Anti-inflammatory effects of vicenin-2 and scolymoside in vitro and in vivo

Kang, Hyejin,Ku, Sae-Kwang,Jung, Byeongjin,Bae, Jong-Sup Springer-Verlag 2015 Inflammation research Vol.64 No.12

Tau positron emission tomography using [¹⁸F]THK5351 and cerebral glucose hypometabolism in Alzheimer's disease

Kang, Jae Myeong,Lee, Sang-Yoon,Seo, Seongho,Jeong, Hye Jin,Woo, Sung-Ho,Lee, Hyon,Lee, Yeong-Bae,Yeon, Byeong Kil,Shin, Dong Hoon,Park, Kee Hyung,Kang, Hyejin,Okamura, Nobuyuki,Furumoto, Shozo,Yanai, Elsevier 2017 NEUROBIOLOGY OF AGING Vol. No.

<P><B>Abstract</B></P> <P>This study aims to evaluate the clinical validity of [<SUP>18</SUP>F]THK5351 positron emission tomography (PET) for the assessment of disease progression and symptoms in Alzheimer's disease (AD). Fifty-one patients with AD dementia, 30 patients with amnestic mild cognitive impairment (aMCI), and 43 controls with normal cognition (NC) were included. All subjects underwent [<SUP>18</SUP>F]THK5351 PET, 3.0-T magnetic resonance imaging, and detailed neuropsychological tests. Regions of interest and voxel-based statistical analyses were performed. In patients with AD dementia, [<SUP>18</SUP>F]THK5351 retention was greater in most association cortices as well as the limbic area compared to NC or aMCI participants. Patients with aMCI also showed higher THK5351 retention in those areas compared to NC. [<SUP>18</SUP>F]THK5351 retention significantly correlated with neuropsychological test results. Negative correlations between [<SUP>18</SUP>F]THK5351 and [<SUP>18</SUP>F] fluorodeoxyglucose were observed in AD dementia and aMCI groups. Mirror images of [<SUP>18</SUP>F]THK5351 retention and glucose hypometabolism in [<SUP>18</SUP>F] fluorodeoxyglucose were noticeable in the focal variants of AD. [<SUP>18</SUP>F]THK5351 PET reflects disease severity and symptoms in AD. Our results suggest [<SUP>18</SUP>F]THK5351 is reflective of tau-related AD pathology.</P>

Spore-forming probiotic bacterium Bacillus coagulans influences on the flavor of Gouda cheese using micro-cheese platform

Hyejin Choi,Sangdon Ryu,Daye Mun,Woongji Lee,An Na Kang,Mingeun Kang,Hayoung Kim,Daniel Lee,Sangnam Oh,Younghoon Kim 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10

Bacillus coagulans is a gram-positive, spore-forming and potential probiotic bacterium in food industry. Spore-forming bacteria is enable to survive in the host"s gastrointestinal tract functioning as probiotics that could play a beneficial role in the host health. We evaluated the probiotic characteristics including acid, bile and heat tolerance of B. coagulans SRCM121381 isolated from human breast milk. SRCM121381 showed high resistance to acid and bile, heat tolerance. We employed FIMM (Fermentor for Intestine Microbiota Model) system to evaluate effects of SRCM 121381 on the microbial dynamics in gut environments. SRCM121381 resulted in increased population of Romboutsia and Turicibacter at the genus level, while the abundance of Escherichia decreased significantly. We added SRCM 121381 with starter strains for Gouda cheese using micro-cheese platform and evaluated on the change of cheese flavor. SRCM121381 increased acetic acid (Vinegar) and decreased esters and ketone as undesirable flavor such as bitter taste. Our results propose that potential probiotic bacterium B. coagulans SRCM121381 could be applied on dairy foods as an adjunct starter with flavor productivity.

Three diketopiperazines from marine-derived bacteria inhibit LPS-induced endothelial inflammatory responses

( Hyejin Kang ),( Sae Kwang Ku ),( Hyukjae Choi ),( Jong Sup Bae ) 영남대학교 약품개발연구소 2016 영남대학교 약품개발연구소 연구업적집 Vol.26 No.-

Diketopiperazine is a natural products found from bacteria, fungi, marine sponges, gorgonian and red algae. They are cyclic dipeptides possessing relatively simple and rigid structures with chiral nature and various side chains. Endothelial dysfunction is a key pathological feature of many inflammatory dis-eases, including sepsis. In the present study, three (1-3) of diketopiperazines were isolated from two strains of marine-derived bacteria. The compounds were investigated for their effects against lipopolysaccharide (LPS)-mediated endothelial inflammatory responses in vitro and in vivo. From 1 ~M, 1-3 inhibited LPS-induced hyperpermeability, adhesion, and migration of leukocytes across a human endothelial cell monolayer and in mice in a dose-dependent manner suggesting that 1-3 may serve as potential scaffolds for the development of therapeutic agents to treat vascular inflammatory disorders.

Nutritional Management in a Patient with Citrullinemia Type 1

( Hyejin Kang ),( Mihyang Kim ),( Ji Hyun Lee ) 한국임상영양학회 2021 Clinical Nutrition Research Vol.10 No.3

For patients with citrullinemia type 1, nutritional management is essential to prevent the occurrence of complications associated with hyperammonemia. This report describes a patient who had been receiving nutrition intervention for more than 3 years. A newborn diagnosed with hyperammonemia due to citrullinemia visited Ajou University Hospital and was referred to the nutrition team. After receiving acute treatment, the infant was regularly fed with specialized formula. A protein-restricted diet is recommended for maintaining normal development and achieving long-term survival. Through continuous provision of nutritional intervention, the child showed normal growth and development, and the energy-protein supply was maintained appropriately. This case clearly shows the importance of medical nutrition therapy for patients with citrullinemia.

