Original Articles : Clinical significance of occult hepatitis B virus infection in chronic hepatitis C patients

( Jae Young Jang ),( Soung Won Jeong ),( Sung Ran Cheon1 ),( Sae Hwan Lee1 ),( Sang Gyune Kim ),( Young Koog Cheon ),( Young Seok Kim1 ),( Young Deok Cho1 ),( Hong Soo Kim ),( So Young Jin ),( Yun Soo 대한간학회 2011 Clinical and Molecular Hepatology(대한간학회지) Vol.17 No.3

Background/Aims: We investigated the frequency of occult hepatitis B virus (HBV) infection in anti-hepatitis C virus (HCV)-positive individuals and the effects of occult HBV infection on the severity of liver disease. Methods: Seventy-one hepatitis B virus surface-antigen (HBsAg)-negative patients were divided according to their HBV serological status into groups A (anti-HBc positive, anti-HBs negative; n=18), B (anti-HBc positive, anti-HBs positive; n=34), and C (anti-HBc negative, anti-HBs positive/negative; n=19), and by anti-HCV positivity (anti-HCV positive; n=32 vs. anti-HCV negative; n=39). Liver biopsy samples were taken, and HBV DNA was quantified by real-time PCR. Results: Intrahepatic HBV DNA was detected in 32.4% (23/71) of the entire cohort, and HBV DNA levels were invariably low in the different groups. Occult HBV infection was detected more frequently in the anti-HBc-positive patients. Intrahepatic HBV DNA was detected in 28.1% (9/32) of the anti-HCV-positive and 35.9% (14/39) of the anti-HCV-negative subjects. The HCV genotype did not affect the detection rate of intrahepatic HBV DNA. In anti-HCV-positive cases, occult HBV infection did not affect liver disease severity. Conclusions: Low levels of intrahepatic HBV DNA were detected frequently in both HBsAg-negative and anti-HCV-positive cases. However, the frequency of occult HBV infection was not affected by the presence of hepatitis C, and occult HBV infection did not have a significant effect on the disease severity of hepatitis C. (Korean J Hepatol 2011;17:206-212)

청각 자극용 전기자극기 개발

허승덕,정동근,김리석,김광년,강명구,김재룡,김기련 한국음성과학회 2004 음성과학 Vol.11 No.3

This paper introduces a development of an electrical stimulator for auditory stimulation. The electrical stimulator is useful in neurotological diagnosis, audiological evaluation, candidate selection for cochlear implantation, optimal device selection and decision making of MAP strategy for severe-to-profound hearing impaired persons. The development was based on sound parameters of auditory brainstem responses and auditory electrophysiological characteristic such as effective firing of auditory nerve and recording evoked potentials during refractory period of neuron. Besides pulse parameter could adjustable by programming for more varied electrical stimulation evoked response audiometry. Using the electrical stimulator, electrical square pulse was applied to promontory, and electrically evoked auditory brainstem response and electrically middle latency response were successfully recorded in cats.

뿜칠시공에 의한 단면복구재의 시공성 및 공학적 특성에 관한 실험적 연구

조봉석,김영선,장재봉,김용로,김경덕,김무한 대한건축학회 2004 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.24 No.1

These days, serious concerns of reinforced concrete have been raised recently over steel-bar corrosion, cracking, the deterioration of durability and structural stress resistance and so on, all due to the effects of exterior factors. Such being the case, in domestic, various repair materials and method systems to keep up with these reinforced concrete deteriorated due to salt damage, carbonation, chemical decay et. developed and applied. However, on-site quality control of various repair materials and method systems isn't achieved desirably because it is depend completely on a men of experience' opinions above all else regardless of various on - site environments. In this background, mock up test with due regard to real on-site environments was performed to secure fundamental data for establishment of desirable on-site quality control. Mock up test using repair mortar analyzed from angles of construction methods, mechanical spraying pressures, W 1M. Construction methods were designed manpower method and spraying method, spraying pressures were designed 32, 42, 52 psi, W/M were designed 14.4, 15.4, 16.4 %. And compressive strength, Chloride ion diffusion coefficient, bond strength, SEM of mock up test specimens were evaluated. In conclusion, we confirmed excellency of mechanical spraying pressures, fined extremely excellency of condition of spraying pressure 42 ps, W/M 14.4% within this study. therefore the results of this study will be useful to provide fundamental data for establishment of desirable on-site quality control.

