율무 약침이 고지방식이 급여 흰쥐의 혈액 내 지질 구성 및 Glucose량에 미치는 영향

이준무,이은,이상훈,이지향 경락경혈학회 2006 Korean Journal of Acupuncture Vol.23 No.1

Objective:To investigate the effects of Yullmoo (Coix lachryma-jobi var. mayuen stapf.) Pharmacopuncture on plasma lipid composition and glucose concentration in hyperlipidemic rats. Methods:β-lipoprotein, free fatty acids, triglyceride and total cholesterol levels in Yullmoo (Coix lachryma-jobi var. mayuen stapf.) Pharmacopuncture groups were compared with those in the control group. Results:Concentration of β-lipoprotein showed no significantly different in all treatment groups. Concentration of free fatty acids, triglyceride and total cholesterol in plasma were decreased in the Yullmoo (Coix lachryma-jobi var. mayuen stapf.) Pharmacopuncture groups. In the Yullmoo (Coix lachryma-jobi var. mayuen stapf.) Pharmacopuncture groups, plasma LDL-cholesterol showed a lower value and HDL-cholesterol showed a higher value than those of the control group. Contents of glucose were decreased in the Yullmoo (Coix lachryma-jobi var. mayuen stapf.) Pharmacopuncture groups.Conclusions:The results suggest that Yullmoo (Coix lachryma-jobi var. mayuen stapf.) Pharmacopuncture may have an impact on lipid metabolism to potentially prevent obesity and enhance treatment effect.

율무 약침이 고지방식이 급여 흰쥐의 혈액 내 지질 구성 및 Glucose량에 미치는 영향

이주무 ( Joon Moo Lee ),이상훈 ( Sang Hoon Lee ),이지향 ( Ji Hyang Lee ),이은 ( Eun Lee ) 대한경락경혈학회 2006 Korean Journal of Acupuncture Vol.23 No.1

Objective: To investigate the effects of Yullmoo (Coix Lachryma-jobi var. mayuen stapf.) Pharmacopuncture on plasma Lipid composition and glucose concentration in hyperlipidemic rats. Methods: β-lipoprotein, free fatty acids, triglyceride and total cholesterol Levels in Yullmoo (Coix Lachryma-jobi var. mayuen stapf.) Pharmacopuncture groups were compared with those in the control group. Results: Concentration of β-lipoprotein showed no significantly different in all treatment groups. Concentration of free fatty acids, triglyceride and total cholesterol in plasma were decreased in the Yullmoo (Coix Lachryma-jobi var. mayuen stapf.) Pharmacopuncture groups. In the Yullmoo (Coix Lachryma-jobi var. mayuen stapf.) Pharmacopuncture groups, plasma LDL-cholesterol showed a Lower value and HDL-cholesterol showed a higher value than those of the control group. Contents of glucose were decreased in the Yullmoo (Coix Lachryma-jobi var. mayuen stapf.) Pharmacopuncture groups. Conclusions: The results suggest that Yullmoo (Coix Lachryma-jobi var. mayuen stapf.) Pharmacopuncture may have an impact on Lipid metabolism to potentially prevent obesity and enhance treatment effect.

율무 약침이 고지방식이 급여 흰쥐의 혈액 내 지질구성 및 Glucose량에 미치는 영향

이상훈,이지향,이은,이준무,Lee, Sang-Hoon,Lee, Ji-Hyang,Lee, Eun,Lee, Joon-Moo 경락경혈학회 2006 Korean Journal of Acupuncture Vol.23 No.1

Objective : To investigate the effects of Yullmoo (Coix lachryma-jobi var. mayuen stapf.) Pharmacopuncture on plasma lipid composition and glucose concentration in hyperlipidemic rats. Methods : ${\beta}-lipoprotein$ free fatty acids, triglyceride and total cholesterol levels in Yullmoo (Coix lachryma-jobi var. mayuen stapf.) Pharmacopuncture groups were compared with those in the control group. Results : Concentration of ${\beta}-lipoprotein$ showed no significantly different in all treatment groups. Concentration of free fatty acids, triglyceride and total cholesterol in plasma were decreased in the Yullmoo (Coix lachryma-jobi var. mayuen stapf.) Pharmacopuncture groups. In the Yullmoo (Coix lachryma-jobi val. mayuen stapf.) Pharmacopuncture groups, plasma LDL-cholesterol showed a lower value and HDL-cholesterol showed a higher value than those of the control group. Contents of glucose were decreased in the Yullmoo (Coix lachryma-jobi val. mayuen stapf.) Pharmacopuncture groups. Conclusions : The results suggest that Yullmoo (Coix lach.yma-jobi var. mayuen stapf.) Pharmacopuncture may have an impact on lipid metabolism to potentially prevent obesity and enhance treatment effect.

