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( Hyo Yeon Gwak ),( Jung Eun Lee ),( Ju Young Choi ),( So Yeon Kim ),( Song Mi Park ),( June Seek Choi1,),( Hyun Kyong Ahn ),( Min Hyung Kim ),( Jin Hoon Chung ),( Moon Young Kim ),( Hyun Mee Ryu ),( 대한산부인과학회 2014 대한산부인과학회 학술대회 Vol.100 No.-
목적: To evaluate the positive effects of teratogenic risk counseling in pregnant women inadvertently exposed to medication in early pregnancy. 방법: In a prospective cohort study, 250 pregnant women exposed to medications in early pregnancy were recruited after teratogenic risk counseling at Korean MotherSafe Counsling Center, which has given information about teratogenic risk of medication to pregnant women. Positive effects are evaluated by visual analogue scale(VAS) for perception on teratogenic risk and percent prefering termination of pregnancy after medication exposures in pregnancy. 결과: Mean age of participants is 31.8±5.3years old. Mean gravidity is 2.4±2.1. Medications exposed in early pregnancy include antibiotics, analgesics, anti-inflammatory drugs, antacid and so on. Mean perceptive teratogen risk before and after the counseling is 33.9±1.6% and 15.8±1.6%, respectively. And mean percent prefering termination of pregnancy (≥5) before and after the counseling is 31.1±1.9% and 13.5±1.7%, respectively. 결론: Our data suggest that information on teratogenic risk for pregnant women inadvertently exposed to medication may have positive effects for reassuring pregnant women and preventing termination of pregnancy.
( Hyo Jin Kim ),( Ju Yeon Cho ),( Yu Jin Kim ),( Geum Youn Gwak ),( Yong Han Paik ),( Moon Seok Choi ),( Kwang Cheol Koh ),( Seung Woon Paik ),( Byung Chul Yoo ),( Joon Hyeok Lee ) 대한내과학회 2015 The Korean Journal of Internal Medicine Vol.30 No.1
Background/Aims: The efficacy of tenofovir disoproxil fumarate (TDF) for the treatment of chronic hepatitis B (CHB) patients following prior treatment failure with multiple nucleos(t)ide analogues (NAs) is not well defined, especially in Asian populations. In this study we investigated the effi cacy and safety of TDF rescue therapy in CHB patients after multiple NA treatment failure. Methods: The study retrospectively analyzed 52 CHB patients who experienced failure with two or more NAs and who were switched to regimens containing TDF. The effi cacy and safety assessments included hepatitis B virus (HBV) DNA undetectability, hepatitis B envelop antigen (HBeAg) seroclearance, alanine transaminase (ALT) normalization and changes in serum creatinine and phosphorus levels. Results: The mean HBV DNA level at baseline was 5.4 ± 1.76 log10 IU/mL. At a median duration of 34.5 months of TDF treatment, the cumulative probabilities of achieving complete virological response (CVR) were 25.0%, 51.8%, 74.2%, and 96.7% at 6, 12, 24, and 48 months, respectively. HBeAg seroclearance occurred in seven of 48 patients (14.6%). ALT levels were normalized in 27 of 31 patients (87.1%) with elevated ALT at baseline. Lower levels of HBV DNA at baseline were signifi- cantly associated with increased CVR rates (p < 0.001). However, CVR rates did not differ between TDF monotherapy or combination therapy with other NAs, and were not affected by mutations associated with resistance to NAs. No significant adverse events were observed. Conclusions: TDF is an effi cient and safe rescue therapy for CHB patients after treatment failure with multiple NAs.
곽효연,이상도,Gwak, Hyo-Yeon,Lee, Sang-Do 대한인간공학회 1999 大韓人間工學會誌 Vol.18 No.3
Nowadays, VCR(Video Cassette Recorder) has various functions, but users use to fail operating these function because of the complexity of operation. The process of operating VCR contains user's cognitive characteristics. It is necessary for designing it that we must identify a user's mental process in the behind of operational behaviors. This effort, as well as considering physical dimensions and layout, can make VCR easy to use. In this research, VCR remote controller are analyzed by the cognitive method and experiments. Three types of VCR remote controllers, cognitive VCR models and two non-cognitive(typical) VCR models, are adopted as experimental objects to test the validation of the suggested user's cognitive mode of VCR. As results, when VCR was operated by the cognitive prototype of remote controller, task completion time was reduced to 80.5%, and the number of errors was reduced to 96.8%.
