색소생산 및 색소비생산 Serratia marcescens 배양액에 의한 면역반응항진과 균의 항균제 및 인혈청에 대한 내성

임선영,하대유,김재흔 대한미생물학회 1985 大韓微生物學會誌 Vol.20 No.1

This study was undertaken to assess the susceptibility of pigmented and nonpigmented strains of Serratia marc escens to antibiotics and hurnan sera, and the effect of culture filtrates from pigmented and nonpigmented of Serratia marcescens on humoral and cellular immune responses in mice to thy- mus-depender.t and -indepependent antigens. Humoral immune response was measured by hemaggluti- nin (HA) and hemolysin (HE) to sheep red blood cell (SRBC), and Arthus or antibody response to pol- yvinylpyrrolidone (PVP). The cellular immune response was measured by delayed-type hypersensitivity (DTH) determined by footpad swelling reactin to SRBC. The resistance of pigmented strains of Serratia marcescens to the bactericidal action of heat- inactiv- ated human serum was insignificantly greater than that of nonpigmented strains. However, the pigme- nted strains were significantly more resistant to the bactericidal action of heat-untreated human serum than that of nonpigmented strains. The clinical isolates of Serratia marcescens was also tested for their resistance to several antibiotics, There was no difference between the pigmented and non-pigmented strains in the resistance to carbe- nicillin. However, nonpigmented strains were more resistant to gentamicin, kanamycin and tobramycin than the pigmented strains. The intraperitoneal Administration of culture filtrates from the pigmented or nonpigmented strains into mice caused enhancemented of antibody response to SRBC or PVP, and of DTH to SRBC. Besides, their enhancement of immune responses was more prominent when culture filtrate from the pig- mented strains was administered.

요양병원 여성 암 환자의 사회적 지지와 암 환자 특이형 외상 후 성장이 삶의 질에 미치는 영향

임선영(Lim, Sun-Young),박혜선(Park, Hye-Sun) 한국웰니스학회 2018 한국웰니스학회지 Vol.13 No.4

본 연구는 요양병원 여성 암 환자의 사회적 지지와 암 환자 특이형 외상 후 성장을 파악하고 삶의 질에 미치는 영향을 규명하여 요양병원에 입원한 여성암환자의 삶의 질 증진을 위한 간호중재 기초 자료를 제공하고자 시도되었다. 본 연구 대상자는 S시 소재의 요양병원 2곳에서 여성 암 환자 101명을 대상으로 하였다. 본 연구 결과, 요양병원 여성 암 환자의 사회적 지지는 암 진단 받은 기간(p=.042)에서 통계적으로 유의한 차이를 보였고, 삶의 질은 암 병기(p=.048)에서 통계적으로 유의한 차이를 보였다. 요양병원 여성 암 환자의 사회적 지지, 암 특이형 외상 후 성장과 삶의 질의 상관관계는 암 환자 특이형 외상 후 성장(r=.201, p<.05)이 삶의 질과 통계적으로 유의한 양의 상관 관계가 있어 암 특이형 외상 후 성장이 높을수록, 삶의 질이 높은 결과를 보였다. 요양병원의 여성암 환자의 삶의 질에 암 특이형 외상 후 성장이 영향을 미치는 요인으로 나타났다. 그러므로 요양병원 여성 암 환자에게 암 진단 받은 기간과 암 병기를 고려한 간호중재의 중요성을 인식하고 암 특이형 외상 후 성장의 영향요인을 파악하여 여성 암 환자의 삶의 질을 증진시키는 프로그램 개발이 요구된다. The purpose of this research is to identify social support and cancer-specific post-traumatic growth and its effect on quality of life in long-term care hospital female cancer patients, to provide base line data for the development of nursing intervention improving quality of life in female cancer patients. The subjects were 101 women at 2 long-term care hospital in S city. As the result, the social support of female cancer patients was significantly different by period of diagnosis of cancer(p=.042). Quality of life was different by stage of cancer(p=.048). Cancer-specific post-traumatic growth and the quality of life had significant pogitive relation(r=0201, p<.05). Cancer-specific post-traumatic growth significant effects on the quality of life in female cancer patients in long-term hospital. Therefore, we recognize the importance of nursing intervention considering the period of cancer diagnosis and cancer stage in women with cancer. It is necessary to develop a program to improve the quality of life in female cancer patients by identifying the influence factors of cancer-specific post-traumatic growth.

