Primary intraosseous carcinoma of the mandible

Hwang, Eui-Hwan,Choi, Yong-Suk,Lee, Sang-Rae 대한구강악안면방사선학회 2005 Imaging Science in Dentistry Vol.35 No.4

A very uncommon tumor, primary intraosseous carcinoma (PIOC), is a carcinoma arising within the jaw. The definite diagnosis of PIOC is often difficult as the lesion must be distinguished from alveolar carcinoma that may invade the bone from the overlying soft tissues or from the tumors that have metastasized to the jaw from a distant site. A case of PIOC arising in the mandible is presented. The clinical, radiologic, and histologic features are described. This rare lesion should be considered in any differential diagnosis of a jaw radiolucency.

파노라마방사선사진을 이용한 경상돌기에 관한 연구

황지영,황의환,이상래 대한구강악안면방사선학회 2005 Imaging Science in Dentistry Vol.35 No.2

Purpose : To find statistically based information about the natural variation in the length of the styloid process and to show the influence of the gender and age on the length of the styloid process. Materials and Methods : 1,300 panoramic radiographs were retrieved from inactive files at the Dental Hospital of Kyung Hee University. Measurements of the length of the styloid process were made directly on the radiographs from the inferior margin of the tympanic plate to the tip of the styloid process. Results : The mean length of 948 styloid processes was 25.2 mm±6.6. The median was 24.5 mm, and the interquartile range was 7 mm. The mean length was 25.7 mm for male and 24.6 mm for female. All percentile was greater for male than for female. The median is 25 mm for male and 24 mm for female. Conclusion : This study suggests that the difference of the styloid process length between genders was statistically significant and the length of styloid process was significant increased with age until 30 years.

타액선 질환의 조영촬영법과 방사성동위원소 스캔법을 이용한 임상적 연구

황의환,이상래,박윤경 大韓口腔顎顔面 放射線學會 1999 Imaging Science in Dentistry Vol.29 No.1

The purpose of this study was to established the characteristic radiographic features in salivary gland diseases by means of sialography and scintigraphy. Sialograms and scintigrams with diseases of salivary gland were examined. In this group were 5 salivary stones, 14 sialadenitis, 17 Sjogren's syndromes and 8 benign tumors. The obtained results were as follows; 1. In the configuration of the shape of main duct, those revealed that modified curvilinear and curvilinear types were predominant in Sjogren's syndromes but reverse sigmoid and angular types were in sialolithiasis and sialadenitis combined with sialodochitis. 2. In the configuration of the course of main duct, those revealed that smooth types were predominant in sialadenitis and irregular types were predominant in Sjogren's syndromes and benign tumors and irregular types were seen in all salivary stones and sialadenitis combined with sialodochitis. 3. In the type of intraglandular pattern, those revealed that destructive changes of salivary duct system and parenchyma were severe in sialadenitis and salivary stones and predominantly severe in Sjogren's syndromes. 4. The function of salivary gland was decreased severely in Sjogren's syndrome, and also decrease in salivary stone and sialadenitis. In benign tumor, the uptake of radioisotope was not seen in lesion and the function of salivary gland decreased in its remaining normal parenchyma.(J Korean Oral Maxillofac Radiol 1999:29:175-189)

형질변형성장인자가 손상골 재생능에 미치는 영향에 관한 실험적 연구

황의환,이상래,홍정표,이병도 大韓口腔顎顔面 放射線學會 1995 Imaging Science in Dentistry Vol.25 No.2

The purpose of this study was to observe the effect of TGF-β1, which promotes differentiation and proliferation of osteoblasts, on bone regeneration. Experimental bone defects that measured 3 mm in diameter were created on the mandibles of guinea pig by removal of bone with the use of trephine burns. In one side of mandibular body the experimental groups, bone defects were grafted with Biogran(Orthovita Co., U.S.A.) and TGF-β1(R&D System Co., U.S.A.). IN the remaining side of the mandiblar body, the control groups, bone defects were grafted with only Biogran. Guinea pigs in the control and experimental groups were serially terminated by fours on the 3 days, the 1 week, the 2 weeks, the 3 weeks, and the 4 weeks after experiment, and both sides of the mandibular bodies were removed and fixed with 10% neutral formalin. They were decalcified and embedded in paraffin as using the usual method. The specimen sectioned and stained with hematoxylin and eosin. Also, they were radiographed with a soft X-ray apparatus The obtained results were as follows; 1. Hemorrhagic condition, observed in the granulation tissues, disappeared on the 1 week after experiment in both groups, and more prominent in the experimental group. The granulation tissues of the experimental group had larger number of cells than those of the control group. 2. Osteoblastic differentiation in the margin of grafted material and adjacent bone was observed on the 1 week after experimental in both groups. Also, bone formation was observed in immature form on the 1 week after experiment, and more prominent in the experimental group. 3. In the polarizing microscopic examination, bone matrix was very loose on the 1 week after experiment, but increase in density with time, and more prominent in the experimental group. 4. In the microradiographic examination, newly formed bone was observed in the experimental group on the 2 weeks after experiment, and this was observed earlier than in the control group. Newly formed bone was increased with time and defected area was markedly decreased on the 4 weeks after experiment.

