다발성 전이를 동반한 심부 양성 섬유조직구종

심현보 ( Hyun Bo Sim ),김민지 ( Min Ji Kim ),채수열 ( Soo Yuhl Chae ),이원주 ( Weon Ju Lee ),이석종 ( Seok-jong Lee ),김도원 ( Do Won Kim ),장용현 ( Yong Hyun Jang ) 대한피부과학회 2017 大韓皮膚科學會誌 Vol.55 No.5

Some morphological variants of benign fibrous histiocytoma (dermatofibroma) present with distinct clinical features. In particular, atypical, aneurysmal, and cellular fibrous histiocytoma are associated with a significant risk of local recurrence. Furthermore, very rarely, cutaneous fibrous histiocytoma can lead to metastatic disease. Deep benign fibrous histiocytoma is an uncommon and poorly recognized clinical subtype that arises in subcutaneous or deep soft tissue. Deep benign fibrous histiocytoma has many histologic features in common with cellular fibrous histiocytoma. Deep benign fibrous histiocytoma recurs in approximately 20% of cases and may rarely metastasize. We report a rare case of deep benign fibrous histiocytoma with metastatic potential in a 38-year-old man who presented with a 2-year history of a recurrent hard mass on his left shoulder. (Korean J Dermatol 2017;55(5):301∼304)

유양동에 발생한 양성 섬유조직구종 1예

김요완,신종근,김진,고태용 대한이비인후과학회 2000 대한이비인후과학회지 두경부외과학 Vol.43 No.8

A clinicohistopathological analysis of cutaneous fibrous histiocytomas of the finger

( Sang-woo Park ),( Jin Park ),( Seok-kweon Yun ),( Han-uk Kim ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2

Background: Cutaneous fibrous histiocytoma is a common, benign skin tumor predominantly occurring on the extremities or trunk. However, cutaneous fibrous histiocytoma on the finger is uncommon. Objectives: This study was undertaken to examine the clinicohistopathologic features of cutaneous fibrous histiocytoma of the finger. Methods: This is a retrospective study of 12 cutaneous fibrous histiocytomas located on fingers in a tertiary hospital in Korea. All case slides were retrieved from saved files for diagnostic verification. Results: Cutaneous fibrous histiocytomas of the finger affected 9 to 48 year-olds in a 1.4:1 male to female ratio. Picker’s nodule or wart was the most common clinical diagnosis. In only 2 out of the 12 cases was the pre-biopsy diagnosis of cutaneous fibrous histiocytoma ventured. Fibrocollagenous type was the most common histologic type. Majority of cases were mitotically inactive, exhibiting only 0-1 mitoses per 10 high power field and there was no recurrence. Tumor cells were uniformly CD34 negative. Conclusion: Because cutaneous fibrous histiocytoma can resemble malignancies including dermatofibrosarcoma protuberans, a lack of familiarity with the occurrence of cutaneous fibrous histiocytoma of the finger may lead to more aggressive treatment. Dermatologists should include cutaneous fibrous histiocytoma in their differential diagnosis of circumscribed nodules on the fingers to ensure proper management.

전두사골동에 발생한 양성 섬유성 조직구종 1예

임영환,이영택,이창기,김성완 대한이비인후과학회 2001 대한이비인후과학회지 두경부외과학 Vol.44 No.9

비배부에 발생한 양성 섬유성 조직구종 1예

조인지,허성재,전범수,김정수 대한비과학회 2010 Journal of rhinology Vol.17 No.2

Fibrous histiocytoma usually develops indiscriminately in skin and any soft tissues of the body. To date, tumors occurring in soft tissues of the head and neck, especially around the nose, have been rarely reported. In most cases, benign fibrous histiocytoma develops as a painless mass lesion and most commonly originates in sun-exposed skin, extremities, and orbital tissue. Recently, we experienced a case of benign fibrous histiocytoma in the nasal dorsum in a 36-year-old woman who complained of a mass in the nasal dorsum. To the best of our knowledge, this is the first reported case of benign fibrous histiocytoma originating in the nasal dorsum in a Korean.

상악 치은에 발생한 양성 섬유성 조직구종에 대한 증례 보고

박상준,정지아,서고은,송준호 대한구강악안면병리학회 2010 대한구강악안면병리학회지 Vol.34 No.3

Benign fibrous histiocytomas that is also known asDermatofibroma,Fibrous dermatofibroma, andFibrous histiocytoma are benign skin growths. They are composed of disordered collagen laid down by fibroblasts. In rare cases, basal cell carcinoma may develop in that. Benign fibrous histiocytomas of bone are unusual neoplasms that often are confused with metaphyseal fibrous defects. It is an uncommon neoplasm of the Head and Neck region. It is a rare and usually painless oral tumor. Several cases were reported in mandible, but few in maxilla, especially in maxillary gingiva. We are reporting a case of Maxillay gingival.

