Identification of Predictive Factors for Refractory Relapse in Small Cell Lung Cancer

( Jiwon Ryoo ),( Eung Gu Lee ),( Ah Young Shin ),( Chang Dong Yeo ),( Chan Kwon Park ),( Ju Sang Kim ),( Jin Woo Kim ),( Yong Hyun Kim ),( Hye Seon Kang ) 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.-

Background Sensitivity to initial chemotherapy is one of prognostic factors for survival in small cell lung cancer (SCLC) patients. However, risk factor contributing to progression to refractory relapsed SCLC have not been evaluated. We discussed predictive factors for refractory relapsed SCLC by longitudinal cohort analysis. Methods This study used a lung cancer cohort of the Catholic Medical Center between November 2014 and March 2020. Among 221 patients diagnosed as SCLC, 86 patients who did not receive active treatment or receive only radiotherapy or discontinued 1st line treatment were excluded. Results A total of 135 patients were included in analysis, and 28 (20.75%) were refractory relapsed (recurrence within 3 month), and 107 (79.25%) were sensitive relapsed (recurrence after 3 month). Clinically, the proportion of lung to lung metastasis was higher in refractory relapse group (14.3% vs 1.0%, p=0.001), but that of extensive disease was not different between two groups. In laboratory findings, the proportion of anemia (82.1% vs 55.1%, p=0.009), hypoalbuminemia (57.1% vs 29%, p=0.005) was higher in refractory relapse group. The mean value of LDH (789.54±135.16 vs 485.13±24.32, <0.001), D-dimer (6.42±15.81 vs 2.40±4.48, p= 0.048) were higher, and that of CEA (6.72±7.78 vs 28.27±83.73, p=0.031) was lower in refractory relapse group. OS was significantly shorter in refractory relapse group (186.28 ± 34.45 vs. 46.15 ± 28.70, log rank <0.001) (Fig 1). In Cox proportional hazards model, anemia (hazard ratio [HR]: 3.941; 95% confidence interval [CI]: 1.203-12.913, p=0.024), hypoalbuminemia (HR: 3.574; 95% CI: 1.168-10.939, p=0.026), Higher LDH level (HR: 1.002; 95% CI: 0.991-1.014, p=0.013) were independent predictive factors for refractory relapse. Conclusions Anemia, hypoalbuminemia and higher LDH level are suggested as independent risk factors for refractory relapse in SCLC patients.

Prognostic Factor of Respiratory Failure in Tuberculosis

( Jiwon Ryoo ),( Jongmin Lee ) 대한결핵 및 호흡기학회 2023 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.136 No.0

Clinical Impact of COVID-19 Pandemic on Patients’ Care with Tuberculosis Infection: A Single Center Study 2019~2020

( Jiwon Ryoo ),( Ji Young Kang ),( Hyeong Jun Cho ),( Jongmin Lee ),( Chinkook Rhee ),( Seung Joon Kim ),( Seok Chan Kim ),( Young Kyoon Kim ),( Kyongmin Sarah Beck ),( Jun-pyo Myong ) 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.-

Background On COVID-19 pandemic, patients who have respiratory symptoms have less access to hospital and early treatment is difficult. We investigated the clinical impact of COVID-19 on management in patients with tuberculosis in a longitudinal cohort analysis. Methods This study was conducted retrospectively in Seoul St. Mary hospital between January 2019 and December 2020. Among 500 TB subjects, 52 patients who did not take an initial diagnosis with TB in our hospital were excluded. Results Out of 448 patients, 267 (59.6%) were diagnosed as TB in 2019 and 181 (40.4%) were diagnosed in 2020. The duration of from symptom onset to diagnosis was not distinctive between in both group. But the proportion of hospital admission related with TB infection increased after COVID-19 epidemic (38.7% vs 62.4%, p <.0001). We further analyzed in subgroups diagnosed with pulmonary TB. The patients with pulmonary TB were higher in 2019 than in 2020 (59.12% vs 40.88%, p< 0001). The average age, history of tuberculosis were similar between two groups. The portion of having underlying diseases was increased in the 2020 group with pulmonary TB (59.04% in 2019 vs 70.77% in 2020, p= 0.0398). The percentage of AFB stain positivity and TB involved area in chest X-ray were higher and more severe in the 2020 group, diagnosed with pulmonary TB after COVID-19 pandemic. TB treatment outcome was contrasting between two groups. Favorable outcome including cure or completion of TB showed higher in the 2019 than in the 2020 (Cure, 12.5% vs 10%, p= 0.0027; treatment completion, 65.9% vs 50%, p=0.0027). Conclusions In pulmonary TB, higher mycobacterial TB burden, more extensive area of TB in Chest X-ray, lower rate of treatment outcome were revealed in the 2020 patients than in the 2019, suggesting that COVID-19 pandemic affected detrimental to the patients’ care with TB infection.

