Abdominal wall mass suspected of endometriosis: clinical and pathologic features

( Heekyoung Song ),( Sanghee Lee ),( Min Jeong Kim ),( Jae Eun Shin ),( Dae Woo Lee ),( Hae Nam Lee ) 대한산부인과학회 2020 Obstetrics & Gynecology Science Vol.63 No.3

Objective To evaluate the clinical and pathological characteristics of lower anterior abdominal wall masses suspicious for endometriosis. Methods A retrospective review of 38 patients who underwent surgery for a lower anterior abdominal wall mass suspicious for endometriosis was performed. Those with skin and intraperitoneal masses, lipomas, hernias, and metastatic malignant masses were excluded. Patient age, body mass index, delivery history, dysmenorrhea, and mass size and location were analyzed. Results Thirty-seven (97.3%) patients had a relevant surgical history, including 35 (92.1%) with a history of cesarean section (C/S). Among the three patients with no history of C/S, 1 underwent total abdominal and another total laparoscopic hysterectomy, and 1 had no previous surgical history. The mean (±standard deviation) size of the abdominal masses was 3.2±1.2 cm. One patient developed a recurrent mass after excision of abdominal wall endometriosis. Trocar site endometrioma was found in one patient following total laparoscopic hysterectomy. According to the final pathology reports, endometriosis was found in 35 (92.1%) of patients. The remaining 3 patients (7.9%) had malignancy: adenocarcinoma, squamous cell carcinoma, and extra-gastrointestinal stromal tumor. Before surgery, only 3 patients (7.9%) underwent fine-needle aspiration biopsy of the masses, which were all postoperatively confirmed to be pathologically benign. Conclusion Although most abdominal wall masses in the present sample were endometriosis occurring at the scar site from a previous operation, 7.9% of patients ultimately exhibited malignancy. Therefore, all patients with suspected anterior wall endometriosis should undergo preoperative biopsy to identify the few that will have an alternative diagnosis.

Prediction for Platinum Resistance of Chemotherapy in Epithelial Ovarian Cancer patients based on Magnetic Resonance Images

( Heekyoung Song ),( Jae Yeon Woo ),( Jimin Cha ),( Seo Yeon Youn ),( Sung Jong Lee ) 대한산부인과학회 2022 대한산부인과학회 학술대회 Vol.108 No.-

Objective: To investigate a preoperative multi-sequence MRI (Magnetic Resonance Imaging) and clinical factors for prediction of platinum-based chemotherapy sensitivity in patients with epithelial ovarian cancer (EOC). Methods: The complete data of 168 patients with EOC confirmed by surgery and pathology in Seoul St. Marys Hospital was retrospectively analyzed. Only patients underwent pre-treatment MRI examination were included this study. All patients underwent platinum-based chemotherapy after cytoreductive surgery. The values of total ovarian cyst area with diameter, area for solid fraction, area ratio of solid to total cyst, peritoneal dissemination grade, and apparent diffusion coefficient (ADC) of solid fraction were evaluated on MRI images by a gynecologist and a radiologist, respectively. Clinical factors also were also analyzed to find predictor of platinum-based chemotherapy sensitivity. Results: Total 168 patients were included 97 high grade serous ovarian cancer (HGSOC) patients and 71 non-HGSOC patients. Sensitive group was included 96 patients who responded 1st adjuvant chemotherapy and the others (n=50) who recurred in platinum sensitive state. Resistance group was included refractory patients (n=14) and 8 patients who were changed from sensitive to resistance group. Among two groups, the ratio of solid portion to total cyst, peritoneal seeding, initial CA 125 etc. were noted significant meaning in univariate analysis. In ROC curve of prediction for platinum resistance, CA 125 and the ratio of solid to total area were noted 0.758, 0.687, each. When applying the machine learning algorithm, the deep learning algorithm showed the highest AUC value (0.814). In Cox regression, the HR significantly increased as the area of the solid portion increased (HR: 1.033, p=0.014). Conclusion: Initial CA 125 and the area ratio for solid portion to total cyst are meaningful factors to predict response of platinum-based chemotherapy in EOC.

