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      • KCI등재후보

        계격산(啓膈散)의 항암(抗癌) 및 면역반응(免疫反應)에 관(關)한 실험적(實驗的) 연구(硏究)

        이지향,류봉하,박동원,류기원,Lee, Ji-Hyang,Ryu, Bong-Ha,Park, Dong-Won,Ryu, Gi-Won 대한암한의학회 1997 大韓癌韓醫學會誌 Vol.3 No.1

        In order to investigate the effects of Kyegyoksan on antitumor effects after Sarcoma 180 cells transplantation into the peritoneal cavity or left groin in mice, and immune depression in mice induced by methotrexate, the extracts of its herbal medicines were orally administered for 14 or 21 days. Experimental studies were performed for measureance of $IC_{50}$ in MTT assay, mean survival days, tumor and body weights for antitumor effects, delayed type hypersensitivity, hemagglutinine titer, hemolysin titer, rosette forming cells, interleukin-2 productivity, lymphocyte transformation, natural killer cell activity and phagocytic activity for immune responses in the immune depressed ICR mice, and SGOT, SGPT, BUN and creatinine for liver and kidney protective function in SO-rats. The results were obtained as follows: 1. From the results of MTT assay, the Kyegyoksan exstracts for SUN-1 and SUN-C4 were inhibited cell viability. 2. Mean survival time in Kyegyoksan-treated group was slightly increased with no effectiveness, as compared with the control group. 3. Tumor weight in Kyegyoksan-treated group was depressed with the statistical significance, as compared with the control group(p<0.01). 4. Body weight in Kyegyoksan-treated group was incresed with the statistical significance, as compared with the control group(p<0.05). 5. Delayed type hypersensitivity in Kyegyoksan-treated group was slightly incresed with no effctiveness, as compared with the control group. 6. Hemagglutinin titer in Kyegyoksan-treated group was incresed with the statistical significance(p<0.05), but hemolysin titer was slightly incresed with no effectiveness, as compared with the control group. 7. Rosette forming cells in Kyegyoksan-treated group was incresed with the statistical significance, as compared with the control group(p<0.001). 8. Interleukin-2 productivity in Kyegyoksan-treated group was incresed with the statistical significance, as compared with the control group(p<0.001). 9. Lymphocyte transfomation in Kyegyoksan-treated group was incresed with the statistical significance, as compared with the control group(p<0.01). 10. Natural killer cell activity in Kyegyoksan-treated group at E/T ratio 100 : 1 was incresed with the statistical significance(p<0.01), but at E/T ratio 50 : 1 and 10 : 1 was slightly incresed with no effectiveness, as compared with the control group. 11. Phagocytic activity in Kyegyoksan-treated group was slightly incresed with no effectiveness, as compared with the control group. 12. The levels of serum glutamic oxalacetic transaminase, serum glutamic pyruvic transaminase, blood urea nitrogen and serum creatinine in Kyegyoksan-treated group were not effective change, as compared with the control group. According to the above results, it could be suggested that Kyegyoksan have prominent antitumor effects, enhance both cellular and humoral immunity, and have no injury to liver and kidney functions.

      • Studies on Body Fat Ratio and Nutrient Intakes of College Students

        이지향,송경희 한국영양학회 2005 Nutritional Sciences Vol.8 No.1

        The aim of this study researchs status of the nutrient intake between male and female students and the nutrient intake by BMI. This study was done to investigate the body composition and nutrient intakes of 340 college students (170 males, 170 females) in Gyeonggi area. Weight, height, BMI, and blood pressure of these college students were measured. Nutrient intake was assessed using the 24-hour recall method, and then calculated using the nutritional evaluation program[CAN Pro 2.0 professional (Korean Nutrition Society, 2002)]. Average height and weight were 176±5.1 cm, 70.60±1.1 kg in male students and 162.2±4.5 cm, 54.4±7.7 kg in female students respectively. Subjects were divided into three groups by BMI: underweight (less than 18.5), normal weight (18.5 to less than 23), and overweight (more than 23). The ratios of male and female subjects among these groups were 5.3% and 17.6% in underweight, 50% and 65.3% in normal weight, and 44.7% and 17.2% in overweight. Systolic and diastolic blood pressures were 124.0±1.5 mmHg and 76.1±14.8 mmHg in males and 110.1±12.9 mmHg and 70.1±10.8 mmHg in females, all in the normal range. Using nutrient values of the 7th Recommended Dietary Allowances, the nutrient intake was calculated to Korean RDA (%). Nutrients below 75% Korean RDA were Calcium, Vitamin B2, and Folate and nutrients above 100% RDA were Protein, Fe, Phosphorous, and Vitamin B6. BMI showed positive correlations with body fat (%)(p<0.01) and WHR(p<0.01). Nutritional education is desirable for the improvement of dietary behaviors, body composition and nutrient intake of college students.

