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Relaxation Patterns of Human Gastric Corporal Smooth Muscle by Cyclic Nucleotides Producing Agents
김영철,최웅,성노현,김헌,유라영,박선미,윤세진,김미정,송영진,Wen-Xie Xu,이상진,윤효영 대한약리학회 2009 The Korean Journal of Physiology & Pharmacology Vol.13 No.6
To elucidate the mechanism of cyclic nucleotides, such as adenosine 3',5'-cyclic monophosphate (cAMP) and guanosine 3',5'-cyclic monophosphate (cGMP), in the regulation of human gastric motility, we examined the effects of forskolin (FSK), isoproterenol (ISO) and sodium nitroprusside (SNP) on the spontaneous, high K+ and acetylcholine (ACh)-induced contractions of corporal circular smooth muscle in human stomach. Gastric circular smooth muscle showed regular spontaneous contraction, and FSK, ISO and SNP inhibited its phasic contraction and basal tone in a concentration-dependent manner. High K+ (50 mM) produced sustained tonic contraction, and ACh (10μM) produced initial transient contraction followed by later sustained tonic contraction with superimposed phasic contractions. FSK, ISO and SNP inhibited high K+-induced tonic contraction and also ACh-induced phasic and tonic contraction in a reversible manner. Nifedipine (1μM), inhibitor of voltage-dependent L-type calcium current (VDCCL), almost abolished ACh-induced phasic contractions. These findings suggest that FSK, ISO and SNP, which are known cyclic nucleotide stimulators, inhibit smooth muscle contraction in human stomach partly via inhibition of VDCCL.
Relaxation Patterns of Human Gastric Corporal Smooth Muscle by Cyclic Nucleotides Producing Agents
Kim, Young-Chul,Choi, Woong,Sung, Ro-Hyun,Kim, Heon,You, Ra-Young,Park, Seon-Mee,Youn, Sei-Jin,Kim, Mi-Jung,Song, Young-Jin,Xu, Wen-Xie,Lee, Sang-Jin,Yun, Hyo-Yung The Korean Society of Pharmacology 2009 The Korean Journal of Physiology & Pharmacology Vol.13 No.6
To elucidate the mechanism of cyclic nucleotides, such as adenosine 3',5'-cyclic monophosphate (cAMP) and guanosine 3',5'-cyclic monophosphate (cGMP), in the regulation of human gastric motility, we examined the effects of forskolin (FSK), isoproterenol (ISO) and sodium nitroprusside (SNP) on the spontaneous, high $K^+$ and acetylcholine (ACh)-induced contractions of corporal circular smooth muscle in human stomach. Gastric circular smooth muscle showed regular spontaneous contraction, and FSK, ISO and SNP inhibited its phasic contraction and basal tone in a concentration-dependent manner. High $K^+$ (50 mM) produced sustained tonic contraction, and ACh $(10\;{\mu}M)$ produced initial transient contraction followed by later sustained tonic contraction with superimposed phasic contractions. FSK, ISO and SNP inhibited high $K^+$-induced tonic contraction and also ACh-induced phasic and tonic contraction in a reversible manner. Nifedipine $(1\;{\mu}M)$, inhibitor of voltage-dependent L-type calcium current $(VDCC_L)$, almost abolished ACh-induced phasic contractions. These findings suggest that FSK, ISO and SNP, which are known cyclic nucleotide stimulators, inhibit smooth muscle contraction in human stomach partly via inhibition of $VDCC_L$.
옥종한(Jong Han Ok),강영진(Young Jin Kang),김태진(Tae Jin Kim),이성미(Seong Mi Lee),엄재화(Jae Hwa Eom),정재성(Jae Seong Jeong),정영기(Yeong Ki Jeong) 대한소화기학회 1993 대한소화기학회지 Vol.25 No.1
N/A Carcinoma of the stomach is one of the most prevaleni maliganancies in Korea and the prognosis is usually poor. However, the prognosis for the early gastric cancer (EGC) has been reported excellent and this is why emphasis is put on the early diagnosis and treatment of this grave problem. This study analyzes the incidence, morphological clas.ification, location of the lesion, size of the lesion, depth of invasion, lymph node metastasis, diagnotic accuracy of double contrast X-ray and endoscopy. histopathologic claesification and clinical sym,ptoms of 45 cases of EGC operated on from 1983 to 1990 at Maryknoll Hospital. The incidence of EGC was 5. 6% of all stomach cancer diagnosed during the same period and 11.1% to the resected cases. Out of 45 cases of early gastric cancer, 29 cases were male, 16 cases female, the ratio of male to female was 1.8: 1, and the mean age was 52.6 years old. The most common types of early gastric cancer were IIc type (26.7%), and its combined type (37.3%). The common sites were antrum (53.3%) and lesser curvature (33.3%). 25 cases (55. 5%) were between 1-2 cm in size and less than 3 cm was found in 41 cases (91.1%). Of the 9 cases with mucosal lesion, none had lymph node metastasis. But, 5 (13.9%) out of 36 cases with submucosal invasion showed lymph node metastasia The depth of invasion was related to the incidence of lymph node metastasis (P,0.05). But the size of the losion was not related. The diagnostic accuracy of EGC for endoscopy was 66.7%, and for double contrast X-ray it was 35.6%. The most common type of EGC was tubular type of adenocarcinoma. Common complaints were epigastric discomfort and pain (62. 2%), weight loss (17. 8%), and epigas' tric fullness(8. 9%). And the duration of symptoms lasted within 1 year (77.8%).
