비안와대뇌형 모균증 치험 3례

문영일,김종남,홍순관,이지애,정옥경,김문정 梨花女子大學校 醫科大學 醫科學硏究所 1997 EMJ (Ewha medical journal) Vol.20 No.3

Rhinocerebral mucormycosis is a well-described fulminant fungal infection that typically presents in a rapidly fulminant manner. This condition is more likely to occur among patient with diabetes mellitus, malignant tumors, who have long-term steroid treatment, or who suffer from some debilitating diseases. We report 3 cases of rhinoorbitocerebral mucormycosis, all suffered from diabetes mellitus. In all 3 cases, endoscopic sinus surgery was done and the antifungal agent(amphotericin B) was administered intravenously, and two patients died. One survivor who had focal extension of paranasal sinus and orbit, required one surgical intervention without orbital exenteration and he is alive without recurrence disease. The severity of the disease is probably dependent upon the gost resistance to the invasion of phycomycetes. Early diagnosis and immediate, effective treatment are the key for cure of the disease.

말기 위암 외래 환자에게 제공된 통증관리의 염려 및 주저정도에 미치는 효과

공성화,이상홍,정자현,김지영,이수연,김순애 임상간호사회 2004 임상간호연구 Vol.10 No.1

Purpose: This study was designed to evaluate the effect of cancer pain-management-education on the concerns and hesitancy of pain-management in out-patient of terminal gastric cancer. Method: 24 terminal gastric cancer patients who had not surgery, were assigned to the control group and 24 were assigned to the experimental group receiving pain-management-education. As Measurement-instrument of concern on pain-management and questionnaire on degrees of hesitancy were used the questionnaire developed by Ward( 1993) and translated by Kim Hong-Soo(1998). Data were analyzed per descriptive analysis, x²-test and t-test with the SPSS 10.0 program. Result: Degrees of concern of cancer-patient on pain-management between experimental-group and control-group showed significant difference: Experimental-group changed from 2.52 to 1.13 point(maximum 5 point) and control-group from 2.59 to 2.40 point(p=.000). Degrees of hesitancy of cancer-patient on pain-management between two groups showed significant difference. Experimental-group changed from 2.33 to 1.35 point and control-group from 2.77 to 2.52 point(p=.000). Conclusion: Above findings showed that pain-management-education reduces the concern and hesitancy on pain-management in out-patient of terminal gastric cancer. We conclude that the pain-management-education in this study was identified the effective nursing program.

각이등분법 및 평행법에 의한 전악구내 표준 촬영시 두경부 피부 흡수선량 비교

유명진,김현자,도시홍,나경수,김애지 大韓口腔顎顔面 放射線學會 1990 Imaging Science in Dentistry Vol.20 No.2

This study was performed to measure the skin absorbed doses from full mouth standard intraoral radiography(14 exposures) in bisecting angle and paralleling techniques. Thermoluminescent dosimeters were used in a phantom. Circular tube collimator(60mm in diameter, 20cm in length) and rectangular collimator(35mmX44mm, 40cm in length) were set for bisecting angle and paralleling techniques respectively. All measurement sites were classified into 8 groups according to distance from each point of central rays. The results were as follows: 1. The skin absorbed doses from the paralleling technique were significantly decreased than those from the bisecting technique in both points at central ray and points away from central ray. The percentage rates of decrease were greater at points away from central ray than those at central ray. 2. The skin absorbed doses at the lens of eye, parotid gland, submandibular gland and thyroid region were significantly decreased in paralleling techniuqe, but those of the midline of palate remained similar in both techniques. 3. The highest doses were measured at the site 20mm above the point of central ray for the mandibular premolars in bisecting angle technique and at the point of central ray for the mandibular premolars in paralleling techniques. The lowest doses were measured at the thyroid region in both techniques.

