서울시에서 산발적으로 분리된 Salmonella enterica Serotype Typhi 임상분리균주들의 분자역학적 분석

이희무,김철현,손장욱,김민자,박미선,이복권 대한감염학회 2000 감염 Vol.32 No.5

반려동물용 BCG 센싱 데이터에서 호흡 및 맥박 신호를 분리하는 방법

곽호영,장진욱,김수균,송우진,윤영민 한국컴퓨터정보학회 2022 韓國컴퓨터情報學會論文誌 Vol.27 No.2

Currently, as the number of families living with companion animals increases, the demand for information about the health status of companion animals has increased. As the demand for this increases, there is a need for a method to measure respiration and pulse in companion animals. Considering the characteristics of hairy companion animals, we want to measure respiration and pulse signals using BCG, which is different from adsorption ECG. Since this BCG method is made by mixing respiration and pulse signals into one signal, it is necessary to separate the respiration signal waveform and the pulse signal waveform from one signal waveform. In this paper, a wearable device for BCG measurement was implemented to measure the signal, and a method of separating the signal input from the BCG wearable device into a respiration signal and a pulse signal was proposed. 현재 반려동물과 함께 사는 가정이 매우 늘어나면서 반려동물의 건강 상태에 대해서 알고 싶어하는 요구가 늘었다. 이에 대한 요구의 증가에 따라 반려동물에게서 호흡과 맥박을 측정하는 방법이 필요한데 반려동물의 특성상 털이 있다는 것을 고려하여 흡착식의 심전도와는 다른 방법인심탄도 방식을 이용하여 호흡과 맥박 신호를 측정하고자 한다. 이 심탄도 방식은 호흡과 맥박 신호가 하나의 신호에 섞여 만들어지기 때문에 하나의 신호 파형에서 호흡 신호 파형과 맥박 신호파형을 분리할 필요가 있다. 본 논문에서는 심탄도 측정을 위한 웨어러블 기기를 구현하여 신호를 측정할 수 있게 하고, 이 심탄도 웨어러블 장치로부터 입력된 신호를 호흡 신호와 맥박 신호로 분리하는 방법을 제안하였다.

귀마개 사용 유무에 따른 혈압과 맥박의 변화 -치석제거술을 중심으로-

김현숙 ( Hyun Sook Kim ),김은희 ( Eun Hee Kim ) 한국위생과학회 2009 한국위생과학회지 Vol.15 No.1

소하천 유역에서의 오염 유입량 예측

김동필 ( Dong Phil Kim ),전민우 ( Min Woo Jeon ),임동희 ( Dong Hee Yim ) 한국환경과학회 2008 한국환경과학회지 Vol.17 No.4

낙뢰에 의해 손상된 레이저 흡수 구조물의 비파괴 및 스텔스 성능 평가에 관한 연구

장재경(Jae-Kyeong Jang),현종민(Jong-Min Hyun),손대성(Dae-Sung Son),이정률(Jung-Ryul Lee) 한국항공우주학회 2018 한국항공우주학회 학술발표회 논문집 Vol.2018 No.11

회전익 항공기용 유성 기어박스에 대한 하중 분배 연구

박정후(Jeong Hoo Park),이광희(Kwang Hee Lee),박구환(Goo Hwan Park),박연수(Youn Su Park) 한국추진공학회 2022 한국추진공학회 학술대회논문집 Vol.2022 No.5

