학생선수용 체육진로흥미검사지의 다집단 동일성 검증

권형일(Kwon, Hyung-Il),한시완(Han, Si-Wan) 한국체육과학회 2017 한국체육과학회지 Vol.26 No.3

Career should be understood as a process of continuous changes and development, rather than a fixed choice at a certain time (Super, 1990). Career guidance for student-athletes should reflect cultural specificity that both study and exercise are required at the same time, and should be conducted systematically by utilizing proper tools suitable for each development stage. The purpose of this study is to test if sport career interest inventory (SCII) for student-athletes, which was developed in the previous studies (Kwon Hyung-il, Bang Shin-woong, Han Si-wan, Yoo Jeong-ae, 2016), can be used in common by a group, that is, by school and class. For the study, 342 subjects (172 high school students and 170 university students) received multi-group construct invariance test of SCII. As a result, configural invariance and measurement equivalence were tested. These results provide supportive materials for construct invariance of SCII and can be utilized for comparative study by school and class to explore career according to the change in grade of the students.

항원결합에서 항-Z-DNA 단클론항체 Z44의 재조합 중쇄 및 경쇄 가변영역의 역할

권명희,주민경,서정규,김형일 大韓免疫學會 1996 大韓免疫學會誌 Vol.18 No.3

It has long been known that both heavy(VH) and light chain variable region(VL) of antibody are involved in antigen binding. Recently, reports for anti-DNA Abs such as Z22 and Hed-10 have revealed that VH chain is more important than VL in recoginizing antigen. However, it is not certain yet whether the VH chain alone of these specific anti-DNA antibodies has dominant role or such dominance of VH chain can be applicable to other anti-DNA Abs. To investigate this possibility in connection with the role and contribution of VL chain, experiments were performed using mAb Z44 which binds to Z-DNA but rocognizes different epitopes from Z22 which share 95% sequence homology. The recombinant proteins including Z44VH and Z44VL were produced by E.coli. After purification of the these antibodies, the affinity and specificity of recombinant Ab proteins to DNA antigens were tested. The results were as follows; Z44VH bound most strongly to Z-DNA and bound also to ssDNA, whereas Z44VL did not bind to B-DNA, ssDNA, and Z-DNA. In vitro association of Z44VH with Z44VL has increased the affinity to Z-DNA synergistically compared with Z44VVH alone. In the case of association of Z22VH with Z22VL affinity to Z-DNA has showed synergistic increment compared with Z22VH alone. However, the associations of Z44VH with Z22VL or Z22VH with Z44VL did not show any significant increments of affinity. From our findings that Z44VH alone could bind to Z-DNA or to ssDNA and that Z 44VL could not, it could be concluded that Z44VH has dominant role in recognizing the antigen. In addition, it may be suggested that Z44VL can increase the affinity of Z44VH and play some role in changing the specificity of Z44VH.

흉막삼출의 유무에 따른 쯔쯔가무시증 환자간의 비교

권세훈,김형호,강지인,하재하,한경택,이재록,김동민,권용은,윤성호,이승일 朝鮮大學校 附設 醫學硏究所 2007 The Medical Journal of Chosun University Vol.32 No.1

Scrub typhus is a potentially fatal infectious disease caused by the organism Orientia tsutsugamushi. Clinical manifestations are fever, skin rash, eschar and varying degree of respiratory distress. The pleural effusion in scrub typhus is rare and secondary to the destruction of vascular endothelium. Because the respiratory symptoms are generally mild and the pleural effusion in scmb typhus is rare than in interstitial pneumonia, there are few comments about the characteristics of scmb typhus with pleural effusion. So we made the comparative study of scmb typhus patients between with pleural effusion and without pleural effusion. 연구배경 치명적일 수 있는 감염질환 중 하나인 쯔쯔가무시중(Scrub typhus)에서 드문 흉막삼출을 동반한 환자에 대한 고찰은 다른 문헌에서도 자주 언급되지 않았다. 따라서 본 저자들은 흉막삼출이 있는 경우와 없는 경우에 따른 쯔쯔가무시중 환자들을 비교하고자 하였다. 방법 2003년에서 2006년까지 조선대학교 병원 내과에 입원중인 환자 중 쯔쯔가무시중 진단을 받은 총 109명의 환자를 대상으로 하여 흉부 X선 검사 및 혈청학적 검사(CPK, LDH, ESR, CRP, AST, ALT, ADA), 혈액학적 검사(WBC, PLT) 및 백분율 검사등을 실시하였다. 결과 흉막삼출이 있는 환자들의 경우 흉막 삼출이 없는 환자들에 비해 ESR 수치가 통계학적으로 의의있게 높았다(p-vaule < 0.05). 결론 흉막삼출 유무에 따른 쯔쯔가무시중 환자간의 비교에 있어 ESR 수치가 통계학적인 의의를 가졌다.

