Selenium 이 마우스 혈중 마크로파지의 탄소입자 탐식능에 미치는 영향

최지선,표명윤 숙명여자대학교 약학연구소 2004 약학논문집-숙명여자대학교 Vol.20 No.-

Effects of Selenium (Se) on the carbon clearance activity of macrophage in blood were investigated in mice. Se was orally administered in drinking water for 18 days (1ppm or 3ppm) or intraperitoneally with a single dose of 0.05, 0.25, 0.5mg'kg b.w. to normal and CY-treated ICR mice. Cyclophosphamide (CY) was injected i.p. to mice with a single dose of 20 mg/kg b.w. on the last day of Se-administration. Carbon suspension was injected i.v. at 0.01ml/g b.w. in mice 48hrs after the administration of experimental chemicals. Blood was collected from retro-orbital venous plexus of mice 5min, 10min after injection of carbon suspension and carbon clearance (t_(1/2), min) was assessed. The treatment of Se alone slightly increased carbon clearance activity of circulating macrophage when compared with control group. Carbon clearance activity was significantly enhanced in Se plus CY when compared with the treatment of CY alone. These results indicate that Se seemed to significantly restore the reduction of phagocytic activity induced by CY.

냉수 가글링과 젖은 거즈를 이용한 구강간호가 비강수술 환자의 갈증 및 구강상태에 미치는 효과 비교

이인선,심명숙,나은희,강재연,김지혜,황민영,윤계숙,성영희 병원간호사회 2006 임상간호연구 Vol.11 No.2

Purpose: This study researched the comparison of oral care methods between the wet gauze and the water gargling for nasal surgery patients. It executed to find out more effective method to relieve thirst. Method: We divided two groups; the wet gauze and the cold water garaling. We assessed patient's oral cavity state and sebjective oral dryness for three times; firstly before the intervention, secondly 15 minutes after 1st intervention and thirdly 15 minutes afrer 2nd intervention. Result: As the intervention, there was no difference on oral condition subhectvely, but there was a difference on thirsty reduction objectively. As the aral dryness has relieved through both methods. It showed the repeated gargling helps more to relieve oral dryness effectively than the wet gauge. At PACU, post nasal surgery patient's oral dryness was decreased with gauze more than two times, patient's oral dryness was relieved. Whereas the dryness was relieved after applying the cold water gargling for just one time. Conclusion: The water gargling is more effective intervention than the wet gauze. Especially, oral dryness was improved in the section of objetive oral assessment index.

쌓기 활동에서 유아들의 친 사회적 행동 출현에 대한 맥락적 이해

박화윤,마지순,최재숙 한국영유아보육학회 2002 한국영유아보육학 Vol.0 No.31

The purpose of this ethnographic study is to explore the emergent context of prosocial behavior and to find the children's character promoting of prosocial that within the area of block. The result are as follows: 1) It appeared that emergent context of prosocial; behavior is completion of structures, participation of symbolic play using them and clean-up. 2) It appeared that children's character promoting prosocial behavior that appearence of altruism by children's perspective-taking, exchage of idea and problem-solving.

신규간호사와 프리셉터가 인지하는 프리셉터의 교수효율성 비교

김지양,김영선,김춘실,박현숙,신미영,윤연숙,조유숙,박미미,유문숙 한국간호과학회 간호행정학회 2009 간호행정학회지 Vol.15 No.2

Objective: The purpose of this study was to compare preceptors and new graduate nurses on their perception of preceptor teaching effectiveness. Methods: The participants were 90 new nurses and 90 preceptors who worked in A medical center. The data were collected from July 1 to September 30, 2008. A cross-sectional descriptive survey was done using a structured questionnaire. Results: New nurses' perception (4.07±.44) of the preceptor teaching effectiveness was significantly higher than perception of the preceptors (3.57±.37). Fifty five percent of new graduate nurses reported a lack of coherence in the preceptor's practice guidelines. For 5 causal factors classified on the teaching effectiveness, the factor of 'Professional knowledge and ability' showed the highest score, but 'Interpersonal and communication skill' got lowest score for both group. Preceptors responded that they did not have enough time to teach well because of their heavy workloads. Conclusions: These results suggest that the preceptors need appropriate compensation and education opportunities, and new graduate nurses need consistent education by the teaching professionals. Therefore, it is important to give preceptors full charge of the preceptorship. Also, it will be necessary to develop education programs to enhance interpersonal and communication skill for preceptors and new nurses.