회전익 항공기의 동력 전달 장치는 엔진에서 로터로 동력을 전달하는 역할을 수행하며, 안전과 직결되는 중요한 구성품으로 구성된다. 그 중 유성 기어 박스는 하중 분배 그리고 동력 전달 밀도 등의 장점 때문에 널리 사용되어 왔으며, 최근 eVTOL, tilt rotor, UAVs와 같은 VTOL 적용의 관심이 집중되어 수요가 증가하고 있다. 본 연구에서는 초기 개념 설계 단계에서 회전익 항공기 유성 기어박스 기어 및 베어링 평가를 위한 하중 분배 계수 (Load Sharing Factor) 즉, 안전 계수에 대해 고찰하였다. EC225 사고 조사 보고서 및 베어링 해석 보고서에 명시된 EC225 유성 기어 제원 그리고 수리온 MGB 하우징 모델을 이용하여 EC225 5단 유성 기어 모델링 및 해석을 수행하였으며, 각 유성 기어에 적용되는 하중 분배가 주변 구조물의 강성(Stiffness) 그리고 토크의 크기에 따라 어떤 유의미한 경향을 가지는지 고찰해 보았다. The drivetrain in rotorcraft transmits power from the engines to the rotor system, which consists of a series of safety critical components. The planetary gearbox has been widely used due to its advantage of power density and load sharing, and its demand has been increased due to the recent focus of VTOL applications such as eVTOL, tilt rotor, UAVs. In this study, we discuss Load Sharing Factor (i.e. Safety Factor) for evaluating planetary gearbox gear and bearing of rotorcraft at the initial concept design stage. We choose EC225 5th Stage planetary gear as a case study to demonstrate its influence. The planetary gear stage was modeled, and analysis was performed with reference to the information provided in the EC225 Accident Investigation Report, the Bearing Analysis Report and 3D model of Surion MGB housing. The study shows how the load sharing of each planetary gear changes according to the stiffness of surrounding structures and the magnitude of torque.

數脈의 虛實과 未發現

홍승민(Seungmin Hong),박휘은(Hwi-eun Park) 한국한의학연구원 2010 한국한의학연구원논문집 Vol.16 No.3

Pulse diagnosis is considered one of the most important diagnostic methods in traditional Korean medicine. Nonetheless, there have been troubles of using pulse diagnosis practically, for the lack of its differential standards and standardized terminology. Rapid pulse belongs to the several traditional pulse types. Rapid pulse was first mentioned in the chinese medical book Haungdineijin that matched it to the fever as well as yang in the human body. Meanwhile, chinese doctors in Ming Ching dynasty of China suggested that rapid pulse meant more of the yin, cold-related reaction than yang and fever. In this study, we organized the past arguments of the rapid pulse and went back tracking what biological activities could be possibly linked to the rapid pulse. Thus, we figured out that the inflammatory mechanism has a close connection with the rapid pulse. The definition of the rapid pulse in Haungdineijin was indicating the acute inflammatory response, while in Ming Ching dynasty, it indicated the chronic inflammation. This is the deficiency-excess pattern of the rapid pulse. Furthermore, we discussed the nonexpression pattern of the rapid pulse which could be happened in case of the heat stroke, etc.

