http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
오늘 본 자료
Chaetoglobosin A, an Inhibitor of Bleb Formation on K562 Cells Induced by Phorbol 12,13-Dibutyrate
KO, HACK-RYONG,KIM, BO YEON,AHN, SOON-CHEOL,OH, WON KEUN,KIM, JIN-HEE,LEE, HYUN SUN,KIM, HWAN-MOOK,HAN, SANG-BAE,MHEEN, TAE0ICK,AHN, JONG-SEOG 한국미생물 · 생명공학회 1998 Journal of microbiology and biotechnology Vol.8 No.6
Eisenia bicyclis Inhibits Body Weight Gain and Fat Accumulation Induced by High-Fat Diets in Mice
Won-Hee Choi,Ji-Yun Ahn,Suna Kim,Tae Wan Kim,Tae-Youl Ha 한국식품영양과학회 2010 Preventive Nutrition and Food Science Vol.15 No.4
This study was performed to investigate the anti-obesity effect of Eisenia bicyclis in mice fed a high-fat diet (HFD). Male C57BL/6J mice were divided into three groups that were fed a normal diet, an HFD, or an HFD supplemented with a 5% powder of Eisenia bicyclis (PEB) for 8 weeks. The PEB group showed lower body weight gains than the HFD group. The PEB group also exhibited reduced body fat mass and adipose cell size in epididymal adipose tissue. The concentrations of serum cholesterol, leptin, and insulin in the PEB group were significantly lower than those in the HFD group. Liver triglyceride content was significantly decreased by PEB supplementation. Furthermore, hematoxylin and eosin staining revealed that PEB supplementation reduced lipid droplet formation in the liver induced by HFD. These results suggest that PEB supplementation reduces body weight gain and fat accumulation in HFD-induced obese mice.
Increased immunoreactivity of c???Fos in the spinal cord of the aged mouse and dog.
Ahn, Ji Hyeon,Shin, Myoung Chul,Park, Joon Ha,Kim, In Hye,Lee, Jae-Chul,Yan, Bing Chun,Hwang, In Koo,Moon, Seung Myung,Ahn, Ji Yun,Ohk, Taek Geun,Lee, Tae Hun,Cho, Jun Hwi,Shin, Hyung-Cheul,Won, Moo-H SPANDIDOS PUBLICATIONS 2015 MOLECULAR MEDICINE REPORTS Vol.11 No.2
<P>Expression of c-Fos in the spinal cord following nociceptive stimulation is considered to be a neurotoxic biomarker. In the present study, the immunoreactivity of c-Fos in the spinal cord was compared between young adult (2-3 years in dogs and 6 months in mice) and aged (10-12 years in dogs and 24 months in mice) Beagle dogs and C57BL/6J mice. In addition, changes to neuronal distribution and damage to the spinal cord were also investigated. There were no significant differences in neuronal loss or degeneration of the spinal neurons observed in either the aged dogs or mice. Weak c-Fos immunoreactivity was observed in the spinal neurons of the young adult animals; however, c-Fos immunoreactivity was markedly increased in the nuclei of spinal neurons in the aged dogs and mice, as compared with that of the young adults. In conclusion, c-Fos immunoreactivity was significantly increased without any accompanying neuronal loss in the aged spinal cord of mice and dogs, as compared with the spinal cords of the young adult animals.</P>
Infliximab induced vitiligo in patients treated for ulcerative colitis
( Tae Hyung Ryu ),( Dae Yeon Kim ),( Dong Won Lee ),( In Hyuk Kwon ),( Jae Eun Choi ),( Hyo Hyun Ahn ),( Young Chul Kye ),( Soo Hong Seo ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1
Infliximab, an anti-tumor necrosis factor(TNF) α inhibitor, is the first biologic drug approved for the treatment of ulcerative colitis(UC). The widespread use of this drug has shown a wide range of skin-adverse reactions, such as alopecia areata, atopic dermatitis, acne, lichenoid-drug reaction etc. Vitiligo is a depigmentating skin disorder resulting from the loss of melanocytes in the epidermis. Although the exact etiology of vitiligo has not yet been established, the abnormal immune responses have been frequently observed in vitiligo patients. A 34-year-old male presented with multiple hypopigmented patches on right facial area; upper medial eyelid, perioral, mandible. The cutaneous lesions appeared 4 months after initiating intravenous infliximab therapy at a dose of 5 mg/kg, when he had received 4 infusions of this drug. Wood test was positive. Thyroid function test, anti-thyroglobulin antibodies and fluorescent antinuclear antibodies screening test were within normal range. The patient was put on therapy for vitiligo in the form of topical tacrolimus 0.1% ointment, combined with excimer laser. After twice excimer laser treatment, the patient refused the treatment. The development of biological auto-immunity is a well-known side effect of anti-TNF α agents. Therefore, despite the great therapeutic advantages of TNF α blocking agents, dermatologist should be aware of adverse cutaneous reactions.