現行 稅法上 更正請求制度에 관한 硏究

정지선,박정우,육윤복 한국기업법학회 2004 企業法硏究 Vol.16 No.-

Texes are imposed through formation and decision of tax payment. There are government imposition way and self-assessment way on the decision method of tax payment, and most taxes are confirmed by self-assessment way because exuviating in traditional decision method in modern taxes. Tax payment by self-assessment system is primary decision method of the tax payer because he knows his assessment well, and reserve decision right of taxation government office to secondary or complemental position. These tax payment system by self-assessment is accepted in the U.S.A. traditionally, and say that is own imposition system in meaning that tax payment establishes oneself standard of assessment and amount of a tax. It is most situation, indeed, taking tax payment by self-assessment way individual income tax, corporate income tax, education tax, traffic tax and etc, in Korean tax system. These self-assessment system can be thought that is suitable to tax payment usage which is democratic because it establishes own tax amount, but when tax return is reported overmuch by mistake of statute etc, it creates the problem to relieve very hardly. So, when taxpayer files overpaid taxes or littleness deficit amount of money, we introduced the claim system for reassessment since 1995 to correct this in case do. This claim system for reassessment has various kinds of problems because the enforcement time is short up to now and the research is not gone abuzz. Therefore, this research examines problems of current the claim system for reassessment and compares with foreign tax laws and groped the improvement way. The improvement ways of current claim system for reassessment are as following if they list important things. First, it is problems about extension of claim period for reassessment. Current claim period for reassessment is that is within 2 years from the date the return was filed in general claim for reassessment's case, and in the case of claim for reassessment by after flare reason arrive within 2 months from a day that reason happens. This can be thought that the period is insufficient in right relief because correspond to short term. Therefore, in general claim for reassessment's case, the period must be extended within 5 years from the date the return was filed, and must be extended within 6 months from a day that reason happens encountering in the claim for reassessment by reason that is after flare. Second, it is problem about unclearable nature of reason in the claim for reassessment by reason that is after flare. Currently, in the case of the claim for reassessment by reason after flare, a analytic part that become an issue is when it cancels contract by inevitable reason, whether correspond to the reassessment claim's subject, and when it correspond to the reassessment claim's subject, inevitable reason usually intends cancellation of sum, that is deciding each differently about the reassessment claim's target in reason after flare time at time of cancellation of sum in case of transfer income tax, gift tax and acquisition tax. Third, it is problem by pleading not guilty of reassessment claim system in local tax law. Current local tax is recognizing right redress through correction report, application and so on. But the claim system for reassessment is not recognized by local tax. As such result, when taxpayer overpays local taxes through mistake, the method of the right relief is blocked effectively in that case and is implying various kinds irrational standpoint being real condition. Therefore, local tax law have to introduce not only general claim system for reassessment but also reassessment claim system by reason after flare as soon as possible.

마우스에서 Selenium 이 Natural Killer Cell 활성능에 미치는 영향

최지선,표명윤 숙명여자대학교 약학연구소 2003 약학논문집-숙명여자대학교 Vol.19 No.-

Effect of Selenium (Se) on natural killer (NK) cell activity of spleen in mice was investigated. Se lppm or 3ppm was orally administered to ICR mice in drinking water for 18 days. Cyclophosphamide (CY) was injected i.p. to mice with a single dose of 10 mg/kg b.w. on the last day of Se-administration. Spleen cells were obtained 24h after CY-injection and used as effector cells. NK cell cytotoxicity (%) was assessed in a 4h ^(51)Cr-release assay against YAC-1 target cells. The treatment of Se alone significantly increased NK cell cytotoxicity at low dose (lppm), but decreased at high dose (3ppm) when compared with control group. The NK cell activity (LU_(30)) was significantly enhanced in Se (lppm) plus CY, but inhibited in Se (3ppm) plus CY when compared with the treatment of CY alone.

복막투석복막염 환자에서 발생한 창자벽공기증 1예

정선영,나지훈,최윤정,고성애,조규향,박종원,도준영,윤경우 영남대학교 의과대학 2009 Yeungnam University Journal of Medicine Vol.26 No.1

Peritonitis is a serious problem in patients undergoing peritoneal dialysis. Rarely pneumatosis intestinalis can occur as a complication of this infectious process. Pneumatosis intestinalis is a potential life threatening condition with a challenging management. The mortality of peritoneal dialysis patients with pneumatosis intestinalis secondary to mesenteric ischemia is almost 100%. We describe a rare case of pneumatosis intestinalis in a peritoneal dialysis patient who developed Staphylococcus aureus peritonitis which was initially treated with appropriate antibiotics. Since initial response to therapy was not achieved, an abdominal computerized tomography was done which revealed a pneumatosis intestinalis. A laparotomy was performed and small bowel necrosis was seen. A segmented resection with ileostomy, jejunostomy was done. Though surgical treatment was performed, the patient died in 2 weeks after admission. Pneumocystitis intestinalis in peritoneal dialysis peritonitis is a uncommon complication which requires prompt evaluation to rule out mesenteric ischemia as it carries a high mortality and its management will be surgical.

