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Fatal Hypermagnesemia in Patients Taking Magnesium Hydroxide
( Da Hye Jou ),( Su In Kim ),( In Hong Choi ),( Su Hyun Song ),( Tae Ryom Oh ),( Sang Heon Suh ),( Hong Sang Choi ),( Chang Seong Kim ),( Soo Wan Kim ),( Eun Hui Bae ),( Seong Kwon Ma ) 대한전해질학회 2023 Electrolytes & Blood Pressure Vol.21 No.2
Hypermagnesemia is a rare but potentially fatal electrolyte disorder often overlooked because of its unfamiliarity. Magnesium is regulated through a balance of bone, intestinal absorption, and renal excretion. Hypermagnesemia typically arises from excessive magnesium intake or reduced renal excretion; however, it also occurs in patients with normal kidney function. Herein, we report two cases of hypermagnesemia in patients taking magnesium hydroxide for constipation. The first case involved an 82-year-old woman with end-stage renal disease who developed metabolic encephalopathy due to hypermagnesemia, after taking 3,000mg of magnesium hydroxide daily for constipation. Her magnesium level was 9.9mg/dL. Her treatment involved discontinuing magnesium hydroxide and continuing hemodialysis, which led to her recovery. In the second case, a 50-year-old woman with a history of cerebral hemorrhage and mental retardation developed hypermagnesemia despite having normal renal function. She was also taking magnesium hydroxide for constipation, and her magnesium level was 11.0mg/dL. She experienced cardiac arrest while preparing for continuous renal replacement therapy (CRRT). After achieving return of spontaneous circulation, CRRT was initiated, and her magnesium level showed a decreasing trend. However, vital signs and lactate levels did not recover, leading to death. These cases highlight the importance of prompt diagnosis and intervention for hypermagnesemia and the need to regularly monitor magnesium levels in individuals receiving magnesium-containing preparations, especially those with impaired kidney function.
Kim, Da Yeon,Kim, So-Hyun,Ahn, Hye Min,Lim, Sa Rang,Oh, Junsang,Choi, Seulgi,Lee, Hong-Jin,Auh, Joong-Hyuck,Choi, Hyung-Kyoon The Korean Society for Applied Biological Chemistr 2015 Applied Biological Chemistry (Appl Biol Chem) Vol.58 No.1
Highbush blueberries (Vaccinium corymbosum L.) are cultivated worldwide for their fruit with unique taste and potential health benefits. Blueray, Bluecrop, and Spartan are prominent among the various blueberry cultivars. We performed gas chromatography-mass spectrometry (GC-MS)-based metabolic profiling to differentiate the fruits of these three cultivars, and built an optimal partial least squares-discriminant analysis (PLS-DA) model to separate them. Amino acids, fatty acids, organic acids, phenolic compounds, and sugars were identified in the fruits. The optimized PLS-DA model for different cultivars of the fruits was obtained by selecting variables based on a variable importance in the projection (VIP) cut-off value of 1.0. Caffeic acid, aspartic acid, acetic acid, threonolactone, inositol, xylose, glucoside, linolenic acid, mannose, altrose, glycine alanine, and valine were found to be relevant and contributing compounds for differentiating cultivars. In addition, a hierarchical cluster analyses dendrogram pattern was correlated with the PLS-DA. This study suggested that GC-MS-based metabolic profiling coupled with multivariate statistical analysis could be used to differentiate the fruits of three major highbush blueberry cultivars.
도시공원에서 피크닉을 즐기는 사람들의 목적에 따른 행태 유형 - 대전광역시 한밭수목원 일대를 중심으로 -
홍다혜(Hong, Da-Hye),양시현(Yang, Sihyeon),김호영(Kim, Hoyoung) 대한건축학회 2022 대한건축학회 학술발표대회 논문집 Vol.42 No.2
Urban parks provide citizens with outdoor green spaces that are insufficient for the city and play a role as leisure spaces for citizens through various park facilities and programs. Due to the recent increase in the picnic population, the function and importance of urban parks have been emphasized. Dunsan Grand Park is a picnic attraction that is in the spotlight by Daejeon and nearby citizens. As the number of people enjoying picnics in the city increases, research on users for appropriate space and operation is needed. This study aims to understand the characteristics of users gathered to use picnics in Hanbat Arboretum and to find out the factors that determine the picnic location of users.
