카드뮴 첨가된 α형 산화철에 의한 일산화탄소의 촉매산화 반응연구

이성한,김용록,김돈,정원양,김규홍,최재시 연세대학교 자연과학연구소 1983 學術論文集 Vol.11 No.-

α형 산화철에 카드뮴을 4mol%, 8mol% 및 12mol%로 각각 첨가시켜 외성영역의 특성을 갖는 산화물들을 제조하였다. 이 산화물들을 촉매로한 일산화탄소의 산화반응 속도론적 연구를 통하여 본산화물의 결함구조, CO 산화반응에 대한 촉매성 및 불순물 첨가효과등을 조사하였다. 또한 450℃에서 O_2 및 CO를 여러압력으로 도입시켜 Cd-doped α-Fe_2O_3의 전기전도도를 측정하고 이를 반응속도론적 데이타와 결부시켜 본산화물상에서 CO 의 산화반응 메카니즘과 율속단계를 제안하였다. 반응온도범위 350~460℃에서 산출된 활성화에너지는 10.1~11.3kcal.mol^-1이었다. CO_2흡착에 의한 CO산화반응의 억제효과는 본실험의 반응온도 영역인 350~460℃에서는 나타나지 않았으며 CO 산화반응의 전반응속도 차수는 1.5차로서 일산화탄소에 대해서는 1차, 산소에 대해서는 0.5차임이 밝혀졌다. 반응속도론적 데이타와 전기전도도 데이타에 의해 본촉매의 활성은 카드뮴도프로 인해 생성된 산소공위(Vo"-2e^-)에 기인한 것이었다. 카드뮴의 첨가량이 증가할수록 반응속도는 증가하였으나 12mol% 이상의 카드뮴이 첨가된 산화철상에서는 반응속도가 크게 증가하지 않는 것으로 나타났다. CO와 O_2는 근본적으로 화학흡착하며 CO의 흡착자리는 격자산소(O^-2_(latt))와 기흡착원산소 (O^-_(ads)), 그리고 O_2의 흡착자리는 산소공위(Vo"-2e^-)로 밝혀졌다. The α-Ferric oxide containing 4, 8, and 12mol% with cadmium were prepared. The oxidation rates of carbon monoxide in the presence of these oxide systems were measured to investigate the defect structure, the catalytic activity for the oxidation of carbon monoxide, and the impurity effect. The conductivity was also measured at 450℃ under the various pressures of oxygen and carbon monoxide. From the agreement between the kinetic and conductivity data, the oxidation mechanism of carbon monoxide and the rate determining step on this oxide catalyst were suggested. In the temperature range from 350 to 460℃, the calculated activation energy for the CO oxidation over Cd-doped α-Fe_2O_3 systems were 10.1∼11.3kcal·mol^-1. The inhibition by an adsorbed CO_2 during the CO oxidation was not observed in the above temperature range. The overall reaction order for the CO oxidation is 1.5; the first order with respect to CO and the one-half order with respect to O_2. The catalytic activity of this oxide system is due to oxygen vacancies induced by Cd-doping. The oxidation rates increase with increasing the amount of dopant and above 12mol%, however, don't highly increased. CO and O_2 are essentially chemisorbed as ions and the adsorption sites for CO are the lattice oxygens (O^2-_(latt)) and prechemisorbed oxygens (O^-_(ads)), the adsorption site for O_2 is the oxygen vacancies (Vo¨-2e^-).

Multiple myeloma 환자에서 Bortezomib치료 후 발생한 마비성 장폐색증 1례

김준영,이원식,손창학,박성길,진한영,박석주,조영완,정은욱,강명주,박정하,주영돈 인제대학교 2006 仁濟醫學 Vol.27 No.-

Bortezomib is the first clinically available proteasome inhibitor that is clinically effective in the treatment of multiple myeloma. A proteasome inhibitor acts through multiple mechanisms to arrest tumor growth, tumor spread, and angiogenesis. The main adverse effects of bortezomib are gastrointestinal symptoms, cytopenia, fatigue, and peripheral neuropathy. To date, severe paralytic ileus has not been reported as a toxic effect of bortezomib treatment in multiple myeloma. Bortezomib is a novel agent that has only been used clinically for 30 months, so a need exists to further evaluate its toxicity. We report a case of grade Ⅲ (NCI CTCAE v3.0) or grade Ⅳ(SWOG toxicity criteria) paralytic ileus in a 65-year-old man with relapsed multiple myeloma who underwent one cycle of single-agent bortezomib treatment scheduled in a 21-day cycle (1.3 mg/㎥ as a single i.v. bolus on days 1, 4, 8, and 11).

