Treatment of Recurrent Respiratory Papillomatosis Using Laser and Available Adjuvant Therapies

우승훈,Phil-Sang Chung,이상준 대한의학레이저학회 2020 MEDICAL LASERS Vol.9 No.2

Recurrent respiratory papillomatosis (RRP) is a benign tumor that occurs in the respiratory tract, especially in the larynx. The etiology of RRP is human papillomavirus (HPV). According to the age of occurrence, RRP is divided into childhood-onset and adult-onset types. Generally, childhoodonset RRP shows a high recurrence rate and diffuse involvement in the respiratory tract. Adult-onset RRP is more localized and appears more frequently as a solitary lesion. It may be the result of sexual transmission or the proliferation of latent HPV infections. At present, the treatment of choice for RRP is CO2 laser ablation. In addition, pulse dye laser or KTP (KTiOPO: potassium-titanyl-phosphate) lasers are also used. Nonsurgical adjuvant therapies can be applied in cases requiring repetitive surgery or with diffuse extensions. This review will introduce the clinical features of RRP and various treatment options including lasers.

대용량 SWITCHING 전원 장치 기술

우승훈,홍원호 대한전자공학회 1993 전자공학회지 Vol.20 No.9

Favorable Vocal Fold Wound Healing Induced by Platelet-Rich Plasma Injection

우승훈,정한신,김진평,고은하,이선욱,진성민,김동훈,손진희,이상혁 대한이비인후과학회 2014 Clinical and Experimental Otorhinolaryngology Vol.7 No.1

Objectives. To introduce a new injection material for vocal fold diseases, which could be readily translated to clinical prac- tice, we investigated the effectiveness of platelet-rich plasma (PRP) injection on the injured vocal fold in terms of his- tological recovery. Methods. Blood samples were drawn from New Zealand White rabbits and PRP was isolated through centrifugation and separation of the samples. Using a CO 2 laser, we made a linear wound in the 24 vocal fold sides of 12 rabbits and in- jected each wound with PRP on one vocal fold side and normal saline (NS) on the other. Morphologic analyses were conducted at 2, 4, and 12 weeks after injection, and inflammatory response, collagen deposit, and changes in growth factors were assessed using H&E and masson trichrome (MT) staining and western blot assay. Results. PRP was prepared in approximately 40 minutes. The mean platelet concentration was 1,315,000 platelets/mm 3 . In morphological analyses, decreased granulation was observed in the PRP-injected vocal folds (P<0.05). However, the irregular surface and atrophic change were not difference. Histological findings revealed significant inflammation and collagen deposition in NS-injected vocal folds, whereas the PRP-injected vocal folds exhibited less (P<0.05). Howev- er, the inflammatory reaction and fibrosis were not difference. In western blot assay, increased amounts of growth factors were observed in PRP-injected vocal folds. Conclusion. Injection of injured rabbit vocal folds with PRP led to improved wound healing and fewer signs of scarring as demonstrated by decreased inflammation and collagen deposition. The increased vocal fold regeneration may be due to the growth factors associated with PRP.

Photodynamic therapy for SNU-80 anaplastic thyroid cancer cells

우승훈,Kun-Woo Kim,Phil-Sang Chung,이상준 대한의학레이저학회 2022 MEDICAL LASERS Vol.11 No.2

Background and ObjectivesAnaplastic thyroid carcinoma (ATC) is one of the lethal human neo-plasms. Photodynamic therapy (PDT) is based on the interaction of a photosensitizer and light with a specific wavelength, and induces destruction of cancer cells. The purpose of this study is to evaluate the effect of the PDT with photofrin on SNU-80 anaplastic thyroid cancer cells.Materials and MethodsAfter PDT, cell viability was measured by MTT assay. The experiments were done at photofrin concentration of 1.6 to 3.2 μg/ml. Subcellular localization of photofrin were observed by ER-TrackerTM and Mito-Tracker®. Hoechst and propidium iodide (PI) double stained cells were analyzed to measure the cellular apoptosis and necrosis using confocal microscope at 4, 8, and 24 hours after laser irradiation. Caspase activation was measured by western blot analysis.ResultsCytotoxicity was increased accordingly to increasing photofrin concen-tration in MTT assay. The photofrin was localized at cytoplasm and mitochondria inside SNU-80 cells. Apoptosis and necrosis cells were increased on confocal microscope, as time after irradiation was progressed. The expression of caspase-3, -9 and poly (ADP-ribose) polymerase (PARP) were detected by Western blot analysis indicating that Photoprin-PDT showed cytotoxicity to anaplastic thyroid cancer cells in dose-dependent pattern.ConclusionPhotofrin-PDT led to in vitro cell death of SNU-80 cells through mito-chondrial mediated apoptosis. PDT could be used as a part of multimodal treatment for ATC.

Treatment of atypical longitudinal vocal polyp with CO2 laser

우승훈 대한의학레이저학회 2022 MEDICAL LASERS Vol.11 No.3

Vocal cord polyps are benign reactive lesions usually resulting from phonotrauma and congenital origins. A 24-year-old female visited the hospital with a husky, breathing voice. The patient had no history of general anesthesia or intubation. Atypical longitudinal vocal cords were identified under laryngoscopy. During the operation, the direct laryngoscope and histological findings revealed an atypical longitudinal polyp of the vocal cords. This paper presents a rare case of a longitudinal vocal polyp removed with a CO2 laser.

