운동 강도의 차이가 고밀도 지단백 콜레스테롤의 구성성분 및 동맥경화지표에 미치는 영향

성기운 ( K. W. Sung ),이용수 ( Y. S. Lee ),김시영 ( S. Y. Kim ) 한국운동생리학회(구 한국운동과학회) 2011 운동과학 Vol.20 No.3

성기운, 이용수, 김시영. 운동 강도의 차이가 고밀도 지단백 콜레스테롤의 구성성분과 동맥경화지표에 미치는 영향. 운동과학, 제20권 제3호. 309-318, 2011. 본 연구의 목적은 비만인의 high-density lipoprotein(HDL)-C 구성성분과 동맥경화지표에 있어 운동 강도와 시기에 따른 영향을 알아보는데 있다. 이를 위해 체지방율 25% 이상의 성인 남성 10명을 대상으로 최대지방연소 운동 강도(MFOEI, VO2max의 40∼60%)와 고강도 운동(VO2max의 80%)을 각각 무선 배정하여 트레드밀 운동을 실시하였다. 운동 전, 직후, 회복기 30분, 1시간, 2시간에 혈액을 채취하여 total cholesterol(TC), triglyceride(TG), HDL-C, HDL2-C, HDL3-C, apolipoprotein(Apo) A-I, Apo B, Apo B/Apo A-I 및 paraoxonase(PON1) 활성도를 알아보았으며, 결과는 2x5 반복측정 이원변량분석을 통해 분석하였다. 그 결과, VO2max의 80%에서는 TC, TG, LDL-C, HDL-C, Apo A-I 및 Apo B가 운동 전에 비해 운동 직후 일시적으로 증가하였으며(p<.05, p<.01, p<.001), PON1은 회복기 1시간에 유의하게 감소하였다(p<.01). 반면, MFOEI에서 회복기 2시간까지 TG의 유의한 감소가 나타났으며(p<.05), HDL3-C과 PON1의 활성은 VO2max의 80% 운동에 비해 유의하게 증가하였다(p<.05). 이상의 결과를 종합하였을 때, 비교적 낮은 강도에 해당하는 MFOEI의 경우 TG의 지속적인 감소는 물론 HDL3-C의 농도와 PON1의 활성에 증가를 가져오는 것으로 나타나 항 동맥경화에 효과적인 운동 강도로 보인다. The present study examined the effects of exercise intensity and time on high-density lipoprotein (HDL)-C subparticles and atherogenic index. Ten adults over 25 percentage of body fat were submitted to single session of aerobic exercise. The subjects (23.1±3.9 yrs) participated in two random trials: in maximum fat oxidation exercise intensity (MFOEI) (40∼60% VO2max) and high intensity (80% VO2max) exercise tests. For each trial, blood samples were collected at pre-exercise, post-exercise, 30 min, 1 and 2 h after exercise. Samples were analyzed for total cholesterol (TC), triglyceride (TG), HDL-C, HDL2-C, HDL3-C, apolipoprotein (Apo) A-I, Apo B, Apo B/Apo A-I, and paraoxonase (PON1) activity. Data were analyzed using 2x5 two-way repeated ANOVA. Transient increase in TC, HDL-C, LDL-C, Apo A-I, and Apo B concentrations were significant at post-exercise with 80% VO2max. With MFOEI, no differences in TC, DHL-C, Apo A-I, and Apo B were found. LDL-C was significantly increased after 1 and 2 h post-exercise at MFOEI. TG significantly reduced with MFOEI and 80% VO2max trials. HDL3-C measurement after MFOEI trial was higher compared with it measured after high intensity exercise with 80% VO2max trial. However, there was no difference in HDL2-C between MFOEI and 80% VO2max trials. PON1 activity was significantly increased after 1 and 2 h post-exercise at MFOEI. On the other hand, in 80% VO2max trial, the activity was significantly decreased 1 h after exercise. Apo B/Apo A-I ratio was not different between or within trials. These results indicate that MFOEI appear to be promoting more benefits on HDL-C subparticles and atherogenic index than high inensity.

