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- 저자 : ( Ga Ram Lee ) (검색결과 191 건)
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Ga-Ram You,Seon-Young Park,Hye-Su You,Seung-Young Seo,Sung-Kyun Yim,Byung-Chul Jin,Jung-In Lee,Young-Dae Kim,Suck-Chei Choi,Chan-Guk Park,Wan-Sik Lee 대한상부위장관ㆍ헬리코박터학회 2023 Korean Journal of Helicobacter Upper Gastrointesti Vol.23 No.4
Objectives: Gastrointestinal cytomegalovirus (CMV) disease is a major contributor to mortality in immunocompromised patients. Few studies have discussed upper gastrointestinal CMV (UGICMV) disease in immunocompetent patients. We compared the clinical outcomes of UGI-CMV between immunocompromised and immunocompetent patients.Methods: This retrospective study included patients with UGI-CMV disease from five tertiary hospitals across Korea (2010– 2022). Patients’ clinical data and outcomes were recorded.Results: UGI-CMV was diagnosed in 54 patients; 27 (50.0%) had esophageal, 24 (44.4%) had gastric, and 3 patients (5.6%) had duodenal involvement. Patients’ median age was 64 years (interquartile range 53–75 years), and the most common comorbidities included hypertension (57.4%) and diabetes (38.9%). The predominant symptom was abdominal pain (46.3%), and the most common endoscopic finding was ulcers (70.4%). Antiviral treatment was administered to 31 patients, and 23 patients underwent observation without treatment. We investigated 32 immunocompromised (59.3%) and 22 immunocompetent (40.7%) patients and observed no intergroup differences in comorbidities and in laboratory and endoscopic findings. Immunocompromised patients had longer length of hospitalization (median 46.2 days vs. 20.0 days, <i>p</i>=0.001). However, treatment outcomes, including the need for intensive care unit admission and mortality did not significantly differ. The overall mortality rate was 13.0%; one patient from the immunocompromised group died of UGI-CMV disease. The treatment success rate was higher in immunocompromised patients who received antiviral therapy (<i>p</i>=0.011).Conclusions: UGI-CMV disease is not uncommon in immunocompetent patients, although symptoms are milder than those in immunocompromised patients. Our findings emphasize the importance of clinical vigilance for accurate diagnosis of CMV infection, particularly in susceptible symptomatic patients and highlight the need for active antiviral treatment for management of immunocompromised patients.
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Prognostic utility of paraspinal muscle index in elderly patients with community-acquired pneumonia
Lee Ga Ram,Ko Seok Hoon,Choi Hang Sung,Hong Hoon Pyo,Lee Jong Seok,Jeong Ki Young 대한응급의학회 2024 Clinical and Experimental Emergency Medicine Vol.11 No.2
Objective This study investigated the associations between paraspinal muscle measurements on chest computed tomography and clinical outcomes of elderly patients with community-acquired pneumonia (CAP). Methods This single-center, retrospective, observational study analyzed elderly patients (≥65 years) with CAP hospitalized through an emergency department between March 2020 and December 2022. We collected their baseline characteristics and laboratory data at the time of admission. The paraspinal muscle index and attenuation were calculated at the level of the 12th thoracic vertebra using chest computed tomography taken within 48 hours before or after admission. Univariable and multivariable logistic regression analyses were conducted to evaluate the association between paraspinal muscle measurements and 28-day mortality. Receiver operating characteristic (ROC) curve and area under the curve (AUC) analyses were used to evaluate the prognostic predictive power. Results Of the 338 enrolled patients, 60 (17.8%) died within 28 days after admission. A high paraspinal muscle index was associated with low 28-day mortality in elderly patients with CAP (adjusted odds ratio, 0.994; 95% confidence interval, 0.992–0.997). The area under the ROC curve for the muscle index was 0.75, which outperformed the pneumonia severity index and the CURB-65 (confusion, urea, respiratory rate, blood pressure, age ≥65 years) metric, both of which showed an AUC of 0.64 in predicting mortality. Conclusion A high paraspinal muscle index was associated with low 28-day mortality in patients aged 65 years or older with CAP.
