한국 정상 성인 남자에서의 혈청 총 쿨레스테롤치 변화에 관한 최근 5년간 추적조사 - 포항 지역 거주 직장인을 대상으로 -

김경현(Kyung Hyun Kim),이재성(Jae Seung Lee),박태규(Tae Gyu Park),김희식(Hee Sik Kim),하영준(Young Jun Ha),남시현(Si Hyun Nam),김종연(Jong Yeun Kim) 대한내과학회 1999 대한내과학회지 Vol.56 No.2

N/A Objectives : The serum total cholesterol is supposed to be increased as dietary pattern is westernized recently in our country. We studied the longitudinal change of serum total cholesterol levels in normal adult Korean male workers and analyzed the influence of lifestyle on change of serum total cholesterol levels. Methods : The 7677 healthy adult male workers were studied during recent 5years(1992 and 1997). Those who suffered from hypertension, diabetes mellitus, ischemic heart disease, nephritis were excluded. Those who ingested antilipidemic drugs were also excluded. Serum total cholesterol were measured by the same enzymatic method and their levels were analyzed during fasting state. Data on lifestyle were obtained using self administered questionnaires. Results : 1) The serum total cholesterol levels increased by 9.45±23.99mg/dl(1.89mg/dl per year) between 1992 and 1997 surveys. 2) The increment of serum total cholesterol levels was most prominent in the twenties (3.45mg/dl per year) and less prominent in 5th, 6th decades. 3) A change of 1kg/m2 in body mass index contributed a change of 3.449mg/dl in serum total cholesterol. 4) The change of body mass index(BMI) was most significantly correlated with that of serum total cholesterol levels among the influencing variables.( =3.449 p=0.0001 r2=0.035) 5) The changed value of serum total cholesterol levels was significantly correlated with smoking and exercise, however, was not significantly correlated with the amount of alcohol ingestion. Conclusion : The serum total cholesterol levels increased by 9.45mg/dl(1.89mg/dl per year) during recent 5 years. The increment of serum total cholesterol levels was more prominent in younger age group. The changed value of BMI was most strongly correlated with that of serum total cholesterol levels of all influencing variables.