Asphalt와 Carbon Black을 처리한 TYPE Ⅰ,Ⅱ,Ⅴ 시멘트의 몰탈 및 콘크리트 특성

황의환,조헌영,홍원표 忠南大學校 産業技術硏究所 1987 산업기술연구논문집 Vol.2 No.2

ACTPC(Asphalt and Carbonblack Treated Portland Cement) Ⅰ, Ⅱ, Ⅴ were made with TYPEⅠ, TYPEⅡ and TYPEⅤ cements by treating 0.5% straight asphalt and 0.4% carbon black, and their characteristics of paste, mortar and concrete were compared with those of TYPEⅠ, Ⅱ, Ⅴ cements. The results are as fallows. 1. The cumulative hydration hear of ACTPCⅠcement was appeared to be the middle stage of TYPEⅠand TYPEⅡ cements. 2. During the hydration reaction, the dorment period of ACTPCⅠ cement is longer than that of TYPEⅠ cement, but the hydration heat of ACTPCⅠ cement measured after 16hours from water mixing increased more than that of TYPEⅠ cement. 3. ACTPCⅠ cement mortar showed nearly same resistance against H₂SO₄solution as that of TYPEⅤ(sulfur resisting cement). 4. The concrete flexural strength of ACTPCⅠ cement is increased to 60∼65% than that of TYPEⅠ cement and 20∼23% than that of TYPEⅡ cement. 5. The concrete tensile strength of ACTPCⅠ, Ⅱ and Ⅴ cements are increased to 5∼7% than that of TYPE Ⅰ, Ⅱ and Ⅴ cements.

치성 및 비치성 조직이 악골 창상치유에 미치는 영향에 관한 실험적 연구

황의환,이상래,김소정,홍정표 大韓口腔顎顔面放射線學會 1996 Imaging Science in Dentistry Vol.26 No.2

This study was for comparing healing patterns and effects between with odontogenic and nonodontogenic tissues on the defected mandible. Experimental bone defects that measured 3 mm in diameter were created on the mandibular body of guinea pig by removal of bone with the use of trephine burs and bone defects were grafted with Biogran(Orthovita Co., U.S.A.)and covered with Dura Mata(Pfrimmer-Viggo GmbH Co., Germany). Guinea pigs were serially terminated by fours on the 3 day, the 1 week, the 2 weeks. the 3 weeks, the 4 weeks, and the 5 weeks after experiment, and the mandibular body was removed and fixed with 10% neutral formalin. They were decalcified adnembedded in paraffin as using the usual methods. The specimen sectioned and stained with hematoxylin and eosin and toluidine blue. They were observed with a light microscope and a polarizing microscope. The obtained results were as follows: 1. Defected bone was healed fast from the odontogenic tissues in early stage of the experiment. 2. The arrangement of the bone matrix was relatively regular in the bone from the nonodontogenic tissues, but irregular in the bone from the odontogenic tissues. 3. Compact bone has started to be resorbed and changed to the pattern of matrix bone tissue from 3 weeks after experiment.

전도도법에 의한 치환 피리딘들의 해리상수 측정과 그의 온도와 압력에 따른 영향

黃正儀,鄭倧在,金學成,尹永炷,朴義煥 慶北大學校 物理化學硏究所 1985 硏究論文集 Vol.6 No.-

Generally, pyridine and most of substituted pyridines act as base in aqueous solutions. The strengths of their basicities can be expressed quantitatively by the dissociation constant of base or its conjugated acid. Generally, the acidity of substituted pyridines can be expressed by K_a of the following reaction. ◁그림삽입▷(원문을 참조하세요) The dissociation constants of these subtituted pyridines have not been reported under high pressure but under atmospheric pressure. In this papers, the dissociation constants of some substituted pyridines were measured under high pressure by the conductometry. From the ionic conductivity of hydrogen ion, the dissociation constants(K_a) were calculated. The K_a values were increased with increasing temperature and were decreased with increasing pressure. The characteristics of dissociation process of some substituted pyridines were deduced from the thermodynamic properties calculated from the dissociation constants.

염화아세트산들의 해리반응에 미치는 온도와 압력의 영향

황정의,정종재,박용태,지종기,박의환 慶北大學校 物理化學硏究所 1984 硏究論文集 Vol.5 No.-

The temperature and pressure dependences of the dissociation constants of mono-, di- and tri-chloroacetic acids were studied by the conductimetry in the range of 20-35℃ and 1-2500 bars. The thermodynamic parameters ΔH, ΔS, and ΔV were evaluated from the dissociation constants. The dissociation constants were increased as the temperature and pressure was increased respectively. The pressure effects can be explained by the fact that the increase of the charges of reaction species enhances the solvation of ions and reduces the reaction volume. As the more chlorines were substituted to acetic acid, the effect of pressure on the dissociation constants was decreased because of the enhanced solvation effect. From the thermodynamic data it can be estimated that there are two types of dissociation reactions. They are an enthalpy-dominated reaction and an entropy-dominated one.

