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      • 참외에 發生하는 바이러스의 同定 및 發生生態 究明

        박석진 忠南大學校 大學院 2010 국내석사

        RANK : 247631

        In the year of 2008 to 2009, 1,171 samples of oriental melon were collected from Seongju, the largest oriental melon production region in Korea. These samples were analyzed by electron microscopy and subjected to RT-PCR by using primers specific to cucurbit infecting viruses, CGMMV, CMV, KGMMV, MNSV, PRSV, SqMV, WMV2, and ZYMV. The results indicate that CGMMV, WMV2 and ZYMV were found to infect oriental melon. Especially both CGMMV and WMV2 were confirmed as the most prevalent viral pathogens in oriental melon. However, no sample was infected by the others, CMV, KGMMV, MNSV, PRSV, and SqMV. CGMMV was detected relatively early growth stage and the infection rate was increased and reached up to 100% in April, mid-growing season. Otherwise, WMV2 was initially detected in June and the infection rate was increased to up to 96%in July. The fruits, so called 'Yebigun' showing mosaic spot on the surface, were infected by CGMMV with no exception. The symptomless fruits collected from May to July had unexpectedly high infection rate, 89% by CGMMV, 74% by WMV2, and 66% by co-infection. There were not related between virus infection and morphological features of fruit except for mosaic symptom. CGMMV was detected in all part of oriental melon tissue but roots originated from pumpkin, was easily transmitted throughout the contact of tendril, stem and pruning shear. The pumpkin of oriental melon rootstock were not infected by CGMMV in sap inoculation test, also the seedlings of oriental melon using them were not infected in soil transmission test of CGMMV. The amino acid sequences of the coat protein CGMMV isolated from oriental melon were almost identical to those of 19 isolates of CGMMV originated from other cucubits. When 21 isolates of WMV2 in the collection were compared, the nucleotide and amino acid sequences of coat protein of the virus were 92.8-100% and 95.7-100% identical, respectively. The amino acid sequence of the coat protein ZYMV in this study was identical with that of ZYMV previously reported in cucumber at Sangju in Gyeongbuk province.