비지가 고지방 식이 흰쥐의 혈청 지질성분에 미치는 영향

김한수,김군자,김용균 密陽産業大學校 農業技術開發硏究所 1999 農業技術開發硏究所報 Vol.3 No.2

비지가 혈청중 지질대사에 미치는 영향을 검토하기 위해 Sprague-Dawley계 숫 흰쥐에 lard와 cholesterol, 비지 및 비지에 함유된 섬유소 비율로 cellolose를 첨가한 식이를 5주간 급여한 후 혈청중의 지질성분 함량을 검토한 결과, 고지방 식이군은 체중과 식이섭취량이 감소하였으나 비지와 cellulose의 급여에 의하여 식이효율이 증가하였다. 간장, 신장, 심장, 비장의 체중은 증가량에 따라 증가하는 경향을 보였으며, 혈청중 AST, ALT 활성은 고지방 식이군(HF군)에 비해 비지를 급여한 군에서는 유의한 감소를 나타내었으며 cellulose 급여군에서는 유의성이 없었다. 혈청중 total lipid, cholesterol 및 phospholipid의 함량은 고지방 식이군(HF군)에 대조군에 비하여 증가하였고, 비지 30% 급여군에서는 감소하였으나 여타 실험군에서는 유의성이 없었다. 혈청중 HDL-cholesterol 함량은 고지방 식이에 비해 비지 30% 급여군에서 증가하였으나 cellulose 급여균에서는 감소하였다. 혈청중 VLDL·LDL-cholesterol함량은 대조군에 비해 고지방 식이군(HF군)은 증가하였으며 비지를 급여한 급여수준을 증가함에 따라 감소하였다. 혈청중 동맥경화지수는 대조군에 비해 고지방 식이군이 증가하였다. 고지방 식이군에 비해 비지를 급여한 군에서는 감소를 보인 반면에 cellulose급여군에서는 차이를 볼 수 없었다. 혈청중의 tirglyceride 의 함량은 대조군에 비해 고지방 식이군은 유의한 증가를 보였고 비지와 cellolose를 급여한 군에서는 유의한 차이가 없었다. 이상의 결과, 비지가 혈청중의 지질성분을 저하시켜 고지혈증 개선작용을 하므로 대사성질환의 예방에 도움을 끼칠 것으로 생각된다. This study has been undertaken to investigate the effect of supplementated soybean curd refuse(dry form) and cellulose to rat food on the lipid composition and the activities of AST, ALT in high fat rat of serum. Forty-eight males of Sprague-Dawley strains weighed about 100~110g were divided into 8 groups, with each group receving a different diet for 5 week; i.e. control diet, high fat diet plus 10% of soybean curd refuse, high fat diet plus 20% of soybean curd refuse, high fat diet plus 30% of soybean curd refuse, high fat diet plus 3.6% of cellulose, high fat diet plus 7.2% of cellulose and high fat diet plus 10.8% of cellulose. Total lipid, total cholesterol, phospholipid, triglyceride, HDH-cholesterol, aspartate aminortansferase and alanine aminotransferase were determined in serum. Rats given feed containing high fat showed significant decrease in net weight gain and feed intake, but supplement of soybean curd refuse and cellulose to the rat feed caused an increase in feed efficiency ratio. Each of the liver, kidney, heart and spleen weight of experimental groups was tended to be increased with increasing net weight gain of them. Activity of AST, ALT in serum and contents of soybean curd refuse added groups were significantly decreased as compared with high fat fed group. The contents of total lipid, total cholesterol and phospholipid in serum were significantly increased in high fat fed group but 30% of soybean curd refuse fed group decreased as compared with control group. But there was no change in contents of them in serum of other groups. The contents of HDL-cholesterol in serum were significantly increased in soybean curd refuse added groups but decreased in cellulose containing groups compared to high fat fed group. The contents of VLDL·LDL-cholesterol in serum were significantly increased in high fat fed group compared with control group. Contents of the soybean curd refuse added groups were tended to be significantly with increasing dietary soybean curd refuse. The atheroscleterotic index, content ratio of VLDL·LDL-cholesterol and HDL-cholesterol of serum were significantly increased in high fat fed group compared with control group, but that was lower in soybean curd refuse added groups and no change in cellulose containing groups compared with high fat fed group. Contents of tirglyceride in serum of the high fat fed group were significantly increased as compared with the control group, but soybean curd refuse and cellulose containing groups were not significantly different compared as the high fat fed group. From the above experimental results it seems that soybean curd refuse would improve the serum lipid component and prevent the metabolic disease by improving hyperlipemia.

늑막삼출환자에서 늑막액 Cholesterol 농도와 늑막액 / 혈청 Cholesterol 비의 진단적 의의

김성숙(Seong Suk Kim),신경철(Kyeong Cheol Shin),최희진(Hee Jin Choi),류헌모(Hon Mo Ryu),서정일(Jeong Ill Suh),임종식(Jong Sik Lim),이재성(Jae Seong Lee),정진홍(Jin Hong Chung),이관호(Kwan Ho Lee),이현우(Hyun Woo Lee) 대한내과학회 1994 대한내과학회지 Vol.46 No.3

N/A Objectives: To validate the use of pleural cholesterol and the pleural cholesterol/serum cholesterol ratio (P-/S-CHOL) for differentiating between transudates and exudates in pleural effusion of diverse etiology and to compare the diagnostic efficacy of these parameters with those of Light criteria. Methods: Between September 1991 and June 1992, 118 patients with pleural effusion were studied. We measured pleural protein/serum protein ratio, pleural LDH, pleural LDH/serum LDH ratio, pleural cholesterol and pleural cholesterol/serum cholesterol ratio. Mean values of the parameters in transudates group and exudates group were compared, and the misclassification rate and the diagnostic efficacy for each parameters were calculated. Results: 1) The pleural cholesterol (P-CHOL) values were 21.88±8.86rng/dl for transudates, 86.38±30.09mg/dl for tuberculous exudates, 76.96±18.63 mg/dl for neoplastic exudates, and 85±24.69mg/dl for the parapneumonic effusion group (p<0.001 in tuberculous and neoplastic exudates, p<0.05 in parapneumonic effusion group). And the pleural cholesterol/serum cholesterol ratio (P-/S-CHOL) were 0.17±0.07 for transudates, 0.64±0.16 for tuberculous exudates, 0.52±0.16 for neoplastic exudates, and 0.68±0.17 for the parapneumonic effusion group (p<0.001). 2) Misclassification rates for each parameters in seperating the exudate group from the transudate group were as follows; pleural protein/serum protein ratio (P-/S-PROT) 1 69%, P-/S CHOL 2.54%, P-CHOL 3.38%, pleural LDH (P-LDH) 4.23%, pleura LDH/serum LDH ratio (P-/S-LDH) 4.23%. 3) With a cut-off value of 50mg/dl, P-CHOL had a sensitivity of 96% and a specificity of 10096 for diagnosis of exudates, and with a cut-off value of 0.3, P-/S-CHOL had a sensitivity of 98% and a specificity of 94%. 4) Diagnostic efficiencies for each parameters in seperating the exudate group from transudate group were as follow; P-/S-PROT 98%, P-/S-CHOL 97%, P-CHOL 96%, P-LDH 95%, and P-/S-LDH 95%. 5) In the exudate group, pleural cholesterol was significantly correlated with serum cholesterol (r=0.5S84, p<0.001) and the pleural LDL/Cholesterol ratio was significantly correlated with the serum LDL/Cholesterol ratio (r=0.4408, p<0.001). Conclusion: we think that measurements of P-CHOL and P-/S-CHOL is of great value for distinguishing between pleural exudates and transudates, and high P-CHOL and P-/S-CHOL values appear to be related to increased permeability of pleural capillaries. Therefore, we suggest that determination of these parameters should be included in routine laboratory analysis of pleural effusions.