The Use of Individual Anaerobic Threshold for the Measurement of Blood Lipid Profiles

( Dong Ho Park ),( Kwang Hoi Kim ) 한국스포츠정책과학원(구 한국스포츠개발원) 2002 International Journal of Applied Sports Sciences Vol.14 No.1

In this study, we investigated the effect of different exercise intensities as a criterion of exercise intensity on acute high-density lipoprotein-cholesterol (HDL-c) changes in 17 healthy college aged-men completing two-counterbalanced running trials at different exercise intensities: trial 1 at individual anaerobic threshold (IAT) intensity, and trial 2 at 68% VO2max intensity. For each trial, blood samples were collected at pre-exercise (baseline), 15 min post-exercise (15m PE), and 24 hours post-exercise(24h PE). Serum samples were analyzed for HDL-c, HDL2-c and HDL3-c subfraction, LDL, VLDL, total cholesterol (TC), free cholesterol (FC), cholesterol ester(CE) and triglycerides(TGs). In addition, capillary blood samples were collected for analysis of blood lactate concentrations during incremental test to determine individual anaerobic threshold(IAT). All samples were corrected for plasma volume changes and compared to pre-exercise (baseline; BE). In assessing the lipid and lipoprotein variables, the increases in HDL-c(p< .05,) at both 15m PE(HDL2-c= ↑6.04%, HDL3-c= ↑10.15%) and 24h PE(HDL2-c= ↑6.74% HDL3-c = ↑10.37%) were due to the increases in both HDL2-c and HDL3-c. The increase 15m PE TC, both at IAT and 68% VO2max intensities, occurred. Although there were no significant changes in TG and VLDL between baseline and 15m as well as baseline and 24h, increased 15m PE TG and VLDL in comparison to baseline TG and VLDL were decreased at 24h PE. These decreases in the concentrations of TG and VLDL-c contributed to change in 24 h HDL-c concentration. Consequently, the significant increases in both 15m and 24h PE HDL-c occurred only at IAT intensity, expending about 350kcal. In addition, reduced 24h PE TG and VLDL can favorably alter the lipid profile. In this study, this finding indicates that although individuals exercise with the same relative exercise intensity, subjects` metabolic responses may vary and may result in different results due to the metabolically different workloads. Therefore, the use of IAT as a criterion of exercise intensity may be better than that of VO2max and HRmax, with respect to individualized metabolic stress for each individual as well as reduction of metabolic and physiological variables.

저 HDL-C 여성 노인의 장기간 운동 트레이닝 후 HDL-C 기능성 및 심혈관질환 위험 요인의 변화

안나영 한국생활환경학회 2020 한국생활환경학회지 Vol.27 No.3

The purpose of this study is to analyze the effect of long-term exercise for the prevention of CVD in elderly women with low HDL-C levels on HDL-C levels, functional HDL-C and inflammatory factors. The subjects were divided into normal HDL-C group (≥50 mg/dL, Normal high density lipoprotein cholesterol: NHDL-C group, n=16) and low HDL-C group (<50 mg/dL, Low high density lipoprotein cholesterol: LHDL-C group, n=14) based on HDLC concentration in the elderly women over 65 years old. The aerobic and resistance exercise program consisted of a combination of silver dance and band exercise, 60 minutes a day, three times a week, and conducted at a medium intensity level for 24 weeks. As a result of the study, the LHDL-C group significantly (p<.05) increased plasma HDLC levels, APOA-1 and HSP70 levels. Physical fitness was significantly improved (p<.05) in both groups. The LHDLC group also significantly (p<.05) decreased IL-6 concentration and the risk of cardiovascular disease within 10 years. Therefore, the long-term exercise program of the elderly women with low HDL-C level can have the effect of improving physical fitness, reducing inflammatory factors, improving qualitative HDL-C function, and cell regeneration mechanism.

신생아에서의 HDL-C와 LDL-C 値에 관한 연구

한병길,정용헌 충남대학교 의과대학 지역사회의학연구소 1996 충남의대잡지 Vol.23 No.1

The values of serum HDL-C and LDL-C were measured in 70 newborn infants with gestational ages from 35-43 weeks, birth weight from 2000 to 4500 gm, Apgar score 7 or more at 1 & 5 minutes and normal physical examination. 1. In all newborn infants, the mean HDL-C values & ranges were 31.99 ±6.67 mg/dl, from 21.5 to 49.8mg/dl, and the mean LDL-C values & ranges were 41.42 ±21.39mg/dl from 15.1 to 94.3mg/dl. 2. In term newborns with AGA, the mean HDL-C & LDL-C values were 32.85 ±6.75mg/dl and 45.85 ±21.39mg/dl respectively. 3. The HDL-C and LDI-C values of female were significantly higher than those of male. 4. The correlation of HDL-C by weight for gestational age was not significant, but that of LDL-C value was significantly lower in SGA than those of AGA & LGA. 5. The correlations of HDL-C & LDL-C according to birth weight, gestational age and Ponderal Indices were not significant.