Pulsed-field Gel Electrophoresis를 이용한 Mycobacterium fortuitum의 유전형 분석

김성광,도인아,이태윤 영남대학교 의과대학 1995 Yeungnam University Journal of Medicine Vol.12 No.2

항산균 감염증의 예방 및 치료를 위하여는 역학적인 연구가 중요하다. 본 연구에서는 감염증의 분자역학적 연구를 위한 기법중 아직 항산균을 대상으로 pulsed-field gel electrophoresis (PFGE) 분석법을 확립하고자 하였다. PFGE분석에 적절한 제한효소는 DraI, AsnI 및 Xbal 등이었고 각 제한 효소마다 최적의 PFGE조건은 서로 달랐다. DraI의 경우는 두단계로 나누어 전기영동을 시행하였다. 제1단계의 initial pulse는 10초 final pulse는 15초였으며 제 2단계는 initial pulse는 60초 final pulse는 70초 이었다. 전기영동시간은 각 단계마다 각각 14시간씩이었다. Xbal의 경우는 제2단계 없이 initial pulse 가 3초 final pulse가 12초였고 전기영동시간은 22시간이었다. AsnI의 경우는 제2단계 없이 initial pulse가 5초 final pulse가 25초였고 전기영도시간은 22시간이었다. 모든 경우에 있어서 전압은 200v로 하였다. 표준균주로는 M. bovis BCG, M. tuberculosis 및 M. fortuitum등을 사용하였는데 PFGE분석상 동일균종내에서 표준균주들 간의 차이는 발견할수 없었다. 임상에서 분리된 9주의 M. fortuitum 균주를 대상으로 AsnI 제한효소로 PFGE분석을 시행한 결과 2주만을 제외하고는 서로 간의 유전형 분류가 가능하였다. 균주간의 유전적 거리를 결정하기 위하여 cluster analysis를 시행한 결과 M. fortuitum균주들은 크게 두집단으로 나뉘었다. 제한효소 Asnl으로 동일 균종의 분류가 안되는 M. fortuitum 균주들은 Xbal 제한효소을 사용한 PFGE분석으로 유전형의 구분이 가능하였다. cluster analysis를 시행한 결과 크게 두집단으로 나뉘었던 M. fortuitum 균주들은 보다 복잡한 집단으로 분류되어 Xbal을 사용한 PFGE분석법이 M. fortuitum 균주분류를 위하여는 보다 적절함을 알 수 있었다. cluster analysis에서 얻은 최대 % dissimilarity 값은 0.74 (Asnl) 및 0.75 (Xbal)로서 이 값은 arbitrarily primed polymerase chain reaction(AP-PCR)법보다는 높고 restriction fragment length polymorphism(RFLP) 법보다는 낮아 PFGE법이 RFLP를 보완하거나 대치할 수 있는 세균 유전형 분석법임을 알 수 있었다. Epidemiological studies are important in both the prevention and treatment of mycobacterial infections. This study was initiated to establish the pulsed-field gel electrophoresis (PFGE) method, which are not yet extensively studied. The most apprpriate restriction endonucleases included DraI, AsnI, and XbaI. The optimal PFGE condition was different according to the enzymes used. Two stage PFGE was performed, in case of DraI first stage was performed with 10 seconds of initial pulse and 15 seconds of final pulse, while the second stage was performed with 60 seconds of initial pulse and 70 seconds of final pulse. The electrophoresis time for DraI-PFGE was 14 hours for each stage. Electrophoresis was performed for 22 hours, in case of Xbal, with 3seconds of initial pulse and 12 seconds of final pulse. Electrophoresis was performed for 22 hours, in case of AsnI, with 5 seconds of initial pulse and 25 seconds of final pulse. In all cases the voltage of the electrophoresis was maintained constantly at 200 voltage. Standard mycobacterial stains, which included Mycobacterium bovis BCG, M. tuberculosis, and M. fortuitum, could not be differentiated by PFGE analysis. PFGE analysis was performed to differentiate 9 clinically isolated M. fortuitum strains using AsnI. All M. fortuitum strains showed different genotypes except 2 strains. Cluster analysis divided M. fortuitum strains into 2 large groups. PFGE analysis was performed to further differentiate M. fortuitum isolates using Xbal. The undifferentiated 2 M. fortuitum strains showed different PFGE patterns with Xba I. Cluster analysis of the XbaI-PFGE patterns showed more complex grouping than AsnI-PFGE patterns, which showed that XbaI-PFGE analysis was better than AsnI-PFGE in M. fortuitum genotyping. The top dissimilarity values of AsnI-PFGE and XbaI-PFGE were 0.74 and 0.75, respectively. This value was higher than that of arbitrarily primed polymerase chain reaction (AP-PCR) analysis and lower than that of restriction fragment length polymorphism (RFLP) analysis. This suggested that PFGE can be used as a supportive or alternative genotyping method to RFLP analysis.