      • 코스닥시장과 증권거래소시장간의 회계이익정보 공시효과에 관한 연구 : 이익반응계수(ERC)를 중심으로

        박석진 연세대학교 대학원 2001 국내석사

        RANK : 247631

        본 논문의 목적은 우리나라에 현재 존재하고 있는 대표적인 두 주식시장인 증권거래소시장과 코스닥시장의 회계이익정보에 대한 반응 정도를 이익반응계수(Earnings Response Coefficients ; ERC)를 중심으로 비교하는데 있다. 본 연구에서의 거래소시장의 상장기업의 회계이익정보효과가 코스닥시장의 등록기업보다 클 것이라는 가설을 바탕으로 실증을 해 나갔는데, 이러한 가설을 설정하게 된 이유는 다음과 같다. 첫째, 등록요건이 상장요건에 비해 완화되어 있으므로 인해 회계자료가 상장기업에 비해 미약할 가능성이 높다는 점이다. 이는 벤처기업의 경우에 더욱 완화되어 나타나고 있다. 둘째, 코스닥시장은 거래소시장에 비해 개인투자자의 비중이 높다는 점이다. 따라서, 전문적인 회계정보의 경우는 이들에게 유용하지 않을 수도 있고, 현실적으로 많은 개인투자자들의 투자의사결정에는 기관투자자나 외국인들보다 기업의 회계정보가 그리 높은 비중을 차지하고 있지는 않다. 세째, 미국 NASDAQ 시장에 대한 동조화 현상을 들 수 있다. 나스닥에 대한 무분별한 동조화로 인해 코스닥시장에서 회계이익정보가 정확하게 반영되지 않을 가능성이 높다. 분석의 대상으로 쓰인 표본은 1997년 이후 증권거래소시장과 코스닥시장에 상장 혹은 등록된 금융업을 영위하지 않는 기업을 대상으로 하였으며, 각 시장별로 403개, 136개 총 539개의 기업이 선정되었다. 비기대이익(UE)은 당기순이익, 영업이익, 경상이익 세 가지로 구했으며, 초과수익률(AR)은 공시일 이전 200일 동안의일별주가를 이용하여 시장모형을 이용해 구하였다. 회계이익의 공시시점으로는 주주총회일을 사용하였으며, 주주총회일을 기준으로 하여 9개의 시점으로 누적초과 수익률을 구하였다. 실증방법은 논문의 회귀식을 이용하여 회계이익정보가 제공하는 새로운 정보량(비기대이익)이 클수록 시장에서 주가가 반응할 것이며, 이러한 반응하는 정도를 거래소시장의 상장기업과 코스닥시장의 등록기업들에 대한 이익반응계수(ERC)의 크기를 비교함으로써, 본 연구에서는 거래소 상장기업의 경우가 코스닥 등록기업보다 더 크게 나타날 것으로 예상하였다. 실증결과 1998, 1999, 2000년 모두를 회귀식을 통해 분석한 바로는 통계적으로 크게 유의하지는 못했지만, 대체적으로 가설을 어느정도 지지하는 것으로 볼 수 있었다. 하지만, 1998년도의 경우 코스닥 시장의 경우 기업별 총거래가능일수 중에서 거래일수를 살펴본 거래빈도가 너무 낮음으로 인해, 통계적으로 유의한 수치가 나오는데는 한계가 있었다. 따라서, 각 연도별로 휘귀분석을 해 본 결과 1998년은 유의적이지 못했고, 1999과 2000년의 경우는 통계적으로 상당히 유의한 값을 가지는 것으로 나타났다. 이러한 결과를 통해서 주총 개최일 이전에 미리 정보가 시장에 반영이 되며, 주총일 이후에도 그 영향으로 주가가 반응하며, 그 반응하는 정도는 코스닥 시장에 비해 거래소시장이 더욱 민감하게 반응하는 것으로 볼 수 있다. The Purpose of this study is to find out the differences of ERC(Earnings Response Coefficients) between the two markets-KSE(Korea Stock Exchange) and KOSDAQ(KOrea Security Dealers Association Quotation). In this thesis, empirical analysis was performed based on the hypothesis-the Disclosure Effect of Accounting Earnings Information in KOSDAQ market is greater than that in KSE Market. The basis of this hypothesis is as follows. First, the requirement of registration in KOSDAQ market is less strict than that in KSE market. Therefore, the accounting data in KOSDAQ is liable to be more insufficient. In case of venture companies(these are belong to KOSDAQ market), the requirement of registration is much easier. Second, the portion of individual investor in KOSDAQ market is higher than that in KSE market. The accounting information may not be easily usable by them because the information is required expert knowledge and abstrusely to under stand. Third, KOSDAQ price index has a tendency to be assimilated to NASDAQ price index despite the accounting earnings information in market. Empirical test is conducted on 539 sample companies, which have been listed in KSE market and registered in KOSDAQ market over the period of 1997 to the end of 1999, and they are manufacturing firms with December 31 fiscal year-end. Cumulative abnormal returns(CAR), which are calculated using market model and summed by nine different point of time in each event are used by dependent variables. And unexpected earnings, which are calculated from net income, ordinary income and operating income deflated by sales, are used by independent variables. The result of empirical study by regression analysis shows that it generally supports the hypothesis of this thesis. Especially, the results of 1999, 2000 are more statistically significant than that of 1998 because before 1999, when experienced some remarkable development s, the frequency of the average daily trading volume in KOSDAQ market are so low. In conclusion, both market are responded by accounting earnings information, this result indicates that accounting numbers are informative in both markets. However, ERC in KSE market is higher than that in KOSDAQ market, that is, the accounting numbers are more informative in KSE market than KOSDAQ market.

      • 우리나라 타이어工業의 現況과 輸出方案에 關한 硏究

        박석진 전남대학교 경영대학원 1974 국내석사

        RANK : 247631

        General economic development and growth of Korea has given its tire industry a great progress. In 1973, the production capacity of the tire industry has increased about 45 % compared to that of 1972. The increased capacity has given a rapid growth in the amount of export. Also the nations for export has been varied than those of 1972. But this rapid growth has several problems to be solved; how to get its competitive market. how to explore and how to maintain its existing market. Of course, all of the problems cannot be solved unless we make a investigation on ever-variable market situation. unless our activity has to strengthen actively. So if We want to seek new markets for our products and to sell more, more positive marketing activities are preceded. And those activities must be made in connection with the factors; 1) The result of investigation concerning political, social and cultural environment of countries which want to export. 2) From the consumer's response and complains, sales tactics must be established. 3) Have a great attention on a large market such as U.S.A., Canada, Japan etc. 4) Through the quality improvement and cost down. we should make our products more competitive in national battle for sales. 5) We must give up our passive attitude which is carried only by distributors as import brokers as letters and take a more active attitude that is carried by ever-living salesman who made a vast marketings and more effective sellings. 6) And we must make the sorts of our products less and less, so the products control system can be reasonable and simplified. especially. in order to prevent our products from stocking long term. 7) To decrease the customer's claims. the quality must be developed. for this, the manufacturing process and technics has to cover the specific situations of importing and used countries such as weather, climate, road condition etc. All of those activities has to be presented in the quality. design and wrapping Now. tires has become national tactical export products and also get a great popularity of every consumers of the world. As to say those are exported from Japan to Bulgaria. In the end, tire industry, through its more reasonable and rational management, expansion of product capacity and increase of export. can be made a great progress, and if so, this very fact will serve a great help to the steady and Continual progress of our national economy.