선형유도전동기의 직접벡터제어를 위한 자속검출에 관한 연구

권병일,송종홍,임형빈,임달호 한양대학교 공학기술연구소 1993 공학기술논문집 Vol.2 No.1

For implementation of vector control it is important to get accurate flux angle of motor. In this paper we investigate two types of flux sensing methods for linear induction motor. The one of which is a method of tapped winding which utilizes coils of motor itself. And the other is a method using hall effect sensor. The experiment for the two flux sensing method is carried out. In comparison of these methods it can be found that the tapped winding method is well suited for flux sensing of linear induction motor.

알코올성 췌장염 환자에서 CYP2E1 유전자형의 다형성

김일환,염윤기,채석,권준택,김형기,박상흠 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Cytochrome P4502E1(CYP2E1) is inducible by ethyl alcohol and activates procarcinogenic N-nitrosodimethylamine(NDMA), benzene, urethane and other lower molecular weight compound. CYP2E1 is also involved in metabolism of certain drugs, for example, alcohol, acetaminophen, tamoxifen, theophylline, flouorinated anesthetics, and chlorozoxazone. CYP2E1 activity was shown to be polymorphically distributed in humans and has been suggested to play a role in hepatocellular carcinoma and alcoholic related disorders. Although genetic predispodition to alcoholism and alcoholic liver disease has been reported, genetic susceptibility to alcoholic pancreatitis is still a matter of debate. The aims of this study were to investigate the allelic frequency of CYP2E1 Rsa I polymorphism in Koreans with alcoholic pancreatitis patients. We investigated the frequency distribution of CYP2E1 Rsa I polymorphism in 212 unrelated healthy Koreans and 64 alcoholic pancreatitis patients. Detection of the CYP2E1 alleles was performed by polymerase chain reaction and restriction fragment length analysis. The genomic DNA was isolated from peripheral blood with conventional phenol: chloroforn extraction method. The allelic frequencies of c1 and c2 in healty volunteers were 0.85 and 0.15, respectively. The allelic frequencies of c1 and c2 in alcoholic pancreatitis patients were 0.8 and 0.2, respectively. The rare type (c2/c2) of CYP2E1 Rsa I polymorphism was 0.005 and 0.031 (p<0.001) in healthy volunteers and alcoholic pancreatitis patients, respectively. However, the CYP2E1 genotype showed no significant relation to the alcoholic pancreatitis patients. It was suggested that the risk of alcoholic pancreatitis diagnosed clinically seem to be not associated with the CYP2E1 genotype.

광섬유 ROTDR 센서를 이용한 사회기반시설물의 보안에 관한 연구

박형준,고광락,권일범 한국비파괴검사학회 2003 한국비파괴검사학회지 Vol.23 No.2

광섬유 ROTDR(Rayleigh optical time domain reflectometry) 센서를 이용하여 중요 보안 대상체인 사회기반시설물에 침투하는 침입자의 위치와 무게 정도를 탐지할 수 있는 기초 연구를 수행하였다. 넓은 면적을 감지할 수 있는 매설형 광섬유 센서탐지판을 제작하고, 인가된 침입물체의 위치와 무게에 따른 신호특성을 고찰하였다. ROTDR 센서는 펄스 폭이 30 ㎱이고, 광섬유의 길이는 10㎞ 이상이다. 위치탐지오차는 약 3m 이내였으며, 무게에 따른 탐지능력은 20kgf, 40kgf, 60kgf의 세단계를 구분할 수 있음을 알 수 있었다. A detection technique is studied to determine the location and the weight of an intruder into infrasturcture using fiber optic ROTDR(Rayleigh optical time domain reflectometry) sensor. Fiber optic sensing plates buried in sand are prepared to measure the intruder effects. The signal of ROTDR was analyzed to confirm the detection performance. The constructed ROTDR system could be used up to 12 ㎞ at the pulse width of 30 ㎱. The location error was less than 3 m and the weight could be detected into three levels of grade, such as 20 kgf, 40 kgf and 60 kgf.

