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홍바리( Epinephelus fasciatus ) 난황형성기 난모세포에서의 성 스테로이드 호르몬 대사
김슬기 ( Seol Ki Kim ),백혜자 ( Hea Ja Bael ) 한국수산과학회 2014 한국수산과학회지 Vol.47 No.6
We studied oocyte steroidogenesis in blacktip grouper Epinephelus fasciatus ovarian follicles during vitellogenesis. Vitellogenic oocytes with average diameters of 0.45, 0.48 and 0.50 mm were incubated in vitro in the presence of [3H]17α-hydroxyprogesterone as a precursor. The steroid metabolites were analyzed using thin layer chromatography (TLC), high performance liquid chromatography (HPLC), and gas chromatography-mass spectrometry (GC/MS). The major metabolites in the vitellogenic oocytes were androstenedione (A4), testosterone (T), estradiol-17β (E2), and estrone (E1). The metabolites of androgen (A4 and T) were higher in the 0.50-mm oocytes than in the 0.45- and 0.48mm oocytes, while the estrogen metabolites (E2 and E1) were lower in the 0.50-mm oocytes. These results suggest that 0.50-mm oocytes are fully vitellogenic following initiation of the maturation process.
김슬기 ( Yoo Jin Shim ),( Aeran Seol ),( Dayong Lee ),( Seul Ki Kim ),( Jung Ryeol Lee ),( Byung Chul Jee ),( Chang Suk Suh ),( Seok Hyun Kim ) 대한산부인과학회 2019 대한산부인과학회 학술대회 Vol.105 No.-
Objective: To investigate the patterns of estradiol-oocyte ratio (EOR) and estradiol-mature oocyte ratio (EMOR) in patients with breast cancer undergoing controlled ovarian stimulation (COS) using letrozole and gonadotropins for fertility preservation. Methods: This retrospective study included 32 breast cancer patients underwent COS for fertility preservation and no patients had previously undergone gonadotoxic treatments. Basal characteristics and in vitro fertilization (IVF) outcomes were compared according to the age of women (age <35 vs. age ≥35) and the starting phase of ovarian stimulation (early follicular phase vs. late follicular phase vs. luteal phase). Results: Patients who were administered with a letrozole-combined regimen, the peak serum estradiol (E2) was maintained at a low level (386.3±346.9 pg/mL). EOR was 52.4±78.8 pg/mL, and EMOR was 71.0±41.2 pg/mL. When the 2 groups were compared according to the age of women (age <35 vs. age ≥35), EOR was 34.5 (22.2-46.5) pg/mL and 40.7 (19.3-65.3) pg/mL, respectively; EMOR was 79.8 (40.8-90.6) pg/mL and 68.8 (44.5-85.9) pg/mL, respectively. There was no significant difference in the IVF outcomes. When the 2 groups were compared according to the starting phase of ovarian stimulation, there were no significant differences in IVF outcomes, EOR and EMOR among the groups. Conclusion: Measuring the peak E2 concentration in breast cancer patients undergoing IVF for fertility preservation with a co-treatment of letrozole allows for the prediction of the numbers of oocytes and mature oocytes.
울진 바다목장 해역에 서식하는 강도다리(Platichthys stellatus)의 번식능력
황인준 ( In Joon Hwang ),이재봉 ( Jae Bong Lee ),최상준 ( Sang Jun Choi ),김슬기 ( Seol Ki Kim ),차형기 ( Hyung Kee Cha ),오택윤 ( Taeg Yun Oh ),백혜자 ( Hea Ja Baek ) 한국수산과학회 2012 한국수산과학회지 Vol.45 No.3
We investigated the reproductive capacity of starry flounder Platichthys stellatus from the Uljin (UJ) marine ranching area and compared it to that of P. stellatus from the coastal waters of Pohang (PH). In UJ, female gonadosomatic index (GSI) peaked in October (3.14±0.87) and male GSI was high in October and December. In PH, female GSI peaked in January (18.64±2.15) while male GSI began to increase in October and remained high until March. Most ovaries of UJ females were immature with perinucleus oocytes, although the testes of UJ males were ripe in January. Both the ovaries and testes of PH starry flounders were ripe from January to March. The plasma estradiol-17b (E2) levels of UJ females were highest in October (4.09±1.90ng/mL) although the testosterone (T) levels of UJ males were highest in December (3.81±0.78ng/mL) and decreased gradually until April. The 17a, 20b-dihydroxy-4-pregnen-3-one (17α20βP) levels of UJ females were not detected. The E2 levels of PH females were highest in December (36.25±33.07ng/mL) and 17a20bP levels were highest in March (5.51±0.95ng/mL). The T levels of PH males were highest in December (4.03±1.34ng/mL) and decreased gradually until October. Taken together, these results suggest that most females from UJ did not reach maturation with a spawning period that was considered to be between December and January.