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난소의 악성 혼합 뮬러리안 종양의 소장 및 대장 재발 1예
이지은 ( Ji Eun Lee ),손장원 ( Jang Won Sohn ),문희정 ( Hee Jung Moon ),이상훈 ( Sang Hoon Lee ),박윤선 ( Youn Sun Park ),최재원 ( Jae Won Choi ),김국현 ( Kook Hyun Kim ),은종렬 ( Jong Ryul Eun ),장병익 ( Byung Ik Jang ),김태년 ( 대한장연구학회 2006 Intestinal Research Vol.4 No.1
Malignant mixed mullerian tumor (MMMT) is rare tumor of the ovary, representing less than 1% of all ovarian malignancies. MMMT is an uncommon tumor containing epithelial and mesenchymal components. Most of all were heterologous type and 80% occur in postmenopausal women. It is a aggressive and rapidly progressive tumor. MMMT is highly malignant and the prognosis is poor because of frequent metastasis and recurrance. The survival rate is very low in spite of surgery, chemotherapy and radiotherapy. The optimal treatment is still controversial. We experienced one recur case of malignant mixed mullerian tumor of the ovary in intestine and report with brief review of literature. (Intestinal Research 2006;4:53-56)
Malignant Mixed Mullerian Tumor Arising from the Uterine Cervix: A Case Report
심종준,심재찬,이혜경,이경은,이기재,김호균,서정호 대한영상의학회 2012 대한영상의학회지 Vol.67 No.4
Malignant mixed mullerian tumors (MMMTs) are a rare uterine tumor and contribute to approximately 1-3% of all corpus malignant tumors. MMMTs are usually in the uterine corpus, but can also arise from the uterine cervix, vagina, ovaries and fallofian tubes. MMMTs of the uterine cervix are extremely rare. MMMTs are highly malignant and tend to maintain a rapid growth and exhibit a high rate of recurrence. Therefore, the prognosis of patients diagnosed with these types of tumors is extremely poor. We report a rare case of a malignant mixed mullerian tumor arising from the uterine cervix and introduce CT and MRI findings. CT and magnetic resonance findings of the uterine cervical MMMT in our case show highly aggressive features, such as parametrial involvement, pelvic and paraaortic lymphadenopathy, and distant metastasis and high enhancement.
강혁재 ( Hyuk Jae Kang ),정민형 ( Min Hyung Jung ),김종준 ( Jong June Kim ),김대연 ( Dae Yeon Kim ),김종혁 ( Jong Hyeok Kim ),서대식 ( Dai Shik Seo ),김용만 ( Yong Man Kim ),김영탁 ( Young Tak Kim ),남주현 ( Joo Hyun Nam ),목정은 대한산부인과학회 2006 Obstetrics & Gynecology Science Vol.49 No.12
목적: 자궁의 악성 혼합성 중배엽 종양 환자들의 특징, 생존율, 예후인자를 평가하고자 하였다. 연구 방법: 1994년 1월부터 2004년 12월까지 본원에서 관찰한 26예의 자궁의 악성 혼합성 중배엽 종양 환자의 의무기록을 후향적으로 분석하였다. 환자들의 특징과 병리결과, 병기, 치료, 예후인자와 생존기간을 분석하였다. 결과: 전체 환자의 중앙 연령은 59세였으며, 대부분의 환자 (76.9%)는 폐경 후 상태이었고, 가장 흔한 증상은 질 출혈 (65.4%)이었다. 환자들은 I기가 17명 (65.4%)이고, II기가 3명 (11.6%)이고, III기가 4명 (15.4%)이고, IV기가 2명 (7.6%)이었다. 병리학 적으로 동종형의 종양이 4개 (15.4%)이고 이종형의 종양이 22개 (84.6%)이었다. 모든 환자들의 5년 생존율은 60%이며 병기에 따라 비교하면 진행된 기수 (III, IV)의 환자들이 조기 (I, II)의 환자들에 비해 훨씬 나쁜 예후를 보였으며 전체적인 (Overall) 생존율에 영향을 주는 인자는 수술 후 병기였다 (P=0.001). 그리고 자궁근층을 침범한 깊이도 역시 환자의 생존율에 의미있게 영향을 준다 (P<0.001). 결론: 자궁의 악성 혼합성 중배엽 종양은 매우 악성의 종양이며 중요한 예후인자는 FIGO 병기와 자궁근층을 침범한 깊이이다. Objective: To review the clinicopathological characteristics and prognosis of patients with malignant mixed Mullerian tumor (MMMT) of the uterus. Methods: Retrospective clinical study was done on 26 patients diagnosed with the MMMT of the uterus at our hospital from Janurary, 1994 to December, 2004. Demographic data, pathologic findings, stages, treatment, prognosis and survival time were reviewed. Results: The median age of patients was 59 years. Most of the patients (76.9%) were in the postmenopausal state. The most common symptom was vaginal bleeding (65.4%). There were 17 patients (65.4%) with stage I, 3 patients (11.6%) with stage II, 4 patients (15.4%) with stage III, 2 patients (7.6%) with stage IV disease in this study. Of the hysterectomy specimens, 4 (15.4%) of them were heterologous tumors, 22 (84.6%) of them were homologous tumors. Overall 5 year survival rate of all stages was 60% and the patients with advanced stages (III, IV) showed poorer prognosis than the patients with early stages (I, II) (P=0.001). Myometrial invasion depth was also significant prognostic factor (P<0.001). Conclusion: The MMMT of the uterus is a highly malignant tumor and the significant prognostic factor is the FIGO stage and myometrial invasion depth.