Epigenetic and Genetic characteristics of intraepithelial neoplasia of cervix

( Heekyoung Song ),( Jae Yeon Woo ),( Seongeun Bak ),( Imhyeon Kim ),( Youn Jin Choi ),( Soo Young Hur ) 대한산부인과학회 2021 대한산부인과학회 학술대회 Vol.107 No.-

한국형 유아 그림 지능 검사(Colored Progressive Matrices: CPM) 척도개발 예비연구

송진숙(Song JinSuk),권희경(Kwon Heekyoung) 한국열린유아교육학회 2002 열린유아교육연구 Vol.7 No.2

본 연구는 유아교육 현장에서 유아들을 대상으로 문항의 내용이 그림으로 표현된 한국형 유아 그림 지능 검사(Colored Progressive Matrices: CPM)를 간결하고 표준화된 검사 도구로 개발하기 의한 예비연구를 하는데 그 목적이 있다. 연구대상은 전국에 거주하는 37개월부터 만 6세까지의 유아들로 34개의 유아교육 기관을 포함한 어린이집 및 사설 학원을 포함한 유아교육기관의 총 773명의 유아들로 구성하였다. 본 연구결과는 다음과 같다. 첫째, 한국형 유아 그림 지능 검사의 총36문항은 본래 검사도구의 요인과 마찬가지로 우리나라 유아들을 대상으로 검사한 결과에서도 요인분석에서 3개의 요인으로 나타났다. 둘째, 전체 한국형 유아 그림 지능 검사의 내적 합치도 지수 cronbach's ?는 .710으로 나타났다. 셋째, 유아의 월령과 가족의 수입에 따라 평균이 차이를 보인 반면, 성별에 따라서는 차이를 보이지 않았다. The purpose of this research were preliminary study to validate Colored Progressive Matrices scale for Korean young children. And also this research was to examine the demographic variables and Colored Progressive Matrices. The subjects were 733 young children from 37month to 6 years old age in Seoul, Daejeon, Chonan, and so on. Results can be summarized as follows: First, the subscales consisted of similarity, orientation, and coordination of intelligence test. Second, Colored Progressive Matrices had adequate internal validity(Cronbach's a .71). Thired, the significant variables which are influenced the Colored Progressive Matrices were young children's age and family income.

유아교육기관에서의 유아의 적응과 유아의 사회적 능력 및 문제행동에 대한 연구

송진숙(Song Jin suk),권희경(Kwon Heekyoung) 한국열린유아교육학회 2003 열린유아교육연구 Vol.8 No.3

본 연구는 전라북도에 소재하고 있는 15개의 유아교육기관(어린이집과 유치원을 포함)에 다니고 있는 유아들의 학부모와 그들의 교사를 대상으로 인구생태학적인 변인들과 유아의 사회적 능력 및 문제행동이 유아교육기관에서의 적응과 어떤 차이가 있는지를 살펴보고자 수행되었다. 이는 유아교육기관에서 유아기 적응을 원활하게 할 수 있는 환경적 제반 요건을 계획하는데 기초 자료를 제공함을 목적으로 한다. 연구 결과 부모의 교육수준, 수입, 교사의 교사경력 유아의 사회적 능력 중에서 유능성괴 사교성 유아의 문제행동 중에서 불안행동, 과잉행동, 비행행동이 유아의 적응에 차이가 있는 것으로 나타났다. 또한 부모의 교육수준과 교사의 교육수준은 유아의 적응을 설명하는 가장 영향력 있는 변인으로 나타났다. This study investigated demographic variables, including child's age, gender, parent's education level, age, income, teacher's education level, career period, child's social ability, and behavior problem on child adjustment in early childhood institute. Subjects were 130 and instruments were questionnaire from the child's social ability scale, child's behavior problem scale, and adjustment scale. Data analysis was by mean, percentile, t-test, ANOVA, Pearson's correlation, and simple regression. Results were as follows: First, there was significant difference between parent's educational level, income, teacher's job career period and child adjustment in early childhood institute. Second, there was significant difference between child's social ability and child adjustment in early childhood institute. Third, there was significant difference between child's behavior problem and child adjustment in early childhood institute. Fourth, parent's educational level, income, child's social ability were related to child's adjustment in early childhood institute.

