최근 10년간 원광의대병원에서 시행한 소아 심장혈관 수술의 임상적 고찰

윤향석,정수미,최두영,오광수,오연균,김종덕,양현웅,이삼윤,김형곤,최종범,최순호,노병석 圓光大學校 醫科學硏究所 1995 圓光醫科學 Vol.11 No.2

We reviewed 10 years experiences of the clinical aspects and early postoperative results in 544 pediatric patients(age less than 16 years old). Among them. 529 cases had the congenital heart diseases, and 15 had the acquired diseases. Open heart surgery was performed in 413 patients. 115 cases were treated with non-open heart surgery. 16 with interventional catheterization. Annual increase of the cardiac patients was not significant in recent 10 years, except slight increase in 1994. The mean age of the study patients had been evidently changed to younger year by year. Total mortality rate of the open heart surgery was 6.4%. The cyanotic congenital heart diseases were high in early postoperative mortality by 25.7%, whereas 4% in acyanotic group. The age group less than one month was most highest in surgical mortality(66.7%). There were no deaths in patients with patent ductus arteriosus(103 cases), atrial septal defect(83 cases) or pulmonary stenosis(17 cases). Among 220 patients with ventricular septal defects(VSD). 10(4.5%) were died early postoperatively. In cyanotic group, the patients with pulmonary atresia with ventricular septal defects(PAVSD), transposition of the great arteries(TGA), interrupted aortic arch(IAA), complex cardiac anomalies with isomerism seemed to be most susceptible to an early death.

老齡者의 建康을 위한 生活習慣 實態調査

申東敏,長鳳愚,李揆文,金賢俊,金昌範,崔宗洙,崔鍾晥,李鍾珏,金圭碩,趙庚旭,金鍾聲,朴鍾振 平生體育硏究所 論文集 1987 平生體育硏究所 論文集 Vol.2 No.-

With a view to examining the habit and method in which old people maintain and improve their health, we consulted 551 men and 444 women who were over 65 years old, and concluded as follows: 1. Habit of eating It's been revealed that most of the old people keep a regular eating hour, control the quantity of meal or eat a little food, and prefer vegetables to meat. 2. Mental health Old people feel the necessity for mental health and most of them (about 80%) keep good mental health without becoming pessimistic. Their chief concenrs have turned out to be about their sons and daughters and their own health and finance. 3. Managing Good Health It has been revelaed that old people do not possess any special kind of secret to keep good health but taking plenty of rest, regular meal, and proper exercise, and many of them (about 60%) have been shown to eat invigorant food that they can easily get around their living area. 4. Physical Functions It has been revealed that many old people are conscious of some symptoms about their parts of body and about to percent of them suffers from neuralgia. Some measures like medical aid especially for old people need to be taken as soon as possible. As we have found that the health-keeping method of old people consists plenty of rest, proper exercise, and appropriate nutrition, we can conclude that the recreatonal and culture facilities and programs for keeping old people in good health should be developed. It is also necessary to study food that contribute to their health and develop ways to get rid of the stresses to which they are exposed in their daily life. Presides, it is natural that government found an administrative department to deal with these matters effectively.

국산 체외 충격파 쇄석기의 음향학적 특성 평가

최민주,이종수,김성삼,조성찬,양형석,손종수,천원기 제주대학교 공과대학 첨단기술연구소 2001 尖端技術硏究所論文集 Vol.12 No.2

In the study we measured and evaluated the acoustical property of a domestic spark gap type extracorporeal shock wave lithotripsy (ESWL). Altering the discharging medium between the electrodes of the shock wave generator (water, 1% an 10% NaCl electrolyte), we measured shock waveforms and sound pressure level (SPL). For the shock waves produced using the discharging medium, water, it was seen that the shock wave peak pressure went up to 70 MPa, and the SPL was in the range of 90 - 100 dB. As the concentration of NaCl increased in the electrolyte. the SPL did not change much and was shown to increase correlation with the discharging voltage. In the case of the discharging medium. 10% NaCl electrolyte, it was found that the shock amplitudes varied in a narrow range when being high in the concentration of NaCl and were large when being high in discharging voltages. While the stone fragmentation was in process, we measured the acoustic emission and compared their spectral properties.

