함암요법으로 골수기능이 억제된 악성종양환자에서 rhG-CSF의 임상적 효과

김원민,서영환,조경상,유병전,김상도,이승일,정춘해 朝鮮大學校 附設 醫學硏究所 1992 The Medical Journal of Chosun University Vol.17 No.2

We have studied the efficacy of rhG-CSF in patients with non-hodgkin's lymphoma, acute leukemia, and small cell lung cancer undergoing anticancer chemotherapy. These patients were below leukocyte count 3,000 cubic millimeter due to myelosuppression induced by the first cycle of intensive chemotherapy. Treatment with rhG-CSF (100㎍ per square meter of body surface area per day in a 30-minute intravenous infusion) was begun two days and for 14 consecutive days after the end of the second cycle of chemotherapy. The results were as follows. 1. The onset of myelosuppression was 6 days after chemotherapy, and the onset of recovery was 16.7 days after chemotherapy, and the duration of granulocytopenia was 10.7 days in patients with malignant tumor during contrast period. 2. The duration of granulocytopenia was shortened 5.2 days in patients administered rhG-CSF than without rhG-CSF, and we observed the shortest duration of granulocytopenia with increasing granulocyte in patients with small cell lung cancer. 3. Observing the differential count of leukocyte checked the highest level of leukocyte in contrast and rhG-CSF period, the persentage of neutrophil was increased in patients with acute leukemia and small cell lung cancer during rhG-CSF period, but not increased in patients with non-hodgkin's lymphoma. 4. rhG-CSF was not influenced on liver faction, renal fuction, uric acid, and glucose metabolism, also had no effect on recovery of platelet. In conclusion, rhG-CSF can be administered to patients with hematologic or nonhematologic malignant tumor that myelosuppression induced by anticancer chemotherapy result in shortening the duration of granulocytopenia and increasing the peripheral neutrophil, therefore full dose chemotherapy can be administered on time, and rhG-CSF may reduce the morbidity and mortality of patients with malignant tumor undergoing chemotherapy.

치매예방을 위한 기능성 보조식품의 섭취 제안

( Byeong Hwan Jeon ) 대한운동사협회 2019 대한운동사협회 운동사대회자료집 Vol.2019 No.-

최대하 운동부하 검사 시 농구용 휠체어의 캠버와 핸드림 크기가 에너지 대사 및 심폐기능에 미치는 영향

전병환 ( Jeon Byeong Hwan ),임비오 ( Im Bi O ) 한국운동생리학회 2004 운동과학 Vol.13 No.1

Jeon, B.H., Lim, B.O. The effect of the camber and handrim size of wheelchair on the energy metabolism and cardiovascular functions during the submaximal exercise test. Exercise science, 13(1): 125-136, 2004. The purpose of this study was to examine that the effect of wheelchair camber and handrim size on the energy expenditure(EE) and fat utilization as the energy metabolism factors and oxygen uptake(??O_(2)) and hreat rate(HR) as the cardiovascular function factors during submaximal exercise test. 5 healthy wheel-chair basketball players without lower extremity paralysis peformed the submaximal exercise protocol as the exercise test with measuring the factors by portable gas analyzer. The results suggest that 20 degree of chamber was higher than 16 degree of it in EE and fat utilization as the energy metabolism factors and ??O_(2) and HR as the cardiovascular function factors during the test. As the conclusion, 20 degree of camber was higher in the aspect of cardiovascular function and energy metabolism than 16 degree was.

The Change of Glutathione Peroxidase Concentration with the Exercise Intensities during the Progressive Maximal Exercise Test

Jeon, Byeong-Hwan,Jun, Tae-Won,Woo, Jae-Hong,Park, Ik-Ryeul,Kim, Kwang-Jun,Suk, Min-Hwa 한국체육무용국제교류학회 2003 한국체육무용국제교류학회지 Vol.9 No.-

This study examines the change of plasma glutathione peroxidase (GRx) concentration during the progressive maximal exercise test performed on 9 untrained males(28.67±2.45yr). The VO_(2max) was determined through the pretest(treadmill running by Bruce protocol). On the main test, the blood of 9 untrained males was sampled on the rest state, the intensities leveled at 50%, 60%, 70%, 80%, 90% and 100% of VO_(2max), as well as 3 minutes and 6 minutes after the recovery. With the collected blood samples, the concentration of plasma GPx was analyzed by ELISA(Enzyme-linked immunosorbent assay). In addition, the changes of lactate concentration and energy expenditure were analyzed to compare with that of plasma GPx concentration. The statistical differences were determined by applying one-way ANOVA (p<0.05). The results suggest that there is no significant change in the plasma GPx concentration with the incremental exercise intensities. Furthermore, there are no noticeable relationships between the GPx concentration and the lactate cancentration. or the energy expenditure in their changes.