Polyimide계 배향막의 합성과 그 입체구조가 액정분자의 프리틸트 각에 미치는 영향

김재창,이상진,허노성,권덕용,이진국 釜山大學校生産技術硏究所 1997 生産技術硏究所論文集 Vol.53 No.-

Polyimide계 배향막은 고온처리 등 디스플레이 제조공정을 거치면서도 액정 배향특성이 유지되며 장시간 사용에도 물리·화학적 안정성이 좋은 장점을 가지고 있어 널리 사용되고 있다. 이 배향막을 연구하는데 있어서 합성기술과 러빙처리에 따른 배향막 표면의 특성분석이 필수적이며, 본 연구에서는 Diamine과 Dianhydride를 NMP용매하에서 용액중합하여 polyamic acid를 합성한 후, ITO코팅된 유리표면위에 스핀개스팅하여 박막을 입히고 열적처리를 하여 이미드화시켰다. 배향막의 배향을 위해서 러빙처리를 하고, 러빙처리 전후의 접촉각 측정을 통한 배향막 표면장력변화를 harmonic-mean 방법으로 구했고 2차 고조파 신호 (SHG) 분석을 통한 배향막 표면분자들의 방향성 분포를 검토해 보았다. Polyimide의 반복단위구조를 컴퓨터 그래픽 프로그램 (CS Chem3D Pro)을 사용하여 3차원적으로 시뮬레이션함으로서 polyimide의 입체구조를 알아보았다. 그리고 그 입체구조와 프리틸트 각과의 상관관계를 분자간 상호 작용설을 근거로 하여 살펴보았다. Polyimide has been widely used as the alignment film for liquid crystal displays because of their excellent properties, such as thermal can chemical stability. In this experiment, polyamic acid is rapidly formed at ambient temperatures when a diamine and a dianhydride are added into NMP. Polyimide films were fabricated by spin-coating solution on ITO-coated glass substrates. Polyimide films were baked at 80oC and then cured at 150oC 250oC for 30min at each temperature. The polyimide-coated substrates were rubbed by a rubbing machine with a roller. We measured the contact angles and the second-harmonic signals on the surface of samples to know the surface tension and the surface orientation of samples. and We also measured the pretilt angle of liquid crystal molecules in order to find the effect of the rubbing strength and the steric structure of polyimides on it.

인증기관 구성 및 운영정책 요구사항 분석

김영덕,정재수,최용락 대전대학교 산업기술연구소 1999 산업기술연구소 論文集 Vol.10 No.1

This study purposes to analyze the configuration of CAs(Certification Authorities) and the operating policy of CAs for cross-trusted authentication services. The CA is an authority trusted by one or more users to create and assign certificates being used to user authentication in the network. In this paper, each country's law related to Electronic Commerce and the requirement of PKI(Public Key Infrastructure) components are analyzed, and the guideline to organize CA mechanism in the domestic is mentioned

C형 및 S형 단백 결핍에 의한 하지 심부 정맥혈전증

김향경,조용필,이덕희,안재홍,장혁재,김지수,김용호,한명식 대한혈관외과학회 2002 Vascular Specialist International Vol.18 No.2

Purpose: Protein C and S deficiencies are frequently described as causes of the hypercoagulable states. The aim of this study was to evaluate the clinical features and prognosis of deep venous thrombosis associated with protein C and/or S deficiencies and to determine an adequate treatment modality for such cases. Method: A total of consecutive 42 patients with deep venous thrombosis of the lower extremity were seen in our hospital between September 2000 and August 2002. Hypercoagulability studies were done before systemic anticoagulation therapy, and the diagnosis of protein C and/or S deficiencies was confirmed if antigenic protein C and/or S levels were less than 60%. Result: Seven patients (16.7%) were diagnosed with deep venous thrombosis associated with protein C and/or S deficiencies. Of these, 5 patients with acute iliofemoral deep venous thrombosis were treated with catheter-directed thrombolysis therapy, and 2 with systemic anticoagulation therapy. There were no major complications or clinically detectable pulmonary emboli. Conclusion: Protein C and/or S deficiencies are one of the common causes of deep venous thrombosis. Considering that patients with deep venous thrombosis and protein C and/or S deficiencies should be treated with life-long anticoagulation for the prevention of recurrence, patients presenting with deep venous thrombosis without evidence of other risk factors should be evaluated for hypercoagulable states.