공황증 환자에서의 혈청 Cholesterol과 Triglyceride 수치

김영철,우행원 梨花女子大學校 醫科大學 醫科學硏究所 1995 EMJ (Ewha medical journal) Vol.18 No.3

The author compared plasma lipid levels in 74 patients with panic attack with those innormal controls. SCL-90-R was performed to evaluate the relationship between psychiatricsynlptoms and serum levels of cholesterol and triglyceride in Panic patients. The resultswere : 1) No significant differences in levels of serum cholesterol(mg/d1) and triglyceride(mg/dl) were found between the two groups. But in male panic patients level of serum triglyceridewas somewhat higher than in controls without statistical significance(169.9±79.5 : 136.1±54.6)(0.05<p<0.1). 2) Serum levels of cholesterol and triglyceride were not significantly different in patientswith Higher depression and anxiety score from those in normal controls. The level of serumcholesterol was higher in patients(178.3±93.3) with higher phobic score than in controls(136.1±54.6, p<0.O5) but that of serum triglyceride was somewhat higher in patients with higher phobicscore without statistical significance(0.05<p<0.1) 3) Serum cholesterol level was significantly higher in male patientts(202.5± 46.3) with higherphobic score than those(158.0±21.6) with lower score(p<0.05). But in the same patient groupsthe triglyceride level was not significantly different(178.3±93.3 : 106.4±25.5).