Selenium이 마우스의 일차 체액성 면역반응과 접촉성 과민반응에 미치는 영향

최지선,표명윤 숙명여자대학교 약학연구소 2005 약학논문집-숙명여자대학교 Vol.22 No.-

Effects of Selenium (Se) on the primary humoral immune response and contact-delayed type hypersensitivity (CDTH) to 2,4-dinitro-l-fluorobenzene (DNFB) in normal and cyclophosphamide (CY)-treated mice. Se was orally administered via drinking water for 18 days (1ppm or 3ppm) or via intraperitoneal (i.p.) injection with a single dose of 0.05, 0.25, 0.5 mg/kg b.w. to normal and CY-treated mice. CY was i.p, injected to mice with a single dose of 10 or 50 mg/kg b.w. on the last day of Se-administration. When only Se was administered simultaneously with or after immunization, splenic IgM plaque forming cells (PFC) and hemmaglutinin-titer (HA-titer) in mice were not changed, however, decreased in the mice which were administered with high dose of Se before immunization. In addition, they were significantly increased in the concomitant treatment of CY and Se, compared to them in the only CY-treatment. Se significantly decreased DNFB-induced CDTH and inhibited the CY-enhanced CDTH. These results indicate that Se may inhibit the immunotoxicity induced by CY.

새로운 백금착체인 tetrachloro [bis(2-chloroethyl)ethylenediamine-N,N']platinum(IV)과 cisplatin이 마우스의 면역반응에 미치는 영향

표명윤,유경미,최지선,오현정 숙명여자대학교 약학연구소 1993 약학논문집-숙명여자대학교 Vol.9 No.-

Effects of a new platinum complex, tetrachloro-[bis(2-chloroethyl) ethylenediamine-N,N']platinum(IV)[PtCl₄-2(CEen)] and cisplatin on the immune response were investigated. Male ICR mice were treated at the respective LD50(20% or 60% LD50) of cisplatin and PtCl₄-2(CEen). The results were as following : LD50 of PtCl₄-2(CEen) for male ICR mouse was 122.5mg/kg(i.p.) and higher than cisplatin(16.3mg/kg, i.p.). Body-, spleen-, thymus-, liver-weight, number of WBC and RBC were reduced dependently on the dose and day of administeration of cisplatin and PtCl₄-2(CEen). But these toxicities produced by PtC^-^CEen) appeared to be relatively less and to improve faster than by cisplatin. The titers of hemagglutinin and hemolysin to SRBC in mice received cisplatin and PtCl₄-2(CEen) were decreased significantly and independently on the day of antigen injection. Cisplatin and PtCl₄-2(CEen) stimulated significantly contact hypersensitivity to DNFB when administered prior to sensitization(DNFB), but suppressed slightly when administered after sensitization.

이대생의 체력 및 건강도에 관한 조사 연구

강지용,김종선,윤남식,이희순,한성일 梨花女子大學校 韓國生活科學硏究院 1975 韓國生活科學硏究院 論叢 Vol.15 No.-

The following results were obtained from the survey of health status and the measurements of physical fitness of 914 students of Ewha Womans University by means of CMI, which were conducted from October 7 to October 27 for three weeks. The purpose of the research mainly consists in the improvement of university health adiministration and of physical education. A. Survey of Health Status 1. The average Number of Complaints are 26.8 for items A-L, 15.3 for items M-R, and 42.1 for items A-R. In terms of classes, the Numbers of Complaints are revealed on a decreasing scale as follows: sophomores, 44.0, the highest; seniors, 42.6; freshmen, 42.1; and juniors, 40.5. 2. Among all the items, the following figures of average Numbers of complaints per person are conspicuous: the seniors have shown 5.3 for item D, which is the highest; and the sophomores, 0,7, which is the lowest. Among the physiological item, D, which corresponds to the ailments of digestion system, shows the highest rate; and among the items for mental diseases, item M, which corresponds to non­adjustment, is 5.2, the highest. 3. The percentiles on the lower echelons of the Number of Complaints are the following: 26.1% for freshmen is the highest; 22.2% for sophomores, the lowest. The sophomores have shown 27.1%, the highest figure, of students who have Number of Complaints of four or above. 4. The percentile figures of 10 or above of Number of Complaints are displayed by seniors with 2.4% and by sophomores with 1.5%. On the other hand, the percentile figures of 80 or above are revealed by seniors with 5.4% and by sophomores with 5.3%. B. Physical Fitness Measurements The figures for the physical fitness measurements are found as given below: 1. Pull­up Freshmen 18.4 seconds Juniors 9.3 seconds Sophomores 7.5 seconds Seniors 7.0 seconds 2. 100 Meters Dash An approximation of 19 seconds is recorded by freshmen, and the tendency is to be slower as the years go up. 3. Sit­ups The freshmen recorded 13 sit­ups, and the tendency is to be fewer as the years go up. 4. Throwing An approximation of 19 meters is marked by freshmen, and the tendency is to be shorter as the years go up. 5. Long Jump The freshmen marked 249.5 centimeters, and the tendency decreases as the years go up. 6. 800 Meters Run 4'1"8"'(4 minutes 1 seconds 8 points) is obtained for freshmen, and the tendency is to be slower as the years go up. 7. Shuttle Run 12.5 seconds is recorded for freshmen, and the tendency is to be slower as the years go up. 8. Trunk Flexion 18 centimeters is marked by freshmen, and the tendency is to be decreasing as the years go up.