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Midazolam 의 중추신경계에 미치는 영향과 Flumazenil 의 길항작용에 대한 연구
김문호,이정은,최세진,한능희,손수창 대한마취과학회 1991 Korean Journal of Anesthesiology Vol.24 No.2
The effects of midazolam and diazepam which were used as an induction agent of general anesthesia were evaluated. And flumazenil which is a potent competitive inhibitor of the specific binding of benzodiazepines at the receptor level was evaluated too. Sixty patients were divided into three groups as follows: Group I (n=20); Midazolam (average 0.24 mgkg-1) was administered as an induction agent and flumazenil (average 0.24 mgkg-1) was administered in recovery room Group II (n=20); Diazepam (average 0.35 mgkg-1) was administered as an induction agent and flumaxenil (average 0.25 mgkg-1) was administered in recovery room Group III (n=20); Midazolam (average 0.24 mgkg-1) was administered as an induction agent and normal saline was administered in recovery room instead of flumaxenil The result were as follows: 1) Systolic and diastolic blood pressure and heart rate were not changed significantly, except diastolic blood pressure decreased significantly (p$lt;0.05) in group II, after intravenous administration of midazolam and diazepam. But these were all increased significantly (p$lt;0.001) after endotracheal intubation in all groups. 2) Systolic and diastolic blood preasure and heart rate were not changed significantly after intravenous administration of flumazenil in group I, II and there were no significant differences between each groups. 3) Tidal volume was increased significantly (p$lt;0.05) in group 1 from 15 min after administration of flumazenil. There were no significant changes in all groups in respiratory rate. SaO₂ was increased significantly (p$lt;0.05, p$lt;0.001) in group I, II from 5 min after administration of flumazenil. But it was increased significantly (p$lt;0.05) in group III from 20 min after administration of normal saline too. EtCO₂ was decreased insignificantly in all groups. 4) Recovery from anesthesia according to Modified Steward Coma Scale was much improved immediately after administration of flumazenil and was significant (p$lt;0.001) statistically in group I, II from 5 min after administration of flumazenil and reached complete recovery from 20 min after administration of flumaxenil. It was increased gradually and become significant in group III from 10 min after administration of normal saline. These changes of group I, II were significant (p$lt;0.05) compared with group III and reached complete recovery from 60 min after administration of flumazenil.
金文鎬,尹在卓 경북대학교 교육대학원 1984 논문집 Vol.16 No.-
This study was carried out to find the major conditions of infection of rice sheath blight disease at the machine-transplanted paddy field. The results summarized as follows 1. Infection degree of machine-transplanting method was heavier than that of conventional transplanting, and in cultivars, infection degree was heavier in Tae-beg cultivar than in Jin-ju cultivar. 2. From early in july, rice sheath blight disease was started to appear first and outbursted after early in August. 3. The earlier rice plant was transplanted, the heavier the infection degree was, and the same results both in lesion's height and severity degree. 4. It was estimated that average air temperature and humidity promoted to infect more than number of stem. 5. Two time's spraying control with Barimum Lq. after panicle formation stage was effective and one time's spraying control with Neo Asojin Lq. and Pencyclone wp. was also effective during penicle formation stage.