Role of Mononuclear Cells of IgA Nephropathy on ICAM - 1 Expression in Mesangial Cells
(Tae Won Lee),(Jai Kyung Park),(Jae Hyung Ahn),(Chun Gyoo Ihm),(Myung Jae Kim) 대한내과학회 1998 The Korean Journal of Internal Medicine Vol.13 No.1
N/A Objectives : To investigate the possible role of mononuclear cells and their pro- ducts in the pathogenesis of IgA nephropathy, in vitro expression of ICAM-1 on cultured mouse mesangial cell(MC) was examined after stimulation with mononuclear cell culture supernatant from patients with IgA nephropathy. Methods : Peripheral blood mononuclear cells (PBMC) were isolated and cultured from 18 patients with primary IgA nephropathy, 8 normal controls and 5 patients with non-IgA nephropathy (FSGS 1, MGN 3, MPGN 1). ICAM-1 expression on cultured mouse MC by TNF-α, IL-1β and culture supernants of PBMC were analyzed using a cell ELISA method. The concentration of IL-1β and TNF-α in culture supernatants was measured by using a commercially available radioimmunoassay kit. Results : Addition of human recombinant TNF-α induced an increased ICAM-1 expression in a dose-dependent manner. The expression of ICAM-1 was further in- creased after co-stimulation with TNF-α and IL-1β. Addition of PBMC culture superna- tants into mouse MC induced significantly higher expression of ICAM-1 by supernatants from the patients with IgA nephropathy compared with that from normal controls. The concentration of TNF-α and IL-1β in supernatants from the patients with IgA nephropathy was significantly higher than that from those with non-IgA nephropathy. Conclusion : TNF-α and IL-1 released from mononuclear cells induced the up-regula- tion of ICAM-1 expression and this may be related to the immune pathogenesis of IgA nephropathy.
Perianal Bowen’s disease in HIV patient which was refractory to 5% imiquimod treatment
( Tae Hyung Ryu ),( Dong Won Lee ),( In Hyuk Kwon ),( Heesang Kye ),( Jae Eun Choi ),( Hyo Hyun Ahn ),( Young Chul Kye ),( Soo Hong Seo ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1
Perianal bowen’s disease is squamous cell carcinoma(SCC) in situ occurring in the perianal skin. It is not only having the potential to progress SCC, but also difficult to treat. The incidence of perianal bowen’s disease is increasing among the HIV infected man. In previous studies, topical 5% imiquimod cream, a topical immune response modifier that stimulates the production of interferon alfa and other cytokines, is an effective alternative treatment option for patients and body sites that are unsuitable for surgery. A 57-year-old man, who infected with HIV, presented with a 3~4 months history of persistent black pigmented plaques based on background erythema in the perianal region and coccyx area, histologically consistent with bowen’s disease. The lesions treated with 5% imiquimod cream three times a week for 3months, but unresponsive. In recent study, topical imiquimod has been successfully used in the treatment of anogenital neoplasia, but may be less efficacious in HIV positive individuals with low CD4 counts. The patient’s WBC counts 5,910/uL and CD4 counts 790/uL(nl: 410 - 1540/uL) where within normal range. The patient was referred to general surgery department for excision operation. After the wide excision, margin involvement was reported. The patient has followed up closely. This case highlights the difficulties faced in the treatment of perianal bowen’s disease in HIV infected patients.