브랜딩·스타일링·마케팅을 결합한 스페이스 디자인 프로세스 연구 - 작품‘Fill the Red, Feel the Red'를 중심으로 -

은다솜,장효실,최해원,홍지현,이진민,장미정,이성애 숙명여자대학교 디자인연구소 2018 숙명디자인학 연구 Vol.25 No.-

본 연구는 디자인 분야와 마케팅 분야의 전략을 종합하여 전략적 연결점을 찾아내 요소들 간 융합을 이루는 사례를 제시하여 브랜드·스페이스·마케팅에서 새로운 방향성과 아이디어를 제시하는데 목적을 둔다. 이에 본 연구는 2017년 9월~12월까지 ㈜애경과 산업 연계하여 진행된 숙명여대 환경디자인학과 ‘브 랜딩·스타일링·마케팅’ 교과목에서 도출된 ‘fill the red, feel the red’ 프로젝트를 마케팅 및 디자인 프로세스, 결과물을 도출하여 그 과정들을 밝힌다. 아울러 본 연구는 브랜드 스페이스 마케팅에 대한 이론적 고찰을 통해, 브랜드 스페이스(팝업스토어)를 개발 및 스타일링하며 ㈜애경의 화장품 브랜드 ‘LUNA’를 브 랜딩, 스타일, 마케팅적 측면에서 종합적으로 연계하여 도출되는 과정들을 제안함으로서 향후 브랜드 스페이스 디자인과 마케팅 분야에 체계적이고 창의적인 방법들로 결과물을 도출하는데 기초자료로 활용하는데 의의가 있다.

정신분열병의 유전적 고위험군에서 인지, 정서 및 사회기능 연구

이경진,위휘,유소영,이애라,송지연,하태현,홍경수,김명선,권준수 大韓神經精神醫學會 2006 신경정신의학 Vol.45 No.1

Objectives : Vulnerability marker in biological relatives of schizophrenia may be very useful in identifying the propensity for the development of schizophrenia. This study suggests that the relatives at risk for genetically developing schizophrenia have impairments in several domains of cognition, social function and affective function as a vulnerability marker. Methods : A neurocognitive function test, a social function test and an affective function test were administered to fifteen healthy relatives from families with two or more patients with schizophrenia (geneticallly high risk subjects). Fifteen healthy controls matched for age and gender were recruited in this study. Results : Compared to the control subject, the genetic high risk subjects performed significantly more poorly in the selective attention and recall memory of neurocognitive function. The high dsk subjects also had lower scores in independence-performance and independence-competence of the social function test and emotion control of the affective function test. Conclusion : Selective attention, recall memory, independence-performance, independence-competence and emotion control ability may be a valuable marker for genetic study of schizophrenia.

EphA2 Receptor Signaling Mediates Inflammatory Responses in Lipopolysaccharide-Induced Lung Injury

Hong, Ji Young,Shin, Mi Hwa,Chung, Kyung Soo,Kim, Eun Young,Jung, Ji Ye,Kang, Young Ae,Kim, Young Sam,Kim, Se Kyu,Chang, Joon,Park, Moo Suk The Korean Academy of Tuberculosis and Respiratory 2015 Tuberculosis and Respiratory Diseases Vol.78 No.3

Background: Eph receptors and ephrin ligands have several functions including angiogenesis, cell migration, axon guidance, fluid homeostasis, oncogenesis, inflammation and injury repair. The EphA2 receptor potentially mediates the regulation of vascular permeability and inflammation in response to lung injury. Methods: Mice were divided into 3 experimental groups to study the role of EphA2 signaling in the lipopolysaccharide (LPS)-induced lung injury model i.e., IgG+phosphate-buffered saline (PBS) group (IgG instillation before PBS exposure), IgG+LPS group (IgG instillation before LPS exposure) and EphA2 monoclonal antibody (mAb)+LPS group (EphA2 mAb pretreatment before LPS exposure). Results: EphA2 and ephrinA1 were upregulated in LPS-induced lung injury. The lung injury score of the EphA2 mAb+LPS group was lower than that of the IgG+LPS group ($4.30{\pm}2.93$ vs. $11.45{\pm}1.20$, respectively; p=0.004). Cell counts (EphA2 mAb+LPS: $11.33{\times}10^4{\pm}8.84{\times}10^4$ vs. IgG+LPS: $208.0{\times}10^4{\pm}122.6{\times}10^4$; p=0.018) and total protein concentrations (EphA2 mAb+LPS: $0.52{\pm}0.41mg/mL$ vs. IgG+LPS: $1.38{\pm}1.08mg/mL$; p=0.192) were decreased in EphA2 mAb+LPS group, as compared to the IgG+LPS group. In addition, EphA2 antagonism reduced the expression of phospho-p85, phosphoinositide 3-kinase $110{\gamma}$, phospho-Akt, nuclear factor ${\kappa}B$, and proinflammatory cytokines. Conclusion: This results of the study indicated a role for EphA2-ephrinA1 signaling in the pathogenesis of LPS-induced lung injury. Furthermore, EphA2 antagonism inhibits the phosphoinositide 3-kinase-Akt pathway and attenuates inflammation.