음주자와 비음주자의 식이습관에 따른 혈청지질 수준 비교 연구

김명석,김선애 알코올과 건강행동학회 2008 알코올과 건강행동연구 Vol.9 No.2

술이 약물로 분류됨에도 불구하고 금주를 옹호하는 사람들은 거의 없다. 사실, 술은 미국에서도 가장 흔히 사용되는 약물 중에 하나이다. 그런데 이런 술은 중독성이 있고, 죽음의 원인이 되기도 하는데, 미국정부 조사에 따르면 미국에서 매년 10만 명 이상의 사람들이 술로 인해 죽음을 맞이한다고 한다(Rice, 1993). 우리나라도 세계보건기구가 주요 알코올정책의 대상으로 정하고 있는 세 가지 사망원인 중 외적사인 사망률이 3위의 국가이다(천성수, 2001). 그러나 이렇게 술로 인한 외적사인 사망률이 높음에도 불구하고, 술이 심장에 도움이 된다는 일부 연구로 인해 적당한 음주를 절대적으로 옹호하는 경우가 있는데, 그런 일은 절대 없어야 한다(Nedly, 2004). 설령, 술이 심장에 도움이 된다 하더라도, 다른 신체기관에 많은 해를 입히고, 잠재적으로 중독 가능성이 있는 유해한 약물을 한 방울이라도 함부로 사용하는 일에 동의할 수는 없는 것이다. 모든 위험한 약물이 그렇듯이, 적정하다고 생각되는 음주라도 음주복용량이 많아질수록 더 큰 위험에 빠지게 된다. 미국 내에는 술을 남용하는 사람의 수가 1,500만 명을 넘을 것이라고 추산되고 있으며(US Department of Health and Human Services, 1993), 현재 술을 마시는 사람들 중에 15% 정도가 이와 같은 문제 있는 음주자나, 실제 알코올 중독자가 될 수 있다고 한다(Rankin, 1992). 세계적으로 고혈압의 권위자인 노르만 카플란 박사는 하루에 한 잔 이상 술을 마시는 사람들 중에 고혈압이 있는 사람은 “음주량을 줄이도록 강력히 권장되어야 한다.”라고 한다(Kaplan, 1995). 남녀 모두에게 있어서 하루 3~4잔의 술은 고혈압에 걸릴 확률을 50% 상승시키며, 6~7잔의 술은 고혈압에 걸릴 위험을 금주자에 비해 2배로 만든다(MacMahon, 1987). 미국 내의 많은 수의 고혈압 환자들이 술로 인해 이 질병에 걸렸으며, 미국 성인 남자의 모든 고혈압 환자 중 30% 정도가 술과 관련된 이유로 인한 고혈압 증상을 나타내는 것으로 밝혀졌다(US Department of Health and Human Services, 1993). 알코올이 혈압에 미치는 해로운 영향은 미국 내의 고령자들에게 특별한 걱정거리이다. 왜냐하면 65세 이상의 미국인들에게 가장 자주 나타나는 사망과 장애의 원인은 심장과 혈관 질환들이기 때문이다(Dawson,1987). 고혈압은 그런 질환들에 대한 주된 위험 인자들 중 하나이며, 이 연령층에 속하는 사람의 54% 이상이 고혈압 증상으로 고통을 받고 있다(National Center for Health Statistics, 1986). 65세를 넘긴 많은 미국인들이 술 섭취를 줄이기는 하지만, 알코올은 명백하게 여러 가지 심장질환들과 관련이 있다. 만성적인 과음자나 급격하게 술에 취한 사람들은 심박동 장애를 나타낼 위험이 있으며, 부정맥이라고 불리는 이 현상은 작게는 가슴이 두근거리는 느낌으로 나타나지만, 심한 경우 돌연사로 이어질 수 있다. 사실, 과음자들에게 나타나는 높은 비율의 돌연사의 경우는 어느 정도 이런 부정맥에 의한 것이다(US Department of Health and Human Services, 1993). 심근장애는 알코올 섭취와 관련된 또 다른 위험하고 치명적인 심장질환이다. 심근장애는 심장 근육 질환이다. 관상동맥질환이 심장마비나 심근장애의 원인이 되지만, 현재 통계에 의하면, 미국 내 심근장애 환자의 20%~30%정도는 알코올의 영향만으로 이 질병에 걸린 것으로 추정된다(US Department of Health and Human Services, 1993). 가벼운 음주자나 보통의 음주자가 상대적으로 적은 양의 알코올을 섭취한다 해도, 이는 혈중 중성지방의 농도를 상당량 높이는 결과를 가져오게 하며(U.S. Dept. of Health and Human Services, 1988), 혈액 내의 지방 운반체인 초저밀도 지단백의 증가가 일어나서 콜레스테롤 수치 역시 높아지게 된다. 콜레스테롤과 마찬가지로, 중성지방의 수치가 높아지면 심장질환의 위험 역시 높아지게 된다. 중성지방의 수치가 매우 높은 경우, 췌장염의 발병 위험 또한 상당히 높아지게 된다(Bartke, 1993). 혈중 중성지방 증가의 원인은 고지방, 고칼로리식, 고당질식, 알코올 등의 식이성 인자와 비만증, 당뇨병, 동맥경화증, 대사이상, 가족성, 기타 내분비 질환 등과 관련이 있다. 즉, 죽상경화증의 여러 원인들 가운데서도 혈역학적 압력변화에 대한 동맥내막세포의 반응이며, 죽상 경화증의 발생에서의 식사의 역할은 아직 증명된바 없으나 식사성분자체보다는 오히려 그 성분의 대사 또는 산화과정에서 생긴 화합물에 의한 것이 아니겠느냐하는 문제를 제기하고 있다(Alkers, 1974). 가벼운 음주자나 보통의 음주자가 상대적으로 적은 양의 알코올을 마신다 해도, 이는 혈중 중성지방의 농도를 상당히 높이는 결과를 가져 온다고 주장한다(Nedly, 2004). 알코올은 의존성과 탐닉성으로 인해, 매일 일정소량을 마시는 행동 자체를 유지하기가 현실적으로 매우 힘들다. 오히려 심맥관계의 질병의 예방을 위해서는 식이습관과 운동요법을 행하는 것이 더욱 건강을 위해 효과적인 방법이라 생각된다. 음주는 자주하게 되면 알코올의 대사산물인 아세트알데히드가 심장근육을 손상시키기 때문에 장기적인 음주를 하게 되면 관상동맥질환을 야기시켜 심부전증이 발병된다. 소량의 음주가 심장에 좋다는 연구도 있지만 대부분 음주를 반복적으로 하게 되면 혈압이 올라가게 되고 부정맥이 발생하며 뇌출혈의 위험이 높아지고 심근염이 발생되는 사실은 알코올의 위험성을 증명해 주는 것이다(World Health Report, 2002). 