South Korean Culture Goes Global : K-Pop and the Korean Wave

김은미,Jiwon Ryoo 한국사회과학협의회 2007 Korean Social Science Journal Vol.34 No.1

This paper is an attempt to understand the explosive consumption of South Korean cultural exports in Asia, and its reproduction in South Korea. The more commonly available explanations about the success of Hallyu, which cannot adequately explain why Hallyu has taken Asia by storm while popular cultures from other Asian nations have not, include the following: (1) cultural proximity; (2) common historical and cultural legacy; (3) common 20th century experience of rapid industrialization in the region; (4) rapid increase in intra‐regional trade, investment, tourism, etc.; and (5) the development of information technology (IT) industry and other modern industries in South Korea. We offer three alternative scenarios to help explain Hallyu’s success using global and local cultural explanations. First, Hallyu is analyzed from the perspective of an alternative form of globalization of culture from the South implying the diversification of world cultures. Neither rejecting nor reacting to the dominant cultures of the West, we postulate that Hallyu is more an alternative and revision of the US‐dominated cultural globalization. Second, taking a more region‐bound perspective, we analyze whether Asia’s history of colonialism and the fight for supremacy between two regional super powers ─i.e., Japan and China ─, have led South Korea to become a more palatable cultural hegemon in the region. Third, the paper uses the Korean concept of “Hanp’uri” (dissolution of “Han”) to understand how Hallyu has been embraced in South Korea as a source of national pride and helped its reproduction. Finally, we argue that the future of Hallyu will rest on whether it can become identified as a new world culture with distinct traits of its own and enrich the world’s cultural scene.

장소 맥락에 따른 로봇 얼굴 디자인에 대한 사용자 인식 차이 ‑ 공공장소와 사적장소를 중심으로

윤지선(Yoon, Jisun),류한영(Ryoo, Han Young),최지원(Choi, Jiwon),정승은(Chung, Seungeun) 인제대학교 디자인연구소 2021 Journal of Integrated Design Research (JIDR) Vol.20 No.1

