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朴時興,康秉秀 대한본초학회 2001 大韓本草學會誌 Vol.16 No.1
The antioxidation effects of Cinnamomi Cortex (CC), Cinnamomi Ramulus (CR), Cinnamomi Petiole (CP) on the radical scavenging ability from the contents of glutathione (GSH), lipid peroxidase (LPO) and activities of superoxide dismutase (SOD), catalase in rat liver cells were examined. In in vivo studies, the acetaminophen-induced inhibitions of SOD, LPO and catalase activities were significantly recovered by the treatments of CC, CR, and CP extracts. The recovery by CR extract has similar effects on the antioxidation compared with ascorbic acid, well-known antioxidant. The decrease of GSH contents in rat liver induced by acetaminophen was completely recovered to the normal levels by the treatment of CC extract. There were slight increases in its contents in CR-treated group. The data indicate that CR has a depressive effect on the production of free radicals and changes in the activities of enzymes involved in the antioxidation. On the other hand, CC seemed to have the most significant effect on the increase of GSH contents. Compared to other, CP had smaller effects on the antioxidation. These results suggest that CR seems to have more potent effects on the antioxidation than other parts of Cinamomum cassia and different mechanisms might be involved in the anitoxidation processes of CC, CP, and CR.
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人蔘의 配合에 따른 數種 韓藥材의 抗酸化作用에 關한 硏究 (Ⅱ)
朴時興,康秉秀,朴涌基 대한본초학회 1999 大韓本草學會誌 Vol.14 No.2
This study was carried out in order to investigate the anti-oxidant effect of main tonic medicine, Ginseng Radix with combination of other well-known herb medicines such as Rehmammiae Radix Preparat, Astragali, Poria, Aconiti lateralis Preparata Radix, Gecko and Bupleuri Radix. These herbs were mixed with Ginseng Radix to measure inhibitory activity lipid peroxidation of linoleic acid mixture and rat liver and hydrogen-giving-temper effect by DPPH. The study showed the following valuable results. 1. In inhibitory activity of water extract against lipid peroxidation of linoleic acid mixture, Ginseng Radix-Gecko compound herbal medicine showed the highest anti-oxidant activity. Ginseng Radix -Rehmammiae Radix Preparat compound herbal medicine showed the lowest anti-oxidant activity when compared with the examined samples. 2. In inhibitory activity of water extract against lipid peroxidation of rat liver, Ginseng Radix-Gecko showed the highest anti-oxidant activity. Ginseng Radix-Rehmammiae Radix Preparat showed the lowest anti-oxidant activity. 3. In hydrogen-giving-temper effect of water extract by DPPH, Ginseng Radix-Gecko compound herbal medicine showed the highest anti-oxidant activity. 4. In the linoleic acid mixture, Ginseng Radix-Gecko compound herbal medicine showed the highest anti-oxidant activity in Butanol fraction. 5. In the lipid peroxidation of rat liver, Ginseng Radix-Gecko compound herbal medicine showed the highest anti-oxidant activity in Butanol fraction. 6. In hydrogen-giving-temper effect of water extract by DPPH, Ginseng Radix-Gecko compound herbal medicine showed the highest anti-oxidant activity in Butanol fraction. From the above results, it was concluded as follows. All the six compound herbal medicine including Ginseng Radix showed the anti-oxidant activity. Especially, Ginseng Radix-Gecko compound herbal medicine showed the highest anti-oxidant activity among them.
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朴時興,康秉秀,朴涌基 대한본초학회 1999 大韓本草學會誌 Vol.14 No.1
This study was carried out in order to investigate the anti-oxidative effects of main tonic herb medicine, Ginseng Radix, Rehmammiae Radix Preparat, Astragali Radix, Poria, Aconiti Iateralis Preparata Radix, Gecko and Bupleuri Radix. These herbs were measured on inhibitory activity against lipid peroxidation of linoleic acid mixture and rat liver and hydrogen-giving-temper effect by DPPH. The study showed the following valuable results: 1. In inhibitory activity of water extract against lipid peroxidation of linoleic acid mixture, Gecko showed the highest anti-oxidant activity among the some herbal medicine and Rehmammiae Radix Preparat showed the lowest anti-oxidant activity when compared with the examined samples. 2. In inhibitory activity of water extract against lipid peroxidation of rat liver, Gecko showed the highest anti-oxidant activity among the some herbal medicine and Rehmammiae Radix Preparat showed the lowest anti-oxidant activity. 3. In hydrogen-giving-temper effect of water extract by DPPH, Gecko showed the highest anti-oxidant activity. 4. In the linoleic acid mixture, Gecko showed the highest anti-oxidant activity in Butanol fraction. 5. In the lipid peroxidation of rat liver, Gecko showed the highest anti-oxidant activity in Butanol fraction. 6. In hydrogen-giving-temper effect of water extract by DPPH, Gecko showed the highest anti-oxidant activity in Butanol fraction. From the above results, it was concluded as follow: All the seven herb medicine including Ginseng Radix showed the anti-oxidant activity. Especially, Gecko showed the highest anti-oxidantactivity among them.
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