우리나라에서도 최근에 죽상 경화증과 그 합병증의 발생빈도 및 사망률이 증가하고 있으며, 이에 따라서 혈청지질에 관한 연구를 하고 있으나 전반적으로 영양실태를 파악하는 연구가 대부분이었다(김장숙, 1995. 송숙자, 1985). 현재 국내 연구 중 음주자와 비음주자의 혈청지질 수준 연구는 소수만의 연구가 있을 뿐이다(김명희, 1999. 양경미, 1999). 본 연구는 혈중콜레스테롤 농도에 미친 영향을 규명하기위해서 유전적인 요인 이외에 음주자들의 콜레스테롤 수준에 따른 혈청지질과 식이습관을 파악하고, 동시에 생활습관의 관련성을 알아보아 비음주자와의 혈청지질 수준에 미친 요인을 탐색하여 질병의 조기예방을 위한 기초자료를 제공하고자 한다. 그러므로 이를 위해 알코올을 섭취하는 집단과 알코올을 섭취하지 않는 집단의 식생활습관의 비교를 통해 다음과 같은 목적으로 연구를 수행하였다. 첫째, 음주자와 비음주자의 혈청콜레스테롤, 혈압, 비만도는 차이가 있어 고지혈증 예방에 위험지표로 이용될 수 있다. 둘째, 음주와 비음주의 식이습관의 차이를 규명하고 혈청지질 및 혈압에 미치는 영향요인을 파악하여 고지혈증을 예방하는 자료로 제공할 것이다. The main purpose of this investigation was to examine the difference of serum lipid levels between Alcohol drinkers and non-Alcohol drinkers.They were investigated by using questionnaire, weight, height, blood pressure, smoking habit, drinking habit, coffee, exercise, water and also Total cholesterol, triglyceride, HDL-C, and LDL-C. The results were as follow.1. The distribution of this study population was composed of total 334 men, male Alcohol drinkers (N=178), female Alcohol drinkers (N=12), male non-Alcohol drinkers (N=80), and female non-Alcohol drinkers (N=64). All participants of two groups according to their ages were divided into 20's (N=34), 30's (N=165), 40's (N=77), above 50's (N=58).2. According to the result of χ2-test in the difference of eating habits between Alcohol drinkers and non-Alcohol drinkers, There were significant differences statistically between two groups in all comparisons.3. The average score of BMI consisted of Alcohol drinkers (23.75±4.82), non-Alcohol drinkers (22.09±2.47). Blood pressure was compared, and it was found that Alcohol drinkers had mean systolic(SBP) 6mmHg and diastolic blood pressure(DBP) 4mmHg higher than non-Alcohol drinkers. There were statistically significant differences between two groups. 4. The mean serum lipid values for Alcohol drinkers were 189.52±34.62 mg/dl for total cholesterol, 148.03±78.03 mg/dl for triglyceride, 56.66±14.94mg/dl for HDL-C and 103.26±31.87 mg/dl for LDL-C. The mean serum lipid values for non-Alcohol drinkers were 176.85±37.55 mg/dl for total cholesterol, 109.67±51.68mg/dl for triglyceride, 47.58±10.64 mg/dl for HDL-C, and 107.34±32.24 mg/dl for LDL-C. Statistically there were all significant differences except LDL-C between two groups.5. The comparison of serum lipid levels by SBP showed that Statistically BMI, Acohol drinker, exercise (2~3times/week) were significant, and that of serum lipid levels by DBP showed that Statistically Female, Age, BMI, exercise (5~6times/week) were significant.6. Age, BMI, non-vegetarian, exercise (2~3times/week) were significant In the comparison of serum lipid levels by Total cholesterol. The comparison of serum lipid levels by HDL, LDL showed that Statistically BMI, Alcohol drinker were significant.Age, BMI were significant In the comparison of serum lipid levels by Triglyceride.We can conclude that if alcohol is consumed with a normal diet, total serum lipid levels are to increase.

