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치과 기공사들에게서 나타나는 호흡기 증상과 이의 관련 요인
김웅철,오세윤,김지환,김진완,이준석,이가영,이세훈,유진호,김태석 高麗大學校 倂設 保健大學 保健科學硏究所 2001 保健科學論集 Vol.27 No.1
This study was carried out to investigate subjective respiratory symptoms and their attributable factors in Korean dental laboratory technicians. A questionnaire was mailed to randomly selected 1,900 dental laboratory technicians. Among them, 1,344 dental technicians completed the questionnaires and returmned them. Validity and reliability tests on the questionnaires were carried out before the main survey. To investigate risk factors on respiratory subjective symptoms, we performed analysis on distribution of characteristics, and then investigated univariate analysis and multiple logistic regression analysis. The prevalence rate of wheezing, cough and phlegm, and dyspnea was 4.8%, 33.9%, 54.9%, respectively. Statistically significant factors inducing subjective respiratory symptoms by multiple logistic regression analysis were sex, smoking, exercise, health examination, work hours a day, investment gas, investment dust, metal fume, resin vapor, and asbestos dust. Considering the results above, it seems that most subjective respiratory symptoms are related with health habits and occupational environmental-related factors. The result, consideration in mind, suggest that health promotion programs for smoking cessation, regular health examination, and physical exercise in health habit, and improvement on casting and resin work in dental technological environment be necessary.
MMP-2 and MMP-9 Inhibitory Effects of Different Solvent Fractions from Corydalis heterocarpa
Ga Hyun Yu(유가현),Fatih Karadeniz(카라데니즈 파티),Chang-Suk Kong(공창숙) 한국생명과학회 2021 생명과학회지 Vol.31 No.11
염주괴불주머니(Corydalis heterocarpa)는 두해살이 풀로 노란 꽃이 피고 염주처럼 잘록한 열매를 맺는 것이 특징이다. 또한 우리나라 갯벌에서 서식하는 염생식물로 내건성, 내염성과 같은 독특한 생리적 기전을 가지고 있으며 민간에서 진통 경련 완화 치료제로 사용하고 있다. 본 연구에서는 항산화, 항염증, 항노화 등의 효과가 있는 것으로 보고되어 있는 염주괴불주머니(Corydalis heterocarpa)을 이용하여 용매분획물(H₂O, n-BuOH, 85% aq. MeOH, n-hexane)을 제조하였으며 이를 이용하여 PMA로 유도된 인간 섬유육종세포 HT-1080 세포에서 MMP-2, MMP-9의 발현 조절에 미치는 영향을 확인하였다. 염주괴불주머니 분획물 처리시 TIMP-1 및 TIMP-2를 증가시키면서 MMP-2 및 MMP-9의 mRNA 및 단백질 발현을 감소시키는 것으로 나타났다. 또한 염주괴불주머니 용매분획물 처리시 MAPKs 신호 전달 경로인 p38, JNK, ERK의 인산화를 억제하여 MMPs 발현을 감소시키는 것을 확인할 수 있었다. 특히 염주괴불주머니의 85% aq. MeOH와 n-hexane 용매분획물에서 MMP-2 및 MMP-9 발현이 효과적으로 억제되어 MMP 억제활성이 높은 물질이 들어있을 것으로 사료되며, 이를 통해 염주괴불주머니의 암 전이 억제 소재 개발을 위한 기초자료로 활용될 수 있을 것으로 기대된다. Natural products have always been an attractive source in terms of novel anti-metastatic compounds which can hinder MMP expression and activity. Corydalis heterocarpa is a salt marsh plant found in the seashores throughout Korea. Its yellow flowers and spikes have been an ingredient in folk medicine to treat spasm and contractions. The present study assessed the potential of different solvent-based fractions from the crude extract of Corydalis heterocarpa (CHE), a halophyte with reported bioactivities, to suppress the PMA-induced MMP expression in human fibrosarcoma HT-1080 cells. The solvent fractions which were named after the solvent used for fractionation (n-hexane, 85% aqueous (aq.) methanol (MeOH), n-butanol (BuOH), and H₂O were shown to inhibit the both elevated mRNA and protein expression levels of MMP-2 and MMP-9 and simultaneously relieved the suppression on the expression of the endogenous MMP inhibitors TIMP-1 and TIMP-2. Results indicated that the CHE fractions might intervene with the PMA-induced activation of the MAPK signaling which is the upstream activator of MMP overexpression. Among tested samples, 85% aq. MeOH and n-hexane fractions of CHE was determined to be the most active and future studies to isolate the bioactive substances responsible for the regulation of the MMP expression are, therefore, urged. In conclusion, C. heterocarpa was shown to be a potential source of anti-metastatic compounds and n-Hexane and MeOH fractions might yield lead molecules to develop novel MMP inhibitors.
