기능성 Catechol-O-Methyltransferase 유전자 다형성과 한국인 정신분열병의 관련성

박태원,홍영준,박임순,김형섭,최인미,배수영,윤경식,강대희 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.4

연구목적 : Catechol-O-Methyltransferase(COMT)는 카테콜아민 신경전달물질의 불활성화를 담당하는 효소로서, 정신분열병과 관련된 후보 유전자로서 알려져 왔다. 최근, 기능성 COMT유전자 다형성과 정신분열병의 관련성이 제기되었는데, 한국인 정신분열병에서도 이러한 관련성이 있는지를 살피기 위해 본 연구를 시행하였다. 방 법 : 정신분열병으로 진단된 환자군 103명과 성별 및 연령별로 1:1 짝짓기 대조군 사이에 유전자형과 대립유전자의 분포를 비교하였다. 또한, 환자군은 공격적 행동, 가족력, 아동기 발병 여부에 따라 두 군으로 나누어 비교하였다. DNA의 다형성 부의를 중합효소연쇄반응에 의해 증폭한 후 ,NlaⅢ제한효소법과 전기영동을 실시하여 유전자형을 판별하였다. 결 과 : 환자군 전체와 대조군 사이에 유전자형과 대립유전자 빈도의 차이가 없었다. 가족력이 있는 환자군을 대조군과 비교하였을 때는, 대립유전자 L을 포함하는 유전자형과 그렇지 않은 유전자형의 분포에 있어 유의한 차이를 보였다(p=0.02, OR=3.9, 95% Cl=1.1∼14.3). 결 론 : 한국인 정신분열병과 기능성 COMT 유전자 다형성 사이에 유의한 관련성이 없었다. 따라서, 기능성 COMT 유전자 다형성이 한국인 정신분열병의 발병에 영향을 주지 못한다. 그러나, 정신분열병 가족력과 기능성 COMT유전자 다형성의 관련성이 시시돠어, 향후 본 연구에서 나타난 방법론적인 문제점을 보완하고 추가 대상자를 확보한 연구가 필요하다. Objectives : Catechol-O-methyltransferase(COMT) is involved in the degradation of catecholamine meurotransmitters and has been investigated as a candidate gene in schizophrenia. Recently, possible relationship between functional COMT gene polymorphism and schizophrenia has been suggested. To address the possible role of functional COMT gene polymorphism in the predisposition to schizophrenia, we carried out an association study in Korean schizophrenic patients and controls. Methods : One hundred and three Korean inpatients diagnosed as schizophrenia and 103 age and sex matched controls were selected as study subjects. Patients were subgrouped into two groups on the basis of history of aggressive behavior, family history of schizophrenia and related disorders, and age at onset. We determined COMT genotypes using PCR of the relevant region followed by digestion with NlaⅢ and electrophoresis. Results : No significant differences of allele and genotype frequencies were noted between patients and controls. However, when patients were categorized by the presence of family history of schizophrenia and related disorders, patients with family history showed almost 4 fold higher frequency of having COMT L allele containing genotype compared to controls(p=0.02, OR=3.9, 9.5% CI=1.10-14.33). Conclusion : Although our results do not support an association between functional polymorphism of COMT gene and schizophrenia overall, the findings suggest an association between functional COMT gene polymorphism and familial schizophrenia. Further studies with large samples are needed to confirm this association.

전립선 암종에서 Proliferating Cell Nuclear Antigen(PCNA) 표출에 대한 면역 조직화학적 연구

박대준,김대중,김창진 순천향의학연구소 1996 Journal of Soonchunhyang Medical Science Vol.2 No.2

The prostate carcinoma is one of the frequent malignant tumor in male. Recently its prevalence has been increased along with the increase of the aged. Most of this tumor arise in the aged of above 60 years. The prognostic factors of this tumor are clinical sgres, histologic grades and DNa ploidy. The proliferating cell nuclear antigen(PCNA) is nonhistone DNA polymerase delta auxiliary protein which molecular weight is 36,000. It increased in S-phase of cell cycle in peak stage and it is known to be important in the initiation of cell proliferation. This study was conducted to see the cellular proliferation rate of prostate carcinoma according the Gleason's histologic grade in comparison with benign brpstate hypertrophy(BPH) by immunohistochemistry of PCNA. The results were as follows; 1. The basal cells beneath the glandular epithelial cells showed strong and extensive positivity for PCNA in benign prostatehypertrophy. Some stromal smooth cells also showed strong positivity for PCNA. 2. The intensity score of PCNA positivity for BPH and prostate carcinoma were 236.9±25.4 and 227.4±23.9 respectively.(P>0.05) 3. The intensity score of PCNA positivity according to the Gleason's grade were 234.7±7.8, 263.5±5.4 and 223.6±6.5 for the groups of below 4, between 4 to 8, and above 8 respectively.(P>0.05) Above results showed that the basal cells of hypertrophic glands have high rate of cellular proliferation and there is no significant difference in cell proliferation between basal cells of hypertrophic glands and prostate carcinoma, which implies that PCNA is expressed highly in normal proliferating cells As materials examined were needle biopsied, fragmented tissue. Gleason's histologic grading could be incorrect, and there were no difference of PCNA expression between the Gleason's grading group. Further studies with sufficient materials should be done for the relationship between Gleason's histologic grades and PCNA expression.