자간증 환자의 마취 유도 중 발생한 뇌실질내 출혈 및 뇌 경색에 의한 사망 1례 : A Case Report

우승훈,김정원,홍기혁 인제대학교 1994 仁濟醫學 Vol.15 No.1

현대 마취의들이 전자간증과 자간증의 마취 유도 및 유지에 있어 혈압 상승을 유발할 수 있는 약물들을 피함으로써 그에 의한 뇌실질 내 출혈 및 뇌경색에 의한 사망례는 드물어졌다. 본 교실에서는 태아곤란으로 응급 제왕절개술을 시행하기 위해 마취유도를 하던 중 뇌실질 내 출혈과 뇌경색으로 인해 사망한 자간증 환자를 경험하였기에 문헌적 고찰과 함께 보고한다. While the mordern anesthesiolosists prefer the drugs that may not elevate the blood pressure in preeclampsia and eclampsia, during induction and maintenance of anesthesia, the fatal case resulted of ICH and cerebral infarction rarely occur. We experienced a case of ICH and cerebral infarction due to eclampsia during inductuon of anesthesia for emergency Cesarian section. She was net awakened after cessation of the operation, and died of multiple organ failures from the complication of eclampsia.

구강 접근을 통한 갑상설관 낭종 수술

우승훈 대한갑상선학회 2016 International Journal of Thyroidology Vol.9 No.2

A thyroglossal duct cyst (TGDC) is one of the most common causes of anterior midline neck mass. Successful management of a TGDC requires histopathology and an understanding of the embryogenesis of the thyroid. Traditional TGDC surgery uses a transcervical approach, which results in an external neck scar. In contrast to the surgical removal of a benign neck mass, TGDC surgery should include removal of the cyst, the hyoid bone, and the thyroid remnant track from the foramen cecum to the hyoid bone. Considering the embryological development of the TGDC, it was evident to us that an entirely transoral approach to the TGDC region was an option. Before its descent, the TGDC originates from the bottom of the tongue. The TGDC is located behind the strap muscles of the neck and the hyoid bone. Following this naturally predetermined access alongside the TGDC, we were able to develop a new surgical approach to the TGDC area and introduced the transoral TGDC excision.

ACTIVE DIFFERENTIAL CONTROL FOR IMPROVED HANDLING PERFORMANCE OF FRONT-WHEEL-DRIVE HIGH-PERFORMANCE VEHICLES

우승훈,차현수,이경수,장성윤 한국자동차공학회 2021 International journal of automotive technology Vol.22 No.2

This paper presents an active differential control system to improve handling and acceleration performance. Conventional front-wheel-drive cars have certain disadvantages including a lack of acceleration and excessive understeer during acceleration in turn. To address this problem, we propose understeer prevention logic. First, for a rapid response, the driving torque is distributed in advance to the inner and outer wheels according to the magnitude of the estimated traction potential in the wheels. If wheel spin occurs, then additional driving torque is transmitted to the outer wheel in proportion to the increment of the inner wheel speed versus the outer wheel. However, the torque transfer to the outer wheel is limited in proportion to the excess speed of the outer wheel compared with the non-driving wheel to prevent power slides. Oversteer prevention logic can improve yaw damping. The algorithm transmits driving torque from the outer wheel to the inner wheel in proportion to the yaw rate that exceeds the target. This algorithm was then evaluated via vehicle tests. The electronic limited slip differential with the proposed algorithm was applied to mass production, and it received positive feedback from international media.

증후성 설상골 주위 부골: 증례 보고

우승훈,신원철,Woo, Seung Hun,Shin, Won Chul 대한족부족관절학회 2021 대한족부족관절학회지 Vol.25 No.2

An extremely rare accessory bone of the foot located in the distal portion of the navicular that articulates with the medial cuneiform was observed. Os paracuneiforme is usually located medial to the medial cuneiform or the naviculocuneiform joint. Although os paracuneiforme is often referred to as an accessory bone around the foot, few cases of this type of accessory bone have been reported. This paper reports a patient with a painful Os paracuneiform who underwent surgical excision of the accessory bone.

이중 스카이훅 알고리즘을 사용한 반 능동 현가장치의 제어기 설계

우승훈,류제하 한국자동차공학회 1996 한국자동차공학회 춘 추계 학술대회 논문집 Vol.1996 No.11_1

This paper presents a new double Sky-hook algorithm for controlling semi-active suspension system in order to improve road-holding property that the conventional theoretical Sky-hook algorithm can not achieve. The proposed double Sky-hook algorithm uses combination of damper coefficients, one from the chassis motion and the other from the wheel motion. It is observed that the proposed algorithm is the most effective in the vicinity of wheel hop resonant frequency. Computer simulation using 1/4 car with road condition classified by ISO shows the effectiveness of the proposed method.<br/>