> <LI> Pre- and post-treatments with HQ significantly protects neurons from transient cerebral ischemia. </LI> <LI> Pre- and post-treatments with HQ significantly attenuate ischemia-induced gliosis. </LI> <LI> HQ could be a novel compound for postischemic therapy after cerebral ischemic insults. </LI> </UL> </P>
Park, Joon Ha,Lee, Choong Hyun,Yan, Bing Chun,Ahn, Ji Hyeon,Lee, Young Joo,Park, Chan Woo,Cho, Jun Hwi,Choi, Soo Young,Lee, Yun Lyul,Won, Moo-Ho,Lee, Hui Young Kluwer Academic/Plenum Publishers 2012 Neurochem Res Vol.37 No.7
<P>Ribosomal protein S3 (rpS3), a multi-functional protein, has been known to participate in DNA repair mechanism. In this study, we investigated changes in rpS3 immunoreactivity and its protein levels in the sub-regions of the gerbil hippocampus following subacute and chronic restraint stress. Serum corticosterone levels were increased in both the subacute and chronic-stress-groups compared to the control-group: the level in the subacute-stress-group was much higher than that in the chronic-stress-group. We could not find any neuronal damage in all the sub-regions of the hippocampus after both the subacute and chronic restraint stress. In the subacute-stress-group, rps3 immunoreactivity was not different compared to the control-group. However, rps3 immunoreactivity in the chronic-stress-group was decreased compared to the subacute-stress-group: especially, the immunoreactivity was markedly decreased in the pyramidal cells of the hippocampus proper (CA1-CA3 region) and granule cells of the dentate gyrus. In addition, western blot analysis also showed that rpS3 protein levels in the chronic-stress-group were significantly decreased compared to those in the subacute-stress-group. These findings indicate that chronic stress, not subacute stress, can decrease rpS3 immunoreactivity.</P>
Park, Seung Min,Park, Chan Woo,Lee, Tae-Kyeong,Cho, Jeong Hwi,Park, Joon Ha,Lee, Jae-Chul,Chen, Bai Hui,Shin, Bich-Na,Ahn, Ji Hyeon,Tae, Hyun-Jin,Shin, Myoung Cheol,Ohk, Taek Geun,Cho, Jun Hwi,Won, Mo Medknow PublicationsMedia Pvt Ltd 2016 Neural regeneration research Vol.11 No.7
<P>Ischemic preconditioning (IPC) is a condition of sublethal transient global ischemia and exhibits neuroprotective effects against subsequent lethal ischemic insult. We, in this study, examined the neuroprotective effects of IPC and its effects on immunoreactive changes of antioxidant enzymes including superoxide dismutase (SOD) 1 and SOD2, catalase (CAT) and glutathione peroxidase (GPX) in the gerbil hippocampal CA1 region after transient forebrain ischemia. Pyramidal neurons of the stratum pyramidale (SP) in the hippocampal CA1 region of animals died 5 days after lethal transient ischemia without IPC (8.6% (ratio of remanent neurons) of the sham-operated group); however, IPC prevented the pyramidal neurons from subsequent lethal ischemic injury (92.3% (ratio of remanent neurons) of the sham-operated group). SOD1, SOD2, CAT and GPX immunoreactivities in the sham-operated animals were easily detected in pyramidal neurons in the stratum pyramidale (SP) of the hippocampal CA1 region, while all of these immunoreactivities were rarely detected in the stratum pyramidale at 5 days after lethal transient ischemia without IPC. Meanwhile, their immunoreactivities in the sham-operated animals with IPC were similar to (SOD1, SOD2 and CAT) or higher (GPX) than those in the sham-operated animals without IPC. Furthermore, their immunoreactivities in the stratum pyramidale of the ischemia-operated animals with IPC were steadily maintained after lethal ischemia/reperfusion. Results of western blot analysis for SOD1, SOD2, CAT and GPX were similar to immunohistochemical data. In conclusion, IPC maintained or increased the expression of antioxidant enzymes in the stratum pyramidale of the hippocampal CA1 region after subsequent lethal transient forebrain ischemia and IPC exhibited neuroprotective effects in the hippocampal CA1 region against transient forebrain ischemia.</P>
박준희(Joon-Hwi Park),최응칠(Eung Chil Choi),김병각(Byong Kak Kim) 한국생약학회 1987 생약학회지 Vol.18 No.1
To examine antihypertensive components of Ganoderma lucidum in Korea, two kinds of fruiting bodies (J and K) were used for extraction with water and the extracts were purified by ethanol precipitation and dialysis. Three fractions, i.e., the aqueous total extract (A), the ethanol supernatant(B) and the purified precipitate(C), were compared for antihypertensive activity in anesthetized spontaneously hypertensive rats (SHR). Although fractions A and B showed the activity, fraction C did not. Particularly, fraction B of sample K produced 44.3% reduction in diastolic blood pressure and 30.6% reduction in heart rate after i.v. administration of a dose of 10㎎/㎏. Direct effects of this fraction B to the heart were observed in the isolated blood perfused heart preparation of the dog. It induced positive chronotropic and isotropic responses dose-dependently in the case of sample J. In the case of sample K, marked chronotropic and isotropic effects on atrial muscle but not on ventricular muscle were induced. In both sample, coronary blood flow(CBF) was dose-relatedly increased.