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양에스더,김진용,양수현,이은수,선웅,이현우,김현 한국뇌신경과학회 2019 Experimental Neurobiology Vol.28 No.6
The habenula (Hb) is small but important brain structure, anatomically and functionally links the forebrain with the midbrain to modulate various neuropsychiatric functions associated with drug addiction and emotion-associated dysfunctions. Several reports suggested that the dysfunction of Hb-related functions affected the Hb structurally and functionally. However, the technical limitation has awaited the solid conclusion of whether Hb change due to depression is likely to occur in certain subnuclei of the Hb. To probe this possibility, we developed 3-dimensional reconstruction methods for the high-resolution volumetric analysis of Hb and the mRNA levels at the given volume in normal or lipopolysaccharide (LPS)- mediated mouse model of depression. Notably, we discovered that the volume reduction was prominent in medial Hb but not in lateral Hb after LPS treatments. On the other hand, the RNA expression levels of known Hb regional markers such as Tac1 (dorsal part of medial Hb), ChAT (ventral part of medial Hb), and Tacr1 (medial and lateral Hb) were all decreased in all Hb subnuclei in LPS-injected mice. Accordingly, accurate volumetry with marker labeling was not feasible. Collectively, these established 3D analyses of mouse Hb successfully and precisely determine the volumebased changes of small brain structure, which should be applicable in a wider range of mouse models or pathological specimens.
권영우,정용수,채에스더,안나영,이승국,문원재,양대승,김창근 韓國體育大學校附屬 體育科學硏究所 1996 韓國體育大學校附屬 體育科學硏究所論文集 Vol.15 No.1
The purpose of the present study is to investigate racial difference in immune function and exercise performance. Well trained fifteen athletes in martial art (Tae Kwon Do) participated in this study from Egypt(n=7) and Vietnam(n=8). Immune cells was investigate at rest and heart rate, lactate were measured during and recovery after maximal aerobic exercise. No significant difference was found in total leucocyte; whereas neutrophil was slightly greater in Vietnamese than in Egyptian athletes. However, lymphocyte showed significantly lower in Vietnamese athletes than that of Egyptian athletes. Monocyte and eosinophil showed no significant different between Vietnamese and Egyptian athletes. Although the speed of recovery of blood lactate was tended more faster in Egyptian than Vietnamese athletes, No significant difference was found in both groups. In conclusion, total leucocyte was not altered in both groups, but leucocyte subpopulation presented differently. This suggested that interindividual differences was existed in Egyptian and Vietnamese athletes, and the plausible explanation of reason of this difference may due to the different dietary pattern and environment.