방풍의 항염 효과 기전

노성일 ( Sung Il Noh ),김상돈 ( Sang Don Kim ),박성철 ( Sung Cheul Park ),서병윤 ( Byung Yun Seo ),염승룡 ( Seung Ryong Yeom ),권영달 ( Young Dal Kwon ),신병철 ( Byung Cheul Shin ),송용선 ( Yung Sun Song ) 한방재활의학과학회 2005 한방재활의학과학회지 Vol.15 No.2

목적 : 방풍은 임상적으로 관절염을 포함한 다양한 염증성 질환 치료제로 사용되어 왔다. 본 연구에서는 인간 비만세포를 이용하여 세포 독성에 영향을 주지 않는 농도에서 방풍의 항염 효과 및 그 기전을 검토했다. 방법 : 인간의 HMC-1세포를 IMDM에서 페니실린, 스트렙토마이신, 모노티오글리세린를 첨가하여 배양하고 방풍추출액을 투여하였다. 그 다음 MTT, ELISA, RT-PCR, 세포내 칼슘측정, 핵단백분석을 이용하여 TNF-α, IL-6, IL-8 각각의 형성과 mRNA발현, 세포내 칼슘 수준, NF-κB 발현에 대한 방풍추출액의 반응을 측정하고 통계처리 하였다. 결과 : 방풍은 PMA와 calcium ionophore A23187로 활성화된 비만세포에서 세포내 칼슘 수준과 NF-κB, TNF-α와 IL-6의 발현을 억제 시켰고 RT-PCR을 이용한 mRNA 발현에서 TNF-α와 IL-6의 발현을 억제하였다. 결론 : 방풍은 비만세포내 칼슘 수준 및 NF-κB의 활성을 억제하고 염증성 세포 활성 물질인 TNF-α와 IL-6의 분비도 억제하여 항염 효과를 나타냄을 암시하고 있다.

Individually free-standing piezoelectric nanotubes-based BaTiO₃/CoFe₂O₄ magnetoelectric thin films

Noh, Byung-Il,Yang, Su Chul Elsevier 2019 Materials letters Vol.242 No.-

<P><B>Abstract</B></P> <P>In this study, individually free-standing piezoelectric nanotubes-based magnetoelectric thin films were synthesized by complexation of one-dimensional (1D) BaTiO<SUB>3</SUB> as the piezoelectric phase, and CoFe<SUB>2</SUB>O<SUB>4</SUB> as the magnetostrictive phase. Particularly, the individually TiO<SUB>2</SUB> free-standing nanotubes were developed onto a Ti substrate via metal anodizing to obtain a high standing stability of 1D piezoelectric structure and a filling volume of magnetostrictive phase, simultaneously for fabrication of magnetoelectric thin films. After BaTiO<SUB>3</SUB> perovskite conversion from the TiO<SUB>2</SUB> nanotubes, an enough volume still remains for sufficient self-filling of CoFe<SUB>2</SUB>O<SUB>4</SUB> between the BaTiO<SUB>3</SUB> nanotubes. Finally, BaTiO<SUB>3</SUB>/CoFe<SUB>2</SUB>O<SUB>4</SUB> magnetoelectric films were found to exhibit a dense structure being suitable for strong magnetostriction-mediated piezoelectric voltages. The structure design, based on individually free-standing nanotubes, would be feasible for flexible magnetoelectric devices such as health monitoring sensors, energy harvesters, and memory devices.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Development of 1–2 type BaTiO<SUB>3</SUB>/CoFe<SUB>2</SUB>O<SUB>4</SUB> magnetoelectric thin films. </LI> <LI> Synthesis of individually free-standing TiO<SUB>2</SUB> nanotubes via Ti anodizing. </LI> <LI> Hydrothermal conversion of BaTiO<SUB>3</SUB> from TiO<SUB>2</SUB> nanotubes. </LI> <LI> Dense filling of CoFe<SUB>2</SUB>O<SUB>4</SUB> in an interspace between BaTiO<SUB>3</SUB> nanotubes. </LI> </UL> </P>