연구배경 오늘날 로봇들은 인간의 감성적인 부분까지도 보살필 수 있는 존재로 주목받으며 다양한 서비스 분야에 적용되고 있다. 이러한 서비스 로봇들의 외형을 살펴보면 대부분 인간형 디자인을 적용하고 있으며, 공통적으로 얼굴이 있다는 특징을 지닌다. 로봇에게 있어 얼굴이 중요한 이유는 사용자들이 이들과 상호작용할 때 가장 먼저 마주하게 되는 부분이기 때문이며, 로봇에 대한 첫인상을 결정하는 데 가장 큰 영향을 미치기 때문이다. 또한 인간의 대면 상호작용에 있어 공공장소와 사적장소로 분류되는 장소 맥락은 상호작용의 결과에 주요한 영향을 미치는 요소라 할 수 있는데, 이러한 사실은 인간-로봇의 상호작용의 과정에도 동일하게 적용 가능한 사실로 판단된다. 연구방법 다양한 수준으로 나타나고 있는 인간형 로봇의 얼굴 디자인을 얼마나 인간적으로 느껴지는 지에 따라 분류하였으며, 그 분류를 활용하여 공공장소와 사적장소에서 수준별 로봇의 얼굴들이 호감도와 지각된 유용성에 대해 어떻게 다르게 인식되는지와 특정 수준의 로봇 얼굴 디자인에 대한 인식이 맥락에 따라 차이가 있는지 살펴보았다. 연구결과 수준별 분류 조사 결과 로봇의 얼굴 디자인을 인간적인 정도에 따라 5개의 수준으로 분류할 수 있었으며, 이에 대해 가장 추상적인 디자인부터 가장 인간적인 디자인까지를 수준1에서 수준5로 정의하였다. 장소 맥락에 따라 수준별 로봇의 얼굴에 대한 호감도 인식을 분석한 결과, 공공장소에서는 수준2, 수준4가 호감도가 높은 그룹으로 분류되었고, 사적장소에서는 수준1, 수준2, 수준4가 호감도가 높은 그룹으로 분류되었다. 수준1의 경우 장소 맥락에 따른 호감도의 차이가 통계적으로 유의미하게 나타났다. 장소 맥락에 따라 수준별 로봇의 얼굴에 대한 지각된 유용성 인식을 분석한 결과, 공공장소에서는 수준2, 수준4가 지각된 유용성이 높은 그룹으로 분류되었으며, 수준3과 수준4는 지각된 유용성이 중간인 그룹에도 포함되었다. 사적장소에서는 수준1, 수준2, 수준3, 수준4는 지각된 유용성이 높은 그룹으로 분류되었다. 하지만 로봇의 장소 맥락에 따른 지각된 유용성의 차이는 통계적으로 유의미하지 않았다. 결론 본 연구의 결과를 통해 사용자들은 로봇 얼굴의 인간적인 정도를 판단하는 데에 얼굴형보다 얼굴요소 개수에 영향을 받지만, 공공장소와 사적장소에서의 호감도나 지각된 유용성의 경우 얼굴 요소개수와 상관없이 인상을 좌우하는 얼굴형이나 얼굴 요소 간의 비례 등에 영향을 크게 받는 것을 확인할 수 있었다. 또한 사적장소에서는 공공장소에서와 달리 추상적인 로봇 얼굴 디자인이 거부감을 낮추는 요인으로 작용하여 호감도가 높은 것을 확인할 수 있었고, 지각된 유용성의 경우 장소 맥락에 따른 인식의 차이가 없음을 알 수 있었다. 이는 향후 로봇 얼굴을 디자인할 때 사용자가 로봇을 대면하게 되는 장소와 로봇 얼굴 인상에 대한 고려가 필요함을 시사한다. Background Today’s robot has been recognized as a being to care human emotion, and applied to various service fields. Most service robots have human-like design and a human face in common. Designing a face for a robot is important in human-robot interaction because user faces its face at first, and it has the greatest effect on determining the first impression. Furthermore, the context of a place which can be classified as public and private is a major factor for the outcome of the human’s face-to-face interaction, and this seems to be equally applicable to the process of human-robot interaction. Methods This research categorized human-type robot face designs into various levels of similarity with human face, and explored how robot faces are perceived differently for likeability and perceived usefulness in public place and private place and differences of users’ perception about different levels of robot faces depending on the context of places using levels of robot faces, which were derived from the categorizing research. Result In classification research, designs of robot faces were categorized into 5 different levels. The least human-like face design was defined as level-1, and the most human-like face design was defined as level-5. As a result of analyzing the likeability of the robot face according to the context of the place, level-2 and level-4 were classified as high group in public places, and level-1, level-2, and level-4 were classified as high group in private places, In the case of Level 1, the difference in likeability according to the context of the place was statistically significant. As a result of analyzing the perceived usefulness perception of the robot face according to the context of the place, level-2 and level-4 were classified into groups with high perceived usefulness in public places, and level-3 and level-4 were also included in middle group. In private places, level-1, level-2, level-3, and level-4 were classified as high group. However, the difference in perceived usefulness according to the context of the place of the robot face was not statistically significant. Conclusion Through the results of this study, users are influenced by the number of facial elements rather than the face shape in determining the humanity of the robot"s face. But in the case of likeability and perceived usefulness in public and private places, they are more influenced by the proportionality between facial elements. In addition, we find that in private places, unlike in public places, abstract robot face design serves as a factor in reducing repulsion. This suggests that it is necessary to consider the place where the user faces a robot when designing the robot face in the future.