Case Reports : Deep Penetrating Benign Fibrous Histiocytoma of the Foot Associated with Throbbing Pain

( Ji Min Chung ),( Sun Nam Koong ),( Ji Hyun Sim ),( Joong Sun Lee ),( Seung Phil Hong ),( Myung Hwa Kim ),( Byung Cheol Park ) 대한피부과학회 2011 Annals of Dermatology Vol.23 No.2s

Compared to cutaneous benign fibrous histiocytoma (BFH), deep-seated BFH is very rare and poorly recognized. Both cutaneous and deep-seated BFH are usually asymptomatic. We herein report a 25 year-old woman who presented with a painful mass in her foot that was poorly controlled by analgesics and associated with walking difficulty. After preoperative ultrasonographic evaluation, the mass was completely excised and histologic exam showed spindle cells loosely arranged in storiform architecture, with CD34-, desmin-, S-100-, focal CD68+, vimentin+, smooth muscle actin+, and factor XIIIa+. The patient was diagnosed with deep-seated BFH based on the histologic, radiologic and intraoperative findings. (Ann Dermatol 23(S2) S239~S242, 2011)

비전형적인 임상 양상을 보인 심부 동맥류성 양성 섬유조직구종 1예

김경오,김예슬,배유인,박영립,조문균,이상훈 대한피부과학회 2014 大韓皮膚科學會誌 Vol.52 No.11

피부 양성 섬유조직구종(cutaneous benign fibrous histiocytoma)은 피부섬유종(dermatofibroma) 또는 경화 혈관종 (sclerosing hemangioma)이라고도 불리는 비교적 흔한 피부연조직 종양으로 성인 여성의 하지에 갈색 혹은 적갈색을 띤 단일 결절의 형태로 호발하며, 병리조직학적으로 섬유모세포, 조직구, 혈관의 증식이 주로 진피내에 국소적인 형태로 나타난다1,2. 구성하는 세포 및 위치 등 특징적인 조직학적 소견에 따라 세포성(cellular), 비정형성(atypical), 상피모양(epitheloid), 동맥류성(aneurysmal), 하부(deep) 및 여러 가지 변형들이 보고되었으며 드물게 이들 변형 중 둘이상의 변형이 한 병변 내에서 함께 관찰되기도 한다3. 19세 여자 환자가 왼쪽 상완에 발생한 촉지되는 색소성 결절을 주소로 내원하였다. 약 2년 전에 왼쪽 어깨에 갈색의 색소침착이 발생하였고 자각증상이 없어 그대로 방치하였으나 2개월 전부터 크기가 갑자기 커져 결절 형태로촉지되었고 압통을 동반하였다. 환자는 평소에 앓고 있던기저 질환이나 복용 중인 약물은 없었으며, 외상의 과거력도 없었다. 피부 소견 상 왼쪽 상완에 직경 2.5 cm의 경계가 불분명한 멍든 것 같은 옅은 갈색의 색소 반으로 중심부에는 진한 갈색의 색소침착이 있었다(Fig. 1). 촉진 시비교적 단단한 피하지방 결절의 형태로 압통이 있었다. 피부 병변에서 실시한 병리조직학적 소견에서 표피는 과각화증과 가시세포증을 보였고, 하부진피와 피하지방층에 걸쳐 주위와 경계가 불분명한 세포증식과 색소침착 소견 보였다(Fig. 2A, B). 병변의 중앙부에는 다수의 혈액이 차있는 낭종성 공간이 관찰되었으나, 그 둘레로 내피세포는 관찰되지 않았으며, 방추형 섬유아세포와 포말형 세포질이나 헤모시데린을 함유한 조직구 그리고 거대세포들이 다수 관찰되었다(Fig. 2C). 면역조직화학적 소견에서 종양은 CD68에는 양성 소견을 보였으며, SMA, Melan A, CD34, Factor VIII에는 음성 소견을 보였다. 이상의 임상 및 병리조직학적 소견을 바탕으로 심부 동맥류성 양성 섬유조직구종으로 진단하였고, 외과적 절제술로 제거하였으며, 현재까지 추적 관찰 중으로 아직까지 재발의 소견은 없다. 동맥류성 양성 섬유조직구종(aneurysmal benign fibrous histiocytoma)은 모든 섬유조직구종의 1.7%를 차지하는 드문 변형으로4, 1981년 Santa cruz와 Kyriakos1가 임상 및 병리조직학적 소견이 일반적인 양성 섬유조직구종과 분명히 구별되는 변형으로 처음 기술하였다. 동맥류성 양성 섬유조직구종이 일반적인 섬유조직구종과 다른 임상적 특징으로 대개 크기가 더 크고, 색소 침착을 보이며, 종양 내부의 출혈로 인해 급격한 성장을 보인다는 점이 있다4. 따라서 환자들은 대개 갑작스런 크기의 증가나 색깔의 변화를 주소로 내원한다. 현재까지 동맥류성 양성 섬유조직구종은 국내 문헌에서는 총 3예가 보고되었으나, 3예 모두가 주위와의 경계가 명확하게 구분되는 원형 또는 둥근 지붕모양의 돌출형 결절성 종양이었으며, 병리조직학적 소견에서도 종양은 진피내 종양 형태로 관찰되었다. 문헌검색상 피하지방층에 위치한 심부 동맥류성 양성 섬유조직구종 단독보고는 국내외에서 보고를 찾을 수 없었으며, 양성 섬유조직구종의 분석 보고에서 일부 유사한 형태에 대한 보고가 있었으나 표피 및 진피 내 병변이 함께 있었는지 본 증례와 같이 주로 피하지방층에만 위치 했었는지는 확인하기 어려웠다2,5. 본 증례는 임상적으로 표피 변화가 거의 없는 피하지방성 결절의 형태이고, 병리조직학적으로 주로 피하지방층에 위치하는 하부 양성 섬유조직구종의 형태로 나타났다는 점에서 현재까지 보고된 동맥류성 양성 섬유조직구종과 차이점이 존재한다. 이에 저자들은 좌측 상완에 발생된 비전형적인 임상 양상을 보인 심부 동맥류성 양성섬유조직구종 1예를 경험하고 임상적으로 드문 예라 생각하여 문헌고찰과 함께 보고한다.

