Ginsenosides Rb1 and Rg1 Decrease Proliferation but Increase Neuronal Differentiation of Hippocampal Neural Progenitor Cells

윤영주,이준석,김영숙,양병환,손현 한국발생생물학회 2006 발생과 생식 Vol.10 No.3

전세계적으로 널리 복용되고 있음에도 불구하고 인삼이 중추신경계에 미치는 효과에 대한 세포수준에서의 증거는 별로 없다. 따라서 본 연구자들은 지금까지 보고된 30여종 이상의 ginsenosides 중에서 인삼 효과의 주된 활성성분으로 알려져 있는 Rb1과 Rg1을 이용해 해마신경전구세포의 분화와 증식에 미치는 효과를 연구하였다. 증식실험결과 Rb1과 Rg1을 3일 동안 해마신경전구세포에 처리하면 대조군에 비해 BrdU(+)세포수가 상당히 감소한 반면에 분 Ginseng is the best known and most popular herbal medicine used worldwide. In spite of reported beneficial effects of ginseng on the CNS, there is few scientific evidences established at the cellular level. Among more than 30 ginsenosides, Rb1 and Rg1, the active ingredients of ginseng, are regarded as the main compounds responsible for many pharmaceutical actions of ginseng. Daily treatment with Rb1 or Rg1 for 3 d significantly decreased the number of bromodeoxyuridine(BrdU)(+) cells in primary neural progenitor cells(NPCs) isolated from hippocampi at embryonic day 16.5(E16.5). In contrast, treatment with Rb1 or Rg1 greatly increased the number of microtubule associated protein(MAP2) (+) cells. In addition, the transcription factors, Ngn1 and Hes1, proneural members of the basic helix-loop-helix(bHLH) family, significantly increased in Rb1 or Rg1 treated-NPCs. Based on these results, we suggest for the first time that ginsenosides Rb1 and Rg1 decrease proliferation but promote neuronal differentiation of hippocampal NPCs.

악교정수술에서 교정치료의 역할

윤영주 대한치과의사협회 1999 대한치과의사협회지 Vol.37 No.10

최근 10년간 조선대학교 부속치과병원 교정과에 내원한 부정교합 환자에 관한 역학적 연구(1990${\sim}$1999)

윤영주,김광원,황미선,Yoon, Young-Jooh,Kim, Kwang-Won,Hwang, Mee-Sun 대한치과교정학회 2001 대한치과교정학회지 Vol.31 No.2