율무추출액이 비만쥐의 지질강하 및 혈당치에 미치는 영향

임상철(Sang-Cheol Lim) 한국자원식물학회 2006 한국자원식물학회지 Vol.19 No.1

Effects of Coix lachryma-jobi var. mayuen stapf. ext. on lipidlowering and serum glucose were investigated in hyperlipidemic rat. Concentration of glucose and triglyceride in plasma showed a tendence to decrease in Coix lachryma-jobi var. mayuen stapf. ext. groups. However the values of 100mg/kg treatment group showed no significant difference in control group. Plasma total cholesterol and LDL-chol. showed a low values than those of control group. However HDL-chol. showed no significant difference in all treatment groups, Concentration of liver total cho. and triglyceride showed a tendence to decrease in Coix lachryma-jobi var. mayuen stapf. ext. groups. Concentration of plasma and liver TBARS showed a low values in Coix lachryma-jobi var. mayuen stapf. ext. groups. The values of GSH-Px, SOD and CAT activity showed a tendence to increase in the Coix lachryma-jobi var. mayuen stapf. ext. groups. 율무 추출액이 비만을 유도한 흰쥐의 지질강하 및 혈당저하효과에 미치는 영향을 검토했다. 혈장내 Glucose 및 Triglyceride농도는 대조군과 비교하여 율무 처리군이 낮은값을 보였으나 율무 100mg/kg처리군의 Glucose량은 대조군과 유의한 차이를 나타내지는 않았다. 총콜레스레롤 및 LDL-chol. 농도는 율무 처리군 모두가 대조군보다 현저하게 하락한 값을 나타내었다. HDL-chol.은 대조군이 율무 처리군보다 낮은 값을 보였으나 유의한 차이는 아니었다. 간장내 총콜레스테롤과 Triglyceride 량은 율무 처리군이 대조군 보다 현저히 낮은 값을 보였다. 혈장 및 간장내의 TBARS농도는 율무 처리군 모두에서 대조군 보다 낮은 값을 나타내었다. GSH-Px, SOD 및 CAT 활성치는 율무 처리군에서 높은 활성치를 보였다.

율무(Coix lachryma-jobi var. mayuen stapf.) 추출물의 총 폴리페놀 함량 및 항산화 효과

이명재 ( Myoun Jae Lee ),정창덕 ( Chang Duk Jung ),정동화 ( Donghwa Chung ),이재권 ( Jae Kwon Lee ),김태근 ( Tae Keun Kim ) 충북대학교 과학교육연구소 2016 과학교육연구논총 Vol.32 No.1

The aim of this study was to investigate the total polyphenol content and antioxidant activity from different parts of Coix lachryma-jobi var. mayuen stapf. extract. The total polyphenol contents of whole pant, root and grain extracts using different solvents (ethanol and water) indicated that ethanol extracts of whole pant (35.82±0.74 mg/g) and root (31.84±0.62 mg/g) showed relatively higher total polyphenol contents. ABTS free radical scavenging activity was most excellent in the ethanol extract of whole pant (82.67±3.78%) and root (86.95±2.85%) at 400 μ g/ml concentration. The total polyphenol content in the ethanol extracts was correlated with IC₅₀ for ABTS activity sighificantly, but not with DPPH radical scavenging effect.

율무 추출물의 산화 스트레스에 대한 간 세포 보호효과

이명재 ( Myoun Jae Lee ),정창덕 ( Chang Duk Jung ),정동화 ( Donghwa Chung ),이재권 ( Jae Kwon Lee ),김태근 ( Tae Keun Kim ) 충북대학교 과학교육연구소 2016 과학교육연구논총 Vol.32 No.1

Oxidative stress is one of the major causes of hepatocyte injury. The protective effects of Coix lachryma-jobi var. mayuen stapf.(Coix) on tert-butyl hydroperoxide (t-BHP) induced oxidative stress in HepG2 cell damage were investigated in vitro. Cell viability of six extracts of Coix which were extracted with ethanol and water from three different parts was tested by MIT assay. The ethanol extract from whole plant, root and grain exhibited relatively higher protective effect on human HepG2 cells. These results suggest that Coix extracts may be useful as a phytotherapeutic agent for the treatment of liver damage.

율무 추출물의 산화 스트레스에 대한 위 세포 보호효과

이명재 ( Myoun Jae Lee ),정창덕 ( Chang Duk Jung ),정동화 ( Donghwa Chung ),이재권 ( Jae Kwon Lee ),김태근 ( Tae Keun Kim ) 충북대학교 과학교육연구소 2016 과학교육연구논총 Vol.32 No.1

The grain of jacob`s tears(Coix lachryma-jobi var. mayuen stapf.) has been used as anti-inflammatory medicine and health food. The purpose of this study was to investigate gastroprotective effect of the extract of Jacob`s tears against oxidative stress-induced gastric damage. Ethanol extract of grain exhibited significant cell viability and low cytotoxicity in AGS cells. These results indicate that Jacob`s tears could be excellent source for gastroprotective agent.