Endoscopic Laser Treatment of Dieulafoy`s Lesion

Byung Sub Park,Jong Do Choi,Il Jun Lee,Jung Woo Noh,Woo Joong Kim,Kyu Sung Rim 대한내과학회 1988 The Korean Journal of Internal Medicine Vol.3 No.1

Model Development for Multicomponent mass Transfer with Rapid Chemical Reactions in a Small Drop

Noh, Byeong Il,Yoon, Tae Kyung,Moon, Byung Hyun 한국화학공학회 1995 NICE Vol.13 No.2

Multicomponent mass transfer accompanied by instantaneous chemical reactions in a small drop has been modeled and simulated for the case where two different solutes diffuse from a continuous phase into the drop and react rapidly with a third reactant in the drop. The computational results obtained by Galerkin's finite element method are reported in terms of concentration profiles, the locations of reaction front, the cumulative mass flux, and the enhancement factor. The effects of physical parameters, such as diffusivities of the solutes and the reactant, the interfacial concentration of solutes, and the relative amount of the reactant, on the calculated quantities are discussed.

MODEL DEVELOPMENT FOR DIFFUSION WITH INSTANTANEOUS CHEMICAL REACTIONS IN A SPHERICAL MULTICOMPONENT DROP

Noh, Byeong Il,Moon, Byung Hyun,Yoon, Tae Kyung,Kim, Jong Hyun 한국화학공학회 1995 Korean Journal of Chemical Engineering Vol.12 No.5

Diffusion accompanied by instantaneous chemical reactions in a multicomponent drop is modeled. The developed model is then simulated for the case of absorption of one solute from a continuous phase into the drop, followed by fast reactions with two different reactants existing in the drop. The results of the model are obtained by using Galerkin's finite element method and represented by unsteady concentration profiles of all components in the drop, the reaction front positions, and the cumulative mass flux and the enhancement factor of the diffusing solute. The effects of the system parameters, such as diffusivities of the solute and the reactants, the relative amount of the reactants in the drop, and the interfacial concentration of the solute, on the calculated quantities are evaluated.

Model Development for Diffusion with Instantaneous Chemical Reactions in a Spherical Multicomponent Drop

Noh, Byeong Il,Yoon, Tae Kyung,Moon, Byung Hyun 한국화학공학회 1996 NICE Vol.14 No.1

Diffusion accompanied by instantaneous chemical reactions in a multicomponent drop is modeled. The developed model is then simulated for the case of absorption of one solute from a continuous phase into the drop, followed by fast reactions with two different reactants existing in the drop. the results of the model are obtained by using Galerkin's finite element method and represented by unsteady concentration profiles of still components in the drop, the reaction front positions, and the cumulative mass flux and the enhancement factor of the diffusing solute. the effects of the system parameters, such as diffusivities of the solute and the reactants, the relative amount of the reactants in the drop, and the interfacial concentration of the solute, on the calculated quantities are evaluated.

The Mixed - Bed Ion Exchange Performance at Ultralow Concentrations - 1. Variable Feed Concentration and Incomplete Mixing of Resins

Noh, Byeong Il,Yoon, Tae Kyung,Moon, Byung Hyun 한국화학공학회 1996 NICE Vol.14 No.3

Experimental data were obtained to evaluate the performance of mixed-bed ion exchange for the cases of variable feed concentration and incomplete mixing of anion and canon resins observed in large scale industrial units. For variable feed concentration, step changes in feed concentration were arbitrarily introduced into a test ablumn. For incomplete mixing, only anion resin was loaded in the upper 20% of the column and more cation resin in the lower portion. Feed concentrations of 5.0 × 10^(-5) ∼ 2.0 × 10^(-4) M NaCl were used for the experiments, with flow rates of 0.665∼7.0 ml/sec. The effluent from the column was collected periodically and analyzed using on-line/off-line ion chromatography. The step changes in feed concentration affect the breakthrough times of sodium and chloride. Sodium breakthrough curve is more sensitive to the step changes than chloride breakthrough curve. With the same volumes of cation and anion resins, incomplete mixing of resins increases the canon exchange rate slightly and decreases the anion exchange rate slightly. As the cation resin volume increases, the effect of the incomplete mixing of resins decreases. The breakthrough curves of both ions, plotted as the ratio of effluent to the influent concentration versus run time in hour, give some detailed results about the effects of the conditions.

