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( Chanwon Lee ),( Junouk Ha ),( Jayoung Park ),( Seongho Choi ),( Heeseung Park ),( Jaeseung Lee ),( Seungheon Lee ),( Younghwan Lee ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: To investigate the relationship between markers of overall glucose exposure, postprandial glucose excursions and glycemic variability in patients with type 2 diabetes mellitus (T2DM). Methods: Sixty three patients with T2DM (mean age of 56 years) were enrolled, and all wore a continuous glucose monitoring system (CGMS) for 72 hours. We investigated the interrelationships between markers of overall glucose exposure, markers of postprandial glucose excursions and glycemic variability parameters from a CGMS. Results: Spearman`s correlation analysis revealed a signifi cant correlation between all markers of overall glucose exposure and various parameters related to glucose excursion. Percent coeffi cient of variation (CV) showed the strongest correlation with the GA (r = 0.470, p < 0.01). In participants with HbA1c levels < 7.5% (n = 33), almost all of glycemic markers and glycemic variability parameters were signifi cantly correlated with each other. All postprandial glucose excursion parameters also showed signifi cant correlation with other glycemic markers. In participants with HbA1c levels < 7.5% (n = 33), all markers of overall glucose exposure showed signifi cant interrelationships with mean glucose, postprandial glucose excursion and glycemic variability parameters (except CV). However, in participants with HbA1c levels = 7.5% (n = 30), postprandial glucose excursion and glycemic variability parameters were not related with any chronic glycemic marker. Conclusions: The postprandial glucose excursions may explain the glycemic variability and the total glucose exposures in well-controlled diabetic participants.
Lee, Seoyoung,Lee, Seunghyun,Jo, Hyunjin,Bae, Sangki,Kim, Kimin,Song, Jiho,Cho, Younghwan,Kim, Jinsung,Ahn, Hyungsoo,Yang, Min 한국물리학회 2016 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol. No.
<P>The growth temperature dependence of self-aligned beta-Ga2O3 nanostructures grown on an r-plane sapphire substrate by using metal-organic chemical vapor deposition is reported. Periodic self-alignment of the beta-Ga2O3 grains was observed for certain growth temperature windows and the grain size of the beta-Ga2O3 structure varied in response to the growth temperature. At temperatures under 800 A degrees C, self-alignment of the beta-Ga2O3 structures was not observed. The self-alignment tendency began to appear at 900 A degrees C, and obvious self-alignment characteristics in a certain direction were observed at approximately 950 A degrees C. However, as the growth temperature was increased to more than 900 A degrees C the growth mode of the beta-Ga2O3 structure gradually deviated from the self-alignment mode, finally exhibiting a two-dimensional thin film mode at 1100 A degrees C. We surmise that the driving force of beta-Ga2O3 grain self-alignment is the surface-potential difference between the planar and the step regions of the substrate on an atomic scale, which originates from misorientation occurring during the r-plane sapphire cutting process.</P>
Interaction Effects between Ownership Concentration and Leverage on Firm Performance
Younghwan Lee,Sooyee Lee KINFORMS 2014 Management Review Vol.9 No.1
This paper examines the relationship between ownership structure and capital structure on firm performance. Both direct and moderating effects are examined. In this paper, we posit, as a primary relationship, a significant association between ownership concentration and firm performance and then examine whether the level of leverage moderates this relationship. Using a sample of 1827 observations listed on the Korean Stock Exchange (KSE) from 2010 to 2012, the paper finds that ownership concentration has a significant negative effect on firm performance. By using hierarchical regression analysis we further find that the level of leverage has a significant interaction effect on the relationship between ownership concentration and firm performance. Firms with a low level of ownership concentration and lower leverage have better firm performance than firms with a high level of ownership concentration and higher leverage. We conclude that the negative relationship between ownership concentration and firm performance is weaker for firms with higher leverage compared to the firms with lower leverage.