行爲決定 MODEL 作成에 관하여

鄭漢永,金榮敦 서울대학교 교양과정부 1972 論文集 Vol.4 No.-

3차원 애니메이션을 이용한 가상쇼핑공간의 인터페이스 디자인에 관한 연구

이규백,김돈한,이명재 울산대학교 2000 조형논총 Vol.3 No.1

최근 인터넷의 급격한 보급에 따라 가상 환경하에서의 전자상거래 시장이 급격한 신장세를 보이고 있다. 이에 따라 각 기업에서도 마케팅 수단으로서의 사이버 스페이스의 중요성을 인식하여, 가상공간 상에서의 제품구매 과정과 소비패턴의 분석 및 상품 시뮬레이션 기법의 개발에 집중적인 투자를 하고 있다. 이와 같이 가상공간 상에서의 사이버쇼핑을 위한 잠재 소비자의 수효가 급증함에 따라 보다 많은 소비자들에게 개개인의 감성적 취향에 적합한 제품환경을 제공하기 위한 웹기반하에서의 쇼핑공간의 계획과 인터페이스의 구축이 무엇보다 필요하다. 전자상거래는 실물을 손으로 만져보고 눈으로 확인하는 과정을 통해 이루어지던 기존의 상거래 방식이 아닌 가상의 공간 속에서의 제공되는 인터페이스를 통해서 이루어지는 형식이기 때문에 현실감이 현저히 떨어지는 것이 제약 조건이다. 이러한 제약을 극복하기 위한 지원시스템의 개발여부가 전자상거래의 성공여부를 가름하는 중요한 요인으로 되고 있다. 따라서 본 연구에서는 2차원 컴퓨터 그래픽스와 애니메이션 기술을 이용하여 컴퓨터 안에 가상의 쇼핑공간을 구축하고 이 공간을 Walkthrough하는 것에 의해 실제의 쇼핑공간에 보다 근접한 현실감을 느낄 수 있는 전자상거래 지원 시스템을 제안하였다. 연구는 인터넷상에서의 소비자 구매행동을 분석하고, 실제 웹사이트에 구축하기 위해, 디자인 개념 설정, 타겟 설정, 디자인 적용, 업로드 등의 프로세스 구축과 3차원 인터넷 쇼핑몰을 개발하는 순으로 진행하였다.

닭실마을의 경관복원과 정비에 관한 연구

박찬용,김한배,황상돈 한국정원학회 2002 한국전통조경학회지 Vol.20 No.4

This study deals with comprehensive landscape restoration and reorganization of Dagsil Village including physical and cultural resources. Restoration of physical environment, old roads, architecture, gardens, streams, sceneries and Feng-shui tails is planned and existing Village museum is to be relocated to outside of the Village. A Detour road and buffering woods are also planned. As supporting facilities, Confucian cultural exhibition hall, a house for tasting Korean traditional cakes and a village courtyard are to be built. Suggested cultural programs to facilitate development of folklore culture are as follows: learning Feng-shui and field survey, host families for experiencing energy, ceremony restoration and chances of education for garden culture and classics, and festival for Korean traditional cakes.