P199 A clinical and histopathological study of 117 cases of dermatofibroma (benign fibrous histiocytoma)

( Seung Gi Hong ),( Seungwoo Lee ),( Sungeun Song ),( Eunphil Heo ),( Kiwoong Ro ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2

<div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div> Background: Dermatofibroma (DF) is one of the most common benign soft tissue tumors. Various variants of DFs have been described, and it is important to concern the variants of DFs for accurate diagnosis. Objectives: We aimed to evaluate the clinical and histological characteristics of DF by single center review from Eastern Gyeongnam Province. Methods: We retrospectively reviewed the medical records and biospy specimens from 156 patients who were diagnosed with DF in the Samsung Changwon Hospital between Jan 2006 and Dec 2015. Results: From 156 patients, 188 lesions were diagnosed as DFs by biopsy. Among them, only 117 lesions were available for slide review. Among 188 cases, 133 and 46 cases were diagnosed in the Department of Dermatology and Department of Plastic Surgery, respectively. Eighteen lesions (9.6%) were misdiagnosed as other diseases, mostly epidermal cyst. Median age of all patients was 37 years. DFs were more common in women by 2.1 times. The most common site of DF was the lower limb (51%). Eleven lesions (5.9%) were recurrent lesions. Three lesions 1.6%) were associated with trauma. In slide reviews of 117 lesions, the histological variants such as fibrous histiocytoma (90%), aneurysmal (5.1%), cellular (1.7%), epithelioid (0.9%), deep (0.9%), and mixed type (1.7%) were found. Conclusion: In the current study, histological variants were commonly found in DFs from the patients in Eastern Gyeongnam Province. Therefore, caution is necessary to avoid misdiagnosis of DFs.

Benign fibrous histiocytoma with cystic change of the femur; a case report

박정아,문승규,김나라 대한자기공명의과학회 2016 Investigative Magnetic Resonance Imaging Vol.20 No.4

Benign fibrous histiocytoma (BFH) is a rare benign primary skeletal tumor that occurs commonly in the long bones, spine and pelvis. BFH constitutes a diagnostic challenge because it shares clinical background, radiological characteristics, and histological features with other fibrous lesions such as non-ossifying fibroma, giant cell tumor. We present a case of BFH with cystic change that occurred in the distal femur. We did not identify any case of BFH with cystic change involving the majority of the lesion that occurred in the metaepiphysis of the long bone.