[논평문] 「薝園 鄭寅普의 주체적 實心論」을 읽고

임선영 원광대학교 원불교사상연구원 2012 원불교사상연구원 학술대회 Vol.2012 No.2

기독교인의 가족건강성이 결혼생활만족도에 미치는 영향 - 중년기 기혼남녀를 중심으로 -

임선영 수도국제대학원대학교(구 국제신학대학원대학교) 2018 국제신학 Vol.20 No.-

식물성 오메가-3계 지방산 급원인 아마씨 및 들깨의 항돌연변이 및 암세포 증식 억제 효과

임선영(Sun-Young Lim) 한국생명과학회 2009 생명과학회지 Vol.19 No.12

본 연구에서는 식물 종자들 중에서 특히 α-linolenic acid의 급원으로 대표적인 아마씨와 들깨를 중심으로 Ames 실험을 이용한 돌연변이 유발 및 인체 암세포 증식 억제 효과에 대해 비교 검토하였다. 간접돌연변이 AFB1 (0.7 ㎎/plate)에 대해 들깨 메탄올 추출물은 농도의 증가와 더불어 돌연변이 억제효과가 증가하였다. 첨가농도 2.5 및 5 ㎎/plate일 때 각각 86% 및 94%의 돌연변이 억제 효과를 나타내었다. 아마씨 메탄올 추출물의 경우도 첨가농도 2.5 및 5 ㎎/plate일 때 각각 74% 및 75%의 항돌연변이 효과를 보였다. 직접 돌연변이인 MNNG (0.6 ㎎/plate)에 대한 들깨 및 아마씨 메탄올 추출물의 항돌연변이성 실험을 한 결과, 첨가농도 1.25 ㎎/plate일 때부터 활성이 나타나 5 ㎎/plate 일 때는 각각 78, 63%의 돌연변이 억제 효과를 나타내었다. S. typhimurium TA100 균주에 대한 AFB1과 MNNG의 돌연변이 유발실험에서 두 가지 종자인 들깨와 아마씨는 직접돌연변이원에 대해서보다는 간접돌연변이원에 의해 유발된 돌연변이 저해에 더 효과적이었으며 들깨에 의한 항돌연변이 효과가 더 우수하였음을 관찰할 수가 있었다. 한편, 아마씨 메탄올 추출물을 0.5, 1, 2 ㎎/㎖의 농도별로 인체 위암세포(AGS)에 처리했을 때 농도 의존적으로 암세포 증식 억제 효과가 증가하여 1 ㎎/㎖ 첨가농도에서 64%의 암세포 성장 억제 효과를 보였고, 2 ㎎/㎖ 농도에서 79%의 높은 암세포 증식 억제 효과를 나타내었다. 들깨 메탄올 추출물의 경우도 아마씨 메탄올 추출물과 유사하게 농도의존적으로 암세포의 증식을 억제시켰으며 첨가농도 2 ㎎/㎖일 때 68%의 증식 억제효과를 살펴 볼 수가 있었다. 인체 결장암세포(HT-29)의 경우, AGS 세포에 처리했을 때처럼 아마씨 메탄올 추출물은 첨가농도 0.5 ㎎/㎖에서부터 활성을 타나내어 첨가농도 2 ㎎/㎖에서는 72%의 암세포 증식 억제효과를 나타내었다. 들깨 메탄올 추출물의 경우 첨가농도 0.5 ㎎/㎖에서는 43%의 억제효과를 나타내었으나 첨가농도 2 ㎎/㎖에서는 64%로 결장암세포의 증식을 억제시켰다. 인체 간암세포(Hep 3B)에 의한 증식 억제효과는 이상의 암세포에 대한 효과보다 다소 낮았으나 아마씨 및 들깨 메탄올 추출물은 첨가농도 2 ㎎/㎖에서 각각 65% 및 59%의 저해효과를 나타내었다. It has been known that Linum usitatissimum and Perilla frutescens are dietary sources of possible chemopreventive compounds such as lignans and α-linolenic acid. Here, we investigated and compared the inhibitory effects of methanol extracts from Linum usitatissimum and Perilla frutescens on mutagenicity using the Ames test, and growth of human cancer cells (AGS human gastric adenocarcinoma, HT-29 human colon cancer, Hep 3B hepatocellular carcinoma cells). In the Ames test system using Salmonella typhimurium TA100, aflatoxin B1 (AFB1)-induced mutagenicity was significantly inhibited by treatment with the methanol extract from either Linum usitatissimum or Perilla frutescens (p<0.05) in a dose dependent manner. As for N-methyl-N'-nitro-N-nitrosoguamidine (MNNG)-induced mutagenicity, the methanol extracts (5 mg/assay) from Linum usitatissimum and Perilla frutescens showed 63% and 78% inhibitory rates, respectively, indicating that Perilla frutescens possessed stronger antimutagenic activity than did Linum usitatissimum. Inhibitory effects of methanol extracts from Linum usitatissimum and Perilla frutescens on the growth of human cancer cells (AGS, HT-29 and Hep 3B) appeared to increase dose dependently, and the inhibition was more effective against AGS and HT-29 compared to Hep 3B cells. Our results suggested that the methanol extract from Perilla frutescens showed stronger antimutagenic activity than that from Linum usitatissimumas assayed by the Ames mutagenic test, whereas the methanol extract from Linum usitatissimum was more effective than its counterpart for growth inhibition of human cancer cells. It is concluded that intake of Linum usitatissimum and Perilla frutescens as sources of omega-3 fatty acids will be beneficial for preventing cancer.