Evaluation of Dietary Risk Factors for Abnormal Serum Cholesterol in Korean Sedentary Male Adults

Jjn, Bok-Hee,Kim, Young-Ok Korean Society of Community Nutrition 1997 대한지역사회영양학회지 Vol.2 No.5

This study investigated whether dietary factors are more influential factor than other health behavior such as drinking, smoking and exercise on abnormal serum cholesterol level inspite of Korean dietary pattern differences compared to Europeans and Americans. A double case control study model has been used for the study design. One model consisted of high blood cholesterol cases and control. the other model consisted of low blood cholesterol cased and controls. 5.398 sedentary male workers who had taken medical examinations at a university hospital were used as the study subjects. Out of the study subjects, 36individuals with high blood cholesterol cases and 30 individuals with low blood cholesterol cases were selected. For the 66 individual control selection, the individual control selection, the individuals matching method was adopted. The food frequency method was used to collect the data for assessment of the dietary factors. A standardized questionnaire was used to investigate other health behavior. logistic regression analysis was employed to measure the relative importance between the factors considered. There were no statistically significant differences observed in nutrients consumption or other health behavior among the low, normal and high blood cholesterol groups, An overmatching effect had been suspected as the cause of those findings. However, the results of logistic regression analysis to identify the factors influencing high serum cholesterol showed that odd ratios of dietary factors such as tocopherol(3.0) and saturated fatty acid(1.6) were higher than I. I of smoking and 1.2 of drinking. Similar results were also observed incases of low serum cholesterol. The above findings imply that although the dietary pattern is quite different from that of Europeans and America, the dietary factor is still a significant factor for abnormal blood cholesterol in Koreans. Therefore, the dietary risk factor identified in high fat consumption populations are still relevant for the relatively healthy Korean as guideline for preventive health practices. (Korean J Community Nutrition 2(5) : 721∼727, 1997)

초등학생의 비만 이환율 및 비만도에 따른 지방 섭취량·혈청 총콜레스테롤/중성지질 수준 연구

최동희,박은숙 동아시아식생활학회 2005 동아시아식생활학회지 Vol.15 No.1

The obesity incidence rate of children in Korea has increased from 2 to 3% in 1970 to 15% in 2004. The purpose of this study was to evaluate the effect of diet on obesity, and serum cholesterol and triglyceride concentrations by obese index in Korean elementary school students. The subjects were three hundred and thirteen students(male 157, female 156). Height, weight and body fat were measured. Dietary records by the 24-hr recall method were taken for 3 days, and serum cholesterol and triglyceride concentrations were determined. The obesity index was calculated by the Korean of Pediatrics Association standards. Nutrient intakes were calculated by CAN PRO. Almost twenty percent(19.8%) of the subjects were underweight, 60.1% were normal, 10.2% were overweight and 9.9% were obesity. The obesity incidence rate of the males was not different from the females. Energy and nutrients intakes containing fatty acids were not significantly different by the obesity index. All the subjects had 59.7%~61.1% of carbohydrate and 24.2%~25.6% of fat for energy. Serum cholesterol concentrations of the obesity group(177.3 ㎎/dl) was higher than those of the underweight group(161.8 ㎎/dl) and normal weight group(163.5 ㎎/dl) and overweight group(163.8 ㎎/di). Twenty nine percent of the obesity group had serum cholesterol concentrations over 200㎎/dl, as compared with 4.8% of the normal and underweight group. Serum triglyceride in the obesity group(103.0㎎/dl) was higher than those of the underweight group(79.7 ㎎/dL), normal weight group(81.0 ㎎/dl and overweight group(81.1 ㎎/dl). Serum total cholesterol concentrations were correlated with the obese index, PIBW, R hrer index at p<0.001, with BMI at p<0.01 and with waist/hip ratio at p<0.05. Serum triglyceride concentrations were correlated with the obese index, PIBW, R hrer index at p<0.01. It is concluded that obesity increases serum total cholesterol concentrations and triglyceride concentrations, and that the obesity preventive program for normal weight children, and weight reduction program for obese children are necessary for elementary school children's education.