만성폐쇄성폐질환의 중증도와 폐고혈압 및 폐성심으로 진행과의 상관관계

김형호,박철진,이준,장광표,하성일,이재록,하재화,권세훈,권용운,윤성호,이승일 朝鮮大學校 附設 醫學硏究所 2007 The Medical Journal of Chosun University Vol.32 No.2

Background: From many previous studies, Pulmonary hypertension is the known independent predictive factor of the mortality in COPD. Also pulmonary hypertension is the major cardiovascular complication of COPD and is associated with the progression to cor pulmonale and poor prognosis. Author want to analyze the correlation between pulmonary hypertension and the severity of COPD which are classified by forced expiratory volume in one second, and the extent of progression to corpulmonale. Methods: Retrospectively we investigated the medical records of 118 patients with COPD who had pulmonary function test and echocardiogaphy more than one times during one-year follow-up (from June, 2005 to May, 2006) at respiratory division in chosun university hospital, and then 50 patients were enrolled in this study. We classified the severity from FEVl in pulmonary function test based on the GOLD guideline, also this was comparably analyzed with RVSP, RVIDd, Visual Grading from echocardiography. Results: 16 patients out of 50 were classified as moderate severity, 25 patients were severe, and 9 patients were very severe group. RVSP was higher in more severe groups than less severe groups but when it comes to pulmonary hypertension that RVSP is over 35 mmHg, there was no valid difference lies in those groups. As FEVl decreases RVSP and RVIDd increases, and observed relationship between RVSP which was classified as below 35 mm and above 35 mm groups and visual grading which was classified as normal and dilatated groups revealed valid correlation, Conclusion: As pulmonary function decreases, progression to pulmonary hypertension and cor pulmonale increases but there was no remarkable difference of prevalence in above moderate severity groups. 연구배경 폐고혈압은 이전의 많은 연구에서 만성폐쇄성폐질환에서 독립적인 사망의 예측인자로 알려져 있다. 또한 폐고혈압은 만성폐쇄성폐질환의 주요한 심혈관계 합병증이며, 폐성심으로의 진행 및 불량한 예후와도 관련되어 있다. 이에 저자는 폐고혈압과 1초간 노력성호기량으로 분류되는 만성폐쇄성폐질환의 중증도 및 폐성심으로의 진행 정도를 비교 분석하여 이들의 상관관계를 밝혀보고자 한다. 방법 2005년 6월부터 2006년 5월까지 1년 동안 본 병원 호흡기 내과에서 폐기능검사와 심장초음파 검사를 각각 1회 이상 시행한 적이 있는 118명에 한하여 의무기록을 후향적으로 조사하여 이 중에서 50명을 대상으로 하였다. 폐기능검사 시행 결과 얻은 1초간 노력성호기량을 바탕으로 GOLD guideline에 따라 중증도를 분류하였으며 이를 심초음파 시행 결과 얻은 우심실수축기압, 확장기말 우심실내부간격, 시각등급과 비교분석하였다. 결과 대상 환자 50명중 16명은 중등증, 25명은 중증, 9명은 최고중증 그룹으로 분류되었다. 우심실수축기압은 중증도가 높은 그룹에서 낮은 그룹에 비해 더 높게 나타났으나 폐고혈압에 해당하는 우심실수축기압이 35 mmHg이상인 환자에 있어사는 각 그룹간에 유의한 차이를 보이지 않았으며, 확장기말 우심실내부간격, 시각등급 또한 중증도와 유의한 차이를 보이지 안항ㅆ다. 1초간 노력성호기량이 감소함에 따라서는 우심실수축기압, 시각등급은 증가하였으며 우심실수축기압을 35mmHg 미만과 이상인 그룹으로, 시각등급을 정상과 확장이 있는 그룹으로 분류하여 비교한 결과에서는 유의한 상관관계를 나타냈다. 결론 폐기능이 감소할수록 페고혈압 및 폐성심으로의 진행이 증가하였으나 폐기능검사에서 중등도 이상의 그룹에서 유병률의 차이는 크지 않았다.