Regional Cerebral Blood Flow Abnormalities Associated With Apathy and Depression in Alzheimer Disease

Kang, Ji Yeon,Lee, Jae Sung,Kang, Hyejin,Lee, Hae-Woo,Kim, Yu Kyeong,Jeon, Hong Jin,Chung, June-Key,Lee, Myung Chul,Cho, Maeng Je,Lee, Dong Soo RAVEN PRESS PUBLISHERS 2012 ALZHEIMER DISEASE AND ASSOCIATED DISORDERS Vol.26 No.3

The aim of this study was to identify brain areas related to apathy or depression in patients with Alzheimer disease (AD). Eighty-one AD patients were enrolled in this prospective study. Tc-HMPAO single photon emission computed tomography was performed to evaluate regional cerebral blood flow (rCBF). According to the Neuropsychiatric Inventory subscores of apathy and depression, 9 patients were classified as clinically significant (cs) depressed and non-cs-apathetic (D+) groups and 9 were classified as cs-apathetic and non-cs-depressed (A+) groups. In addition, 18 patients were classified as age-matched and Mini-Mental State Examination-matched disease control groups (D−, A−). The significance of rCBF differences between groups and the correlation between rCBF and subscores in 81 AD patients were estimated by SPM (uncorrected P<0.005) analysis. D+ patients had significantly lower perfusion in the right orbitofrontal and inferior frontal gyri than D− patients, whereas A+ patients had this in the right amygdala, temporal, posterior cingulate, right superior frontal, postcentral, and left superior temporal gyri than A− patients. The negatively correlated areas with depression subscores included the left inferior frontal and the right middle frontal gyri and those with apathy subscores included the right temporal and right medial frontal gyri. We suggest that this finding may indicate that apathy and depression in AD patients involve distinct functional circuits.

Laparoscopic pancreaticoduodenectomy with segmental resection of superior mesenteric vein-splenic vein-portal vein confluence in pancreatic head cancer

Hyejin Park,Incheon Kang,Chang Moo Kang 한국간담췌외과학회 2018 Annals of hepato-biliary-pancreatic surgery Vol.22 No.4

The feasibility of laparoscopic pancreaticoduodenectomy (LPD) in the treatment of pancreatic cancer is still disputed. However, advances in surgical technique and accumulating experience have led to the use of LPD with combined vascular resection and reconstruction as a safe and feasible procedure, especially in pancreatic cancer with major vascular involvement. A 64-year-old woman presented with obstructive jaundice secondary to pancreatic head cancer. Contrast abdominopelvic computed tomography revealed a pancreatic head tumor measuring approximately 22 mm in diameter that was abutting the first jejunal branch of the superior mesenteric vein at an angle of <180°. The patient underwent LPD, which failed to resect the pancreatic head tumor invading the superior mesenteric vein. Consequently, segmental resection of the confluence of the superior mesenteric vein, splenic vein, and portal vein (SMV/SV/PV) was completely performed in laparoscopic approach without complication. The patient recovered without any event and was discharged on postoperative day 9. LPD combined with vascular resection and reconstruction is feasible in cases involving major blood vessels. Further surgical expertise and education are required before LPD can be used as a standard procedure.

Investigation of PM10 Concentrations in Expressway Tunnels

Hyejin Kang,Heeman Kang,Jugoang Lee 대한환경공학회 2015 대한환경공학회 학술발표논문집 Vol.2015 No.10

Study on the Relationship between Traffic Volume and Air Quality on Jungbu-naeryuk Expressway

Hyejin Kang,Heeman Kang 대한환경공학회 2015 대한환경공학회 학술발표논문집 Vol.2015 No.10

The neural correlates of cross-modal interaction in speech perception during a semantic decision task on sentences: A PET study

Kang, Eunjoo,Lee, Dong Soo,Kang, Hyejin,Hwang, Chan Ho,Oh, Seung-Ha,Kim, Chong-Sun,Chung, June-Key,Lee, Myung Chul Elsevier 2006 NeuroImage Vol.32 No.1

<P><B>Abstract</B></P><P>Speech perception in face-to-face conversation involves processing of speech sounds (auditory) and speech-associated mouth/lip movements (visual) from a speaker. Using PET where no scanner noise was present, brain regions involved in speech cue processing were investigated with the normal hearing subjects with no previous lip-reading training (<I>N</I>?=?17) carrying out a semantic plausibility decision on spoken sentences delivered in a movie file. Multimodality was ensured at the sensory level in all four conditions. Sensory-specific speech cue of one sensory modality, i.e., auditory speech (A condition) or mouth movement (V condition), was delivered with a control stimulus of the other modality whereas speech cues of both sensory modalities (AV condition) were delivered during bimodal condition. In comparison to the control condition, extensive activations in the superior temporal regions were observed bilaterally during the A condition but these activations were reduced in extent and left lateralized during the AV condition. Polymodal region such as left posterior superior temporal sulcus (pSTS) involved in cross-modal interaction/integration of audiovisual speech was found to be activated during the A and more so during the AV conditions but not during the V condition. Activations were observed in Broca's (BA 44), medial frontal (BA 8), and anterior ventrolateral prefrontal (BA 47) regions in the left during the V condition, where lip-reading performance was less successful. Results indicated that the speech-associated lip movements (visual speech cue) rendered suppression on the activity in the right auditory temporal regions. Overadditivity (AV?>?A?+?V) observed in the right postcentral region during the bimodal condition relative to the sum of unimodal speech conditions was also associated with reduced activity during the V condition. These findings suggested that visual speech cue could exert an inhibitory modulatory effect on the brain activities in the right hemisphere during the cross-modal interaction of audiovisual speech perception.</P>