흰쥐에서 동백 잎 추출물의 국소 뇌혈류량 조절 효과

조수인 대한본초학회 2004 大韓本草學會誌 Vol.19 No.4

Objectives : In brain disorders such as ischemic stroke, the final outcome depends largely on the duration and the degree of the ischemia as well as the susceptibility of various cell types in the affected brain region. In the present study, the effects of Camelliae Japonicae Folium extract(CJE) were tested for the anti-oxidative action in vitro and changes of MABP and rCBF in vivo. Methods : Anti-oxidative activity in vitro was measured by rancimat method, and changes of MABP and rCBF were determined by LDF methods. The rancimat method is commonly used to evaluate the antioxidative potency of various antioxidants and is based on the increase of electrical conductivity due to the formation of volatile dicarboxylic acids as a result of lipid oxidation. LDF allows for real time, noninvasive, continuous recordings of local CBF. The LDF method has been widely used to trace hemodynamic changes in the superficial or the deep brain structures in experimental stroke research. Results : MABP in CJE treated rats showed no significant change despite of the increase of CJE from 0.001 to 10 ㎎/㎏(i.v.). CJE i.v. administration showed no change on MABP in normal rats. But CJE i.v. administration showed significant increase of rCBF as dose dependent manner. Propranolol pretreated MABP showed no significant change despite of the increase of CJE. rCBF of propranolol pretreated rats showed significant change from the i.v. injection concentration of 0.01 ㎎/㎏. Conclusion : The ischemia/reperfusion induced oxidative stress may have contributed to cerebral damage in rats, and the present study provides clear evidence for the beneficial effect of CJE on ischemia induced brain injury. And the action mechanism of elevating effect of CJE on rCBF might not be concerned with the role of β-adrenoceptor. The action of CJE as an ROS-scavenger might underlie the mechanism. The exact component and mechanism remains for the future study.

薑黃 추출물이 유방암 세포주 MCF-7 증식 억제에 미치는 영향

조수인,정선,김형우,박지은,김영균 대한본초학회 2006 大韓本草學會誌 Vol.21 No.1

치매 치료를 위한 한약 자원 탐색에서 네트워크 약리학 분석법의 유용성

조수인,Suin Cho 턱관절균형의학회 2022 턱관절균형의학회지 Vol.12 No.1

Objectives: Dementia is a disease in which a person maintains a normal intellectual level during the growth period, but has acquired cognitive impairment and personality change. In this study, we tried to check whether the network pharmacology analysis method is useful in the search for herbal medicine resources for the treatment of dementia. Methods: The Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) database is a database frequently used in Chinese medicine research. We used the TCMSP to identify herbal medicines and their molecular targets that can be used for dementia by using network pharmacology research methods. Results: It was possible to select 28 types of components that are expected to be active by applying them to the living body, and 75 types of targets that these components act on were secured. In addition, 16 kinds of drugs were identified by checking the drugs containing 28 kinds of ingredients, and it was found that Radix Salviae contained 2 kinds of the selected 28 kinds of ingredients. Conclusions: Through this study, we were able to identify ingredients, drugs, and targets that can be used for basic and clinical research on dementia.

Genome Wide Expression Analysis of the Effect of Woowhangchongshim-won on Rat Brain Injury

조수인,Kim, Bu-Yeo,Lim, Se-Hyun,Kim, Hyun-Young,Kim, Young-Kyun,Lim, Chi-Yeon,Cho, Su-In 대한한방내과학회 2009 大韓韓方內科學會誌 Vol.30 No.3

Objectives : ICH breaks down blood vessels within the brain parenchyma, which finally leads to neuronal loss, drugs to treat ICH have not yet been established. In this experiment, we measured the effect of Woowhangchongshim-won (WWCSW) on intracerebral hemorrhage (ICH) in rat using microarray technology. Methods : We measured the effect of WWCSW on ICH in rat using microarray technology. ICH was induced by injection of collagenase type IV, and total RNA was isolated. Image files of microarray were measured using a ScanArray scanner, and the criteria of the threshold for up- and down-regulation was 2 fold. Hierarchical clustering was implemented using CLUSTER and TREEVIEW program, and for Ontology analysis. GOSTAT program was applied in which p-value was calculated by Chi square or Fisher's exact test based on the total array element. Results : WWCSW-treatment restored the gene expression altered by ICH-induction in brain to the levels of 76.0% and 70.1% for up- and down-regulated genes, respectively. Conclusion : Co-regulated genes by ICH model of rat could be used as molecular targets for therapeutic effects of drug including WWCSW. That is, the presence of co-regulated genes may represent the importance of these genes in ICH in the brain and the change of expression level of these co-regulated genes would also indicate the functional change of brain tissue.