부신 제거 백서에 티타늄 임플랜트 매식후 주위 골형성에 관한 연구

최갑림,김종렬,박봉수,성일용 대한악안면성형재건외과학회 2000 Maxillofacial Plastic Reconstructive Surgery Vol.22 No.3

The use of dental implants has increased tremendously in recent years and is expected to increase even more in the future. The successful outcome of any implant procedure is surely dependent on interrelationship of the various components of an equation that includes biocompatibility of implant material, macroscopic and microscopic nature of the implant surface, the status of implant bed, surgical technique, undisturbed healing phase and subsequent prosthetic design and long-term loading phase. The purpose of this study was to clarify the effects of adrenalectomy on the osseointegration of pure titanium implants. Seventy rats, 11 weeks of age, were divided into two groups : an adrenalectomized group and a control group. Titanium screw implant(diameter, 2.0mm ; length, 3.5mm) was placed into left tibia of 70 rats, 35 in control group and 35 in the experimental group. The rats were sacrificed at different time interval (1, 2, 3, 4, 6, 8, and 12 weeks after implantation) for histopathologic observation, histomorphometric analysis and immunohistochemistry with fibronectin and CD44 antibody. The results obtained from this study were as follows : 1.Histopathogically, findings, newly formed bone was seen at 3 weeks control group and became lamellar bone at 12 weeks. At 6 weeks, lipocytes were observed in bone marrow space. Thickness of regenerated trabecular bone increased till 6 weeks after then, that decreased gradually. 2.By histomorphometric analysis, marrow bone density and contact ratio of marrow bone to implant decreased significantly from 8 to 12 weeks in experimental group compared to control group and also total bone to implant contact ratio decreased significantly from 4 to 12 weeks in experimental group compared to control group. 3.Fibronectin immunoreactivity was very strong at 3 and 4 weeks control group. And after that reduced gradually. But it was continuously strong from 1 to 12 weeks experimental group. 4.CD44 immunoreactivity was very strong in the newly formed osteoblasts at 3 and 4 weeks control group. But it reacted minimally later. However, it reacted continuously strong from 3 to 12 weeks experimental group. From these results, bone to implant contact ratio decreased gradually from 4 weeks in adrenalectomized group compared to control group. CD44 and fibronectin immunoreactivities were strong at all times in adrenalectomized rats. Therefore, it could be stated that immature bone remained continuously for a long time and not readily proceeded into mature status.

제1요수 불완전 하반신 마비 환자에서의 기능적 전기자극에 의한 훈련 증례보고

최현주,이수영,김종문,강선화,정순열,강곤,정진상 건국대학교 의과학연구소 1996 건국의과학학술지 Vol.5 No.-

Functional electrical stimulation(FES) is known to increase muscle bulk and strength and prevent muscle atrophy in complete paraplegic patients. And other benefits include peripheral adaptations which improve muscle endurance, girth, and appearance, as well as central circulatory adaptation which enhances aerobic(cardiopulmonary) capacity. Good candidates for FES include spinal cord injured patients who have clinically complete upper motor neuron lesion between T4-T12. But we experienced incomplete L1 paraplegic patient who has improved maximal knee extension power, endurance, circumference and cross-sectional area of the thigh and the shank after FES-induced exercise for 44 weeks. So we recommend more trial of the FES-induced exercise to not only complete but also incomplete lumbar paraplegic patients.

餘暇生活 實態 推移에 관한 文獻考察

崔淙洙,韓正煥 忠北大學校師範大學附設 平生體育硏究所 1993 平生體育硏究所 論文集 Vol.6 No.-

The role and the function for the modern people are being deversified and varied in many ways owing to the material culture. With the representative books selected for the definite period, the wants I have considered the variation of the leisure are follows; 1) Accordign to the industrialization, the working hour is decreasing and leisure time is increasing, but the activity for this situation is not enough. 2) Female sex has more leisure time than male sex, but the leisure activity for female is wanting. 3) the ones who are over thirties have more leisure time than any other ages. 4) There are much different quantities of leisure time according to the kind of their vocation, so the leisure activity program for his own job is necessary. As a result of my studying for these situations. I have got the follwing conclusions. 1) The need for sports and creative recreations increasing. 2) Male is sleeping much time in sports, travel, and other activities, but female is spending her time in sleeping and domestic chore. 3) More educated people are enjoying more creative activities and sports, but less educated people are spending their time in sleeping, domestic chore, and watchig TV. A rural area has worse leisure time than a urban one an this present situation has been depended in the modernization of korea. Therefore the betterment should be made after due consideration of the difference of leisure time and quality of leisure action.