EphA2 Receptor Signaling Mediates Inflammatory Responses in Lipopolysaccharide-Induced Lung Injury

( Ji Young Hong ),( Mi Hwa Shin ),( Kyung Soo Chung ),( Eun Young Kim ),( Ji Ye Jung ),( Young Ae Kang ),( Young Sam Kim ),( Se Kyu Kim ),( Joon Chang ),( Moo Suk Park ) 대한결핵 및 호흡기학회 2015 Tuberculosis and Respiratory Diseases Vol.78 No.3

Background: Eph receptors and ephrin ligands have several functions including angiogenesis, cell migration, axon guidance, fluid homeostasis, oncogenesis, inflammation and injury repair. The EphA2 receptor potentially mediates the regulation of vascular permeability and inflammation in response to lung injury. Methods: Mice were divided into 3 experimental groups to study the role of EphA2 signaling in the lipopolysaccharide (LPS) -induced lung injury model i.e., IgG+phosphate-buffered saline (PBS) group (IgG instillation before PBS exposure), IgG+LPS group (IgG instillation before LPS exposure) and EphA2 monoclonal antibody (mAb)+LPS group (EphA2 mAb pretreatment before LPS exposure). Results: EphA2 and ephrinA1 were upregulated in LPS-induced lung injury. The lung injury score of the EphA2 mAb+LPS group was lower than that of the IgG+LPS group (4.30±2.93 vs. 11.45±1.20, respectively; p=0.004). Cell counts (EphA2 mAb+LPS: 11.33×104±8.84×104 vs. IgG+LPS: 208.0×104±122.6×104; p=0.018) and total protein concentrations (EphA2 mAb+LPS: 0.52±0.41 mg/mL vs. IgG+LPS: 1.38±1.08 mg/mL; p=0.192) were decreased in EphA2 mAb+LPS group, as compared to the IgG+LPS group. In addition, EphA2 antagonism reduced the expression of phospho-p85, phosphoinositide 3-kinase 110γ, phospho-Akt, nuclear factor κB, and proinflammatory cytokines. Conclusion: This results of the study indicated a role for EphA2-ephrinA1 signaling in the pathogenesis of LPS-induced lung injury. Furthermore, EphA2 antagonism inhibits the phosphoinositide 3-kinase-Akt pathway and attenuates inflammation.

Utility of Routine Culture for Tuberculosis from Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration in a Tuberculosis Endemic Country

( Ji Young Hong ),( Ji Ye Jung ),( Young Ae Kang ),( Byung Hoon Park ),( Won Jai Jung ),( Su Hwan Lee ),( Song Yee Kim ),( Sang Kook Lee ),( Kyung Soo Chung ),( Seon Cheol Park ),( Eun Young Kim ),( J 대한결핵 및 호흡기학회 2011 Tuberculosis and Respiratory Diseases Vol.71 No.6

Background: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a technique developed to allow mediastinal staging of lung cancer and also to evaluate intrathoracic lymphadenopathy. In a tuberculosis-endemic area, tuberculosis should be considered as an etiology of mediastinal lymphadenopathy. The aim of this study was to investigate the utility of the routine culture for tuberculosis from specimens of EBUS-TBNA. Methods: We prospectively performed routine culture for tuberculosis from aspiration or core biopsy specimens got from 86 patients who had undergone EBUS-TBNA due to mediastinal lymphadenopathy between March 2010 and March 2011. Results: A total of 135 lymph node aspiration and 118 core biopsy specimens were included in this analysis. We confirmed the malignancy in 62 (72.9%), tuberculosis in 7 (8.1%), sarcoidosis in 7 (8.1%), asperogillosis in 2 (2.3%) and pneumoconiosis in 2 (2.3%) patients. One lung cancer patient had pulmonary tuberculosis coincidentally and 5 patients had unknown lymphadenopathy. The number of positive culture for Mycobacterium tuberculsosis by EBUS-TBNA is 2 (1.5%) from 135 lymph node aspiration specimens and 2 (1.7%) from 118 core biopsy specimens. Out of eight patients confirmed with tuberculosis, only one patient had positive mycobacterial culture of aspiration specimen from EBUS-TBNA without histopathologic diagnosis. Conclusion: These results propose that routine culture for tuberculosis from EBUS-TBNA may not provide additional information for the diagnosis of coincident tuberculous lymphadenitis. However, if there is any possibility of tuberculous lymphadenopathy or pulmonary tuberculosis, it should be considered to perform EBUS-TBNA in patients who have negative sputum AFB smears or no sputum production.