장이간 이뇨제 남용중인 특발성 또는 자가획득 부종간의 병태생리의 차이

민경환(Kyung Hwan Min),김호중(Ho Jung Kim),유준호(Jun Ho Ryu),한상웅(Sang Woong Han),강석우(Seok Woo Kang),문중돈(Jung Don Mun) 대한신장학회 2000 Kidney Research and Clinical Practice Vol.19 No.1

N/A Patients suffering from idiopathic or self-induced edema are uniformly characterized by chronic use of furosemide, which leads to vicious cycle of edema. Among chronic furosemide users who don't have any other specific edema forming diseases, 9 patients from the outpatient clinic(OC) and 6 patients examined at the emergency room(ER) used it mainly for weight reduction and for cyclical edema, respectively. All of the ER group patients were presented with severe hypokalemia(2.04±0.2mEq/L; range 1.3 to 2.7 mEq/L) and alkalosis(748±0.01; range 7.44 to 7.51) but none from the OC group showed such results. Other baseline parameters including Plasma renin activity(PRA) and aldosterone level on recumbency, and FEn₂were similar in both groups. In contrast, daily working hours(6.1±0.5 vs 10±0.6hr, p<0.01), average body weight gain between AM and PM(0.4±0.1 vs 0.9±0.lkg, p<0.01), peak weight gain interval(9±0.8 vs 5±0.1day, p<0.05), PRA(7.6±1.5 vs 23.5±7.2ng/ml/h, p<0.05) and aldosterone level(22.1±4.2 vs 64.8±10.4 ng/dl, p<0.01) on ambulation, and FEk. on normokalemia(ll±2A vs 36±7.7%, p<0.01) were statistically different between the two groups. In comparison to the OC group, both the amout of urine(617±39 vs 358±26ml, p<0.01) and the percent change of PRA(-14±4 vs -3±2%, p<0.05) and al-dosterone level(-17±5 vs -4±3%, p<0.05) after saline loading(lL over 1hr, IV) following ambulation were smaller in the Elt group. Moat of the ER group patients(5/6) required aldosterone antagonist (spironolactone) added to K(+) supplement, but all of the OC group patients were managed to maintain an edema-free status with conservative treatment. In conclusion, patients with idiopathic edema seem to have more fluid transudation out of intravascular space during orthostasis with a prominent degree of deranged renin-aldosterone axis and K(+) metabolism than those with self-induced edema.

한국의 발톱진균증 환자의 삶의 질에 관한 연구

조백기,박종갑,김형옥,김성욱,백승철,김진우,김시용,안규중,전재복,오지원,김낙인,이규석,오칠환,김수남,김상태,손숙자,신용우,김동석,이원우,권경술,서대헌,황규왕,이종석,고재경,강원형,정기양,최응호,김기홍,박석돈,강승주,함정희,명기범,김방순,구상완,김병수,원영호,김한욱,송은섭,정병수,노병인,홍창권,박장규,한지윤,김광중,구대원,김종민,김재홍,유희준,양경미 대한의진균학회 1998 대한의진균학회지 Vol.3 No.2

Background: Onychomycosis, especially toenail onychomycosis has become one of the common fungal infection and has historically been regarded as a cosmetic rather than medical problem by many patients, even by physicians. Recently, however, there are several reports that is a refractory disease which may cause a deleterious effect on patiets quality of life (QOL). Objective: The purpose of this study was to investigate the impact of toenail onychomycosis on QOL in Korea and to assess the chandes of QOL after treatment. Methods: Total 1004 patients with toenail onychomycosis which was confirmed by clinical findings and KOH preparation were were enrolled at 47 dermatologic centers in Korea, and interviewed with standardized QOL questionnaire before and after sytemic antifungal treatment. Responses to the questionnaire were scored by 5-point scale (1∼4) and averaged, and were analyzed for 5 dimensions of emotional impact, social impact, symptorn and functional impact, patients views concerning treatment, and relationship with doctor. Results: 1. Before and after treatment, the most serious impact was emotional dimension showing 1.90 and 1.30 in average score (AS), and social (AS: 1.14 and 0.83) and symptom and functional impact (AS: 1.05 and 0.92) was also affected. 2. In female rather than male, statistically more significant impact on patients QOL was observed in all dimensions. 3. After treatment, 3 of 5 dimensions were improved significantly - emotional dimension (AS : from 1.90 to 1.30), social dimension (AS: from 1.14 to 0.83), patients view concerning treatment (AS: from 1.34 to 1.02). 4. The drgree of patients satisfaction at the therapeutic effect was very high- 62.4% (immediately after treatment) and 65.8% (9 months affer initiation of treatment) of patients answered excellent or good. Conclusion: This study confirms that toenail onychomycosis has significant impact on the overall QOL of patients. Also the effect of antifungal therapy on patients QOL were watisfactory. Therefore, both doctor and patient should pay more attention to the treatment of onychomycosis. [Kor J Med Mycol 3(1): 115∼124]