방사선조사가 저칼슘식이 백서의 하악골에 미치는 영향에 관한 실험적 연구

황의환,이상래 大韓口腔顎顔面 放射線學會 1992 Imaging Science in Dentistry Vol.22 No.2

The purpose of this study was to investigate the changes of morphology and structure of bone tissue in the irradiated mandibular bone in rats which were fed a low calcium diet. In order to carry out this experimant, 64 seven-week old Sprague-Dawley strain rats weighing about 150gms were selected and equally divided into one experimental group of 32 rats and one control group with the remainder. The experimental group and the control group were then subdivided into two groups when the rats reached ten-week old, 16 were assigned rats for each subdivided group, exposed to irradiation. The two irradiation groups received a single dose of 20 Gy in the jaws area only and irradiated with a cobalt-60 teletherapy unit. The rats in the control and experimental groups were serially terminated by fours on the 3rd, the 7th, the 14th, and the 21st day after irradiation. Following termination, both sides of the dead rats mandibular bodies were removed and fixed with 10% neutral formalin. One side of the mandibular body was radiographed with a soft X-ray apparatus. Thereafter, the obtained microradiographs were observed by a light microscope. The specimen sectioned and stained with hematoxylin and eosin, and Rabit Anti-Human Tumor Necrosis Factor-α, observed by a light microscope. The obtained results were as follows; 1. Microradiogram revealed that thinning of the cortex and a decrease in the trabecula of the interradicular bone and mandibular body were observed and noted from the start to finish throughout the experiment in the non-irradiated rats on the low calcium diet rather than in the non-irradiated rats on the nor-irradiated rats on the normal diet. 2. Microradiogram revealed that thinning of the cortex and a decrease in the trabecula of interradicular bone and mandibular body were more marked after 7 days in the irradiated rats on the low calcium diet rather than in the non-irradiated rats on the low clacium diet. 3. Microradiogram revealed that thinning of the cortex and a decrease in trabecula of interradicular bone and the mandibular body were more marked from the strart to finish throughout the experiment in the irradiated rats on the old calcium diet rather than in the irradiated rats on the normal diet. In immunocytochemical findings, a few bone marrow cells including tumor Necrosis Factor were observed in the irradiated rats on the normal diet, but was not observed in the rats on the low calcium diet. 4. In immunocytochemical findings, a few bone marrow cells including Tumor Necrosis Factor were observed in the irradiated rats on the normal diet, but was not observed in the rats on the low calcium diet.

Streptozotocin유도 당뇨병이 백서하악 절단과두 치유에 미치는 영향의 실험적 연구

황의환,이상래,홍정표,김원철 大韓口腔顎顔面 放射線學會 1994 Imaging Science in Dentistry Vol.24 No.2

The purpose of this study was to investigate the remodeling process of the streptozotocin-induced diabetic rat's resected condyle. This experiment was performed with male Sprague-Dawly strain rats weighing approximately 250gm, which were rendered diabetic by an intravenous injection of streptozotocin(70 ㎎/㎏ body weight). After condylectomy, experimental rats were serially terminated on the 1st week, the 2nd week, the 3rd week, and the 4th week. The following termination, the mandibles were dissected out to make specimens. Each mandibular condyle was radiographed with Hitex HA-80(Hitex Co., Ltd. Japan). In addition to radiographic observation, the mandibular condyles, further decalcified and embedded in paraffin, were sectioned and stained with Hematoxylin and Eosin, Toluidine blue and Masson's trichrome. The were observed with a light microscope and a polarizing microscope. The results were as follows. 1.Soft X-ray radiograms revealed proliferation of bone after 1 week in both groups. Irregularly repaired bones and dense trabeculae were clearly observed in experimental group. 2.The resected condyles were repaired by intramembraneous and endochondral bone formation in both groups. 3.Bone tissue repair was initiated from the adjacent margin of resected bone, and cartilginous tissues were observed at the top of repaired one in both groups. 4.The number of osteoblasts of experimental group was small, compared with control group. Each osteoblast was small and flap. The thin trabeculae were irregularly formed. 5.Collagens of bone were gradually matured in both groups, but the degree of maturation was lower in experimental group. 6.Fibrous tissues covered the upper parts of repaired bone were densely arranged in the both groups. Conclusively, atrophied osteoblasts, immature collagen of bone, and this and irregular trabeculae which were characterized in the diabetes experimental group showed diabetes disturbed osteoblastic function and caused disturbance of remodeling process of bone.