실험연구 : 말초신경손상 쥐에서 중추신경계 α2-아드레날린성 수용체 아형의 발현 = The Expression of α2-Adrenergic Receptor Subtypes in the Central Nervous System of Peripheral Nerve Injured Rats

다국어 초록 (Multilingual Abstract)

Background: The change of expression of the α2-adrenergic receptor (α2-AR) subtypes in the thalamus and hypothalamus were investigated in a neuropathic pain rat model. Methods: The left sciatic nerve was clamped for creating a neuropathic pain model in five rats. A sham operation was done in three rats as control group. Behavioral tests for pain were conducted by using mechanical stimuli applied to the hind paws. After 7 days, the expression of α2-AR subtype mRNA in the rat thalamus and hypothalamus was measured using real time polymerase chain reaction. Results: Mechanical allodynia were developed on postoperative 1, 3, and 7 days in the neuropathic pain model. The expression of α2A-AR, α2B-AR, and α2C-AR was significantly higher in the thalamus and hypothalamus in the neuropathic pain model (P ＞ 0.05). Conclusions: These results would suggest that the subtypes of α2-AR in thalamus and hypothalamus may contribute to produce neuropathic pain. (Korean J Anesthesiol 2006; 51: 468~75)

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