멀티미디어 원격 교육 시스템 설계 : MDLS

박길철,황대준 成均館大學校 科學技術硏究所 1995 論文集 Vol.46 No.1

Providing both teachers and students with features for natural interaction is important issues on exploiting the benefits from multimedia collaboration learning session. With these facts Multimedia Distance Learning System(MDLS) has been come up with interesting functionalities: presentation configurator, and session management for multiple instance and concurrent sessions. The presentation configurator featured with MDLS allows teachers to find out the best way of delivery of the lectures to the students participating virtual classroom during distance learning session. This would be of great help for teachers to draw spontaneous committment from the students taking lectures.

관동맥 재개통 후 QTc간격분산의 감소 : 정량적으로 측정한 심근 허혈의 호전 정도와의 연관성 Relationships with the Quantitative Degree of Improvement in Myocardial Ischemia

박상선,최기준,남기병,이철환,홍멸기,박성욱,박승정,신중우,문대혁,김유호 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.8

재난관리 행정에 대한 네트워크적 분석

박석희,노화준,안대승 서울대학교 행정대학원 2004 行政論叢 Vol.42 No.1

우리나라에서 재난관리행정(disaster management system)에 대한 논의는 대부분 지엽적이고 기술적(technical)인 측면에서만 이루어지고, 재난관리행정의 본질적 특성에 대한 논의는 소수에 불과하였다. 재난관리행정의 중요성을 강조하면서도 재난관리행정의 접근을 위한 이론적 논의나 체계적인 분석은 배제한 채 재난관리에 대한 재구조화에 대한 논의만 무성하였다. 이러한 논의들은 대부분 전통적 관료제적 접근을 전제로 하고 있다. 재난관리행정은 재난관리서비스의 특성과 재난 관리행정조직의 특성상 네트워크 거버넌스를 통한 연계성과 통합성의 실천으로 이해되어야 함에도 불구하고, 관료제적 위계의 방식으로 접근하는 오류를 범하고 있다. 본 논문에서는 재난관리행정의 특성에 대한 분석을 바탕으로 재난관리행정의 규범적 모델로서 네트워크 거버넌스(network governance)에 입각한 지역 거버넌스 모형의 적용가능성을 모색하였다. 먼저 네트워크를 전통적 서비스 공급방식인 시장 및 관료제와 비교하여 네트워크에서의 서비스 교환조건과 사회 메커니즘의 작용을 분석하였다. 이러한 분석을 토대로 재난관리서비스의 특성과 교환조건을 분석하고 우리나라에서 재난관리 네트워크 형성의 제약요인을 검토하였다. 마지막으로 극장의 논의를 기반으로 재난관리행정의 규범적 모델로서 네트워크 거버넌스적 설계방식을 제시하였다. The Disaster Management System(DMS) in Korea has been addressed in unessential and technical aspect, while the discussions on the essential attribute of it have been just a few. The importance of DMS has been highlighted, but the theoretical approach and systematic analysis on in has been excluded. The arguments only on the restructuring of DMS have prevailed. These arguments are usually based on the traditional bureaucratic approach that are very hierarchical. However, considering the characteristics of the organizations and services that compose DMS, it should be recognized as the practice of connectedness and integratedness through network governance, not as the hierarchical bureaucracy. Analyzing the attributes of DMS, this paper searches for the applicability of regional governance model grounded on the network governance as a normative model of DMS. Firstly, this research compares network with market and bureaucracy which are traditional way of service delivery, and analyzes the service exchange condition and operation of social mechanism on network. Secondly, it analyzes the characteristics and the exchange condition of disaster management service on the basis of analysis above, and reviews the factors that restricts the building up of disaster management network in Korea. Finally, it presents the network governance design as a normative model on the basis of the argument above.