본 연구는 부정교합 유형이나 지역 분포 및 시대적 변화 등을 파악하고 이해함으로써 환자의 적절한 의사소통을 위한 자료나 정보제공을 용이하게 하기 위해, 적절한 진단과 치료계획을 수립하는 데 도움을 주기 위해, 다가오는 21세기에 변모될 치의학을 준비하고 발전의 도약을 마련하기 위해, 향후 부정교합 치료의 방향성을 설정하기 위해 시행하였다. 이를 위해 1990년부터 1999년까지 10년간 조선대학교 부속치과병원 교정과에 내원하여 진단받은 부정교합 환자 중 진단용 모형과 진료기록부가 잘 보존된 3,070명을 대상으로 하여 부정교합의 양상과 내원환자의 분포 및 변화추세를 조사 연구한 결과 다음과 같은 결론을 얻었다. 1. 내원환자의 수는 매년 증가 추세에 있었으며, 남자가 43.5%, 여자가 56.5%로 여자가 남자보다 약 1.3배 더 많았다. 2. 연령별 분포에서 7세에서 12세 군의 내원율이 37.9%로 가장 높게 나타났으며 다음으로는 13세에서 18세 군이 32.0%, 19세에서 24세 군이 19.6%, 25세 이상 군이 7.1%, 0세에서 6세 군이 3.4%으로 가장 낮았다. 3. Hellman 치령별 분포에서 남녀 모두 영구치열의 완성기인 IVa가 54.9%로 가장 높게 나타났다. 4. 내원환자의 거주지 분포에서 광주시내 거주자가 내원환자의 71.0%로 10km이내가 56.3%, 20km이내가 14.7%였다. 5. 내원환자의 주소(chief complaint)별 분포에서 전치부 반대교합이 22.7%로 가장 높게 나타났으며, 하악전돌은 12.6%, 상악전치전돌은 12.2%를 보였다. 6. Angle씨 부정교합 분류별 분포에서 제I급 부정교합이 38.9%, 제 II급 1류 부정교합은 20.7%, 제 II급 2류 부정교합은2.0%, 제III급 부정교합은 38.4%였으며, 남자에서는 제III급 부정교합이, 여자에서는 제I급 부정교합의 비율이 가장 높게 나타났다. 7. 치아의 수직관계이상에 있어서 제II급 1류와 2류 부정교합에서는 과개교합이 24.3%와 56.7%로, 제III급 부정교합에서는 개교합이 21.4%로 가장 높게 나타났다. 8. 골격의 전후방적 부조화에 있어서 제II급 부정교합은 하악골 발육부전으로 인한 경우가 39.3%, 제III급 부정교합은 하악골 과다성장으로 인한 경우가 46.3%로 가장 높게 나타났다. 9. 교정치료시 발치유무에 따른 분포에 있어서 발치 치료는 33.1%, 비발치 치료는 66.9%를 차지하였고, 발치치료 중 38.6%가 상하악 좌우측 제1소구치를 발거하였다. 10. 악교정 수술환자는 매년 계속 증가 추세에 있었으며, 전체 환자의 7.9%가 악교정 수술을 받았다. With socioeconomic development and change of esthetic recognition, the demand for orthodontic treatment and number of orthodontic patients has been increasing so rapidly. And frequency of malocclusion was changed. So this study was done in an attempt to provide an epidemiologic study so that we can accomodate their orthodontic needs adequately and to obtain the reliable quantitative information regarding the characteristics of orthodontic patients. Distribution and trends were examined in 3,070 malocclusion patients who had been examined and diagnosed at Department of Orthodontics, Dental Hospital, Chosun University over 10 year-period from 1990 to 1999. The results were as follows : 1. The number of patients per year was increasing trend and higher visiting rate in female(56.5%) than in male(43.5%). 2. Age distribution had shown 7${\sim}$ 12 year-old group being the largest(37.9%) and each percentage of 13${\sim}$18, 19${\sim}$24, above-19, 0${\sim}$6 year${\sim}$old group was 32.0%, 19.6%, 7.1%, 3.4%. 3. Hellman dental age IVa which is completion of the permanent dentition showed the highest percentage in male and female. 4. Geographic distribution showed a majority of patients in Kwang Ju(71.0%). Group within the distance 10km from Chosun Dental Hospital was 56.3% and group within 20km was 14.7%. 5. Anterior cross bite showed the highest percentage in chief complaints and percentage of Mn. prognathism and protrusion of Mx. teeth was 12.6%, 12.2%. 6. Distribution in the types of malocclusion according to the Angle's classification had shown; 38.9% for Class I, 20.7% for Class II division 1, 2.0% for Class III division 2, 38.4% for Class III. 7. In the dental vertical dysplasia according to the Angle's classification, deep bite was the most frequent in Class II div.1 and div. 2(24.3%, 56.7%) and open bite in Class III(21.4%). 8. In the skeletal sagittal dysplasia, 39.3% of skeletal Class II was due to the undergrowth of the mandible and 46.3% of skeletal Class III was due to the overgrowth of the mandible. 9. Distribution in orthodontic treatment acceding to the extraction and nonextraction had shown 66.9% for nonextraction case, 33.1% for extraction case, and four first bicuspids have been extracted in the highest percentage(38.6%). 10. Patients who had orthognathic surgery comprised 7.9%, with an increasing trend.

설측 이소맹출된 하악 제2대구치의 개선을 위한 Posterior Crossbite Appliance

윤영주,김광원 대한치과의사협회 1997 대한치과의사협회지 Vol.35 No.2

Sonazoid를 이용한 간 내 종양의 Contrast Harmonic Sonography의 유용성에 관한 연구

윤영주,진미경,이원홍 대한초음파의료영상학회 2014 대한초음파의료영상학회지 Vol.5 No.1

목적:CT 또는 MRI 검사로 확인된 간 내 종양은 초음파 유도 하에 조직검사나 고주파 치료술을 시행하는 경우가 있다. 하지만 간 내 종양이 B-mode 초음파로 분명하게 보이지 않는 경우가 있으며, Navigation 초음파로도 진단을 할 수 없는 경우가 있다. 본 저자는 초음파 검사 시 간 내 종양의 진단에 있어 Sonazoid를 이용한 Contrast Harmonic Sonography의 유용성과 임상적 의의를 알아보고자 한다. 대상 및 방법:2013년 3월부터 5월까지 간 내 종양을 평가하기 위해 본원을 내원하여 초음파 검사를 시행한 환자 10명을 대상으로 하였으며, B-mode 초음파를 시행한 후 명확하게 구분이 되지 않는 환자에 대하여 Navigation 초음파 유도 하 Sonazoid를 이용한 Contrast Harmonic Sonography를 시행한 결과를 분석하고 영상을 평가하였다. 결과:10개 병변을 대상으로 Contrast Harmonic Sonography를 시행한 결과 8개의 병변이 확인 되었으며 2개의 병변은 확인되지 않았다. 명확하게 확인된 병변 8개중 5개가 쿠퍼기 영상에서 결손부위로 보였고, 3개가 동맥기에서 조영 증강된 영상으로 확인되었다. 결론 및 고찰:Sonazoid를 이용한 Contrast Harmonic Sonography는 B-mode 초음파 검사로 간 내 종양의 진단이 어려울 경우 조금 더 명확하게 구별하는데 도움을 주며, Sonazoid 조영제의 지속 시간이 길어 쿠퍼기 영상을 획득할 수 있어 초음파 유도 하에 조직검사 또는 고주파 치료를 시행하는데 유용성 및 임상적인 의의가 있을 것으로 사료된다.