Parametric Studies on the Performance of Mixed - Bed Ion Exchange at Ultralow Concentrations : 1 . Multicomponent System

Noh, Byeong Il,Lee, Chang Won,Yoon, Tae Kyung,Moon, Byung Hyun,Lee, Gang Choon,Shin, Choon Hwan 한국화학공학회 1999 Korean Journal of Chemical Engineering Vol.16 No.6

We experimentally evaluated the effects of multicomponent systems of divalent cations on the performance of mixed-bed ion exchange in the concentration range used for ultrapure water processing. Data were collected in the batch and continuous column systems with Dowex Monosphere resins used commercially for ultrapure water applications. The presence of divalent cations in the systems affects significantly the capacity of the units to remove a univalent cation. However, the anion exchange rate increases slightly in the multicomponent systems. The equilibrium and the breakthrough curves of ions, plotted as the ratio of the effluent to influent concentration versus run time or solution volume passed through the experimental column, give detailed results about the effects of the existence of other ionic species on the fate of each ion in MBIE units. The results of the present study are expected to be used to develop and simulate mathematical models and to understand the performance of mixed-bed ion exchange at ultralow concentrations.

MODEL DEVELOPMENT FOR MULTICOMPONENT MASS TRANSFER WITH RAPID CHEMICAL REACTIONS IN A SMALL DROP

Noh, Byeong Il,Yoon, Tae Kyung,Moon, Byung Hyun,Kim, Jong Hyun 한국화학공학회 1995 Korean Journal of Chemical Engineering Vol.12 No.1

Multicomponent mass transfer accompanied by instantaneous chemical reactions in a small drop has been modeled and simulated for the case where two different solutes diffuse from a continuous phase into the drop and react rapidly with a third reactant in the drop. The computational results obtained by Galerkin's finite element method are reported in terms of concentration profiles, the locations of reaction front, the cumulative mass flux, and the enhancement factor. The effects of physical parameters, such as diffusivities of the solutes and the reactant, the interfacial concentration of solutes, and the relative amount of the reactant, on the calculated quantities are discussed.

THE MIXED - BED ION EXCHANGE PERFORMANCE AT ULTRALOW CONCENTRATIONS : 1. VARIABLE FEED CONCENTRATION AND INCOMPLETE MIXING OF RESINS

Noh, Byeong Il,Yoon, Tae Kyung,Moon, Byung Hyun 한국화학공학회 1996 Korean Journal of Chemical Engineering Vol.13 No.2

Experimental data were obtained to evaluate the performance of mixed-bed ion exchange for the cases of variable feed concentration and incomplete mixing of anion and cation resins observed in large scale industrial units. For variable feed concentration, step changes in feed concentration were arbitrarily introduced into a test column. For incomplete mixing, only anion resin was loaded in the upper 20% of the column and more cation resin in the lower portion. Feed concentrations of 5.0×10^(-5)-2.0×10^(-4) M NaCl were used for the experiments, with flow rates of 0.665-7.0 ㎖/sec. The effluent from the column was collected periodically and analyzed using on-line/off-line ion chromatography. The step changes in feed concentration affect the breakthrough times of sodium and chloride. Sodium breakthrough curve is more sensitive to the step changes than chloride breakthrough curve. With the same volumes of cation and anion resins, incomplete mixing of resins increases the cation exchange rate slightly and decreases the anion exchange rate slightly. As the cation resin volume increases, the effect of the incomplete mixing of resins decreases. The breakthrough curves of both ions, plotted as the ratio of effluent to the influent concentration versus run time in hour, give some detailed results about the effects of the conditions.