Distribution of BRCA1/2 mutation and clinical outcomes in epithelial ovarian, peritoneal, fallopian tube cancer: based on multicenter real-world data

( Jiyun Hong ),( Heekyoung Song ),( Yong-wook Kim ) 대한산부인과학회 2022 대한산부인과학회 학술대회 Vol.108 No.-

Objective: This study aimed to review multicenter real-world data for BRCA1/2 gene test and clinical outcomes in epithelial ovarian, peritoneal, fallopian tube cancer. Methods: We reviewed the patients who underwent primary surgery and adjuvant treatment between January 2009 and December 2021 in Seoul, Yeouido, and Incheon St. Marys hospital, the college of medicine, the catholic university of Korea. The following data were retrospectively obtained for analysis: clinical factors such as patient age, levels of tumor markers (CA 125, CA 19-9); International Federation of Gynecology and Obstetrics stage at diagnosis, histological types, and BRCA 1/2 gene test. Results: In total, 652 patients were evaluated and 237 patients (36.3%) were tested BRCA 1/2 mutation. Among all patients who received BRCA 1/2 test, 62 patients (26.2%) were noted BRAC 1/2 mutation. The other of 136 patients (57.4%) were resulted wild type and 39 patients (16.4%) were done variants of uncertain significance. In BRCA1/2 mutation group, 53 had high-grade serous ovarian cancer (HGSOC, n = 53) and 9 had non-HGSOC, consisting of endometrioid carcinoma (n = 5), clear cell carcinoma (n = 2), and mixed carcinoma (n = 2). The portion of HGSOC in BRCA 1/2 mutation group was significant higher than that of BRCA wild type (85.8% versus 61.0%, p<0.001). Overall survival and level of CA 125 of BRCA1/2 mutation group were significantly higher than those of BRCA 1/2 wild group (60.4 vs. 42.9 months, 1750 vs. 1272 mg/dl, respectively). However, only BRCA 1/2 result was reported significantly difference in multivariate logistic regression (Odd ratio: 4.73, 95% confidential Interval, 1.53 to 14.6, p=0.007). Although 26 patients of BRCA 1/2 mutation group were treated PARP inhibitor for maintenance therapy, the use of PARP inhibitor was not significant meaning in multivariate logistic regression. Conclusion: BRCA 1/2 mutation test was essential for epithelial ovarian, peritoneal, and fallopian tube cancer regardless of histologic findings.

유아의 학습관련 사회적 기술을 예언하는 부모양육에 대한 연구

송진숙(JinSuk Song),권희경(Heekyoung Kwon) 한국생활과학회 2007 한국생활과학회지 Vol.16 No.3

Insulin can block apoptosis by decreasing oxidative stress via phosphatidylinositol 3-kinase- and extracellular signal-regulated protein kinase-dependent signaling pathways in HepG2 cells

Kang, Shinhae,Song, Jihoon,Kang, Heekyoung,Kim, Sejae,Lee, Youngki,Park, Deokbae 濟州大學校 基礎科學硏究所 2001 基礎科學硏究 Vol.16 No.1