중년 남성의 경제적 불안, 자기효능감이 재정 스트레스에 미치는 영향

임선영 ( Lim Sunyoung ),박혜선 ( Park Hyesun ) 대한통합의학회 2020 대한통합의학회지 Vol.8 No.3

Purpose : The purpose of this study was to investigate economic anxiety, self-efficacy, and financial stress levels in middle-aged male and identify factors affecting financial stress and provide baseline data for the development of nursing interventions to reduce financial stress in middle-aged male. Methods : Participants were 91 middle-aged male who live in Seoul and Gyeonggi Province. The data collection period was from April 1, 2020, to May 1. In this study, the questionnaire of economic anxiety, self-efficiency, financial stress was used. The data were analyzed by average, standard deviation, minimum, maximum correlation and regression using SPSS version 21.0. Results : In this study, the financial stress of middle-aged male affected economic anxiety with significant results (β=.628, p<.001). The absolute model's explanatory power was 36.8 % (adjusted R2=.368), indicating that economic anxiety affects financial stress levels in middle-aged male (F=27.151, p<.001). Conclusion : This study shows that economic anxiety affects financial stress. Based on the research results, basic data for the development and application of nursing programs to reduce financial stress were presented in consideration of the economic anxiety of middle-aged males. Therefore, there is a need for mediation to help middle-aged men positively recognize real-life situations and changes in society. Such mediation involves the development and application of educational and counseling programs that can reduce financial stress and economic anxiety in middle-aged men.

어머니의 자녀교육에 대한 기대와 학교만족도가 학부모역할 스트레스를 매개로 사교육 의존에 미치는 영향

임선영,이강이 한국아동학회 2022 한국아동학회 학술발표논문집 Vol.2022 No.4

Synchronous hepatocellular carcinoma and cholangiocarcinoma which were incidentally found and successfully treated by liver transplantation

임선영,김지훈 대한내과학회 2011 대한내과학회 추계학술대회 Vol.2011 No.1

Synchronous hepatocellular carcinoma (HCC) and cholangiocellular carcinoma (CCC) is type A carcinoma according Allen and Lisa classification which originate from different cell sites but consisting of a uniform cell type (double cancer or separate types). There is only a limited information regarding clinical features, pathologic features, survival outcomes, and prognostic factors due to the rarity of this double primary cancer. Most of the synchronous HCC and CCC patients have underlying liver cirrhosis as a cause of either viral hepatitis B or C and uncommonly alcohol. Synchronous HCC and CCC is difficult to diagnose based on the image studies only and mostly were diagnosed incidentally after resection. We herein report a case of 51-year-old male patient who was referred for the evaluation of the hepatic mass and ascites. The patient was a chronic alcoholic with negative viral marker. Initially multiple HCCs was diagnosed according to the dynamic liver CT and dynamic MRI and the patient was treated with liver transplantation but histopathologic findings revealed synchronous HCC and CCC. To our knowledge, only one brief case report of alcoholic liver cirrhosis with HCC finally diagnosed as synchronous HCC and CCC after liver transplant had been reported. Therefore this is the first case report of synchronous HCC and CCC which were incidentally found and successfully treated by liver transplanation with image studies and histopathologic findings in more detail.

2024 파리 올림픽 Breaking 도입에 따른 시청의도 분석 : MZ세대의 신기성 욕구에 대한 조절된 매개효과를 중심으로

임선영(Sun-Young Lim),임승재(Seung-Jae Lim) 한국스포츠산업경영학회 2024 한국스포츠산업경영학회지 Vol.29 No.2

청년 실업자의 개인적 특성과 가족지지가 우울에 미치는 영향

임선영,김태현 한국가족관계학회 2005 한국가족관계학회지 Vol.10 No.1

The purpose of this study is to explore the effect of personality and family support on depression of unemployed youths. A Sample of 291 unemployed youths(20-34 years old)living in Seoul was participated. The major findings of this study are as follow. First, the score of self esteem is 3.65 and it is higher than average. The score of depression is 2.29 and it is lower than average. The score of family support is 3.36. And people used emotional coping behavior more than problem-solving coping behavior. Second, the depression of unemployed youths has significant difference by age, economic level, experience of ocuppation. Third, the people who have low self-esteem and low family support had higher depression, And also, the higher they used problem-solving coping behavior perceived higher depression. And finally, Emotional coping behavior, problem-solving coping behavior, and family support are meaningful variables that could explain the subjects' depression. These variables explain the 30% of the subjects' depression.