체육측정평가학 : 혈액 분석기기의 신뢰도 및 타당도 분석

엄한주(HanJooEom),강성기(SeoungKiKang) 한국체육학회 2004 한국체육학회지 Vol.43 No.6

This study investigates the reliability and validity of blood lipid analyzers. Four blood analyzers, two different types (DT 60, Hitachi 7600-110,) with 2 instruments for each type, were used to compute the values of TC, HDL-C, and TG. Also, Lactic acid concentrations were repeatedly obtained by two instruments (DT 60 and Cobas integra, each type having 2 instruments). In all analyses, the same blood samples from each of 6 subjects were used to examine the repeatability and reproducibility of the values measured by all instruments. Data were analyzed to compute coefficient of variations (CV), variance components, correlations and various descriptive statistics with SPSS 11.0. HDL-C and TC values obtained by the same type of analyser for the 3 repeated samples from the same person under each condition were highly consistent, the CV for each being within 5%. However, when the values obtained from two different types of the analyzers were combined, the CV increased up to 12.3% for HDL-C and 21.7 ~ 24.5% for TC, indicating very low reproducibility of the analyzers. The correlations between the values of each measured variables with the same type of analyzers were very high, reaching above .97, but those values obtained by different types of analyzers were considerably lower. The analyses of variance component also revealed that the main source of error variances were mostly due to the difference in the types of analyzer. Thus, these results suggest that the different types of analyzers do not produce the same results although the 2 types are designed and manufactured to have the same function in analyzing blood lipid. For the TG and Lactic acid variables, the results indicated that there was insufficient evidence of both repeatability and reproducibility of the analyzers as the values obtained repeatedly from the same type of analyzers as well as those obtained from different types of analyzers were inconsistent. In general, the blood analyzers for TC and HDL-C were reliable, but not valid. However, the values of TG and Lactic acid were neither reliable nor valid as the values were varied considerably both within the same type and between the different types of analyzers. HDL-C and TC concentration is within coefficient of variation(CV) 5%. A similar Hitachi 7600-110 and DT 60 blood analyzer whole mean concentration of participants lower. However, defined as the calculated HDL-C (CV:12.8-16.36%), TC (CV: 21.68-24.47%), TC concentration should alter with change the analyzer to estimating blood range. Both HDL-C and TC concentration is above correlate .94 respectively. Therefor, to analyse HDL-C and TC, we found high mean different. Variance component estimation of HDL-C and TC are HDL-C(33.88%), TC(11.65%) which is different participant and another variance component estimation is different blood analyzer(HDL-C 6205%, TC 86.11%). To analyse TG and Lactic acid, we found estimation values of blood analyzer. Variance component estimation of TG and Lactic acid are TG(627%), Lactic add(87.9%) of different blood analyzer.