Jin, Wyju,Kim, Min Sun,Jang, Eun Young,Lee, Jun Yeon,Lee, Jin Gyeom,Kim, Hong Yu,Yoon, Seong Shoon,Lee, Bong Hyo,Chang, Suchan,Kim, Jae Hyo,Choi, Kwang H.,Koo, Ho,Gwak, Young Seob,Steffensen, Scott C. Wiley (Blackwell Publishing) 2018 Addiction Biology Vol.23 No.1
<P>There is growing public interest in alternative approaches to addiction treatment and scientific interest in elucidating the neurobiological underpinnings of acupuncture. Our previous studies showed that acupuncture at a specific Shenmen (HT7) points reduced dopamine (DA) release in the nucleus accumbens (NAc) induced by drugs of abuse. The present study was carried out to evaluate the effects of HT7 acupuncture on.-aminobutyric acid (GABA) neuronal activity in the ventral tegmental area (VTA) and the reinstatement of cocaine-seeking behavior. Using microdialysis and in vivo single-unit electrophysiology, we evaluated the effects of HT7 acupuncture on VTA GABA and NAc DA release and VTA GABA neuronal activity in rats. Using a within-session reinstatement paradigm in rats self-administering cocaine, we evaluated the effects of HT7 stimulation on cocaine-primed reinstatement. Acupuncture at HT7 significantly reduced cocaine suppression of GABA release and GABA neuron firing rates in the VTA. HT7 acupuncture attenuated cocaine-primed reinstatement, which was blocked by VTA infusions of the selective GABA(B) receptor antagonist 2-hydroxysaclofen. HT7 stimulation significantly decreased acute cocaine-induced DA release in the NAc, which was also blocked by 2-hydroxysaclofen. HT7 acupuncture also attenuated cocaine-induced sensitization of extracellular DA levels in the NAc. Moreover, HT7 acupuncture reduced both locomotor activity and neuronal activation in the NAc induced by acute cocaine in a needle-penetration depth-dependent fashion. These results suggest that acupuncturemay suppress cocaine-induced DA release in the NAc and cocaine-seeking behavior through activation of VTA GABA neurons. Acupuncture may be an effective therapy to reduce cocaine relapse by enhancing GABAergic inhibition in the VTA.</P>
항암면역(抗癌免疫) 1호방(號方)을 투여(投與)한 위암환자(胃癌患者) 40례(例)에 대(對)한 임상고찰(臨床考察)
유화승,조정효,곽경규,이연월,조진호,조종관,Yoo, Hwa-Seung,Jo, Jeong-Hyo,Gwak, Gyeong-Gyu,Lee, Yeon-Wol,Jo, Jin-Ho,Cho, Chong-Kwan 대한암한의학회 1998 大韓癌韓醫學會誌 Vol.4 No.1
Clinical studies were carried out 40 cases of patients with stomach cancer treated by "Hangammyunyouk I(抗癌免疫1號方)", from September 1th 1997 to May 1th 1998. The results were summarized as follows; 1. Distribution of those attached by stomach cancer, by sex, showed that Male is more then Female, by age, showed that the number of fifties is majority. 2. Distribution of diagnostic stage, on descending order, stage III, stage IV. 3. Distribution of treatment attached by stomach cancer, in descending order: Chemotherapy and operation, chemotherapy, Radiation therapy and operation. 4. After taken herb medicine, the effects according to the symptoms were as follows; Nausea and Vomiting, Constipation, General body weakness, Average efficacy of symptoms were 68.1%. 5. Analysis of hematology attached by stomach cancer, increasing of WBC(61.5%), Hgb(54.5%), Platelet(62.5%) were observed.