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김재준(Jae Jun Kim),고광철(Kwang Cheol Koh),김태호(Tae Ho Kim),송인성(In Sung Song),김정룡(Chung Yong Kim) 대한내과학회 1994 대한내과학회지 Vol.46 No.3
N/A Objectives: The effect of continued supplementation of diet with 10gp sucrose, lactose or glucose solution on rat intestinal disaccharidase specific activity was investigated. Methods: Adult rats were fed a diet with 10% sucrose, lactose or glucose solution supplementation. After 6 weeks, small intestines were removed and disaccharidase specific activities and sucrose mRNA levels were measured. Results: Adult rats when fed a diet with 10% sucrose, lactose or glucose solution supplementation for 6 weeks showed increased intestinal sucrose sperific activity. However, there was no increase of lactase specific activity. Slot blot analysis with radiolabeled rat intestinal sucrase cDNA revealed that mRNA levels of sucrase increased after 10% sucrose, lactose or glucose solution supplementation, and these changes in mRNA levels correlated with the corresponding enzyme specific activity (r=0.36, p<0.05). Conclusion: The results demonstrate that the induction of sucrase activity is directly associated with an increase in sucrase mRNA levels. In conclusion, substrate feeding induces an increase of transcription of rat intestinal sucrase gene.
한국인 태아 및 성인에서 유당분해효소 mRNA 의 발현양상
김재준(Jae Jun Kim),송인성(In Sung Song),김정룡(Chung Yong Kim) 대한내과학회 1997 대한내과학회지 Vol.52 No.5
N/A Objective: The specific activity of lactase-phlorizin hydrolase (LPH) is very high at birth and sharply declines after weaning, producing lactose intolerance. The prevalence of lactose intolerance is up to 85% in Korean adults. Molecular basis of the regulatory mechanisms responsible for the decline of LPH specific activity is still unknown. In order to elucidate the molecular mechanisms regulating the LPH expression during development, LPH specific activity and mI4NA level of Korean fetal and adult intestines were compared. Methods: 20 fetal small intestines (16-27 weeks) were obtained during therapeutic abortion and were divided into 3 equal length. 20 adult jejunal tissues were obtained from patients without small intestinal disease during laparotomy. Mucosal homogenates were prepared for dissacharidases specific activities measurement and total RNA was extracted for northern and slot hvbridization. LPH mRNA level was measured by laser densitometer. Results: LPH specific activities of proximal, middle and distal portion of fetal intestines (n=20) were 36.2±22.5, 38.6±23.2 and 23.2±19.9 mu/mg protein, respectively. LPH specific activity of adult jejunum (n=8) was 5.9±1.8 mu/mg protein and significantly (p<0.05) lower than those of fetal intestines. However, there was no significant difference in sucrase and trehalase specific activities between fetal intestines and adult jejunum. Although LPH specific activity of adult jejunum was lower than those of fetal intestines, LPH mBNA level of adult jejunum was as high as those of fetal intestines. Conclusion: These results show that LPH specific activity and mRNA level do not parallel, indicating the posttranscriptional control of fetal development of LPH expression.
Trinitrobenzene Sulfonic Acid에 의해 유발된 백서의 대장염에서 항염증제제의 치료효과
김재준(Jae Jun Kim),류지곤(Ji Kon Ryu),이동호(Dong Ho Lee),송인성(In Sung Song),김정룡(Chung Yong Kim),김용일(Yong Il Kim) 대한소화기학회 1996 대한소화기학회지 Vol.28 No.2
N/A Background/Aims: The causes and pathogenesis of inflammatory bowel disease remain unknown and no definite therapy exists until now. In order to clarify the effect of Artemisia capillaris, colitis was induced by trinitrobenzene sulfonic acid(TNBS) in rats, and the effect of anti-inflammatory drugs and Artemisia capillaris was compared. Methods: Wel]-grown Sprague-Dawley rats were divided into 7 groups and colitis was induced by TNBS except the control group. Each group was treated with 1% methyl ce]lulose, prednisolone l mg/kg, sulfasalazine 100 mg/kg, prednisolone and sulfasalazine, A.capillaris 1 mg/kg and 10 mg/kg per oral route from the next day. After 2 weeks, rats were sacrificed and gross morphologic features of colons were examined. Resullts: Ulceration, adhesion, thickening and dilatation were noticed in the colonic mucosa after TNHS insti]lation. Adhesion, thickening and di]atation were significantly improved in all the treated groups, but the ulceration was significantly improved only in groups treated by prednisolone and A.capillaris 10mg/kg. Conclusions: The colitis induced by TNBS is sirnilar to the human inflammatory bowel disease and the prednisolone and A.capillaris have a healing effect on rat colitis induced by TNBS. (Korean J Gastroenterol 1996; 2S:224 - 231)
산업용 무선센서네트워크 설계와 음향 세척 장치의 음파 검출을 위한 응용
김아연(A Yeon Kim),한재준(Jae Jun Han),김동식(Dong Sik Kim) 대한전자공학회 2014 전자공학회논문지 Vol.51 No.7
화력발전소와 같은 석유화학 설비, 소각 설비 등에서는 재, 먼지 등의 이물질이 발생하며 이물질을 효과적으로 제거하기 위한 방법으로 음향 세척 장치를 이용하는 방식이 있다. 하지만 이 방법의 경우 이물질로 인하여 혼의 입구가 막혀 오작동할 가능성이 있다는 단점이 있다. 본 연구에서는 음향 세척 장치의 정상 작동을 감시하기 위한 음파 검출 무선 센서를 개발하였으며, 센서의 원리를 설명하였다. 이 음파 검출 무선 센서는 실험을 통하여 고온 혹은 저온의 다양한 산업 환경에서 안정적인 동작을 확인하였다. 또한 음파 검출 무선 센서와 424MHz 대역을 이용한 통신을 하여 데이터를 수신하는 무선 데이터 수집 장치를 개발하여 음파 검출무선 센서의 동작 상태를 외부에서 확인할 수 있도록 하였다. The acoustic cleaning system is widely used to remove foreign materials in factories, such as thermal power plants and incinerators. However, the acoustic cleaning systems tend to be clogged by foreign materials. In this paper, we develop a wireless sensor network for the sound wave detection in order to monitor proper operations in the acoustic cleaning systems. We observe that the developed wireless sensor network for the wave detection shows a stable operation in various industrial environments of wide temperature ranges. We also develop a data gathering device, which displays the current status of the sound generator and several values detected from the wireless sensor.