자연과학분야 : 발레 무용수의 Branched-Chin Amino Acids(BCAA)와 TC/HDL-C ratio의 상관관계

신말연 ( Mal Ryun Shin ) 한국무용과학회 2015 한국무용과학회지 Vol.32 No.3

본 연구는 발레 무용수들을 대상으로 TC/HDL-C ratio, leucine, isoleucine, valine(BCAA)을 관찰변인으로 선정하여 TC/HDL-C ratio와 Branched-Chin Amino Acids(BCAA) 간의 상관관계를 규명함으로써 발레무용수들의 효율적인 무용수행능력과 체력 향상에 필요한 기초자료를 제시하는데 연구의 목적이 있다. 본 연구의 대상자는 연구의 목적을 충분히 이해하고 실험참가에 동의한 S대학교 발레전공 여대생 14명을 무선표집(random sampling)하였고 평상시와 같이 식생활을 유지하도록 하였다. 모든 연구 대상자들의 신체적 측정요인으로는 신장, 체중, 체지방률, 신체질량지수(BMI)를 측정하였다(In-Body 520, Biospace Co., Korea). TC 및 HDL-C 분석에는 Enzymatic Colorimetric, BCAA 분석에는 HPLC(Biochrom 20, U.S.A)으로 분석되었다. 구체적인 통계기법으로는 상관분석(analysis of correlation), 단순선형회귀분석(analysis of simple linear regression)을 사용하여, Durbin Watson검증을 통하여 잔차분석을 하였으며, 이때 유의 수준은 .05로 설정하였다. 연구결과는 발레무용수의 TC/HDL-C ratio을 종속변인으로 Branched Chain Acids(BCAA)인 Isoleucine, Leucine, Valine(BCAA)를 독립변인으로 한 단순회귀분석에서 각각 0.71, 0.50, 0.46의 설명력을 나타낸 회귀식이 성립됨으로써 발레전공 여대생의 TC/HDL-C ratio에 BCAA가 유의하게 영향을 미치는 독립변수로 나타났다. 본 연구에서는 발레 무용수들의 Branched Chain Acids(BCAA)의 농도가 증가할수록 TC/HDL-C ratio가 낮게 나타날 것으로 예측할 수 있으며, 이러한 인과관계는 여성 발레무용수들의 발레 동작 및 연습 시 에너지 대사과정에서 BCAA의 효율적인 활용과 더불어 발레무용수들의 공연향상 뿐만 아니라 건강기능의 향상에 관한 효율적인 자료로 활용될 수 있다고 기대한다. The purpose of this study was to determine the relationship between Branched Chain Amino Acid(BCAA) and TC/HDL-C ratio in female ballet dancers. Fourteen college female ballet dancers(age:18.3±.0.5yrs, BMI:19.2±1.2m²) were participated in this study, and study subjects measured percent body fat, fat mass, weight, body mass index and isoleucine, leucine, valine. were also measured percent body fat, fat mass, weight, body mass index were analyzed using bioelectrical impedance(Biospace Co.). Use blood-gathering analyzed about isoleucine, leucine, valine of Amino Acid(Biochrom 20, U.S.A) and TC/HDL-C ratio(Enzymatic Colorimetric). Analysis of multiple Correlation, Analysis of Simple liner Regression, and Dubin Watson Test were applied for the statistical analysis using SPSS 12.0. This results showed that TC/HDL-C ratio was significantly associated with isoleucine(p<.05), leucine(p<.05), and valine(p<.05) in female ballet dancers. it was found that TC/HDL-C ratio is in proportion to BCAA in female ballet dancer. In conclusion, it does appear that several significant research topics in amino acid biochemistry metabolism as well as ballet dancer and nutrition can be explored profitably in the future using experimental designs involving interaction between amino acid status and exercise performance.

혈액분석 시 대기온도에 의한 혈중지질 성분과 젖산 농도의 변화

강성기 ( Seoung Ki Kang ),김종규 ( Jong Kyu Kim ),엄한주 ( Han Joo Eom ) 한국스포츠정책과학원(구 한국스포츠개발원) 2005 체육과학연구 Vol.16 No.4