      • KCI등재후보

        뮤지컬 산업의 저작권 보호에 관한 인식과 요인 분석

        이지향 한국저작권위원회 2010 계간 저작권 Vol.23 No.3

        본 논문에서는 공연예술 분야에서 나타나는 저작권 관련 문제들 중에서 최근 관련 시장의 급격한 확대와 공연예술시장의 절반 이상을 차지하고 있는 뮤지컬 분야의 저작권보호에 관한 인식과 요인을 제작자와 저작자를 대상으로 실시한 실태조사 결과를 통해 분석하여 공연예술분야의 저작권 문제의 이해를 돕고 그 해결을 위한 제언을 도출하고 있다. 저작물의 침해와 보호에 관한 분쟁은 결과적으로 법학적 기반 위에서 해결 될 수밖에 없기 때문에 여러 예술분야로 구성된 종합예술인 뮤지컬 저작물의 법률적 성질을 저작권법과 기존 판례를 통해 조사하였다. 설문조사 결과에 의하면, 뮤지컬 전문종사자들은 최근 뮤지컬 시장의 확대에 따라 기대수익이 높아지면서 저작권에 대해 더욱 중요시 여기게 되었고 제작자와 저작자들의 인식이 강화되면서 저작권의 중요성을 인식하게 되었음을 본 연구를 통해 알 수 있다. 결국 이해 당사자들이 저작권에 대한 인식이나 이해도가 부족하여 저작권 관련 문제들이 발생하는 것으로 판단할 수 있겠다. 그리고 전문 종사자들은 저작권 관련 교육의 필요성을 느끼고 있는 것으로 조사되었고 저작권의 이해도를 높이면 인식이 강화된다는 점이 검증되고 있다. 저작권에 대한 이해도가 높아지고 인식이 변화하면 더욱 명확하고 합리적인 이해당사자 간의 관계형성이 구축 되게 된다. 이로 인해 저작권의 기능과 역할이 증대되어 작품의 질적 향상을 가져오게 되면 결과적으로 저작권법의 궁극적 목적인 공연문화산업의 발전을 도모할 수 있게 된다. 뮤지컬 저작권 관련 교육을 통한 인식강화와 이해도 증대는 공연예술 분야의 저작권 문제 해결의 첫 단계라는 점을 지적했다. 저작권에 대한 인식강화와 이해도를 확대시키고 이용허락계약의 체결방식, 표준계약서 작성이나 보급, 그리고 저작권료기준제시 등의 실무적 사항들을 조언하고, 교육시켜줄 전문기관의 필요성을 제기했다.

      • SCOPUSKCI등재

        생쥐 1-세포기 수정란의 동결방법에 있어서 초자화동결과 완만동결의 비교

        이지향,한혁동,구혜영,Lee, Ji-Hyang,Han, Hyuck-Dong,Koo, Hye-Young 대한생식의학회 2001 Clinical and Experimental Reproductive Medicine Vol.28 No.3

        Objective : This study was conducted to examine the effect of vitrification on the survival and in vitro development of mice 1-cell zygotes. Method: Effects of exposure to vitrification solution and vitrification, with different concentrations of the cryoprotectant solution, were examined. The 1-cell zygotes were also subjected to a slow freezing-thawing method to compare with vitrification method. Solution composed of ethylene glycol (6.0 M, 5.0 M, 4.0 M) and sucrose (1.0 M) were used as cryopropectant. The experiments employed the method loading the embryos on electron microscope grids. Results: I. The effects of exposure in vitrification solution. 1-cell zygotes were non-toxic at all concentrations of the vitrification solution showing the survival rate between 88.1% and 97.5%. Development into 2-cell was more successful in the higher concentrations of the vitrification solution. Therefore, higher concentrations of the vitirification solution do not seem to cause any problems in vitrification procedure. II. The effects of vitrification method. 1-cell zygotes showed the survival rate between 78.8% and 92.4%. The lowest and the highest survival rate was observed in the 6.0 M and 4.0 M vitrification solution, respectively. 2-cell development rates varied from 77.6% to 91.3%. Blastocyst development rate was shown highest in 5.0 M and the lowest in 4.0 M solution. Therefore, the highest 2-cell and blastocyst development rate was observed in 5.0 M solution. III. Comparison of vitrification and slow freezing-thawing method on 1-cell zygotes. This experiment showed that 1-cell zygotes had the highest survival and development rates in 5.0 M vitrification solution. Vitrified group of 1-cell zygotes, in the 5.0 M vitrification solution, were compared with the group processed in slow freezing-thawing method. The development rate into 2-cell and blastocyst as well as the survival rate were higher in the vitrified group than in the slowly freezed group. Conclusion: 1. The results demonstrate that the best cryoprotectant is a 5.0 M vitrification solution for 1-cell zygotes. 2. Vitrification method significantly increases the survival rate of the 1-cell zygote and its development into 2-cell and blastocyst. Equilibration and exposure time during the vitrification was remarkerbly short in this experiment. Total time, from the exposure to vitirification solution to storage in the liquid nitrogen, was taken only 90 seconds. In contrast, the slow freezing-thawing method have taken more than four hours. Taken together, we presume that the overall time used for the procedure contributes to the results as an important parameter. 3. The loading of 1-cell zygotes on the EM grid is technically more simple and takes less time than the straw or cryo vial method.

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