전압형 인버터에 의한 直流 스폿鎔接器의 定電力制御에 關한 硏究

김재문,김학성,박성수,원충연,김덕헌 成均館大學校 科學技術硏究所 1996 論文集 Vol.47 No.1

In recent years, there is increasing interests in spot welder with industrial growth of automobile. It makes autowelding and short-time welding possible. Conventional spot welders using AC source bring about the depreciation of welding products, because constant current control makes its workpiece spattered during welding process. In this paper, the constant power control strategy using PI controller is proposed to improve the quality of the welding products. PI controller is implemented by l6bit one chip 80C196KB microcontroller. Simulation and experimental results show that DC spot welder with single phase PWM inverter is effectively controlled by the constant power control method in very short-time.

강릉시 사망원인 분석

김상아,곽연희,박웅섭,송재석,이상욱,박덕영,강명근 關東大學校 醫科大學 醫科學硏究所 2002 關東醫大學術誌 Vol.6 No.1

This study was conducted to use for the Community Health Care Plan through analyzing the specific cause of death in Gangneung. The study subject were death in Gangneung that happened from January 1, to December 31 in 2000, and that were enrolled as the citizen of Gangneung. The causes of death were classified according to the 56 selected list for ranking of causes of death in Korean National Statistical Office in order to compare the data of nation. We also estimated Years of Potential Life Lost in order to evaluate the burden of disease in Gangneung.

光州·木浦圈 落後地域의 均衡發展에 관한 硏究 : 羅州市를 中心으로 Focused on Naju-city

金在國,丁英德 東新大學校 工業技術硏究所 2000 工業技術硏究 Vol.6 No.-

As capital circle and Busan region have been extensively developed with economic growth centered policies, population and industries were concentrated at these regions and then urban problems in housing, traffic and environment and unbalanced development among regions have been seriously raised. Therefore great-sphere development project circles are designated at eight regions with the surrounding areas of metropolitans and new industrial areas and their development projects are established for the activation of local economy through the induction of balanced regional development and the active altraction of privale capital. However, great-sphere development project also shows biased regional development remarkably and it is considered that the research for solution of such a problem is urgent. Also industrial and SOC are biased only on Kwangju and Mokpo regions within Kwangju - Mokpo great-sphere development project of Kwangju and Mokpo circle established in 1998 and it resulted in regional polarization. Especially, Naju is located geographically in the center of Kwangju - Mokpo great-sphere development circle and is also the traffic center and although it played the important roles as the capital and was the center of commercial activities, its development as the urban area was dull because of the development of industry, traffic and communication. Accordingly, this study is to suggest the methods for seeking the companion growth among Kwangju, Naju and Mokpo within the same circle by solving the problems due to the bias of industrial and SOC facilities, extending the urban spatial structure for developing Naju-city, a backward region and expanding SOC facilities with the cultivation of distinctive industries.

윌름종양의 치료에 대한 임상적 고찰

김재성,조문준,박경덕,설종구 충남대학교 의과대학 지역사회의학연구소 1995 충남의대잡지 Vol.22 No.2

Wilms' tumor is the paradigm for multimodal treatment of a pediatric malignant solid tumor. Developments in surgical techniques and postoperative care, recognition of the sensitivity of Wilms' tumor to irradiation, and the availability of several active chemotherapeutic agents led to a dramatic change in the prognosis for most patients with this once uniformly lethal malignancy. This article presents four cases of Wilms' tumor managed at Chungnam National University Hospital and reviews current treatment recommendations for patients with Wilms' tumor, based upon the results of the National Wilms' Tumor Studies.