본 연구는 환경적인 요소로 통제되어야 할 대기 온도가 혈중지질과 젖산에 어떠한 영향을 미치는지에 대해 알아보고자 한다. DT 60 혈액 분석기로 네 가지의 온도(18˚, 22˚, 26˚, 30˚)와 각 온도별로 3번 반복 측정된 TC, HDL-C, TG 그리고 Lactic acid의 농도의 변화를 알아보았다. 모든 혈액분석은 6명의 피험자에서 채취된 동일한 혈액에 대한 온도에 따른 재생성과 반복된 결과를 측정하였다. 본 연구의 자료처리는 SPSS Ver 11.0 Program을 통하여 모든 자료의 평균, 표준편차 그리고 각 온도에서 측정한 3회의 자료에 대한 변동계수(CV)를 산출하고, 온도와 분석시기에 따른 TG, TC, HDL-C, Lactic acid 항목에 차이를 알아보기 위하여 two-way(4×3) RM on both ANOVA를 실시하였고, G-이론 모형을 이용하여 피험자(p), 온도(c), 분석시기(t)를 국면으로 설정한 교차 설계로 분산성분 추정치를 통해 각 오차원의 상대적인 영향력(%)을 산출하였다. TC, HDL-C, TG 그리고 Lactic acid 항목은 동일한 온도에서 3번 반복 측정된 결과가 높은 안정성을 보여주고 있었지만, 다른 온도에서 측정된 결과는 안정성이 낮은 것을 알 수 있었다. 각각의 온도에서 측정된 종속변인의 평균을 비교한 결과 HDL-C, TC, TG 그리고 Lactic acid 모두에서 통계적으로 유의한 차이가 나타났다. 분산성분 추정치는 피험자로 인해 발생된 변량을 제외한 오차요인 중 온도가 차지하는 비율에서 HDL-C(48.29%), TC(30.92%), TG(49.24%) 그리고 Lactic acid(31.96%)로 나타났다. 분산성분 추정치의 결과에 의하면, 모든 측정의 오차에 근원이 피험자와 온도에 있는 것을 알 수 있었으며, 이러한 결과를 볼 때, 동일한 온도에서 측정하지 못한 TC, HDL-C, TG 그리고 Lactic acid는 같은 결과를 주지 못할 것으로 사료된다. This study investigates the influence of various Ambient temperatures on the measures of blood lipid and Lactic acid concentration. DT 60 blood analyzer, four different degrees of Ambient temperature (18˚, 22˚, 26˚, 30˚) were used to compute the values of TC, HDL-C, and TG. Also, Lactic acid concentrations were repeatedly obtained. In all analyses, the same blood samples from each of 6 subjects were used to examine the repeatability and reproducibility of the values measured. Data were analyzed using SPSS 11.0 to compute coefficient of variations (CV) and variance components with two-way (4×3) RM ANOVAs and various descriptive statistics. HDL-C, TC, TG and Lactic acid values obtained by the same degrees of Ambient temperature for the 3 repeated samples from the same person under each condition were highly consistent. However, values were inconsistent when measured in different Ambient temperature degrees. The proportion of Subjects Variance components in each variable were HDL-C (65.54%), TC (50.05%), TG (96.70%) and Lactic acid (82.54%). And those for different Ambient temperature were HDL-C (16.64%), TC (15.44%), TG (1.61%) and Lactic acid (5.58%). The analyses of variance component revealed that the main source of error variances were mostly due to the differences in Ambient temperature. Thus, these results suggest that the different degrees of Ambient temperature do not produce the same results in blood lipid and Lactic acid.

장수운동프로그램이 고령여성의 심폐체력과 HDL-C 및 Cystatin C에 미치는 영향

이슬희(Lee, Seul-Hee),박상갑(Park, Sang-Kab),홍가람(Hong, Ga-Ram),김봉조(Kim, Bong-Jo),김은희(Kim, Eun-Hee) 한국체육과학회 2018 한국체육과학회지 Vol.27 No.3

The purpose of this study was to evaluate the effects of cardiorespiratory fitness, HDL-c, and Cys on body mass index (BMI) of 25 or less and control group C was used as an objective index of exercise. The average exercise intensity of the longevity exercise program was “very light” with Borg"s subjective exercise intensity 9-11 for one to four weeks, and “low” for RPG 12-14 for 5 to 12 weeks, Slightly tough, and the following results were obtained. Cystatin C, peak oxygen uptake, and HDL-C were significantly different in the interactions between the groups. There was a significant negative correlation between cystatin C and peak oxygen uptake and HDL-C. Thus, cardiovascular fitness and HDL-c and Cys-C were influenced by exercise intervention after a regular longevity exercise program. Therefore, Cys-C can be used as an objective index of exercise. Based on these studies, it is expected that the longevity exercise program of this study will be used as an exercise program for body composition and physical fitness management of the elderly in the future, and a clear correlation between cystatin C and obesity, physical fitness and blood lipid It is expected to be used as an indicator of health status of the elderly.