Kim, Da-Hye,Won, Sung-Yoon,Choi, Da-Yae,Kim, Hong-San,Jung, Ui-Won,Kim, Hee-Jin,Hu, Kyung-Seok Mutaz B. Habal, MD 2012 JOURNAL OF CRANIOFACIAL SURGERY - Vol.23 No.5
ABSTRACT: The purpose of the present study was to provide precise data regarding the branching pattern of the submental artery, which should be considered in occasions of bleeding during various dentoalveolar surgical procedures of the mandible, such as implant surgeries, tori removal, and iatrogenic injuries.Twenty-six embalmed adult hemifaces from Korean cadavers were used in this study. The vertical distance, horizontal distance, and diameter of the submental artery were measured from the site of the first premolar to the third molar. In cases where there was penetration of the mylohyoid muscle by the main branches of the submental artery, the same items were measured at that point.The vertical distance between the submental artery and the inferior border of the mandible decreased toward the premolar, whereas the horizontal distance from the lingual plate of the mandible increased gradually as it traveled in the anterior direction. The diameter of the artery narrowed slightly toward the premolar. The main branches of the submental artery perforated the mylohyoid muscle in 14 (54%) of the 26 specimens.As a result of this study, the submental artery is located higher from the inferior border and closer to the lingual plate of the mandible in the region of the molar than that of the premolar. Therefore, clinicians should be more careful of bleeding when performing surgery in the molar region compared with the premolar region. Where the mylohyoid muscle is perforated by the main branches of the submental artery, its point of insertion can be observed in diverse locations.
RAW 264.7 대식세포에서 Nrf2/HO-1 신호 전달계 활성화와 MAPKs 경로 억제를 통한 소청자와 소청2호의 LPS 매개 염증성 및 산화적 스트레스 반응의 억제
권다혜(Da Hye Kwon),최은옥(Eun Ok Choi),황혜진(Hye-Jin Hwang),김국진(Kook Jin Kim),Su Hyun Hong,이동희(Dong Hee Lee),최영현(Yung Hyun Choi) 한국생명과학회 2018 생명과학회지 Vol.28 No.2
염증 반응과 산화적 스트레스는 다양한 질환의 발생과 진행에 중요한 역할을 담당한다. 따라서 염증과 산화적 스트레스를 동시에 억제할 수 있는 소재의 발굴은 인체 질환 제어에 매우 유용하게 적용될 수 있다. 본 연구의 목적은 RAW 264.7 대식세포에서 검은콩 품종인 소청자와 소청2호 추출물이 염증성 및 산화적 스트레스에 미치는 영향을 알아보기 위함이다. 본 연구의 결과에 의하면 소청자 및 소청2호 추출물은 LPS에 의한 iNOS와 COX-2의 발현을 억제하여 NO와 PGE2의 생성을 억제하였으며, TNF-α, IL-1β와 같은 염증성 cytokine의 분비와 발현을 감소시켰다. 또한 소청자 및 소청2호 추출물은 LPS로 자극된 세포 내 ROS 축적을 유의적으로 차단시켰고, Nrf2와 HO-1 발현을 증가시켰다. 또한 LPS에 의해 유도된 MAPKs의 활성화도 소청자 및 소청2호 추출물에 의하여 억제되었다. 결론적으로 소청자 및 소청2호 추출물은 RAW 264.7 대식세포에서 MAPKs 경로를 차단시킴으로써 LPS-유도 염증 및 산화 반응에 대한 보호 역할을 할 수 있으며, 이러한 효과에는 최소한 Nrf2/HO-1 경로 활성화가 관련되어 있었다. 이러한 결과를 고려해 볼 때 소청자 및 소청2호 추출물은 대식세포의 과다 활성화로 인한 염증성 및 산화적 반응 차단에 잠재적인 효과가 있음을 일 수 있었다. Inflammatory response and oxidative stress play critical roles in the development and progression of many human diseases. Therefore, a great deal of attention has been focused on finding functional materials that can control inflammation and oxidative stress simultaneously. The purpose of this study was to investigate the effects of Socheongja and Socheong 2, Korean black seed coat soybean varieties, on the inflammatory and oxidative stress induced by lipopolysaccharide (LPS) in RAW 264.7 macrophages. Our data indicated that the extracts of Socheongja (SCJ) and Socheong 2 (SC2) significantly suppressed LPS-induced production of nitrite oxide (NO) and prostaglandin E2, key pro-inflammatory mediators, by suppressing the expression of inducible NO synthase and cyclooxygenase-2. It was also found that SCJ and SC2 reduced the