압자의 압입에 의한 치관 전장용 복합레진의 기계적 성질 평가

최원호,배태성,박광선,박종수 대한치과기재학회 2001 대한치과재료학회지 Vol.28 No.2

This study was performed to evaluate the mechanical properties of four commercially available veneering resin composites for crown (Dentacolor: DC, Artglass: AG, Esternia: ET and Targis: TG). According to the manufacturer's instructions, disc specimens were fabricated in a teflon mold giving 12mm in diameter and 1 mm in thickness. All specimens were immersed in distilled water at 37℃ for 30 days. An indentation test of 68-degree trigonal diamond pyramid was made under 98.06 mN load for 15 seconds. Hardness numbers, charateristic indentation depths, flow and permanent deformation were measured and compared statistically by ANOVA and Tukey's multiple range test. The results obtained were summarized as follows; 1.The highest hardness value of 87.4 was observed in the ET group and the lowest value of 11.8 was observed in the DC group. Hadness values showed no sinificant difference between the AG group and TG group, but others showed the significant difference beween groups (p<0.5). 2.Flow value of the ET group was significantly lower than those of the AG and TG groups of hybrid composite for crowns. 3.Percent strain during the indentation was the lowest in the DC group and the highest in the AG group, but there was no significant difference in each experimental group (p>0.05). 4.The relationship between the hardness number and flow during the indentation was a negative linear on a logarithmic scale.

유기 능동 소자 제작을 위한 유기 박막의 제작 및 전기적 특성

崔淙宣,김대엽,李榕洙 弘益大學校 科學基術硏究所 1999 科學技術硏究論文集 Vol.10 No.2

There are currently considerable interest in the applications of conjugated polymers, oligomers, and small molecules for thin-film electronic devices. Organic materials have potential advantages to be utilized as semiconductors in field-effect transistors and light-emitting diodes. In this study, pentacene thin-film transistors (TFTs) were fabricated on glass substrate. Aluminums were used for gate electrodes. silicon dioxide was deposited as a gate insulator by PECVD and patterned by reactive ion etching (R.I.E). Gold was used for the electrodes of source and drain. The active semiconductor pentacene layer was thermally evaporated in vacuum at a pressure of about 10?? Torr and a deposition rate 0.3Å/s. The fabricated devices exhibited the field-effect mobility as large as 0.07㎠/V.s and on/off current ratio as larger than 10??.

유기 전기발광소자의 주파수 의존 특성

崔淙宣,李榕洙 弘益大學校 科學技術硏究所 2001 科學技術硏究論文集 Vol.12 No.-

The admittance or impedance spectroscopy is one of the useful tools to study the equivalent circuit model of organic thin film devices and electrical properties of the film, such as dielectric relaxation and dielectric loss. We have investigated the frequency dependent characteristics of indium tin oxide/TPD/aluminum single layer device. The conductance increases with the applied DC bias in the low frequency region. This indicates that the electrical conductivity increases with the applied bias. The capacitance is nearly constant with the bias in the measured frequency region, which indicates the device acts as a parallel plate capacitor. The Cole-Cole plot of the admittances takes a one-semicircle shape, which means that the device can be modeled as a parallel resistor-capacitor equivalent circuit. We have also studied the complex permittivity of the device with the DC bias and frequency. The imaginary part of the permittivity shows the dielectric dispersion at the low frequencies and the dielectric absorption in the high frequency domain. The dispersion is a proportional to a reciprocal of the frequency. The dielectric absorption represents the relaxation peak and the dielectric relaxation time is about 2.65 μs.