제조업 근로자의 공복 시 혈당과 혈청지질 및 비만지표와의 관련성

박승경(Sung-Kyeong Park),조영채(Young-Chae Cho) 한국산학기술학회 2017 한국산학기술학회논문지 Vol.18 No.4

본 연구는 제조업 근로자들의 공복 시 혈당과 혈청지질치(TC, TG, HDL-C, LDL-C) 및 비만지표(BMI, 체지방률, 허리둘레, 허리둘레와 엉덩이둘레의 비)와의 관련성을 검토할 목적으로 시도하였다. 연구는 2015년 1월부터 12월까지의 기간에 한 대학병원 건강검진센터에서 종합건강검진을 받았던 30~59세의 근로자 1,473명을 대상으로 하였다. 자료의 분석은 조사대상자의 공복 시 혈당을 정상군과 비정상군으로 구분하여 혈청지질치 및 비만지표의 평균치를 비교하였고, 성과 연령을 조정한 다중 회귀분석을 통해 공복시 혈당에 영향을 미치는 관련요인을 검토하였다. 연구결과, 조사대상자의 TC, TG, LDL-C, BMI 및 허리둘레는 공복 시 혈당이 정상인 군보다 비정상인 군에서 유의하게 높았고, HDL-C는 공복 시 혈당이 정상군보다 비정상군에서 유의하게 낮았다. 조사대상자의 공복시 혈당치는 TC, TG, LDL-C, BMI 및 허리둘레와 유의한 양의 상관관계를 보였다. 공복 시 혈당에 영향을 미치는 요인으로는 TC, TG, BMI 및 체지방률이 유의한 변수로 선정되었다. 이상과 같은 결과는 제조업 근로자들의 공복시 혈당은 TC, TG, LDL-C와 같은 혈청지질치 및 BMI, 체지방률과 같은 비만지표와 유의한 관련성이 있음을 시사한다. The purpose of this study was to investigate the relationship between the fasting blood sugar and serum lipid levels (TC, TG, HDL-C, LDL-C) and obesity indices (BMI, body fat rates, waist circumference, waist to hip ratio). The study sample consists of 1,473 manufacturing workers aged from 30 to 59 years, who underwent a health check-up at a university hospital during the period from Jan. to Dec. 2015. A data analysis was conducted to classify the subjects into the normal and abnormal groups according to their fasting blood sugar levels depending on the average values of the serum lipids and obesity indices. Multiple regression analyzes adjusted for sex and age were conducted for the factors affecting the fasting blood sugar level. As a result, the Serum TC, TG, LDL-C, BMI and waist circumference were found to be significantly higher in the abnormal fasting blood sugar level group than in the normal one, but the HDL-C was significantly lower in the abnormal group than in the normal one The fasting blood sugar level had a significant positive correlation with the TC, TG, LDL-C, BMI and waist circumference. The TC, TG, BMI and body fat were the significant factors affecting the fasting blood sugar. The above results suggest that the fasting blood sugar and serum lipid levels (TC, TG, HDL-C, LDL-C), obesity indices (BMI, body fat rates, waist circumference, waist to hip ratio) of manufacturing workers are significantly associated with each other.

비타민 C 섭취량이 혈중 지질에 미치는 영향

김영주 부산대학교 병원 암연구소 2006 부산대병원학술지 Vol.- No.20

Background: There are several reports on relationships between ascorbic acid and plasma lipid concentrations. The mechanism of effect of vitamin C on atherosclerosis was postulated. First, vitamin C may prevent oxidative modification of low-density lipoprotein (LDL) and second, vitamin C may have direct effects on the plasma concentrations of lipids. So we studied association between vitamin C intake and plasma lipid concentrations. Methods: 6306 subjects who underwent periodic health examination in a university hospital in Busan from January 2005 to February 2006 were recruited. Body mass index, abdominal circumference, fasting glucose, lipid profile, hs-CRP (high sensitivity C-reactive protein), uric acid, cystatin C were checked. The average daily calorie intake and vitamin C intake were evaluated by food frequency questionnaire. Results: Age, calorie intake, vitamin C intake, body mass index, waist circumference, total cholesterol, LDL-cholesterol and fasting glucose were significantly higher in men than those of women. But HDL-cholesterol was higher in women than in men (P<0.05). According to quartile of vitamin C intake per calorie, triglyceride and HDL cholesterol were significantψ different in the overweight and obese subjects. In the overweight and obese subjects, triglyceride was lower and HDL-cholesterol was higher as vitamin C intake was higher. Conclusions: This study show vitamin C intake may have positive effect on triglyceride and HDL-cholesterol in overweight and obese subjects.