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임신중 알코올섭취가 태아발육 및 출생후 제반 생리적 신경반사에 미치는 영향
조태일,나중렬,홍승길 고려대학교 의과대학 1987 고려대 의대 잡지 Vol.24 No.1
Although liquid diets containing ethanol have been widely used in rodent models of the fetal alcohol syndrome, the nutritional adequacy of these diets and the effects of these treatment on the pregnent rat and subsequent pup development has not been sufficiently verified. Beginning on day 5 of gestation, maternal diet consumption, body weight and other physiologic parameters were monitored in rats receiving ethanol diet (Group A), paried-fed diet without ethanol (Group B) and ad libitum solid diet (Group C). The purpose of this investigation was to examine the effects of ethanol diet during pregnancy and postpartum on the developmental / reproductive parameters of pregnant rats and their offsprings. 1. Body weight of pups is suppressed by alcohol treatment - during the first 10 days postpartum, the slope of the increase in weight is significantly less than controls. - After removal of alcohol treatment, the slope of the growth curves are parallel but the ovarall weight of the alcohol treated rats is less. - The alcohol treated rats appear to be 4-6 days behind in growth when compared with controls. This appears to be true until day 8 of age. - At 80 days of age, the pre and postnatal alcohol treatment suppressed the body weight of male and female pups. 2. Duration of pregnancy is not affected by prenatal alcohol treatment, however, pellet diet rats gave birth one day earlier (p < 0.05) than alcohol treated rats. 3. Food intake was reduced (p < 0.01) in alcohol treated rats. The average was about 76 ml/day versus 119 ml/day in controls. 4. Weight gain of the mothers during pregnancy was reduced (p < 0.01) in the alcohol treated rats. The alcohol treated rats gained about 123 gm during days 5-20 of pregnancy whereas liquid and pellet controls gained 196 and 179 gm, respectively. 5. Litter size (number of pups) was not altered by alcohol treatment during pregnancy. 6. Birth weight was reduced by 18 and 10% when compared with liquid and pellet controls, however, not statistically significant. 7. Eye opening was delayed (p < 0.01) 2.4 and 1.4 days respectively, when compared with liquid and pellet diets. 8. Surface righting reflex was delayed (p < 0.01) by 3.7 days in the alcohol treated animals when compared with either controls. 9. Negative geotaxis was delayed (p < 0.01) 2.7 and 2.4 days respectively when compared with liquid and pellet diets. 10. Reflex suspension was delayed (p < 0.01) 3.3 and 3 days respectively when compared with liquid and pellet controls. It suggests that the maternal alcohol consumption plays an important role in the developmental and neurological events in the subsequent pups as described in this study.