Young Chul Kim,Hikaru Suzuki,Wen-Xie Xu,Hikaru Hashitani,Woong Choi,Hyo-Yung Yun,Seon-Mee Park,Sei Jin Youn,Sang-Jeon Lee,Sang Jin Lee 대한생리학회-대한약리학회 2008 The Korean Journal of Physiology & Pharmacology Vol.12 No.6
The properties of voltage dependent Ca<sup>2+</sup> current (VDCC) were investigated in interstitial cells of Cajal (ICC) distributed in the myenteric layer (ICC-MY) of guinea-pig antrum. In tissue, ICC-MY showed c<i>-Kit</i> positive reactions and produced driving potentials with the amplitude and frequency of about 62 mV and 2 times min<sup>−1</sup>, respectively, in the presence of 1</SUP>ՌM nifedipine. Single ICC-MY isolated by enzyme treatment also showed c<i>-Kit</i> immunohistochemical reactivity. These cells were also identified by generation of spontaneous inward current under K<sup>+</sup>-rich pipette solution. The voltage clamp experiments revealed the amplitude of - 329 pA inward current at irregular frequency. With Cs<sup>+</sup>-rich pipette solution at <i>V</i><sub>h</sub>=−80 mV, ICC-MY produced voltage-dependent inward currents (VDIC), and nifedipine (1ՌM) blocked VDIC. Therefore, we successfully isolated c<i>-Kit</i> positive single ICC from guinea-pig stomach, and found that ICC-MY potently produced dihydropiridine sensitive L-type voltage-dependent Ca<sup>2+</sup> currents (VDCC<sub>L</sub>).
김영철,Hikaru Suzuki,Wen-Xie Xu,Hikaru Hashitani,최웅,윤효영,박선미,윤세진,이상전,이상진 대한약리학회 2008 The Korean Journal of Physiology & Pharmacology Vol.12 No.6
The properties of voltage dependent Ca²+ current (VDCC) were investigated in interstitial cells of Cajal (ICC) distributed in the myenteric layer (ICC-MY) of guinea-pig antrum. In tissue, ICC-MY showed c-Kit positive reactions and produced driving potentials with the amplitude and frequency of about 62 mV and 2 times min-¹, respectively, in the presence of 1μM nifedipine. Single ICC-MY isolated by enzyme treatment also showed c-Kit immunohistochemical reactivity. These cells were also identified by generation of spontaneous inward current under K+-rich pipette solution. The voltage clamp experiments revealed the amplitude of - 329 pA inward current at irregular frequency. With Cs+-rich pipette solution at Vh=−80 mV, ICC-MY produced voltage-dependent inward currents (VDIC), and nifedipine (1μM) blocked VDIC. Therefore, we successfully isolated c-Kit positive single ICC from guinea-pig stomach, and found that ICC-MY potently produced dihydropiridine sensitive L-type voltage-dependent Ca²+ currents (VDCCL).
Kim, Young-Chul,Suzuki, Hikaru,Xu, Wen-Xie,Hashitani, Hikaru,Choi, Woong,Yun, Hyo-Yung,Park, Seon-Mee,Youn, Sei-Jin,Lee, Sang-Jeon,Lee, Sang-Jin The Korean Society of Pharmacology 2008 The Korean Journal of Physiology & Pharmacology Vol.12 No.6
The properties of voltage dependent $Ca^{2+}$ current (VDCC) were investigated in interstitial cells of Cajal (ICC) distributed in the myenteric layer (ICC-MY) of guinea-pig antrum. In tissue, ICC-MY showed c-Kit positive reactions and produced driving potentials with the amplitude and frequency of about 62 mV and 2 times $min^{-1}$ respectively, in the presence of $1{\mu}M$ nifedipine. Single ICC-MY isolated by enzyme treatment also showed c-Kit immunohistochemical reactivity. These cells were also identified by generation of spontaneous inward current under $K^+$ -rich pipette solution. The voltage clamp experiments revealed the amplitude of - 329 pA inward current at irregular frequency. With $Cs^+$-rich pipette solution at $V_h=-80\;mV$, ICC-MY produced voltage-dependent inward currents (VDIC), and nifedipine ($1{\mu}M$) blocked VDIC. Therefore, we successfully isolated c-Kit positive single ICC from guinea-pig stomach, and found that ICC-MY potently produced dihydropiridine sensitive L-type voltage-dependent $Ca^{2+}$ currents ($VDCC_L$).