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The Role of Gastrokine 1 in Gastric Cancer
윤정환,최원석,김올가,박원상 대한위암학회 2014 Journal of gastric cancer Vol.14 No.3
Homeostatic imbalance between cell proliferation and death in gastric mucosal epithelia may lead to gastritis and gastric cancer. Despiteabundant gastrokine 1 (GKN1) expression in the normal stomach, the loss of GKN1 expression is frequently detected in gastric mucosainfected with Helicobacter pylori , as well as in intestinal metaplasia and gastric cancer tissues, suggesting that GKN1 plays an importantrole in gastric mucosal defense, and the gene functions as a gastric tumor suppressor. In the stomach, GKN1 is involved in gastricmucosal inflammation by regulating cytokine production, the nuclear factor-κB signaling pathway, and cyclooxygenase-2 expression. GKN1 also inhibits the carcinogenic potential of H. pylori protein CagA by binding to it, and up-regulates antioxidant enzymes. In addition,GKN1 reduces cell viability, proliferation, and colony formation by inhibiting cell cycle progression and epigenetic modification bydown-regulating the expression levels of DNMT1 and EZH2, and DNMT1 activity, and inducing apoptosis through the death receptordependentpathway. Furthermore, GKN1 also inhibits gastric cancer cell invasion and metastasis via coordinated regulation of epithelialmesenchymal transition-related protein expression, reactive oxygen species production, and PI3K/Akt signaling pathway activation. Although the modes of action of GKN1 have not been clearly described, recent limited evidence suggests that GKN1 acts as a gastricspecifictumor suppressor. This review aims to discuss, comment, and summarize the recent progress in the understanding of the role ofGKN1 in gastric cancer development and progression.
워크플로우 관리시스템(WfMS)을 이용한 지적업무 개선방안 연구
윤정환,이성화 한국국토정보공사 2008 지적과 국토정보 Vol.38 No.2
For reducing the distress of the employees of KCSC who have to learn about a new Information System to do for their new charges which is changed their position and charges frequently, the CBES (Cadastral Business Enhancement System) which is the cutomized and applicated Informatin System based on the WfMS (Workflow Management System) has been designed and suggested for being able to reduce the cost, working time, and re-education fees and times. 잦은 보직전환과 담당업무의 변경으로 새로운 정보시스템을 습득·운영하는데 애로를 겪고 있는 대한지적공사 직원들의 어려움을 덜어주고자 워크플로우 관리시스템을 응용하여 가칭 지적업무 고도화시스템 (CBES; Cadastral Business Enhancement System)을 설계하고 제안함으로써 지적 업무의 프로세스 개선을 통한 비용 절감, 작업시간 단축, 재교육 시간과 비용 절감 등을 기대한다.
고객중심의 업무프로세스 재설계 -분할측량업무를 중심으로-
윤정환,우인제,이보미 한국국토정보공사 2008 지적과 국토정보 Vol.38 No.1
본 연구는 지적공사가 지속가능경영을 성취하기 위해 향후의 지적측량이 나아가야 할 고객중심의 업무처리 프로세스는 어떤 것인지를 연구하고 제시하고 있다. 첫째, 현재의 분할측량 업무와 신규 필지의 등기 업무가 어떻게 처리되어지는지 표준안을 작성하고, UML 기법을 이용해 모형화(modeling)하여 제시했다. 다음으로는 고객중심의 업무처리 프로세스 재설계를 위해서 네덜란드 지적청 (Dutch Kadaster)을 벤치마킹 하였다. 끝으로, 분할측량 업무프로세스를 재설계하여 완전 자동화에 바탕을 둔 개선안을 제시하였다. This research studies about the customer oriented business process for being achieved the Sustainable Management of KCSC and provides the way how to achieve it. First, the standardized Business Processes are depicted by the UML modeling technique to explain the current business processes of the Parcel Subdivision and Land Registry. Next, the Netherlands Cadastre Agency (Dutch Kadaster) is benchmarked for re-engineering to achieved the Customer Oriented Business Process. Finally, Improved Business Process is suggested by the re-engineering of the Parcel Subdivision Business Process based on the Conceptual idea of the fully automated procedure.