작약근의 박피와 시료형태가 건조시간 및 Paeoniflorin 함량에 미치는 영향

kijaeKim,ChungHongPark,soDeukPark,jaecheolKim,kyengsokPark 한국약용작물학회 2002 한국약용작물학회지 Vol.10 No.1

The seeds of Coix lachryma=jobi Linne var. mayuen Stapf. are used as dietary food for obesity and diabetes under the names of Yulmu in Korea and Yiyiren(薏苡仁) in China. It is one of the drugs promoting diuresis to eliminate the wetness-evil from the lower warmer in the traditional Korean medicine. According to ancient textvook of the traditional Korean medicine, it should be applied to patients with phlegm and heat, etc. The establishment of the method for the discrimination of Coisis Semen is very important for the quality control of drugs. Random amplified polymorphic DNA(RAPD) analysis and anatomical characteristics were used for the discrimination of Coix lachryma-jobi Linne' var. mayuen STAPF. and C. lachryma-jpbi Linne'. In the PAPD analysis with 20 primers, 8 primers gave informative and reproducible bands with the genomic DNA. From the cluster analysis, the genus Coix were divided into two groups at similarity coefficient of 0.863.

의이인과 염주의 RAPD분석 및 해부학적 특징에 의한 감별

이미영,임성희,김호경,한경식,최용휴,주영승,오승은,고병섭 한국약용작물학회 2002 韓國藥用作物學會誌 Vol.10 No.1

The seeds of Coix lachryma=jobi Linne var. mayuen Stapf. are used as dietary food for obesity and diabetes under the names of Yulmu in Korea and Yiyiren(薏苡仁) in China. It is one of the drugs promoting diuresis to eliminate the wetness-evil from the lower warmer in the traditional Korean medicine. According to ancient textvook of the traditional Korean medicine, it should be applied to patients with phlegm and heat, etc. The establishment of the method for the discrimination of Coisis Semen is very important for the quality control of drugs. Random amplified polymorphic DNA(RAPD) analysis and anatomical characteristics were used for the discrimination of Coix lachryma-jobi Linne' var. mayuen STAPF. and C. lachryma-jpbi Linne'. In the PAPD analysis with 20 primers, 8 primers gave informative and reproducible bands with the genomic DNA. From the cluster analysis, the genus Coix were divided into two groups at similarity coefficient of 0.863.

의이인과 염주의 RAPD분석 및 해부학적 특징에 의한 감별

이미영,임성희,김호경,한경식,최용휴,주영승,오승은,고병섭 한국약용작물학회 2002 한국약용작물학회지 Vol.10 No.1

의이인과 염주는 동속 근연종으로 외부형태가 유사하고 종피를 깎아 유통하기 때문에 육안으로 식별하기에는 한계가 있다. 특히, 염주는 일부 수입품에서 의이인과 비슷한 크기로 염주 종피를 깎아 유통시키고 있어 진 위 판별에 논란이 되고 있다. 본 연구에서는 의이인의 유통품을 외부 형태적 특징으로만 식별하기 어려운 문제를 해결하고자 내부형태 특성조사와 정색반응, RAPD등을 이용하여 감별을 위한 기초자료로 이용하고자 한다. 1. 의이인의 과피는 석세포로 구성된 층과 대보강세포와 섬유상 보강세포로 이루어진 2층 구조로 구분되는 반면, 염주의 과피는 외과피와 내과피는 석세포로 이루어져 있고 중앙의 중과피는 대보강세포와 섬유상 보강세포로 구성되어 뚜렷한 3층의 구조로 이루어진다. 2. TLC를 이용한 확인시험에서 Hexane : EtoAc = 10 : 1의 조건으로 전개하였을때 중국산 염주에서는 Rf가 0.2에서만 밴드가 형성되었다. 3. 중국의 "상용중약감정대전(常用中藥鑑定大典)"에서 제시된 요오드반응법에 의한 의이인과 염주의 정색반응은 구별이 어려웠다. 4. RAPD 분석에서 8개 primer에서 품종간 다형성 밴드가 관찰되었고, UBC primer 355와 362에서 중국 염주와 의성 염주의 특이 밴드(500bp, 1300bp)가 관찰되었다. The seeds of Coix lachryma-jobi Linne var. mayuen Stapf. are used as dietary food for obesity and diabetes under the names of Yulmu in Korea and Yiyiren(薏苡仁) in China. It is one of the drugs promoting diuresis to eliminate the wetness-evil from the lower warmer in the traditional Korean medicine. According to ancient textbook of the traditional Korean medicine, it should be applied to patients with phlegm and heat, etc. The establishment of the method for the discrimination of Coisis Semen is very important for the quality control of drugs. Random amplified polymorphic DNA(RAPD) analysis and anatomical characteristics were used for the discrimination of Coix lachryma-jobi Linné var. mayuen STAPF. and C. lachryma-jobi Linné. In the RAPD analysis with 20 primers, 8 primers gave informative and reproducible bands with the genomic DNA. From the cluster analysis, the genus Coix were divided into two groups at similarity coefficient of 0.863.