컨피던스를 활용한 준지도학습

민영조(Youngjo Min),류광록(Kwangrok Ryoo),김지원(Jiwon Kim),서준영(Junyoung Seo),이규성(Kyusung Lee),김승룡(Seungryong Kim) 대한전자공학회 2022 대한전자공학회 학술대회 Vol.2022 No.6

Intermittent Fasting Attenuates Allergic Airway Disease in OVA Induced Obese Mice via Interplay Between Leptin and Innate Lymphoid Cells

( Ji Young Kang ),( Jung Hur ),( Jiwon Ryoo ),( Hyungjoon Cho ),( Jongmin Lee ),( Hwa Young Lee ),( Chin Kook Rhee ),( Seung Joon Kim ),( Seok Chan Kim ),( Sook Young Lee ),( Soon Seog Kwon ),( Young 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.0

Purpose As obesity is a crucial risk factor in asthma, diet control such as fasting could be beneficial effect in the disease control. Recently innate lymphoid cells (ILCs) are known early pivotal player in asthma pathogenesis and obesity. We investigate to the effect of intermittent fasting and the role of ILCs as its mechanism in an obese allergic asthma model. Methods In 3-week- old C57BL/6, obese asthma was induced by high-fat diet (HFD) for 8 weeks with subsequent ovalbumin (OVA) administration for 8 weeks. Intermittent fasting (IF) group skipped a meal for 24 hours from 12 weeks to 16 weeks. Typical parameters of asthma were measured. Adipokines such as leptin/adiponectin and ILCs profiles were examined. Results In the HFD-OVA group, pathognomic findings of asthma including AHR, airway inflammation, submucosal gland hyperplasia, and collagen deposition were observed prominently. Leptin level in serum increased whereas adiponectin decreased. Expression of ILC2 and ILC3 in the lung tissue were elevated. In the HFD-OVA-IF group, AHR decreased significantly and pathologic findings in asthma by PAS stain and hydroxyproline assay ameliorated. After IF, the concentration of leptin diminished, but that of adiponectin did not change remarkably. Notably, airway inflammation and type 1/2 cytokines increased without any statistical significance. The infiltration of ILC2 and ILC3 in the lung reduced in the HFD-OVA-IF group Conclusion This study reveals that intermittent fasting attenuates AHR and pathologic features such as submucosal gland hyperplasia and collagen deposition, not airway inflammation in an obese asthma model via a modulation of leptin and ILCs.

Effect of Low Dose Pirfenidone on Survival and Lung Function Decline in Patients with Idiopathic Pulmonary Fibrosis (IPF): Results from a Real-life Study

( Eung Gu Lee ),( Tae-hee Lee ),( Jiwon Ryoo ),( Jung Won Heo ),( Hye Seon Kang ),( Soon Seog Kwon ),( Yong Hyun Kim ) 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.-

Purpose IPF is a specific form of chronic and progressive fibrosing interstitial pneumonia of unknown cause. Pirfenidone has been proven to be effective and safe in the treatment of IPF. However, the dose of pirfenidone used in Korea is usually lower than the dose established in global clinical trial. The aim of this study was to evaluate the efficacy of relatively lower dose of pirfenidone on disease progression and survival of IPF patients in real-world. Methods This is a retrospective observational study based on IPF cohort in which IPF patients were enrolled at the time of diagnosis at a single center from 2008 to 2018. The clinical and laboratory data of these patients were collected prospectively using an IPF-specified protocol. We compared the clinical characteristics, overall survival and pulmonary function decline of the patients treated with variable dose of pirfenidone with patients not treated with pirfenidone. Results Of the total 295 patients with IPF, 100 (33.9%) received pirfenidone and 195 (66.1%) were not prescribed antifibrotic agents. Of the 100 patients who received pirfenidone, 24% (24/100), 50% (50/100), and 26% (26/100) were given 600mg, 1200mg, and 1800mg of pirfenidone, respectively. In unadjusted analysis, the survival of the patient group using pirfenidone was significantly better than that of the group not using pirfenidone (HR: 0.69, 95% CI: 0.48-0.99, p = 0.04). After adjusted for age, gender, BMI and GAP score, the survival remained higher in the patients using pirfenidone (HR: 0.56, 95% CI: 0.37-0.85, P = 0.006). In the analysis of pulmonary function, the decline in FVC, FEV1 and DLCO was significantly lower (p = 0.0068, p = 0.0007 and p = 0.0034, respectively) in the group using pirfenidone compared to the group not using it. Conclusion Low dose pirfenidone provided beneficial effects on survival and pulmonary function decline in real-life practice.

신뢰도 기반 영상 정합

민영조(Youngjo Min),류광록(Kwangrok Ryoo),김지원(Jiwon Kim),최수형(Suhyung Choi),조규선(Kyusun Cho),전민혁(Minhyek Jeon),김승룡(Seungryong Kim) 대한전자공학회 2022 대한전자공학회 학술대회 Vol.2022 No.6