Translocator protein (TSPO): the new story of the old protein in neuroinflammation
( Younghwan Lee ),( Youngjin Park ),( Hyeri Nam ),( Ji-won Lee ),( Seong-woon Yu ) 생화학분자생물학회(구 한국생화학분자생물학회) 2020 BMB Reports Vol.53 No.1
Translocator protein (TSPO), also known as peripheral benzodiazepine receptor, is a transmembrane protein located on the outer mitochondria membrane (OMM) and mainly expressed in glial cells in the brain. Because of the close correlation of its expression level with neuropathology and therapeutic efficacies of several TSPO binding ligands under many neurological conditions, TSPO has been regarded as both biomarker and therapeutic target, and the biological functions of TSPO have been a major research focus. However, recent genetic studies with animal and cellular models revealed unexpected results contrary to the anticipated biological importance of TSPO and cast doubt on the action modes of the TSPO-binding drugs. In this review, we summarize recent controversial findings on the discrepancy between pharmacological and genetic studies of TSPO and suggest some future direction to understand this old and mysterious protein. [BMB Reports 2020; 53(1): 20-27]
Analysis and Design of Rod Extractor and Cutter for Spent Fuel Assembly Dismantling in Head-End
Younghwan Kim,SunSeok Hong,Seckmin Hong,JuHo Lee,JaeWon Lee,ChangHwa Lee 한국방사성폐기물학회 2023 한국방사성폐기물학회 학술논문요약집 Vol.21 No.1
An important goal of dismantling process is the disassembling of a spent nuclear fuel assembly for the subsequent extraction process. In order to design the rod extractor and cutter, the major requirements were considered, and the modularization design was carried out considering remote operation and maintenance. In order to design the rod extractor and cutter, these systems were analyzed and designed, also the concept on the rod extraction and cutting were considered by using the solid works tool. The main module consists of five sub-modules, and the function of each is as follows. The clamping module is an assembly fixing module using a cylinder so that the nuclear fuel assembly can be fixed after being placed. The Pusher module pushes the fuel rods by 2 inches out of the assembly to grip the fuel rods. The extraction module extracts the fuel rods of the nuclear fuel assembly and moves them to the consolidation module. The consolidation module collects and consolidates the extracted fuel rods before moving them to the cutting device. And the support module is a base platform on which the modules of the main device can be placed. The modules of level 2 can be disassembled or assembled freely without mutual interference. For the design of fuel rods cutter, the following main requirements were considered. The fuel rod cut section should not be deformed for subsequent processing, and the horizontally mounted fuel rods must be cut at regular intervals. The cutter should have the provision for aligning with the fuel rod, and the feeder and transport clamp should be designed to transfer the fuel rods to the cutting area. The main module consists of 6 sub-modules, and function of each is as follows. The cutting module is a device that cuts the fuel rods to the appropriate depth for notching. The impacting module is a device that impacts the fuel rods and moves them to the collection module. The transfer module is a device that moves the fuel rods to the cutting module when the aligned fuel rods enter the clamp module. The clamping module is a device to clamp the fuel rods before moving them to the cutting module. The collection module is a container where the rod-cuts are collected, and the support module is a base platform on which the modules of the main device can be placed. The module of level 3 can be disassembled or assembled after the cutting module of level 2 is installed, and the modules of level 2 can be disassembled or assembled freely without mutual interference.
Oxidation-resistant titanium carbide MXene films
Lee, Yonghee,Kim, Seon Joon,Kim, Yong-Jae,Lim, Younghwan,Chae, Yoonjeong,Lee, Byeong-Joo,Kim, Young-Tae,Han, Hee,Gogotsi, Yury,Ahn, Chi Won The Royal Society of Chemistry 2020 Journal of Materials Chemistry A Vol.8 No.2
<P>Two-dimensional transition metal carbides (MXenes) have attracted much attention due to their excellent electrical conductivity and outstanding performances in energy storage, telecommunication, and sensing applications. It is known that MXene flakes are readily oxidized in either humid air or aqueous environments. While the chemical instability of MXenes may limit their use in applications involving ambient environments and long-term operation, oxidation behaviour of MXene films has not been addressed. In this work, we demonstrate a hydrogen annealing method to increase the oxidation stability of Ti3C2 MXene in two different aspects: (1) dramatic improvement in the oxidation stability of pristine MXene films against harsh conditions (100% relative humidity, 70 °C), and (2) large recovery in the electrical conductivity of previously oxidized Ti3C2 MXene films. We also demonstrate an electric-field-induced heater capable of stable operation under highly oxidizing conditions, based on the oxidation-resistant MXene film. A total loss of heat generation ability was observed for the as-prepared MXene film, while the hydrogen-annealed one maintained its bright infrared radiation, under the highly oxidizing conditions. This work offers a solution to industrial applications of unprotected MXene films, securing their stable and long-term operation in humid conditions.</P>
Analysis and Design of Down Ender and Dismantler for Spent Fuel Assembly Dismantling in Head-End
Younghwan Kim,SunSeok Hong,Seckmin Hong,JuHo Lee,JaeWon Lee,ChangHwa Lee 한국방사성폐기물학회 2022 한국방사성폐기물학회 학술논문요약집 Vol.20 No.2
Dry head end process is developing for pyro-processing at KAERI (Korea Atomic Energy Research Institute). Dry processes, which include disassembling, mechanical decladding, vol-oxidation, blending, compaction, and sintering shall be performed in advance as the head-end process of pyro-processing. Also, for the operation of the head-end process, the design of the connecting systems between the down ender and the dismantling process is required. The disassembling process includes apparatus for down ender, dismantling of the SF (Spent Fuel) assembly (16×16 PWR), rod extraction, and cutting of extracted spent fuel rods. The disassembling process has four-unit apparatus, which comprises of a down ender that brings the assembly from a vertical position to a horizontal position, a dismantler to remove the upper and bottom nozzles of the spent fuel assembly, an extractor to extract the spent fuel rods from the assembly, and a cutter to cut the extracted spent fuel rods as a final step to transfer the rod-cuts to the mechanical decladding process. An important goal of dismantling process is the disassembling of a spent nuclear fuel assembly for the subsequent extraction process. In order to design the down ender and dismantler, these systems were analyzed and designed, also concept on the interference tools between down ender and dismantler were considered by using the solid works tool.