한국 랜드마크 이미지셋 구축을 위한 인공지능 학습용 데이터셋 유효성 검증 연구

윤영주,사공원,이아네스,정지원,김동현,윤기범,김우주 한국지능정보시스템학회 2020 한국지능정보시스템학회 학술대회논문집 Vol.2020 No.11

노인의 신종 인플루엔자A[H1N1] 예방행위에 미치는 요인

윤영주,한혜진 지역사회간호학회 2010 지역사회간호학회지 Vol.21 No.4

Purpose: The purposes of this study were to examine the relations among anxiety, knowledge, health locus of control and preventive behavior, and to find factors related with preventive behavior. Methods: The subjects were 269 elderly people of over 65 living in C City. Data were collected through a structured questionnaire and analyzed by SPSS. Results: Health promoting behavior was significantly different according to chronic disease, contact with H1N1 patient and perceived health status. The variables that affected the level of preventive behavior were anxiety, knowledge, internal locus of control, external locus of control, chance locus of control and perceived health status. Conclusion: According to this study, promoting preventive behavior for H1N1 on the elderly builds up anxiety, knowledge, and health locus of control.

한약 복용이 간기능에 미치는 영향 : 국내 문헌에 대한 체계적 고찰

윤영주,신병철,이명수,조성일,신우진,박히준,이혜정,Yun, Young-Ju,Shin, Byung-Cheul,Lee, Myeong-Soo,Cho, Sung-Il,Shin, Woo-Jin,Park, Hi-Joon,Lee, Hye-Jung 대한한방내과학회 2009 大韓韓方內科學會誌 Vol.30 No.1

Background : The safety of Korean herbal Medicine (KHM: prescribed herbal medicine by doctors of traditional Korean medicine) is an important issue in Korea. Although both fields. western medicine and traditional Korean medicine. have been studied on the safety of herbs and KHM, their results were not concordance with each other. Objectives : This study aims to review the influence of KHM on liver function in Korean literature systematically. Additionally, we tried to estimate the change of data of liver function test (LFT) and the incidence of liver injury (LI) after the use of KHM. Methods : Systematic literature searches were performed on 4 major databases of Korea from their inception to May 2008. Screening and selection of the studies and the extraction of data were performed independently by two authors. There were no restrictions on the types of publication including grey literatures. Results : Forty studies were included. Only sixteen studies were performed prospectively and fifteen studies collected data from outpatients. Only 8 studies reported the occurrence of LI after the use of KHM. Nineteen cases of LI showed no or mild symptoms and the elevation of LFT was not high. All of LI patients used conventional western drug and KHM concomitantly. and causality of LI was not assessed properly. The incidence of LI related to the use of KHM was estimated as 0.59%-0.76% from all data of these studies. The conflicting results were shown on the change of alanine aminotransferase (ALT) and total bilirubin (TB) after the use of KHM. Conclusions : KHM might be a minor cause of LI in Korea. However the results are not strongly supported as enough to make the safety issue clear because of the limitations of original studies. More rigorous studies are required for answering the safety issue of KHM with the cooperative investigation of both fields of Korean traditional medicine and western medicine.

폐경 전 여성 요실금에 대한 침치료 효과 : 예비연구

윤영주,강경원,양주노,전미선,최종보,양정인 대한침구의학회 2011 대한침구의학회지 Vol.28 No.3

Objectives : The purposes of this preliminary study was to examine the feasibility of recruiting women into a clinical trial designed to examine the effects of acupuncture in treating urinary incontinence (UI) in premenopausal women with delivery history and the feasibility of performing the study procedures. We also tried to determine if there was preliminary evidence to suggest that acupuncture may be effective in reducing UI and improving disease-specific quality of life. Methods : This study was a pragmatic randomized clinical trial. Subjects between the ages of 20 and 49 years were randomly assigned to a treatment(n=11) or control group(n=11) and analyzed. Both groups were supposed to do Kegel exercise at home during 4 weeks and acupuncture was applied to the treatment group twice a week(8 sessions) additionally. Subjects performed 1 hour pad test and completed a 3-day urination diary, international consultation on incontinence modular questionnaire(ICIQ), and incontinence - quality of life(I-QOL) at base line and 5 weeks. Results : Both group showed improvement in 1 hour pad test and the reducing amount of UI was significantly larger in treatment group(p=0.0182). The significant improvements in ICIQ and I-QOL were also observed in treatment group and sustained until the follow-up measurement at 16 weeks. Any adverse reaction related to acupuncture did not happen. Conclusions : It was feasible to recruit subjects and perform the study procedures. The positive results of this study support the requirement for additional research investigating the efficacy of acupuncture in the treatment of UI in women.

국내 한국어교원의 다문화역량 강화 방안 – 질적 사례연구를 중심으로 -

윤영주 국제한국언어문화학회 2022 국제한국언어문화학회 학술대회 Vol.2022 No.11