TP-79 : Thematic Poster ; Factors Associated with Quality of Life Measured by EQ-5D in Patients with Non-Tuberculosis Mycobacterial Pulmonary Disease

( Ji Young Hong ),( Song Yee Kim ),( Kyung Soo Chung ),( Eun Young Kim ),( Ji Ye Jung ),( Moo Suk Park ),( Young Sam Kim ),( Se Kyu Kim ),( Joon Chang ),( Young Ae Kang ) 대한결핵 및 호흡기학회 2013 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.116 No.-

Introduction: EQ-5D is a generic preference - based measure of health that can help to understand the impact of respiratory diseases. The impact of pulmonary nontuberculosis mycobacterial (pNTM) disease on health-related quality of life (HRQoL) has not been studied much. Method: This study was an age and sex-matched case control analysis of 85 pNTM cohorts and 255 national survey participants. Baseline EQ-5D visual analog scale (VAS) scores and EQ-5D utility scores were measured in both groups and compared. In the pNTM patients, the factors affecting EQ-5D were studied with the multiple linear regression analysis. Results: The mean EQ-5D VAS and utility scores were not different in pNTM patients (EQ -5D VAS, 69.18; EQ-5D score, 0.945) compared with control subjects (EQ-5D VAS, 80.78; EQ-5D, 0.946). (EQ -5D VAS, P=0.08; EQ-5D score, P=0.96). Interestingly, the percentage of subjects reporting any problems on the anxiety/depression dimension, was higher for pNTM patients (18.8%) than control subjects (11%) (P=0.05). In multivariable analysis, only FEV1 were significantly associated with EQ-5D VAS and utility scores (EQ -5D VAS, P<0.01; EQ-5D score, P<0.001). Conclusions: Results suggest the EQ-5D do not yield consistent utility values in pNTM patients due to ceiling effect of EQ-5D and mild disease activity. EQ-5D is closely associated with lung function and not explained by sex, age, cavity lesion, BMI, past TB history, radiographic severity or comorbidity. Introduction: EQ-5D is a generic preference - based measure of health that can help to understand the impact of respiratory diseases. The impact of pulmonary nontuberculosis mycobacterial (pNTM) disease on health-related quality of life (HRQoL) has not been studied much. Method: This study was an age and sex-matched case control analysis of 85 pNTM cohorts and 255 national survey participants. Baseline EQ-5D visual analog scale (VAS) scores and EQ-5D utility scores were measured in both groups and compared. In the pNTM patients, the factors affecting EQ-5D were studied with the multiple linear regression analysis. Results: The mean EQ-5D VAS and utility scores were not different in pNTM patients (EQ -5D VAS, 69.18; EQ-5D score, 0.945) compared with control subjects (EQ-5D VAS, 80.78; EQ-5D, 0.946). (EQ -5D VAS, P=0.08; EQ-5D score, P=0.96). Interestingly, the percentage of subjects reporting any problems on the anxiety/depression dimension, was higher for pNTM patients (18.8%) than control subjects (11%) (P=0.05). In multivariable analysis, only FEV1 were significantly associated with EQ-5D VAS and utility scores (EQ -5D VAS, P<0.01; EQ-5D score, P<0.001). Conclusions: Results suggest the EQ-5D do not yield consistent utility values in pNTM patients due to ceiling effect of EQ-5D and mild disease activity. EQ-5D is closely associated with lung function and not explained by sex, age, cavity lesion, BMI, past TB history, radiographic severity or comorbidity.

An Analysis of Integrated-Energy Supply Business Selection Standards according to the Heat and Power Supply Conditions in Korea

Ji-Ae Lee,Won-Hwa Hong,Ji-Hye Ryu 중소기업융합학회 2015 중소기업융합학회 국제학술대회논문집 Vol.2 No.1

As energy demand increases in the growing Korean economy, power demands sharply goes up every year. In the circumstance, Integrated-Energy Business (IEB) emerges as a positive alternative in the energy industry. This study tries to look into the actual conditions of the integrated-energy business supplying energy at present, analyze its different economic feasibility depending on supply scale, and thereby propose realistic integrated-energy supply business selection standards.