전체과제제시와 부분과제연습이 학습자의 사전인지기능에 따라 문제해결과 인지부하에 미치는 영향

조수연(趙修年),정선영(鄭善永) 서울대학교 교육연구소 2011 아시아교육연구 Vol.12 No.2

본 연구는 교육현장에서 복합적 인지기술의 습득을 위한 교수설계모형으로 알려진 4C/ID모형의 네 가지 요 소 중 전체과제제시와 부분과제연습이 학습자의 사전인지기능에 따라 문제해결과 인지부하에 미치는 영향을 검증하였다. 본 연구를 위해 I시 소재 중학교 108명의 학생이 실험에 참여하였다. 본 연구는 ‘엑셀 학습 프로그램’을 총 7주에 걸쳐 실시하였다. 연구 결과, 복합적 인지기술을 필요로 하는 학습과제의 경우 전체과제제시를 제공하였을 때 문제해결을 쉽게 할 수 있었으며, 문제해결에 대하여 학습전략과 사전인지기능 간에 상호작용효과가 있었다. 즉, 전체과제제시는 사전인지기능이 높은 상위집단이 사전인지기능이 낮은 집단보다 상대적으로 효과적이었다. 또한, 전체과제제시는 본유적 인지부하를 높여주었다. 그러나 인지부하에 대하여 학습전략과 사전인지기능 간에는 상호작용효과가 없었다. 본 연구결과 복합적 문제해결을 위해서는 전체과제제시를 사용하는 것이 효과적이라는 것을 시사해 준다. 따라서, 전체과제제시는 문제해결 시 본유적 인지부하를 높여 주는 역할을 하기 때문에, 본 연구는 실제 교실환경에서 복합적 문제해결 시 전체과제제시전략의 사용을 제안한다. The current study is to investigate the effects of whole task practice and part task practice among four components of 4CID model, which is instructional design model for complex cognitive skill acquisition. 108 subjects from middle school located in I city participated. For the purpose, an instructional program for excel was conducted for seven weeks. After completing the program, post-test for problem solving and cognitive load test was administered. As the research results, subjects were able to solve problems better when whole task practice was provided. There was an interaction effects between learning strategies and previous cognitive skills. That is to say, while whole task practice was effective for the subjects with higher previous cognitive skills, part task practice was effective for the subjects with lower previous cognitive skills. Also, whole task practice raised germane cognitive load. Previous cognitive load skills had significant interaction effects for all types of cognitive load. However, there was no interaction effects between learning strategies and previous cognitive skills. The current research results reports that whole task practice is more effective for students with high cognitive skills whereas part task practice is more effective for students with low cognitive skills. Since the whole task practice took a role of raising the germane cognitive load while students solve a problem, we suggest whole task practice strategies for complex cognitive problem solving in the practical classroom learning environment.

[당선작_조수일] 앵글로피쉬의 변명 외 3편

조수일 고요아침 2017 열린시학 Vol.22 No.2

당사자의 증언과 기억을 전승하는 서사 전략 : 김석범의 ｢남겨진 기억｣을 중심으로

조수일(CHO, Su-Il)(趙秀一) 한일민족문제학회 2021 한일민족문제연구 Vol.40 No.-

本稿は、金石範自身に語り継がれた済州4·3事件の証言を初めて形象化した1975年作｢遺された記憶｣を読解した。まず、冒頭分析を通して｢私｣が読者の想像力に働きかける語りの中で生成されることを明らかにした。物語の結末部における語り手｢私｣の死と枠物語化するが、それは死者の声がどのように生者に語り継がれるかを示す装置であり、死者をして語らしめたことの露呈であると捉えた。次いで、〈遺された記憶〉は、単純に宋東丘の記憶が息子の宋有根に残されたということだけを意味しない点を解き明かした。宋有根の語りにおいて伝聞として語り継がれる宋東丘の記憶は、ただ単に彼の網膜に刻まれた〈遺された記憶〉ではなく、それを越えた身体と精神の、つまり全身全霊の感覚に<遺された記憶>であることを読み取ることができた。最後に、済州4·3事件に生み出された密航者である作中人物の共通項の背面には、各々が思い起こされたことに対して語り得ることと語り得ないこととの間で揺れ動く格闘があり、読者は小説表現の空白に光を当て、想像力をもって向き合っていくべきであることを指摘した。 This study read the Memories left behind that embodies the testimony of Jeju 4·3 Incident that Kim Suk-pom himself heard. First, this study analyzed the beginning, and made it clear that “I” is generated in stories that influence the imagination of readers. At the end of the novel, the narrator “I” dies and frame novel is formed, which is a device to show how the voice of the dead is passed down to the living, and to let out the dead spoken. Next, this study considered that this novel’s title Memories left behind is not only meaning which the memories of Song Dong-gu was left behind his son Song Yoo-gun. And this paper figured out Song Dong-gu’s memory, presented as hearsay in Song Yoo-gun’s story, was not just a memory engraved on his retina, but a memory beyond it, that is, a memory left to his whole body and soul. Finally, this study paid attention the common points of the characters in the background that they were stowaways. And it pointed out that behind them, there was struggles between being able to speak and not being able to speak, and that readers should read that the gaps in novel’s expression, with using their imagination.

石菖蒲 추출물이 생쥐의 사회ㆍ심리적 스트레스에 미치는 영향

조수인,김형우,졍용식 대한본초학회 2004 大韓本草學會誌 Vol.19 No.4

Objectives : Stress is one of the deleterious factors for health, and many diseases are likely to be related to stress. The effects of Acorus Graminei Rhizoma extract were tested for the anti-sociopsychological stress action. Methods : 250g of dried Acorus Graminei Rhizoma was extracted(AGE) with pure water and the total extractive was evaporated under reduced pressure to give 39.7g. ICR male mice(20±2g) were fed orally with the dose of 100㎎/㎏/day for five days. Mice were exposed to sociopsychological stress by restraining and seeing foot shock stressed mice for one hour for five days. Results : AGE administered group showed a significant decrease of serum corticosterone secretion compared with control group. Noradrenaline secretions in the dorsal cortex of brain showed no change. Lipid peroxidation of the liver and serum of mice were tested by measuring malondialdehyde, but AGE admistration showed no change. Conclusion : Above results suggest that AGE can rid the sociopsychological stress by decreasing serum corticosterone secretion.

關與中國鄕鎭選擧方式改革的硏究

趙壽星(조수성) 계명대학교 국제학연구소 2006 국제학논총 Vol.10 No.-

당선소감_조수일

조수일 고요아침 2017 열린시학 Vol.22 No.2