LPS-induced secretion of pro-inflammatory cytokines, such as tumor necrosis factor-α and interleukin-1β, which was concomitant with a decrease in the protein levels. In addition, SCJ and SC2 markedly diminished LPS-stimulated intracellular reactive oxygen species accumulation, and effectively enhanced nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase (HO)-1 expression. Furthermore, LPS-induced activation of mitogen-activated protein kinases (MAPKs) was abrogated by SCJ and SC2. Taken together, these data suggest that SCJ and SC2 may offer protective roles against LPS-induced inflammatory and oxidative responses in RAW 264.7 macrophages through attenuating MAPKs pathway, and these effects are mediated, at least in part, through activating Nrf2/HO-1 pathway. Given these results, we propose that SCJ and SC2 have therapeutic potential in the treatment of inflammatory and oxidative disorders caused by over-activation of macrophages.
The detecion of African swine fever virus via hair plucking: An alternative non-invasive approach
Chae-Rin Park(Chae-Rin Park),Tae-Young Suh(Tae-Young Suh),Da-Hye Yi(Da-Hye Yi),Soo-Kyoung Lee(Soo-Kyoung Lee),Seong-Keun Hong(Seong-Keun Hong),Ki-Hyun Cho(Ki-Hyun Cho),Jee-Yong Park(Jee-Yong Park),Yon 한국예방수의학회 2022 한국예방수의학회 학술대회자료집 Vol.2022 No.-
Hong, Hyun Dae,Kim, Eunja,Nam, Soo Hyun,Yoo, Da Hye,Suh, Bum Chun,Choi, Byung-Ok,Chung, Ki Wha Korean Society of Medical Genetics and Genomics 2015 대한의학유전학회지 Vol.12 No.2
Purpose: Mitochondrial diseases are clinically and genetically heterogeneous disorders, which make their exact diagnosis and classification difficult. The purpose of this study was to identify pathogenic mitochondrial DNA (mtDNA) mutations in 2 Korean families with myoclonic epilepsy with ragged-red fibers (MERRF) and Leigh syndrome, respectively. Materials and Methods: Whole mtDNAs were sequenced by the method of mtDNA-targeted next-generation sequencing (NGS). Results: Two causative mtDNA mutations were identified from the NGS data. An m.8344A>G mutation in the tRNA-Lys gene (MT-TK) was detected in a MERRF patient (family ID: MT132), and an m.9176T>C (p.Leu217Pro) mutation in the mitochondrial ATP6 gene (MT-ATP6) was detected in a Leigh syndrome patient (family ID: MT130). Both mutations, which have been reported several times before in affected individuals, were not found in the control samples. Conclusion: This study suggests that mtDNA-targeted NGS will be helpful for the molecular diagnosis of genetically heterogeneous mitochondrial diseases with complex phenotypes.
The anti-obesity effect of GRHE on adipogenesis and lipogenesis in 3T3-L1 Cell
Da-Hye Choi,Joon-Hee Han,Min Hong,Hyun-Ju Lee,Sun-Yeop Lee,Tae-Hyung Kwon,Soo-Ung Lee 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
The GRHE sample has been widely used as nutritious nut in Korea. Therefore, we investigated to elucidate the anti-oxidant and anti-obesity effects of the 20% ethanol extract of GRHE. The GRHE showed markedly strong DPPH and ABTS radical scavenging activities at various concentration. Total lipid accumulation and triglycerides (TGs) decreased in the GRHE-treated 3T3-L1 cells without toxicity. In addition, we identified the inhibited expression of anti-obesity marker genes at the mRNA and protein level. The GRHE effectively suppressed the expression of adipogenesis (PPARγ, and SREBP1c) and lipogenesis (FAS) related genes. These results indicate that the GRHE could have potential application in the prevention and treatment of obesity-associated disorders.