araA를 이용한 AMPK 활성 억제가 인슐린, 근수축, 저산소증, AICAR 유발 골격근내 포도당 이동률에 미치는 영향

전병환 ( Byeong Hwan Jeon ),정수련 ( Su Ryun Jung ) 한국운동생리학회 2010 운동과학 Vol.19 No.4

We used araA to evaluate the hypothesis that AMPK activation is involved in the stimulation of muscle glucose transport by contractions and hypoxia. After 1 week of adaptation period to the laboratory environment, 65 male Wistar rats were fasted for 12 hr. Rats were anesthetized and the epitrochlearis muscles were removed to measure glucose transport rate in muscle. To evaluate the rate of contraction (tetanic, 100Hz-10s, 10min), hypoxia (95% N2, 5% CO2, 80min), AICAR (2mM, 60min), insulin (2mU/ml, 60min) stimulated glucose transport activity after araA treat, we use 5 processing steps (Recovery, preincubation, stimulation, rinse, incubation). After rinse, muscles were incubated with two tracer (14C-mannitol, 3H-3-o-methylglucose) for 10 min, and radioactivity was measured with scintillation counter. Preincubation of muscles with 2 mM araA inhibited the stimulation of glucose transport induced by AICAR, contractions, or hypoxia by ~65%. Insulin-stimulated muscle glucose transport was not inhibited by araA. These findings provide support for the hypothesis that activation of AMPK is involved in the stimulation of muscle glucose transport by contractions and hypoxia. They clearly show that it is possible to inhibit the stimulation of glucose transport by contractions and hypoxia without affecting insulin-stimulated glucose transport in skeletal muscle.

쥐의 골격근에서 리튬, 인슐린 및 근수축 복합처치가 당수송 활성도에 미치는 영향

전병환(Byeong-Hwan Jeon) 한국콘텐츠학회 2009 한국콘텐츠학회논문지 Vol.9 No.4

리튬은 기저수준의 당수송 활성도에 있어 단지 최소한의 효과만 있고, 반면 인슐린에 대한 민감성을 매우 증가시켜 인슐린에 의해 증가된 당수송 활성도를 증가시키는 것으로 알려져 있다. 또한 리튬은 인슐린의 반응성을 증가시키는 효과도 보이고 있다. 한편, 당수송 과정을 증가시키는 리튬의 효과는 인슐린 자극당수송에만 국한되는 것이 아니라, 최대하 수준의 근수축에 의한 당수송의 민감성을 증가시키는 것으로 알려져 있다. 하지만 사전실험을 통해 리튬이 최대수준의 근수축에서도 당수송의 활성도가 증가하는 당수송의 반응성의 가능성이 제기되었다. 따라서 본 연구에서는 최대수준의 당유입을 자극하는 근수축에 대해 리튬이 미치는 영향을 조사하여, 리튬이 근수축에 의한 당수송의 반응성도 강화시키는지의 여부를 확인하고자 하였다. 본 연구의 목적에 따라 쥐의 활차근을 분리하여, 당수송을 최대수준으로 활성화시키는 근수축 자극 그리고/ 혹은 인슐린 자극과 병행하여 리튬을 처치하였다. 그 결과 리튬은 근수축 그리고/혹은 인슐린-자극 당유입을 강화시켜 당수송의 반응성을 향상시키지만, 리튬의 단독 처치는 당수송에 대한 향상에 효과가 매우 적은 것으로 나타났다. 따라서 리튬은 근수축 그리고 혹은 인슐린과의 복합처치를 통해 당수송의 반응성을 증가시킴으로써 인슐린 저항성이나 당뇨 치료에 중요한 역할을 할 수 있는 가능성을 갖는 것으로 사료된다. Lithium has only a minimal effect on basal glucose transport activity, instead that lithium markedly increased the sensitivity of glucose transport to insulin by increasing in insulin induced glucose transport activity. And Lithium increases in insulin responsiveness as well. Previous studies has reported this enhancement of lithium to stimulate the glucose transport process is not only limited to insulin, it also induce the increases in the sensitivity of glucose transport by submaximal contractile activity. The preliminary study, however, leads that Lithium possibly improves the responsiveness of glucose transport with maximal muscle contraction. In this study, we investigated the effect of Lithium on contraction for the maximal glucose transport. For the purpose of this study, Epitrochlearis muscles of SD rat were isolated and treated Lithium with electric contraction and/or insulin to activate the maximal glucose transport. The results support that Lithium improves the responsiveness of glucose transport through potentiates contraction and /or insulin induced-glucose uptake in muscle. Consequently Lithium treated with muscle contraction and insulin has the important potential to improve the insulin resistance and diabetes.