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Ga Ram Kim,Min Sun Na,Kyung Suk Baek,Seung Jin Lee,Kyung Suk Lee,Young Ho Jung,Hye Mi Jee,Tae Hee Kwon,Man Yong Han,Youn Ho Sheen 대한소아청소년과학회 2016 Clinical and Experimental Pediatrics (CEP) Vol.59 No.12
Purpose: Chest radiography is often performed on patients hospitalized with typical clinical manifestations of bronchiolitis. We aimed to determine the proportion of subjects with pathologic chest radiographic findings and the clinical predictors associated with pathologic chest radiographic findings in young children admitted with the typical presentation of bronchiolitis. Methods: We obtained the following data at admission: sex, age, neonatal history, past history of hospitalization for respiratory illnesses, heart rate, respiratory rate, the presence of fever, total duration of fever, oxygen saturation, laboratory parameters (i.e., complete blood cell count, high-sensitivity C-reactive protein [hs-CRP], etc.), and chest radiography. Results: The study comprised 279 young children. Of these, 26 had a chest radiograph revealing opacity (n=24) or atelectasis (n=2). Multivariate logistic regression analysis showed that after adjustment for confounding factors, the clinical predictors associated with pathologic chest radiographic findings in young children admitted with bronchiolitis were elevated hs-CRP level (>0.3 mg/dL) and past history of hospitalization for respiratory illnesses (all P<0.05). Conclusion: The current study suggests that chest radiographs in young children with typical clinical manifestations of bronchiolitis have limited value. Nonetheless, young children with clinical factors such as high hs-CRP levels at admission or past history of hospitalization for respiratory illnesses may be more likely to have pathologic chest radiographic findings.
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Cross-reactivity of Vaccine and Fields Strains of Bovine Coronaviruses in Korea
Lee, Ga-Ram,Song, Jae-Young,Cho, In-Soo,Yoon, So-Rah The Korean Society for Microbiology 2010 Journal of Bacteriology and Virology Vol.40 No.1
Bovine coronavirus (BCoV) causes severe diarrhea in newborn calves, and is associated with winter dysentery in adult cattle and respiratory infections in calves and feedlot cattle. Although the Korean BCoV vaccine strain, BC94, was isolated in 1995, there has still been no report of a molecular characterization of the vaccine strain. To characterize the vaccine strain, relationships between BC94 and field strains were investigated, based on sequence analysis and cross-immunity. We determined the complete sequences of the HE, N, and S genes from BC94 and four NVRQS isolates (SUN5, A3, 0501, 0502). Due to its major role in antigenicity, the spike proteins of the BCoVs were analyzed. BC94 showed distinctive genetic divergence from field isolates collected from 2002 to 2005. BC94, SUN5, and A3 had no virulence-specific sequence and there was a single amino acid change, from asparagine to lysine at residue 175, in the polymorphic region. Strains 0501 and 0502 had virulence-specific sequences at all seven sites. Although the recently isolated Korean BCoVs and BC94 were genetically different, the cleavage site of spike genes at 763~768 (KRRSRR) and the antigenic domain II of the spike protein, amino acid position 528, were conserved in all NVRQS isolates. The antigenic relatedness of KCD9, representative of recent Korean BCoVs, was compared with the Korean vaccine strain BC94. KCD9 showed cross-reactivity against BC94 by virus neutralization (VN) test. These results suggest that BC94 is antigenically closely related to field isolates and is still effective as a vaccine strain.
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최가람 ( Ga Ram Choi ),이솔 ( Sol Lee ),이경애 ( Kyong Ae Lee ),신말식 ( Mal Shick Shin ),김향숙 ( Hyang Sook Kim ) 한국식생활문화학회 2014 韓國食生活文化學會誌 Vol.29 No.1