      • 한국어 성별언어의 실현 양상과 발화 상황 요인 연구 : 하십시요/해요체의 전략적 용법을 중심으로

        박석진 韓國外國語大學校 大學院 2012 국내석사

        RANK : 247631

        This study examines the realization aspects of gender language in Korean, focusing on situations where a speaker uses gender language strategically through violating gender language norms pertaining to usage of the word's endings hasipsio and haeyo. Currently dominant methods to study gender language in Korean unquestioningly assume gender ideology of the male/female division, and apply that same dichotomous framework to gender language, thus, failing to clarify how it is used in reality. For instance, while the word's endings hasipsio and haeyo are prescribed as male language and female language respectively, it is found out that males also use haeyo and females hasipsio as word's endings situationally in TV drama dialogues. Most of the relevant studies, however, dismiss such cases only as exceptional from the scope of their research topics. In this backdrop, this study examines the realization aspects of gender language in Korean generally and questions the concepts of gender language. And then attempts to analyze situational factors of strategic uses of gender language. In the conclusion, it is revealed that males and females use both hasipsio and haeyo as word's endings, employing speech strategies that integrate various factors such as formality, intimacy, power, age as well as gender, not "exceptions". The implications of the study are suggested as follows: firstly, one can understand aspects of a gender language performance in a descriptive sense instead of a prescriptive one, when she/he extends her/his perspective beyond the gender of a speaker. It is the choice and strategy of a speaker whether to observe or to violate gender language norms. When these violation cases are explored as a subject of analysis, speech situations and intentions of the speaker are rightfully highlighted instead of the fact that gender language norms have been “violated.” Secondly, one can more accurately understand contexts a gender language performance by examining other various situational factors. Current studies mostly reckon the gender of a speaker as the pivot of gender language analysis, overlooking different contextual factors beyond it. They mistakenly equate attributes of gender language to those of gender, or, in other words, consider gender attributes as essential to gender language. Due to this, what is currently available is only intuitive knowledge and statistical data on gender language that do not analyze the genderization process of language nor explain what causes people to regard male language as “male” and female language as “female.” When both gender and non-gender aspects of gender language performances are taken into account, a wider range of their situational factors are more properly understood. When this stance is applied to the KFL/KSL(Korean as a Foreign Language/Korean as a Second Language) education, it will provide Korean language learners with practical information on diverse factors of a speech situation, and improve their communication skills.

