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消癌去痰益氣湯의 cyclophosphamide 부작용 형성 억제효과
홍종희,류기원,류봉하,윤상협,김진성 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2002 東西醫學硏究所 論文集 Vol.2002 No.-
Object : It is well known that modern chemotherapy against cancer has side effcts to a living body, especially hemopoietic and immunologial disfunctions. However, there are no effctive ways to reduce them.Recently, traditonal Korean herb medicine has been repoted to have some biological modifying responses. Therefore, we hypothesized that additional application of herb medicine during chemotherapy is more effective to reduce its side effects. While we were studying the effects, we have observed the inhibitory effect of Soamgudamikgitang on formation of side effects derived from Cyclophosphamide, it has been used in clinical practice at Kyung Hee Medicd Center.Methods : We injected 200㎎/㎏ of Cyclophosphamide, one time, to an experimental group, consisting of ten mice. We divided them into eight groups: normal, CPX, SAKT 2㎎, SAKT 10㎎, SAKT 50㎎, SAKI 2㎎+CPX, SAKT 10㎎+CPX, SAKT 50㎎+CPX. We injeted Soamgudamikgitang seven days, five days, three days, and one day before we injected CPX. One day, three days, and five days after CPX injection, we injected Soamgudamikgitang again and then killed all the mice.The parameters determined in this experiment were daily body weight liver and spleen weight, RBC, WBC, and platelet for hemopoietic dysfunction and AST, ALT for hepatotoxicity, BUN, creatine for renal toxcity, Iymphocyte proliferation activity and lymphocyte subsets for immunological toxvity.Results : We have found that Soamgdamikgitang has inhibitory effects on the formation of Cyclophosphamide 's side effects. Significant differences between the group, which contained Cyclophosphamide, and the other group, which contains Cyclophosphamide and 2, 10, 50㎎ of Soamgudamikgitang respectively were observed. Platelets(2㎎ of Soamgudamikgitang, p<O.05 ;10㎎, p<0.Ol ;50㎎, p<0.001), liver weight(SOw p.001), spieen weight(10mg, p<0.05), AST(all groups, p<0.01), ALT(2㎎, p<001 ;10㎎, p<O.05 ;50㎎, p<0.01), BUN(2㎎, p<0.01 ;50㎎, p<0.05). Althought immunological in both lymphocyte proliferation and its subsets were not observed, which shows that Soamgudamikgilang has a strong effect on T cell activities Conclusions : From the above results, we can expect that the combined therapy of Soamgudamikgitang and Cyclophosphamide is more effective for treating cancer Patients.
한방 치료로 호전을 보인 흉선종을 동반한 중증 근무력증 환자 1례
홍종희,박재우,김진석,전우현,조남희,오수완,김진성,류봉하,류기원 대한한방성인병학회 2000 韓方成人病學會誌 Vol.6 No.1
Myasthenia Gravis is an autoimmune disorder characterized by fluctuating muscle weakness and fatigue of different muscle groups. Diagnostic tests include use of anticholinesterase agents(Tensilon test), curare test, repetitive nerve stimulation, acetylcholine-receptor antibody assay and single fiber electromyography. Medical therapy includes use of anticholinesterase agents, immunotherapy, plasmapheresis and thymectomy. We report a case of Myasthenia Gravis diagnosed by acetylcholine-receptor antibody assay, EMG and thymoma on the chest-CT. The major clinical symptoms were low back pain, waddling gait, weight loss and fatigue. This patient was diagnosed as Wea Jeung(위증) and treated by Herbal-medication based on the differentiation of syndromes. As we treated, some of his symptoms were improved.