AMPK와 자식작용의 미토콘드리아 생합성 조절 기전

전병환(Byeong-Hwan Jeon) 한국콘텐츠학회 2009 한국콘텐츠학회논문지 Vol.9 No.4

비정상적인 미토콘드리아에 의해 산화 스트레스가 증가하면 세포내 신호전달 및 유전자 발현에 손상을 일으켜 인슐린 저항성이나 당뇨병 등의 여러 질환들을 유발한다. 그런데 자식작용은 산화 스트레스로 기능이 저하된 미토콘드리아를 제거하여 인슐린 저항성 등을 억제해준다. 한편 운동도 미토콘드리아 생합성을 강화시켜 조직의 기능저하나 퇴행을 회복시켜준다. 따라서 운동과 자식작용이 서로 연관되어 미토콘드리아 생합성을 유도하는 신호체계로 작용할 가능성이 있고, 이 연구를 통해 운동 혹은 AICAR (aminoimidazole-4-carboxamide-1-ß-D-ribofuranoside)처치로 활성화된 AMPK(5‘-AMP- activated protein kinase) 신호전달체계가 미토콘드리아 생합성을 증가시키는 경로에 자식작용이 관여하는지의 여부를 확인하고자 하였다. 연구결과에 따르면, 6시간의 급성운동으로 쥐의 골격근에서 PGC-1(peroxisome proliferator-activated receptor gamma coactivator 1)과 mtTFA (mitochondrial transcription factor A)의 mRNA 발현이 유의하게 증가하였다. 하지만 자식작용 표지제인 LC3(microtubule-associated protein1 light chain 3)의 mRNA 발현은 증가경향을 나타냈지만 유의하지 않았다. 한편 C2C12 근세포에서도 AICAR 처치에 의해 PGC-1, mtTFA mRNA 발현이 모두 증가하였지만, 이러한 증가는 LC3 SiRNA에 의해서 억제되지 않는 것으로 나타났다. 이러한 결과들을 통해 자식작용은 AMPK에 의해 조절되는 신호전달 전달체계와는 다른 경로로 미토콘드리아 생합성에 영향을 미칠 것으로 사료된다. Increased oxidative stress by abnormal mitochondrial function can damage cell signal transduction and gene expression, and induce insulin resistance or diabetes. Autophagy, however, improve insulin resistance by clearance of malfunctioning mitochondria. Exercise also recovers the muscle dysfunction and degeneration by activating mitochondrial biogenesis. As it seems that exercise and autophagy might act as an orchestrated network to induce mitochondrial biogenesis, we investigated whether autophagy is involved in AMPK signal pathway stimulated by exercise or AICAR to increase mitochondrial biogenesis. And it showed that PGC-1 and mtTFA, but not autophagy marker LC3 mRNA expression were significantly increased by 6 hr of acute exercise. On the other hand, PGC-1 and mtTFA mRNA expression were upregulated by AICAR treatment to C2C12 myotube. However these genes were not inhibited by LC3 siRNA transfection. These results provide the evidence that autopahgy affects on mitochondrial biogenesis through different signal pathway from AMPK signal transduction.

혼합 폐포장 필름의 상용성 증진과 강인화

전병환(Byeong Hwan Jeon),윤호규(Ho Gyu Yoon),황승상(Seung Sang Hwang),김정안(Jung Ahn Kim),홍순만(Soon Man Hong) 한국고분자학회 2005 폴리머 Vol.29 No.2

메타버스 사용성 정교화: 공공메타버스의 사이버멀미를 중심으로

전병환(Jeon, Byeong Hwan) 한국지방정부학회 2023 한국지방정부학회 학술대회자료집 Vol.2023 No.8

연신에 의한 폴리(트리메틸렌 테레프탈레이트)의 구조 변형

전병환(Jeon Byeong Hwan),김환기(Kim Hwan Gi),강호종(Kang Ho Jong) 한국고분자학회 2003 폴리머 Vol.27 No.5