      • 건강보험 청구 자료를 이용한 TNF antagonist 투여 류마티스 관절염 환자의 의료비용 분석

        박석진 숙명여자대학교 임상약학대학원 2011 국내석사

        RANK : 247631

        Objectives To analyze characteristics and to estimate costs of rheumatoid arthritis(RA) patients treated with TNF antagonist using the Korea national health insurance(KNHI) claims database in 2007, 2008 and 2009 from insurer’s perspective. Key words : rheumatoid arthritis, cost of illness, direct medical cost, TNF antagonist. Korea National Health Insurance claims database Methods RA patients were identified as adults (age of 19) who had at least one KNHI record with a diagnosis of RA (ICD-10 codes: M05-06) in 2007, 2008 and 2009. TNF antagonist na&iuml;ve patients were defined as RA patients who didn’t have claim record for a TNF antagonist during window period but who had records between Jul.1.2007 and Dec.31.2008. Socio-demographic and clinical characteristics, healthcare utilization, and costs were assessed for following 12 months. Direct medical costs included the total costs for medical services and drug costs except uninsured medical expenses. Multiple logistic regression was used to calculate the effects of several factors on the total costs. All statistical analyses were performed with SAS/STAT&#9415;9.1. Results The number of TNF antagonist na&iuml;ve RA patients was 835 (26,494 claims data for 12 months). Mean age was 52(sd13.6) and women comprised >83% of the study sample. Annual average visit days of outpatients were 37. At the index date, 500 patients received adalilmumab, 266 patients received etanercept and 69 patients received infliximab. 476 patients accompanied with diseases of the digestive system. Annual overall costs per patient were 13.4 million Korean won (KRW), of which 10.5 million KRW (78.6%) was drug costs because of costly TNF antagonist. Inspection cost came next with 5.6% of the total costs, followed by hospitalization cost (4.6%), operation cost (4.0%), and doctor’s fee (3.2%). Mean out-of&#8211;pocket expenditure was 3.7 million KRW, 27.1% of the overall costs. As age increased, so did the total costs. Male, medical aid, and patients with hospitalization or surgery were associated with significantly higher costs than female, health insurance, and inexperienced patients of hospitalization or surgery respectively.(p<0.05) Conclusions Direct medical costs per capita of RA patients receivingTNF antagonist in Korea were 13.4 million KRW. The economic burden of RA patients is strongly influenced by TNF antagonist. 본 연구의 목적은 건강보험 청구 자료를 이용하여 국내 류마티스 관절염 환자 중에서 TNF antagonist를 처음 사용하는 환자의 특성을 살펴보고, 총 의료비용을 산출하는 것이다. 2007년 1월 1일부터 2009년 12월 31일까지의 건강보험심사평가원의 청구 자료를 이용하여 연구를 수행하였다. 19세 이상 TNF antagonist를 처음 사용하는 환자를 대상으로 하기 위해 첫 6개월의 분석 전 유예기간동안 TNF antagonist와 관련한 청구 건이 있는 환자는 대상에서 제외하였으며, 류마티스 관절염(ICD-코드:M05-06) 치료를 목적으로 TNF antagonist를 사용하는 환자를 선별하였다. 환자의 연령, 성별, 의료보장 유형, 의료기관 소재지 등과 같은 사회&#8901;인구학적 특성과 요양기관 종별 환자의 분포, 입원&#8901;외래 이용 분포와 같은 의료서비스 이용 특성, 공존질환 및 대상 환자의 약물 치료와 같은 임상적 특성을 분석하였다. 대상 환자들의 1인당 총 의료비용과 항목별 의료비용을 추계하고, 대상 환자를 입원환자와 외래환자로 나누어 의료기관 종별로 총 비용과 항목별 비용을 산출하였다. 연령, 성별, 보험 형태 등의 독립 변수가 총 의료비용에 미치는 영향을 알아보기 위하여 회귀분석을 실시하였다. SAS/STAT&#9415; 9.1(SAS Institute Inc., Cary, NC, USA)를 이용하여 모든 통계적 분석을 시행하였다. 본 연구의 대상 환자는 835명이었으며, 총 26494건의 명세서를 이용하여 분석을 수행하였다. 대상 환자의 평균연령은 52.0세이고 여성이 84.2%, 건강보험환자가 83.1%를 차지하였다. TNF antagonist의 첫 투여 시에는 상급 종합병원을 가장 많이 이용하였으나, 전체 분석기간 동안에는 의원을 가장 많이 이용한 것으로 조사되었다. 대상 환자 중 48.9%는 입원 경험이 있으며 입원환자 1명당 1년 평균 입원 건수는 2.55회, 1명당 연평균 입원 일수는 26.2일로 나타났다. 연평균 외래 방문 횟수는 37.0 건이었다. 약물치료 특성을 살펴본 결과, 693명(83.0%)이 적어도 1개 이상의 DMARDs를 사용하였고 환자별로 동시에 사용하는 DMARDs의 종류와 개수도 다양하였다. 류마티스 관절염 치료를 위해 TNF antagonist이외에도 DMARDs(83.0%), NSAID(73.9%), Oral steroid(80.3%) 등을 사용하는 것으로 조사되었다. 대상 환자의 1인당 총 의료비용은 연평균 13,400,000원을 사용하며 이중 약제비가 10,525,470원(78.6%)으로 큰 부분을 차지한다. 약제비 중 생물학적 제제의 비용이 95.8%를 차지하였다. 전체 의료비용 중에서 원내와 원외에서 지출하는 본인부담금은 1인당 연평균 3,678,000원 정도로 전체 비용의 27.5%를 차지한다. 상급 종합병원의 1인당 입원 의료비용은 2,348,172원, 종합병원 2,551,076원, 병원 1,707,884원, 의원 727,574원이었다. 외래 환자들의 방문 건당 의료비용은 상급 종합병원 717,079원, 종합병원 595,569원, 병원 124,168원, 그리고 의원 47,428원으로 조사되었다. 본 연구는 비급여비용을 제외한 직접적 보건 의료비용을 산출한 결과이며, 보다 종합적인 비용을 제시할 수는 없었지만, 대상 환자들의 특성과 급여 대상의 의료비용 규모를 파악할 수 있었다. 국내에서는 처음으로 전 국민 건강보험 청구 자료를 이용하여 TNF antagonist를 처음 투여 받는 류마티스 관절염 환자의 의료비용 부담을 추계하였으므로 대상 환자를 대표할 수 있다는 강점이 있으며, 질병 치료 방법과 건강보험 재정 배분의 결정시 근거자료로 활용될 수 있을 것이다.

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