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임신 중 경증 만성 고혈압에 대한 최신 치료 지침 및 항고혈압 요법
안태규,황종윤 한국모자보건학회 2023 한국모자보건학회지 Vol.27 No.3
Up to 5% of pregnant females experience chronic hypertension, which is linked to poor pregnancy outcomes, and along with hemorrhage, is considered one of the main causes of maternal morbidity and mortality. The combined occurrence of preeclampsia, cesarean sections, preterm birth, birth weight less than 2,500 g, neonatal unit admission, and perinatal death was higher in females with chronic hypertension. Pregnancy with systolic blood pressure of 140-159 mmHg or diastolic blood pressure of 90-109 mmHg was considered to have mild-to-moderate chronic hypertension. Blood pressure management during pregnancy is a very important issue and is directly related to fetal growth and maternal health. Many studies have reported that antihypertensive therapy during pregnancy halves the incidence of severe hypertension in all types of hypertensive diseases. However, guidelines for optimal blood pressure management goals during pregnancy remain unclear. This is because the benefits to the mother from lowering blood pressure are uncertain, and there is a risk of fetal disorders due to the possibility of reduced uteroplacental blood flow. In light of a recently released CHAP (Chronic Hypertension and Pregnancy) randomized controlled trial, the purpose of this review was to provide a summary of the current recommendations for pregnant females with mild-to-moderate chronic hypertension.
안태규,정용진 한국공업화학회 2020 한국공업화학회 연구논문 초록집 Vol.2020 No.-
High dielectric constant materials have been extensively investigated for many potential applications including low-voltage-operating organic field-effect transistors (OFETs). In this study, we overcoated fluorinated polymer onto barium titanate (BaTiO<sub>3</sub>) dielectrics toward the fabrication of highly stable OFETs. Surface of BaTiO<sub>3</sub> dielectric layers were effectively modified with poly(pentafluorostyrene) (PFS) overcoating. The PFS/BaTiO<sub>3</sub> bilayer dielectrics significantly controlled leakage currents and surface properties. Featureless surface morphologies of their films induced better crystalline structures of overlying semiconductor molecules. Moreover, the electron-withdrawing character of PFS/BaTiO<sub>3</sub> films effectively blocked hole trapping. Finally, the overcoating of PFS allowed PFS/BaTiO<sub>3</sub> to be utilized as gate dielectric layer for highly stable OFETs during low-voltage operation.
Thienoisoindigo 기반의 고분자 반도체의 대칭적인 곁가지 길이에 따른 트랜지스터 특성 변화 연구
안태규,박태호,김예별,( Michael Ruby Raj ) 한국공업화학회 2019 한국공업화학회 연구논문 초록집 Vol.2019 No.0
Thienoisoindigo 와 thiophenylene vinylene thiophene (TVT)/selenophenylene vinylene selenophene (SVS) 구조를 공중합체해서 대칭적인 곁가지의 길이를 다르게 여러 고분자를 합성하였다. 이렇게 합성한 고분자를 유기트랜지스터의 활성층으로 사용해 트랜지스터의 성능을 살펴본 결과, TVT 계열의 고분자에서는 곁가지 길이가 길어질수록 이동도가 증가되었고 SVS에서는 이동도가 감소한다는 사실을 관찰할 수 있었다. 이러한 성능 차이를 고분자의 결정구조에 기인한다는 것을 X선 산란, 시차열분석법을 통해 설명하였다.
Photodynamic therapy for breast cancer in a BALB/c mouse model
안태규,이병래,Eun-Young Choi,Dong Won Kim,한세준 대한부인종양학회 2012 Journal of Gynecologic Oncology Vol.23 No.2
Objective: Photodynamic therapy (PDT) has been used for superficial neoplasms and its usage has been recently extended to deeper lesions. The purpose of this study was to observe whether or not PDT can cure breast cancer in the solid tumor model,and to define the critical point of laser amount for killing the cancer cells. Methods: Twenty four BALB/c mouse models with subcutaneous EMT6 mammary carcinomas were prepared. Mice were divided into eight groups depending on the amount of illumination, and the tumor size was between 8 mm and 10 mm. We began by peritoneal infiltration with a photosensitizer 48 hours prior to applying the laser light, and then we applied a nonthermal laser light. The energy was from 350 J/cm2 to 30 J/cm2 to the cancer. Results: Regardless of the tumor size from 8 mm to 10 mm, all mice apparently showed positive results via PDT. We also did not find any recurrence over 90 J/cm2. In all models, the color of the breast cancer lesions began to vary to dark on 2 days post PDT and the tumor regression began simultaneously. Also, we confirmed the complete regression of the breast cancer 21 days after PDT. Conclusion: We confirmed that PDT may treat breast cancers that are sized less 10 mm in mouse models. The moderate energy to destruct the breast cancer cells may be 90 J/cm2. Therefore, we can expect that PDT may be utilized to treat breast cancer,but we need more experience, skills and processing for clinical trials.
광패턴이 가능한 지르코늄옥사이드 절연층을 이용한 저전압 구동용 유기 인버터
안태규 한국공업화학회 2016 한국공업화학회 연구논문 초록집 Vol.2016 No.1
높은 절연 상수를 가지는 용액 공정이 가능한 재료는 유기트랜지스터의 저전압 구동을 가능하게 할 뿐만 아니라 유기트랜지스터를 대면적에 제조하기 쉽고 에너지 소모가 적게 들기 때문에 연구가 활발히 진행중이다. 또한 쉬운 방식으로 패턴을 형성하는 것이 중요하게 되는데 본 연구에서는 광패턴이 가능한 전구체인 zirconium acrylate를 유기트랜지스터에 적용하였다. 광패턴된 산화지르코늄 절연층은 누설전류가 낮고 3V 이하에서 트랜지스터를 구동할 수 있었으며 42 이상의 높은 게인 값을 보였다.
안태규,손창규,정태영,유화승,조정효,Ahn, Tae-Kyu,Son, Chang-Gue,Jeong, Tae-Yong,Yoo, Hwa-Seung,Cho, Jung-Hyo 대한암한의학회 2009 大韓癌韓醫學會誌 Vol.14 No.1
Gekko has been used for several diseases including cancer in Oriental medicine and fork herbalogy. Nevertheless, its origin as herbal medicine and its efficacy and mechanism as anti-tumor drug have not yet been thoroughly reported in Korea. This study aimed to investigate anti-tumor effect of Gekko through selected articles from cqvip database in China. In vitro and In vivo, Gekko could obviously inhibit tumor growth, induce tumor cells apoptosis, reduce micro-vessel density in tumor tissue through down regulating VEGF & bFGF protein expression, promote cytotoxicity of lymphocyte. Gekko could improve survival rate, relive clinical symptoms, improve quality of life, and relieve anti-tumor treatment reaction, suggesting that Gekko might be a effective anti-tumor drug.
안태규,정용진 한국공업화학회 2020 한국공업화학회 연구논문 초록집 Vol.2020 No.-
For the possible application of the solution-processed polymer semiconductors to real electronic products, reliable operation of the devices should be guaranteed. In this study, we improved the operation stability of organic field-effect transistors (OFETs) consisting of solution-processed polymer semiconductor/insulator blends. Fluorinated polymer was effectively employed in the polymer semiconductor/ insulator blends, which allowed the blend films to have a high energetic barrier to hole trapping from semiconductor nanowires to insulator matrix. Owing to this high energetic barrier at semiconductor/ insulator interface, the resulting OFETs exhibited almost hysteresis-free transfer and output characteristics and reliable operation under a sustained gate-bias stress both in N<sub>2</sub> and air conditions.