국내 조혈모세포이식 환자에서 Human Cytomegalovirus gB 유전형의 분포와 질환과의 연관성 : 예비 보고

최수미,김진희,이동건,박선희,최정현,유진홍,박철민,이종욱,민우성,황응수,신완식,김춘추 대한감염학회 2007 감염과 화학요법 Vol.39 No.2

목적 : 사람 거대세포바이러스(Human cytomegalovirus, 이하 HCMV) glycoprotein B (gB)는 UL55 유전자에 의해 부호화되는 당단백으로, UL55 유전자의 염기서열변화에 따라 4가지 유전형으로 나뉜다. 본 연구에서는 국내 조혈모세포이식 환자들에서 HCMV gB 유전형의 분포와 그 특성을 알아보고, gB 유전형에 따라 특정 HCMV 질환 발생과 연관이 있는지 그 임상적 의미를 분석해 보고자 하였다. 재료 및 방법 : 동종 조혈모세포이식 환자 52명의 혈액검체 94개에 대해, Chou 등이 제시한 방법에 따라, 먼저 UL55 유전자 부위를 nested PCR로 증폭한 후, RsaI과HinfI으로 Restriction fragment length polymorphism(RFLP) 분석을 시행하였다. 결과 : gB type 1은 73.1% (38/52), gB type 2는 13.5%(7/52), gB type 3는 1.9% (1/52), gB type 1과 type 2에 의한 혼합감염은 9.6% (5/52)로 나타났다. gB type 4는 관찰되지 않았다. 1명(1.9%)에서 gB 유전형을 결정할 수 없었는데, RFLP 패턴으로 보아 Trincado 등이 제시한 gB type 7에 해당하는 것으로 생각되었고, 이 새로운 아형에 대해서는 현재 염기서열 분석 중이다. 52명 중 5명(9.6%)에서 HCMV 질환이 발생하였고, 3명에서 HCMV 폐렴, 1명에서 망막염과 위장관염, 나머지 1명에서 망막염이 발생하였다. 5명 중 HCMV 질환과 관련하여 사망한 예는 없었고, 감염된 HCMV는 모두 gB type 1이었다. HCMV gB유전형과 HCMV 질환 발생 사이에 유의한 연관성은 없었고, 단일 주에 의한 감염과 혼합감염에 따른 HCMV 질환발생 사이에도 유의한 연관성은 관찰되지 않았다. 자료 분석 중 gB type 2에 감염되어 있던 환자에서 gB type 1에 재감염 되면서 발열, 간효소 수치 상승 및 pp65 HCMV 항원혈증이 나타난 예가 있었다. 결론 : 연구결과 gB type 1이 아주 우세하고, gB type 4는 검출되지 않았으며, 혼합감염의 빈도가 비교적 낮은 분포를 보였다. 이는 외국의 보고와는 다른 국내 조혈모세포이식 환자에서의 독톡한 감염 양상으로 추정된다. 본 연구에서 HCMV gB 유전형과 질환 발생과의 연관성을 밝힐 수는 없었으나, HCMV 유전형에 대한 연구는 바이러스 감염의 발병기전이나 전파 경로 및 양식과 같은 역학적 연구에 중요한 자료가 될 것이다. 현재 더 많은 수의 조혈모세포이식 환자를 대상으로 연구가 진행 중에 있으며, 앞으로 다른 질환군의 환자나 건강한 잠복 감염자에서의 추가 연구가 필요할 것으로 생각된다. Background : Human cytomegalovirus (HCMV) glycoprotein B (gB) is the major envelope glycoprotein, encoded by the UL55 gene. Based on sequence variation in the UL55 gene, HCMV can be classified into four gB genotypes. Previous studies have suggested an association between HCMV gB genotypes and clinical outcome in the immunocompromised hosts. The goal of this study was to determine the distribution of HCMV gB genotypes and the effect of gB genotype in the developement of HCMV diseases in hematopoietic stem cell transplant (HSCT) recipients in Korea. Materials and Methods : DNA was extracted from 94 blood specimen of 52 allogeneic HSCT recipients with HCMV infection. HCMV gB genotype was determined using polymerase chain reaction to amplify a region of UL55, followed by restriction fragment length polymorphism (RFLP) analysis based on RsaI and HinfI digestion. Results : The distribution of gB types were as follows: gB1, 73.1% (38/52) of patients; gB2, 13.5% (7/52); gB3, 1.9% (1/52) and mixed infection (gB1 and gB2), 9.6% (5/52). While gB4 was not detected, a new genotype (described as gB7 by Trincado et al, 2000) was identified on the basis of their RFLP pattern. During average 708 days’ follow up period, HCMV diseases developed in 5 patients. All of them had gB1 genotype. There was no statistically significant association between the incidence of HCMV diseases and the gB genotypes. Re-infection with gB1 strain was detected in one patient who had been previously infected with gB2. This episode was associated with fever, elevated liver enzyme and positive antigenemia. Conclusion : HCMV gB1 was the dominant genotype and no gB4 was detected in allogeneic HSCT recipients in Korea, which is an unique pattern compared with the previous reports. Although we can not find significant association between the HCMV diseases and the gB genotypes, genotyping of HCMV will serve in the study of pathogenesis and transmission of this virus in transplant patients. Further study is underway with large study population.