소적건비환과립(消積健脾丸顆粒)이 흰쥐의 위운동성(胃運動性)에 미치는 영향
홍종희,김진성,류봉하,윤상협,Hong, Jong-Hee,Kim, Jin-Sung,Ryu, Bong-Ha,Yoon, Sang-Hyub 대한한방내과학회 2006 大韓韓方內科學會誌 Vol.27 No.1
Background & Objective : The herbal medicine Sojukgunbihwan granule has been used for the treatment of functional dyspepsia, generally categorized as a gastric dysmotility disease. However, its mechanisms are not yet well known. Therefore, the effects of Sojukgunbihwan granules on gastric motility in rats was investigated. Methods : The myoelectrical activity of the gastric smooth muscle was recorded by a bipolar electrode placed at the gastric antrum of rats. The contractile waves were measured for 30 minutes before and after intragastric administration of each solution(normal saline, Pyungwisan 40mg/kg, Sojukgunbihwan granules 60mg/kg) and expressed as the motility index. Gastric emptying was measured by the number of glass beads expelled from the stomach(containing one hundred 1mm glass beads) within an hour after glass beads and test drugs(normal saline, Pyungwisan 40mg/kg, Pyungwisan 120mg/kg, Sojukgunbihwan granules 60mg/kg, Sojukgunbihwan granules 180mg/kg) were administered. In another series of experiments to evaluate the mechanisms of Sojukgunbihwan granules under delayed conditions, the rats were treated with atropine sulfate(1 mg/kg, s.c.), cisplatin(10mg/kg, i.p.), and NAME($N^G$-nitro-L-arginine methyl ester, 75mg/kg, s.c.) respectively. Results : Intragastric administration of Sojukgunbihwan granules increased the myoelectrical activity significantly, gastric motility index rose 25%, and gastric emptying of glass beads was significantly enhanced over a period of 60minutes. Under the delayed gastric emptying induced by atropine sulfate, cisplatin, and NAME, Sojukgunbihwan granules aggravated gastric emptying in the atropine sulfate($5.71{\pm}3.45\;vs\;3.71{\pm}4.42$) and cisplatin($13.86{\pm}3.53\;vs\;5.14{\pm}5.05$, p<0.01) treated groups, but enhanced gastric emptying in the NAME treated group($5.00{\pm}3.21\;vs\;11.71{\pm}5.65$, p<0.05). Conclusions : Results suggest that Sojukgunbihwan granules stimulate gastric motility through cholinergic and 5-hydroxytryptamine 3 receptors. Results are indicative of Sojukgunbihwan as an especially effective remedy in dysmotility-like functional dyspepsia with impaired reservoir functions such as gastric adaptive relaxation.
공장 에너지관리 시스템(FEMS) 기반 동선 제작용 가스용해로 에너지 절감을 위한 공정 핵심모델 개발
홍종희(Hong Jongheui),고락경(Rakkyung Ko),송원준(Song WonJoon) 대한전자공학회 2023 대한전자공학회 학술대회 Vol.2023 No.6
This paper presents a study on FEMS-based process optimization and energy-saving technology for gas furnace of copper wire manufacturing. Realtime measurements and analyses were conducted on the energy supply, operation, and equipment information of the gas furnace melting process in order to establish a core process model. Based on this model, it is aimed to predict a holding furnace level and optimize the gas supply quantity to the gas burner within the melting process in order to reduce gas usage by tens of burners. The paper aims to research an optimized process technology that considers economic efficiency and ecofriendliness.
성,가정,아동폭력에 대한 형사정책연구 ; 가정폭력범죄(家庭暴力犯罪)에 관한 연구(硏究)
홍종희 ( Jong Hee Hong ) 법조협회 2008 法曹 Vol.57 No.1
가정은 인류 사회의 오래되고 보편적 제도로 자녀 양육과 사회화를 통해 재생산을 담당하는 기초단위이다. 가정폭력은 개인에 대한 범죄일 뿐만 아니라 사회의 기초단위인 가족공동체를 붕괴시키는 요인이 되고 학습을 통한 폭력의 사회화를 가져온다. 가정폭력을 사적인 문제로 방치하여서는 안된다는 인식 하에 가정폭력범죄의처벌등에관한특례법과 가정폭력방지및피해자보호등에관한법률이 제정되었으나 그 시행 과정에서 실제적인 제도적 장치의 부족, 정책 방향과 입법구조상의 딜레마 및 입법적 미비점이 노정되었다. 가정폭력에 대한 형사법적 개입은 가해자의 처벌보다는 그 성행을 교정하여 가정을 보호한다는 입법 취지를 반영하는 방향으로 추진되었는바, 이는 가정폭력의 위험성에 따른 적절한 법적 대응이 되지 못하며 피해자 보호에 취약함을 드러냈다. 가정폭력사건의 처리과정에서 실무운영상 발생하는 제반 문제를 극복하고 가정의 보호 그리고 피해자의 인권 보호라는 목표를 달성할 수 있는 방안들을 모색하는 것은 실무가의 몫이다. 최근 형벌 위주의 전통적 형사절차에서 탈피하여 가해자 및 피해자 등 관련자들이 함께 형사사법에 개입하여 범죄로 인해 야기된 문제를 해결해나가는 새로운 대응 방안이 모색되고 있고 검찰은 그 대응 방안으로 상담조건부 기소유예제도를 시행하고 있다.