일개 제조 사업장 근로자들에서 직업성 소음노출과 혈중지질의 관련성

장은철 순천향대학교 순천향의학연구소 2018 Journal of Soonchunhyang Medical Science Vol.24 No.2

Objective: The study aimed to examine the relationship between occupational cumulative noise exposure and serum lipids as risk factor of ischemic heart disease. Methods: Participants (n=1,175) were workers of the steel product manufacturing factory exposed to more than 85 dB(A) of noise. We collected ambient noise and other materials monitoring data in workplace, laboratory test, and structured-questionnaires. Occupational noise exposure was defined as cumulative noise exposure calculated by duration of exposure and level of exposure. Serum lipids were total cholesterol, triglyceride, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and total cholesterol/HDL cholesterol. We examined the relationship between serum lipids and occupational noise exposure. Results: In a noise exposure environment, 657 people (56.8%) worked for more than 10 years. Cumulative noise exposure increased significantly as exposure duration and noise level increased. Cumulative noise exposure were related to total cholesterol (P=0.001), LDL cholesterol (P=0.002), total cholesterol/HDL cholesterol (P=0.005) in correlation analysis. We conducted multiple linear regression analysis using the serum lipids and significant variables including cumulative noise exposure. We identified that total cholesterol was significantly related to cumulative noise exposure (β=0.072). Conclusion: We propose occupational cumulative noise exposure may be significantly related to total cholesterol.

계란의 영양적 특성 및 건강에 미치는 영향

양은주,이영은,문현경 한국영양학회 2014 Journal of Nutrition and Health Vol.47 No.6

Purpose: The aim of this study is to examine the effects of egg consumption and suggest proper guidelines for consumptionof eggs by determining the relationship between eggs and cholesterol. Methods: Literature review was conducted on therelationship between nutritional, functional properties of eggs and serum cholesterol, as well as cardiovascular disease. Results: Eggs, which are a good protein food with complete amino acid composition, contain vitamin A, riboflavin, vitaminB12, folic acid, vitamin D, vitamin E, vitamin K, calcium, iron, choline, selenium, β-carotene, lutein, zeaxanthin, etc. Howeverthe egg yolk has a high cholesterol content, which is associated with chronic diseases, including heart disease andhypertension. As a result, its intake is subject to regulation. Outbreak of heart disease by yolk intake can show differentresults depending on the characteristics of the subjects, amount of egg intake, and the implications of other foods eaten. Itis difficult to determine whether eggs are beneficial, as they are the main supplying source for other major nutritiveelements as well. Several research studies insist that when cholesterol intake increases by 100 mg, the level of serumcholesterol increases by 2.2~4.5 mg/dL and when serum cholesterol increases by 1%, the risk of heart disease increasesby 2%. This indicates that a large intake of eggs can increase the risk of heart disease. Although the cholesterol of egg yolkand serum cholesterol are correlated, it is insufficient to conclude that only cholesterol and not other components arerelated to heart disease. In fact, other components in egg such as various unsaturated fatty acids and phospholipids couldbe related as well. Rather than concluding egg as a ‘good’ or ‘bad’ food according to its cholesterol content, it is importantto define egg as a part of dietary patterns. Conclusion: Generalizing an indiscriminate and uniform amount of egg intake forall seems inadequate. However, patients with diabetes or heart disease should pay particular attention to the amount of eggintake. As for the norm, eating egg with vegetables as a substitute for other animal products seems beneficial.

유동통 우울증군과 무동통 우울증군간의 혈청 총 콜레스테롤치의 차이

박성화,박제민,김명정 大韓神經精神醫學會 1995 신경정신의학 Vol.34 No.5

The authors measured the total serum cholesterol values in 22 patients with major depression and compared the values in the patients with pain and those without pain. The result were as follows : 1) The serum total cholesterol was significantly higher in the depressives with pain than in those without pain. When the subjects were limited to the females, the same trend was seen. 2) A positive correlation was seen between pain symptom and serum total cholesterol. When the subjects were limited to the depressives with pain, the same positive correlation was shown. Consequently, we think that 5-HT dysfunction is related to a subset of depressives with pain and with higher serum total cholesterol.