본 연구는 탕평채의 표준 조리법을 확립하며, 나아가 천연 색소물질을 첨가한 청포묵을 기본 재료로 사용한 오방색 탕평채를 개발하기 위해 실시하였다. 관능검사를 통해 탕평채의 표준조리법 확립과 오방색 탕평채의 개발에 관한 결과는 다음과 같다. 1. 탕평채의 현대 조리서를 고찰하여 전문가 패널을 대상으로 한 시식회를 통해 탕평채를 보완한 결과 재료의 비율은 현대 조리서의 중간 분량을 조합한 평균조리법으로 하였으며, 소고기는 대량화를 위해 편육으로 만들어 소고기 양념을 조린 뒤 무치는 방법으로 변경하였고, 소스의 산도와 간장의 색을 줄이기 위하여 식품영양학과 학생 34명을 대상으로 기호도 검사를 실시 한 결과 청포묵 100 g 기준의 탕평채 분량에 해당하는 간장 6 g, 식초 3 g, 물 12.4 g, 소금 1 g, 설탕 3 g, 깨소금 0.65 g을 첨가하여 만든 초간장이 비교적 높은 기호도를 보였다. 표준조리법으로 조리한 탕평채의 주재료의 분량은 청포묵 100 g 기준으로 편육 20 g, 데친 숙주 21 g, 데친 미나리 21 g, 달걀 1/4개, 김 1/4장이며 초간장 분량은 간장 6 g, 식초 3 g, 설탕 3 g, 깨소금 0.65 g, 물 12.4 g, 소금 1 g이며, 편육을 만들기 위한 분량으로는 우둔 35 g, 대파 2.5 g, 생강 1 g, 통후추 0.4개이며 편육양념의 분량은 간장 4.56 g, 설탕 1.4 g, 물 10 g, 대파 2.62 g, 마늘 1.96 g, 참기름 1 g, 깨소금 0.7 g, 후춧가루 0.1 g였다. 탕평채의 표준 조리법은 다음과 같다. 1) 우둔을 찬물에 1시간 정도 담가 핏물을 빼준 다음 우둔이 잠길 정도로 물을 부은 뒤 뿌리를 포함한 대파, 생강, 후추를 넣고 끓으면 핏물을 뺀 우둔을 넣고 강 불에서 10분, 중불에서 40분을 삶은 뒤 건져내 거즈로 단단하게 싸 식힌뒤 4 cm길이 고깃결 방향으로 채 썰어준다. 2) 편육 양념의 대파와 마늘은 큼직하게 썰어 분량의 간장, 설탕, 물과 함께 졸인 뒤 대파와 마늘을 건져내고 채 썰어놓은 편육과 참기름, 깨소금, 후춧가루를 넣어 버무린다. 3) 청포묵은 0.5×0.5×5 cm로 채 썰어 끓는 물에 데친 후식혀주며, 숙주는 거두절미하고 미나리는 4 cm 길이로 썰어 데친다. 4) 계란은 황백지단으로 부쳐 4 cm 길이로 채 썰어주며, 김은 잘게 부순다. 5) 초간장 분량의 재료를 한 대 섞어 양념을 만든다. 6) 접시에 청포묵, 숙주, 미나리, 양념한 편육을 가지런히 올려놓고 채 썬 지단과 김을 고명으로 올린 후 초간장을 곁들여 낸다. 2. 치자, 오미자, 적양배추, 백년초, 들깨, 검은깨의 최적의 첨가비율을 알아보기 위해 수준별 농도로 청포묵에 첨가되는 천연 색소물질의 양을 조절한 뒤 식품영양학과 대학원생 10명을 대상으로 기호도 검사를 실시한 결과 다음과 같다. 치자는 사용 물 대비 2%첨가군, 오미자는 사용 물 대비 2%첨가군, 검은깨는 사용 전분 대비 4%첨가 군에서 비교적 높은 기호도를 나타내었다. This study attempted to develop a representative mild Korean food, including kimchi, bulgogi, galbi, and bibimbap, while maintaining existing images in order to spread Korean food worldwide. Tangpyeongchae is a mild healthy food with a nutritional balance of carbohydrates from cheongpomuk, protein from beef and eggs, and vitamins and minerals from water parsley, bean sprout, and laver. The food has a history of being favored by the political elite of the Joseon Dynasty and has features in Korean storytelling. Tangpyeongchae is an obangsaek food (five representative colors of Oriental philosophy). This study examined modern recipes of Tangpyeongchae in order to establish a standardized cooking method. Furthermore, the study examined customer interest and marketability of natural pigments to develop obangsaek cheongpomuk (mungbean gel) by adding black sesame, a traditional ingredient in Korea, to the cheongpomuk as well as traditional Korean pigments, chija and omija.
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Kim, Ga Ram,Na, Min Sun,Baek, Kyung Suk,Lee, Seung Jin,Lee, Kyung Suk,Jung, Young Ho,Jee, Hye Mi,Kwon, Tae Hee,Han, Man Yong,Sheen, Youn Ho The Korean Pediatric Society 2016 Clinical and Experimental Pediatrics (CEP) Vol.59 No.12
Purpose: Chest radiography is often performed on patients hospitalized with typical clinical manifestations of bronchiolitis. We aimed to determine the proportion of subjects with pathologic chest radiographic findings and the clinical predictors associated with pathologic chest radiographic findings in young children admitted with the typical presentation of bronchiolitis. Methods: We obtained the following data at admission: sex, age, neonatal history, past history of hospitalization for respiratory illnesses, heart rate, respiratory rate, the presence of fever, total duration of fever, oxygen saturation, laboratory parameters (i.e., complete blood cell count, high-sensitivity C-reactive protein [hs-CRP], etc.), and chest radiography. Results: The study comprised 279 young children. Of these, 26 had a chest radiograph revealing opacity (n=24) or atelectasis (n=2). Multivariate logistic regression analysis showed that after adjustment for confounding factors, the clinical predictors associated with pathologic chest radiographic findings in young children admitted with bronchiolitis were elevated hs-CRP level (>0.3 mg/dL) and past history of hospitalization for respiratory illnesses (all P<0.05). Conclusion: The current study suggests that chest radiographs in young children with typical clinical manifestations of bronchiolitis have limited value. Nonetheless, young children with clinical factors such as high hs-CRP levels at admission or past history of hospitalization for respiratory illnesses may be more likely to have pathologic chest radiographic findings.
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