Pulse pileup correction method for gamma-ray spectroscopy in high radiation fields

Lee, Minju,Lee, Daehee,Ko, Eunbie,Park, Kyeongjin,Kim, Junhyuk,Ko, Kilyoung,Sharma, Manish,Cho, Gyuseong Korean Nuclear Society 2020 Nuclear Engineering and Technology Vol.52 No.5

The detector suffers from pulse pileup by overlapping of the signals when it was used in high radiation fields. The pulse pileup deteriorates the energy spectrum and causes count losses due to random co-incidences, which might not resolve within the resolving time of the detection system. In this study, it is aimed to propose a new pulse pileup correction method. The proposed method is to correct the start point of the pileup pulse. The parameters are obtained from the fitted exponential curve using the peak point of the previous pulse and the start point of the pileup pulse. The amplitude at the corrected start point of the pileup pulse can be estimated by the peak time of the pileup pulse. The system is composed of a NaI (Tl) scintillation crystal, a photomultiplier tube, and an oscilloscope. A 61 μCi ¹³⁷Cs check-source was placed at a distance of 3 cm, 5 cm, and 10 cm, respectively. The gamma energy spectra for the radioisotope of ¹³⁷Cs were obtained to verify the proposed method. As a result, the correction of the pulse pileup through the proposed method shows a remarkable improvement of FWHM at 662 keV by 29, 39, and 7%, respectively.

맥솔(脈率)과 심박변이도(心搏變移度)의 상관성(相關性) 연구(硏究)

양동훈 ( Dong-hoon Yang ),박영배 ( Young-bae Park ) 대한한의진단학회 2006 大韓韓醫診斷學會誌 Vol.10 No.2

Background: Pulse-respiration ratio has been used for estimating subject`s status in oriental medicine. Pulse and respiration is strongly associated with autonomic nerve system. But there is no research about correlation between pulse-respiration ratio and autonomic nerve system. Objectives: We performed this study to know correlation between pulse-respiration ratio and HRV(heart rate variability) that shows autonomic nerve system status well and to clarify clinical meaning of pulse-respiration ratio. Methods: After subject`s 10 minutes rest, we measured subject`s ECG, respiration pattern and HRV. In this research, subject`s number is 95(Male 50/Female 45). We calculated pulse-respiration ratio from ECG and respiration pattern. Then, we analyzed correlation between pulse-respiration ratio and HRV parameters in all subjects, 2 group divided by Wan-Maek(P-R ratio 4.28). We tried to compare HRV parameters among Wan-Maek, Sak-Maek and Ji-Maek group. Correlation analysis between pulse-respiration Ratio and pulse rate, respiration rate is performed. Finally correlation analysis between Respiration and HRV parameters in all subjects, 2 group divided by Wan-Maek(4.28) is studied. Results: 1. Mean pulse-respiration is 4.10±0.67, Mean pulse rate is 68.06±7.82bpm, Mean respiration rate is 16.81±2.72 times per minute in all subjects. 2. Correlation analysis between pulse-respiration ratio and HRV parameters of high pulse-respiration ratio group is not Significant. But, in low pulse-respiration ratio group, HFnorm(correlation coefficient 0.306, p= 0.018), InHF (0.308, p=0.002) is sig-nificantly correlated with pulse-respiration ratio. 3. Comparison of HRV parameters among Wan-Maek, Sak-Maek and Ji-Maek Group is not significant. 4. Pulse-respiration ratio is more affected by respiration rate(correlation coefficient -0.717, p= 0.000) than pulse rate (correlation coefficient 0.396, p=0.000). 5. Correlation analysis between respiration rate and HRV parameters of high pulse-respiration ratio group is not significant. But, in low pulse-respiration ratio group, HFnorm (correlation coefficient -0.327, p=0.011), LF/HF(0.346, p=0.007), 1nHF (-0.355, p=0.006) are significantly correlated with respiration rate. Conclusions: Pulse-respiration ratio and parasympathetic index has positive correlation. The closer Wan-maek, The higher parasympathetic index in low pulse-respiration ratio group. Respiration rate is more related with pulse-respiration ratio than pulse rate. Respiration is negatively correlated with autonomic parameters. And the slower respiration, the higher parasympathetic index in low pulse-respiration ratio group.