S-196 : Echocardiographic and ABPM parameters between 4 groups of hypertensive patients
( Ga In Yu ),( In Kyoung Shim ),( Jung Ho Heo ),( Kyoung Im Cho ),( Hyun Su Kim ),( Jae Woo Lee ),( Tae Joon Cha ) 대한내과학회 2013 대한내과학회 추계학술대회 Vol.2013 No.1
Background: The utility of ambulatory blood pressure monitoring (ABPM) has been recognized, and the practice has been adopted widely. We investigated the clinical characteristics and ABPM profiles between patients with normotension, white coat hypertension, masked hypertension, and sustained hypertension by clinic BP and ABPM. Methods: This study is a retrospective analysis of patients with ABPM from January 2008 to May 2013. After measurement of clinic BP and ABPM, 4 groups of patients were identified namely: (i) NT: normotensive patients (BPs are normal both clinically and by ABPM) (ii) WCHT: white coat hypertensive patients (clinical BP were above limits, but ABPM were normal); (iii) MHT: masked hypertensive patients (clinical BP were normal, but ABPM were high); (iv) SHT: sustained hypertensive patients (both office and ABPM were high). Results: In total 75 patients with NT (mean age 46.5±13.7 years, female 32%), 34 patients with WCHT (mean age 51.6±13.9 years, female 50%), 201 patients with MHT (mean age 48.2±12.9 years, female 44.8%), and 83 patients with SHT (mean age 49.5±13.9 years, female 44.6%) were included. In echocardiographic findings, relative wall thickness and left ventricular mass were higher in MHT than NT (p=0.047, p=0.007) and WCHT (p=0.002, p=0.047). Subjects with NT and WCHT had similar 24 hours BP variability, and the variability among those with MHT was close to that in those with SHT. Conclusion: The short-term variability of BP is similar in MHT and SHT and higher than NT and WCHT. Left ventricular mass were higher in MHT than NT and WCHT. This results showed ABPM was more predictive of target organ damage than clinic BP and BP variability in patients with MHT may contribute to the elevated cardiovascular risk.
주파수추종서비스 제공을 위한 다수 배터리전기저장장치(BESS)의 통합제어 전략
유가람(Ga Ram Yu),최우영(Woo Yeong Choi),국경수(Kyung Soo Kook) 대한전기학회 2016 전기학회논문지 Vol.65 No.7
As an Increased penetration level of renewable resources has caused concerns about primary frequency response, an increase in BESS(Battery Energy Storage System) capacity has been expected because of its fast response to the disturbances in the power system. This paper proposes the Integrated Control Strategy of multiple BESS for effectively providing the primary frequency control in the bulk power systems by coordinating the response, SOC and its recovery of BESS. The proposed strategy prevents multiple BESS from providing exceeding response and keeps the balance between SOC of multiple BESS. In addition, It would recover the SOC of BESS efficiently. The effectiveness of the proposed strategy is verified through various case studies employing Korean power system.