Periventricular white matter hyperintensities and the risk of dementia: a CREDOS study

Kim, Sangha,Choi, Seong Hye,Lee, Young Min,Kim, Min Ji,Kim, Young Don,Kim, Jin Young,Park, Jin Hong,Myung, Woojae,Na, Hae Ri,Han, Hyun Jeong,Shim, Yong S.,Kim, Jong Hun,Yoon, Soo Jin,Kim, Sang Yun,Kim Cambridge University Press 2015 INTERNATIONAL PSYCHOGERIATRICS - Vol.27 No.12

<B>ABSTRACT</B><B>Background:</B><P>Cerebral white matter hyperintensities (WMH) are prevalent incident findings on brain MRI scans among elderly people and have been consistently implicated in cognitive dysfunction. However, differential roles of WMH by region in cognitive function are still unclear. The aim of this study was to ascertain the differential role of regional WMH in predicting progression from mild cognitive impairment (MCI) to different subtypes of dementia.</P><B>Methods:</B><P>Participants were recruited from the Clinical Research Center for Dementia of South Korea (CREDOS) study. A total of 622 participants with MCI diagnoses at baseline and follow-up evaluations were included for the analysis. Initial MRI scans were rated for WMH on a visual rating scale developed for the CREDOS. Differential effects of regional WMH in predicting incident dementia were evaluated using the Cox proportional hazards model.</P><B>Results:</B><P>Of the 622 participants with MCI at baseline, 139 patients (22.3%) converted to all-cause dementia over a median of 14.3 (range 6.0-36.5) months. Severe periventricular WMH (PWMH) predicted incident all-cause dementia (Hazard ratio (HR) 2.22; 95% confidence interval (CI) 1.43-3.43) and Alzheimer's disease (AD) (HR 1.86; 95% CI 1.12-3.07). Subcortical vascular dementia (SVD) was predicted by both PWMH (HR 16.14; 95% CI 1.97-132.06) and DWMH (HR 8.77; 95% CI 1.77-43.49) in more severe form (≥ 10 mm).</P><B>Conclusions:</B><P>WMH differentially predict dementia by region and severity. Our findings suggest that PWMH may play an independent role in the pathogenesis of dementia, especially in AD.</P>

간동맥색전술로 치료한 고칼슘혈증을 동반한 경화성 간세포암 1예

이돈(Don Lee),김인한(In Han Kim),김선후(Seon Hu Kim),이진우(Jin Woo Lee),최원(Won Choi),이돈행(Don Haeng Lee),김범수(Pum Soo Kim),김형길(Hyung Gil Kim),김영수(Young Soo Kim) 대한내과학회 2000 대한내과학회지 Vol.59 No.1

The sclerosing hepatocellular carcinoma is a histopathologically unusual subtype of primary hepatocellular carcinoma characterized by intense fibrous stroma in which the tubular neoplastic structures are embedded. It has been reported that hypercalcemia is much more frequently associated up to 69% in this subtype than in other subtypes of primary hepatocellular carcinoma. As we know, uncontrolled hypercalcemia may result in fatal outcome, and it was reported that hypercalcemia associated with hepatocellular carcinoma could be controlled with the resection of the tumor when it was possible. We report a case of sclerosing hepatocellular carcinoma with hypercalcemia in which the hypercalcemia was controlled with transcatheter arterial chemoembolization (TACE).(Korean J Med 59:104-108, 2000)

Serum Leptin in Hepatic Steatosis

김인한 ( Kim In Han ),최원 ( Choe Won ),김선후 ( Kim Seon Hu ),이진우 ( Lee Jin U ),이돈행 ( Lee Don Haeng ),김범수 ( Kim Beom Su ),김형길 ( Kim Hyeong Gil ),김영수 ( Kim Yeong Su ),최원식 ( Choe Won Sig ) 대한간학회 1999 Clinical and Molecular Hepatology(대한간학회지) Vol.5 No.1(S)