국산화 개발한 치과용 저금합금의 시효경화 거동

김교한,권오원,김형일 대한치과기재학회 1997 대한치과재료학회지 Vol.24 No.1

To define the optimum heat treatment temperature and time of the developed three types of low karat gold alloys, hardness test, DTA and x-ray diffraction methods were used. The results were as follows. *The optimum temperature of heat treatment was at 400℃ in K-Ⅰ, K-Ⅱ and K-Ⅲ alloys. *The proper time of age-hardening was 10 minute in K-Ⅰ alloy, and 10-30-minutes in K-Ⅱ alloys. *The stable phases of three types of low karat gold alloys were Ag-rich α₁ phase, Cu-rich α₂ phase and AuCuⅠ phase in case of K-Ⅰ alloy, and α1 phase and AuCuⅠ phase were coexisted in K-Ⅱ and K-Ⅲ alloy. *The cause of the decrease of hardness by overageing was the α₁ phase and AuCu Ⅰ phase, which were precipitated in the grain boundary.

폐흡충에 의한 무균성 노흉에 대한 돼지꼬리형 도관(pig-tail catheter)을 이용한 치료의 효과

한경택,권세훈,김형호,하재화,선길홍,권용은,윤성호,이승일 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.3

Background: Pulmonary paragonimiasis is caused by consumption of raw or improperlycooked crustacea infected with the laval stage (metacercaria) of Paragonimus westermani. The most characteristic symptoms were rust-colored sputum and cough. Paragonimiasis causes pleural thickening or effusion in 48% of the patients. Pleuro-pulmonary paragonimiasis can be easily overlooked by physicians who do not suspect this disease in the differential diagnosis. Method: We compared the outcomes of 11 patients with paragonimus empyema managed either through thoracotomy or pig-tail catheter drain. These patients were confirmed by food history, clinical and radiological findings, and laboratory data. Results: The male and female ratio was 1.75 : 1, and mean age was 40.0 ± 13.5 years. AII patients had pulmonary symptoms such as cough or chest pain. Serum-ELISA for paragonimiasis were all positive (mean titer was 0.57). AII patients had pleural effusion in radiological findings( 2 patients had bilateral pleural effusion). All patients received praziquantel (75 ㎎/㎏/day for 3days). Two patients were treated with thoracotomy and nine patients were treated with pig-tail drain. Hospital stay were 14.5 days in thoracotomy group and 5.6 days in pig-tail group respectively, Conclusion: Compared to the conventional thoracotomy grouP, the patients with paragonimus empyema who received pig-tail catheters had a significantly-decreased period of drain in situ, were clinically improved earlier, and were discharged earlier.

Anti-inflammatory effect of polyphenol-rich extract from the red alga Callophyllis japonica in lipopolysaccharide-induced RAW 264.7 macrophages

Ryu, BoMi,Choi, Il-Whan,Qian, Zhong-Ji,Heo, Soo-Jin,Kang, Do-Hyung,Oh, Chulhong,Jeon, You-Jin,Jang, Chul Ho,Park, Won Sun,Kang, Kyong-Hwa,Je, Jae-Young,Kim, Se-Kwon,Kim, Young-Mog,Ko, Seok-Chun,Kim, G The Korean Society of Phycology 2014 ALGAE Vol.29 No.4

Despite the extensive literature on marine algae over the past few decades, a paucity of published research and studies exists on red algae. The purpose of this study was to evaluate the potential therapeutic properties of the ethanol extract of the red alga Callophyllis japonica against lipopolysaccharide (LPS)-stimulated macrophage inflammation. The C. japonica extract (CJE) significantly inhibited the nitric oxide (NO) production and the induced dose-dependent reduction of the protein and mRNA levels of inducible nitric oxide synthase and cyclooxygenase-2. Additionally, the CJE reduced the mRNA levels of inflammatory cytokines, including tumor necrosis factor-${\alpha}$, interleukin (IL)-$1{\beta}$, and IL-6. We investigated the mechanism by which the CJE inhibits NO by examining the level of mitogen-activated protein kinases (MAPKs) activation, which is an inflammation-induced signaling pathway in macrophages. The CJE significantly suppressed the LPS-induced phosphorylation of c-Jun N-terminal kinase, extracellular signal-regulated kinase and p38 MAPK. Taken together, the results of this study demonstrate that the CJE inhibits LPS-induced inflammation by blocking the MAPK pathway in macrophages.