국내 말라리아 퇴치사업의 현황 분석과 개선 방안

박재원,홍지영,염준섭,조성래,오대규 대한감염학회 2009 감염과 화학요법 Vol.41 No.1

Background : Vivax malaria had spread rapidly in areas adjacent to the Demilitarized Zone to reach more than 4,000 cases in 2000 in the Republic of Korea (ROK). After year 2000, annual cases decreased rapidly to reach less than 1,000 cases in 2004. However, the number increased again since 2005. Epidemiological characteristics of vivax malaria in the ROK are different before and after 2000. This article was aimed to evaluate the current status of malaria elimination project in the ROK for providing suggestions for its improvement. Materials and Methods : We analyzed the total reported malaria cases during 2005 to 2007 and reviewed the record on the malaria eradication project performed by the authorizations including the Korea Center for Disease Control and Prevention. Results : During 2005 to 2007, 45% of all the vivax malaria occurred in patients living in the non-prevalent areas; the interval between first symptom onset and diagnosis was longer in the non-prevalent areas compared to that in the prevalent areas. Education and publicity on malaria has not been properly performed in the non-prevalent areas. The military didn't take part in the control of the malaria infected discharged soldiers, most of whom might have been infected with malaria during their military service. Conclusion : For the efficient control of malaria and thus improving the effectiveness of the elimination project education and publicity on malaria in the non-prevalent areas should be strengthened and cooperation between private and military sector regarding the ex-soldiers infected with malaria is essential, In addition, there should be bilateral communication among malaria-related teams within the Korea Centers for Disease Control and Prevention and also among all the malaria-related sectors. Furthermore a common database on malaria patients and vector mosquitoes should be formed to grant access to all the malaria-related sectors, Improvement on report and surveillance system is also necessary.

실질적인 원격교육 시스템과 그 원형 구축에 관한 연구

박대훈,남중헌,배재학 울산대학교 1999 공학연구논문집 Vol.30 No.2

본 논문의 주제는 실질적인 원격 교육 시스템의 설계와 그 원형 구축에 관한 연구이다. 원격 교육 시스템에 관한 다양한 장점이 있지만 그것을 설계하고 구현하는 일선교사들에게는 전문성의 부족으로 어려운 실정이다. 본 논문에서는 Lotus Domino/Notes에서 제공하는 웹 페이지 설계 기능과 native 웹 개발 도구들을 비교하고, 그것이 일선교사들에게 원격 교육 시스템을 설계하고, 관리하는데 얼마나 용이한가를 연구하였다. This paper is concerned with the design and implementation of a practical distance learning system. Even though there are various advantages of distance learning systems, it is too difficult for the teachers to design and implement them. In this paper, the followings are studied: (1) comparing native web publishing tools with the web page design facilities which Lotus Domino/Notes provides, and (2) how much easier it will be with the facilities for teachers to design and manage a distance learning system.

CT 유도하의 경피적 폐생검 : 임상적 의의 및 합병증에 관한 연구 A Study of Clinical Significance and Complication

박재성,백상현,차장규,홍현숙,김대호,박성진,조준희,임한혁,이혜경 순천향의학연구소 2003 Journal of Soonchunhyang Medical Science Vol.9 No.2

Purpose : To determine the diagnostic accuracy and predicting factor of pneumothorax on CT-guided percutaneous transthoracic needle biopsy. Materials and Methods : Using automated biopsy devices, 107 CT-guided percutaneous needle biopsies of pulmonary lesions were performed. Final diagnosis was made with operation or other methods. We retrospectively analyzed the frequency of complications and diagnostic yields of 107 biopsies. The clinical features, treatment, and courses of complications were reviewed, and risk factors of pneumothorax such as depth and size of lesion, CT emphysema score of whole lung and pathway of needle, and the result of pulmonary function test were analyzed. Result : 96 biopsies(89.7%) yielded sufficient tissue for pathologic evaluation. For cases of malignant and benign disease, sensitivity was 91.5% and 87.5% respectively; the corresponding figures for diagnostic accuracy were 88.1% and 77.1%. So, sensitivity and diagnostic accuracy of percutaneous transthoracic needle biopsy was 89.7% and 83.2%. Eighteen(16.8%) of 107 patients developed pneumothorax and 3 of these required application of chest tube or percutaneous catheter drainage. In the group with pneumonthorax, the lesion was significantly smaller(p=0.029) and higher CT emphysema score of pathway of needle(p=0.032). But there were no significant difference between two groups(with or without pneumothorax) for depth of lesion, pulmonary function test(% predictive value of FEV1 and FEV1/FVC) and CT emphysema score of whole lung. Conclusion : CT-guided transthoracic needle biopsy of the pulmonary lesions is safe and easy method of obtaining specimens of good quality and quantity. It may be an useful procedure in the diagnosis of localized pulmonary lesions. For the prediction of pneumothorax, size of lesion and CT emphysema score of pathway of a needle are significant risk factors.

手用齒周器具의 硬度와 顯微鏡組織에 關한 硏究

朴準奉,李基大 慶北大學校 齒科大學 1985 慶北齒大論文集 Vol.2 No.1

To evaluate the relationship of the hardness and properties of the periodontal hand instruments, the authors investigated the wearness and surface texture of the instruments with metallurgical microscope and Knoop Hardness Tester. Four Gracey curettes and three sickle scalers were used in the study. The results were as follows; 1. The curette which had the highest hardness valus was the Gracey curette of Hu-Friedy Co. 2. The hand scaler which had the gighest hardness value was Jaquette # 1, the scaler of Hu-Friedy Co. 3. In the view of the metallurgical microscope, all periodontal hand instruments revealed the stainless steel of the Martensite system.

1999學年度 新入生 實態調査

서영대,박주신,원준재 인하대학교 학생생활연구소 2000 學生生活硏究 Vol.20 No.-