Objective : Insulin has well-known activities in controlling energy metabolism, cellular proliferation and biosynthesis of functional molecules to maintain a biological homeostasis. Recently, several studies have suggested that insulin may protect cells from apoptosis in different cell lines: however, little is known about the nature of its anti-apoptotic actigity. In many clinical disorders, including type 2 diabetes mellitus, oxidative stress and the production of reactive oxygen species (ROS) is increased. With these facts as a background, we examined here whether insulin protects HepG2 cells from apoptosis by decreasing oxidative stress and, if so, which signaling steps are involved in this process. Methos : Intracellular DNA content, the degree of nuclear condensation or poly(ADP-ribose) polymerase hydrolysis was measured to verify the occurrence of apoptotic events. Caspase-3 activity and ROS accumulation within cells were also measured. Western blot analysis was performed to identify fignaling molecules activated in response to insulin. Results : Serum starvation resulted in a marked accumulation of ROS, activation of caspase-3, and subsequent apoptotic cell death which were, in turn, markedly blocked by the addition of insulin. The anti-apoptotic activity of insulin was sensitive to blockade of two different signaling steps, activations of phosphatidylinosltol 3-kinase (PI3 kinase) and extracellular signal-regulated protein kinase (ERK). Conclusion : Insulin exerts and anti-apoptotic activity by suppressing the excessive accumulation of ROS within cells though signaling pathways including stimulation of PI3 kinase and ERK in HepG2 cells.

Physical and Chemical Properties of Coir Growth Media for Tomato Plants Depending on Number of Used Years

MunHaeng Lee,HeeKyoung Lee,HwanGu Lee,SunGye Lee,YoungShik Kim,SeungGeun Song,DougYoung Chung 한국원예학회 2014 한국원예학회 학술발표요지 Vol.2014 No.5

온라인 시스템을 활용한 대규모 서답형 평가의 채점 일관성

송미영(Mi-Young Song),김수진(Kim Soojin),김희경(HeeKyoung Kim),남명호(Myung-Ho Nam) 한국교육평가학회 2009 교육평가연구 Vol.22 No.3

대규모 학업성취도 평가의 서답형 문항에 대한 응시자들의 응답은 합숙형 수기 채점 방식으로 채점되어 왔으나,이 방식은 채점자 섭외,채점 장소 확보 등 여러 가지 현실적인 어려움이 있었다.이러한 어려움을 해소하기 위하여 기존 방식의 대안으로 온라인 시스템을 활용하는 방식을 고려할 수 있다.본 연구는 온라인 채점 시스템을 설계․구현하여 실제 적용 가능성을 검증하였다.채점자간 신뢰도를 산출한 결과, 0.810이상의 높은 상관으로 보여 채점자 신뢰도는 상당히 높았다.채점자간 점수 차이가 일정 기준을 초과할 경우 채점자들에 의한 재채점이 진행되었는데,1,2차 시기의 답안을 통합하여 구한 채점의 신뢰도는 1차 시기답안만을 대상으로 한 경우보다 모든 교과에서 증가하였다.이러한 결과로부터 온라인 채점시스템을 활용하면 채점 과정을 실시간으로 인터넷을 통해 모니터할 수 있기 때문에 채점 오류를 최소화하고 채점의 공정성과 신뢰도를 현격히 제고할 수 있으리라 기대된다. National Assessment of Educational Achievement(NAEA) in Korea, a large-scale national assessment has scored students' constructed-response items through in-hands by gathering in one secure dplace. This method had a several difficulties such as recruiting raters, booking a large enough places to keep all the raters and test book lets. This study examined the applicability of on-line scoring system for constructed-response items in a large-scale assessment. The performance samples of about 10,000 nine-graders for five subject areas such as Korean, Social Science, Mathematics, Science, English in NAEA were used. Every construct responses were scored by at least two raters. The responses were re-scored when differences between two raters' scores were greater than a certain criterion. The inter-rater reliabilities were above the 0.81, which is a very high. The result of this study shows that the correlations and agreements between scores by two raters were very high, and re-scoring improved the rater consistency evenmore.This study proved that on-line scoring system would be a stable scoring method of constructed responses for the large-scale assessment.