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실험연구 : 말초신경손상 쥐에서 중추신경계 α2-아드레날린성 수용체 아형의 발현
최소론 ( So Ron Choi ),이형창 ( Hyung Chang Lee ),정찬종 ( Chan Jong Chung ),김해규 ( Hae Kyu Kim ) 대한마취과학회 2006 Korean Journal of Anesthesiology Vol.51 No.4
Background: The change of expression of the α2-adrenergic receptor (α2-AR) subtypes in the thalamus and hypothalamus were investigated in a neuropathic pain rat model. Methods: The left sciatic nerve was clamped for creating a neuropathic pain model in five rats. A sham operation was done in three rats as control group. Behavioral tests for pain were conducted by using mechanical stimuli applied to the hind paws. After 7 days, the expression of α2-AR subtype mRNA in the rat thalamus and hypothalamus was measured using real time polymerase chain reaction. Results: Mechanical allodynia were developed on postoperative 1, 3, and 7 days in the neuropathic pain model. The expression of α2A-AR, α2B-AR, and α2C-AR was significantly higher in the thalamus and hypothalamus in the neuropathic pain model (P > 0.05). Conclusions: These results would suggest that the subtypes of α2-AR in thalamus and hypothalamus may contribute to produce neuropathic pain. (Korean J Anesthesiol 2006; 51: 468~75)
임상연구 : 위절제술 환자에서 술 후 통증 조절 방법이 Cytokine 반응에 미치는 영향
정찬종 ( Chan Jong Chung ),신훈식 ( Hoon Sik Shin ),김태균 ( Tae Gyun Kim ),최소론 ( So Ron Choi ),진영준 ( Young Jhoon Chin ) 대한마취과학회 2006 Korean Journal of Anesthesiology Vol.51 No.4
Background: The postoperative period is associated with the increased production of cytokines, which augments the sensitivity to pain. Epidural analgesia might reduce the postoperative stress response and influence the immune function. This study evaluated the effect of patient-controlled epidural analgesia (PCEA) on the cytokine response, compared with patient-controlled intravenous analgesia (PCTA) in patients undergoing a gastrectomy. Methods: Twenty-nine patients undergoing a gastrectomy were randomly assigned to one of two postoperative pain management techniques: PCTA (fentanyl 15㎍/ml) or PCEA (fentanyl 3㎍/ml in 0.1% ropivacaine). The level of postoperative pain was assessed at rest and during coughing using the visual analog scale (VAS). Blood samples were collected before administering anesthesia and 6, 24, and 48 h after surgery. The plasma concentrations of the tumor necrosis factor (TNF)-α, interleukin (IL)-l β, TL-6, TL-8, TL-lra, TL-l0, and TL-2 were assessed. Results: The patients in the PCEA group showed lower VAS pain scores during the 72 h after surgery, compared with the patients in the PCIA group. There was no change in the levels of TNF-α and IL-2 between the two groups at all times examined. In both groups, the levels of IL-1 β, IL-6, IL-8, IL-1ra, and IL-10 increased after surgery (each group, P < 0.05) but there was no significant differences between the two groups. Conclusions: These results suggest that PCEA has no added influences on the cytokine responses after a gastrectomy. (Korean J Anesthesiol 2006; 51: 443~8)
이규한 ( Kyu Han Lee ),이종환 ( Jong Hwan Lee ),이수일 ( Soo Il Lee ),이승철 ( Seung Cheol Lee ),최소론 ( So Ron Choi ) 대한마취과학회 2009 Korean Journal of Anesthesiology Vol.57 No.4
Stress-induced cardiomyopathy or Takotsubo cardiomyopathy is a recently described clinical entity which is associated with a chest pain occurring during a stress, an abnormal ECG and/or an increase in the troponin blood level and a transient left ventricular dysfunction. Transient left ventricular dysfunction generally involves the midsection and the apex of the heart with an akinesis. We reported a case of a 55-year-old female patient who developed a stress-induced cardiomyopathy after local epinephrine use during ophthalmologic surgery. (Korean J Anesthesiol 2009;57:518∼21)