이천준 ( Lee Cheon Jun ),김원규 ( Kim Won Gyu ) 대한산부인과학회 2003 Obstetrics & Gynecology Science Vol.46 No.11
Malignant mixed mullerian tumor (MMMT) of the fallopian tube is extremely rare with poor prognosis. Primary fallopian tube cancer accounts for approximately 0.3% of all female genital tract malignancies. MMMT of the fallopian tube is extremely rare, accou
이탁,차순도 啓明大學校 醫科大學 1990 계명의대학술지 Vol.9 No.4
Sarcoma of the uterus is a malignant tumor arising from the muscle or connective tissue and very rare malignant tumor. There are only a few case reports in Korea. We have experienced fifteen cases of the uterine sarcoma between 1980 and 1989 for 10 year. The results were obtained as follows: 1. The distribution of uterine sarcoma by histologic-type was 5 cases(33.3%) for leiomyosarcoma, 6 cases(40.0%) fir malignant mixed mullerian tumor, 3 cases(20.0%) for endometrial stromal sarcoma. 2. The average age was 48.9 years and the most frequent occurrence was noted in the groups of fifties. 3. The clinical symptoms were abnormal uterine bleeding(60.0%), abnormal mass(20.0%), abdominal distension(13.3%), and abdominal pain(7.7%). 4. The primary sites were the cervix(7.7%), endometrium(46.7%), and myometrium(26.6%).
난소의 악성 혼합성 뮬러리안 종양 10예의 임상적 고찰
이수호 ( Su Ho Lee ),김철중 ( Chul Jung Kim ),이선주 ( Sun Joo Lee ),이정원 ( Jeong Won Lee ),박창수 ( Chang Soo Park ),김병기 ( Byoung Gie Kim ),이제호 ( Je Ho Lee ),안긍환 ( Geung Hwan Ahn ),손영수 ( Young Soo Son ),배덕수 ( Duk 대한산부인과학회 2004 Obstetrics & Gynecology Science Vol.47 No.10
목적 : 난소의 악성 혼합성 뮬러리안 종양의 임상 양상을 파악하여 향후 치료 및 예후에 대한 도움을 주고자 한다. 연구 방법 : 1999년 1월부터 2003년 12월까지 5년간 삼성서울병원 산부인과에서 진단 및 치료를 받은 총 10예의 난소의 악성 혼합성 뮬러리안 종양 환자의 임상기록을 검토하여 임상적 고찰을 시행하였다. 결과 : 난소의 악성 혼합성 뮬러리안 종양은 폐경기 여성에게서 주로 발병하였고 진단 당시 광범위 전이가 되어있었다. 치료로써 자궁적출 Malignant mixed mullerian tumors (MMMT) of the ovary are rare, constituting less than 1% of all primary ovarian tumors. Histologically, tumors include malignant epithelial and sarcomatous elements. MMMT of the ovary is a highly aggressive and rapidly prog
이천준,김성한 고신대학교(의대) 고신대학교 의과대학 학술지 2006 고신대학교 의과대학 학술지 Vol.21 No.1
Malignant mixed Miillerian tumor (MMMT) is neoplasm consisting of both a sarcomatous and carcinomatous component. MMMT of the ovary is rare,constituting less than 1% of all primary ovarian tumors. Almost all it is found in postmenopausal women,often with low parity and usually in an advanced stage. It is a particularly aggressive and rapidly progressive tumor, especially in advanced stages. It is highly malignant and the prognosis is poor due to frequent metastasis and recurrence. The survival rate is very low in spite of surgery, chemotherapy and radiotherapy. There is no uniform opinion about optimal therapy. We have experienced one case of MMMT of the ovary an公 report this case with the brief review of literature.
김흥열,박은동 고신대학교(의대) 고신대학교 의과대학 학술지 1992 고신대학교 의과대학 학술지 Vol.8 No.2
-Abstract- Sarcoma of the uterus is a malignant tumor arising from the muscle or connective tissue & very rare malignant tumor. There are only a few case reports in Korea. We have experienced twelve cases of the uterine sarcoma between 1986 and 1992 for 6 years. The results were obtained as follows : 1. The distribution of uterine sarcoma by histologic type was 4 cases (33.3%) for leiomyosarcoma, 3 cases(25.0%) for maligangt mixed mullerian tumor, 2 cases(16.7%) for rhabdomyosarcoma. 2. The average age was 44.7 years. 3. The clinical symptoms were abdominal mass(66.7%), abnormal bleeding (33.3%), pelvic or abdominal pain(33.3%). 4. The mean survival time seemed to be decreased with increasing numbers of mitotic figure per 10 high power field.
선우재근 ( Jae Gun Sunwoo ),조인숙 ( In Sook Cho ),전섭 ( Seob Jeon ),배동한 ( Dong Han Bae ),신영우 ( Young Woo Shin ),김창진 ( Chang Jin Kim ),정동준 ( Dong Jun Jeong ) 대한산부인과학회 2008 Obstetrics & Gynecology Science Vol.51 No.3
Malignant mixed mullerian tumors (MMMT) are rare biphasic malignant neoplasm with two components of carcinoma and sarcoma. The most common site of occurrence in female genital tract is the uterine corpus. MMMT of the cervix is extremely rare. MMMT of uterine corpus is highly malignant and the prognosis is poor. Surgery is treatment of choice of uterine cerivx MMMT. The clinicopathologic characteristics of tumor and treatment are uncertain because of lack of clinical data. We experienced one case of malignant mixed mullerian tumor of uterine cervix and report our experience with a brief review of literature.