조기 후두암의 Docetaxel-Cisplatin 유도 화학요법에 대한 임상연구

정주섭,권보란,최영진,왕수건,이병주,조군제 부산대학교 병원 암연구소 2009 부산대병원학술지 Vol.- No.25

한국어판 예일 틱 증상 평가척도 : 신뢰도 및 타당도 연구

정선주,이정섭,유태익,구영진,전성일,김봉석,홍강의 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.5

목 적 : 틱 증상의 심한 정도를 평가하기 위한 도구인 예일 틱 증상 평가척도(Yale Global Tic Severity Scale)를 한국판 가정 평가용 설문지 및 임상 평가용 척도로 개발하기 위하여 본 연구를 시행하였다. 방 법 : 예일 틱 증상 평가척도는 뚜렛 장애 및 기타 틱 장애에서 나타나는 운동틱과 음성틱 각각의 증상의 수, 빈도, 심한 정도, 복합성, 방해 정도 및 장해도를 포괄적으로 평가하도록 고안되어져 있다. 틱 증상을 주소로 정신과외래를 방문한 만 4.3세에서 19세까지의 100명의 환아 및 부모들을 대상으로 한국어로 번역한 예일 틱 증상 평가척도의 가정평가용 설문지를 평가전에 완료하도록 한 후, 면담을 통한 임상평가용 척도를 실시하였으며 수렴타당도 및 변별타당도의 검증을 위해 총괄적인 임상 인상척도-뚜렛 증후군, 강박장애, 주의력결립/과잉운동장애(Clinical Global Impression-TS, OCD, ADHD)를 시행하였다. 결 과 : 자료분석결과 내적일치도, 수렴타당도, 변별타당도 및 검사자간 신뢰도 모두 매우 높게 나타났으며 요인분석상 전 항목척도와 장해도는 운동틱과 음성틱에 해당하는 2개의 요인으로 묶여졌다. 결 론 : 본 연구결과 한국판 예일 틱 증상 평가척도의 높은 타당도 및 신뢰도가 입증되었으며 이는 향후 틱 증상의 객관적인 평가 및 정량화를 위해 유용하게 사용되어질 수 있을 것이다. Objectives : This study was carried out to develop the Korean form of Yale Global Tic Severity Scale(YGTSS)-family & clinical rating version. The severity of motor and phonic tics was rated according to five separate dimensions : number, frequency, intensity, complexity, and interference. Methods : The Korean form of YGTSS was applied to 100 children who visited psychiatric outpatient clinic with chief complaints of tic symptom. Together with YGTSS, Clinical Global Impression for Tourette's syndrome(CGI-TS), Obsessive-Compulsive disorder(CGI-OCD), Attention-Deficit/Hyperactivity Disorder(CGI-ADHD) were administered to all subjects for examining convergent and discriminant validities. Results : We could confirm high internal consistency, convergent and discriminant validities and interrater reliability of YGTSS by analysing data from 100 children with tic disorder. In factor analysis, items were clustered to 2 factors which were identical to motor and phonic tic subscales. Conclusion : The results of this study indicate the Korean form of YGSS is a reliable and valid rating scale for rating tic symptom severity. It can be used to evaluate tic symptom objectively and to quantify the tic severity in the studies for tic disorder.

山地利用面에서 본 墓地制度 改善方案

孫英模,麻鎬燮,鄭永觀 慶尙大學校 1990 論文集 Vol.29 No.1

The demand and supply of land are to be steadily increasing as the population is mounting and the social, economic and indusrial development gradually grows. Therefore the effcient use of land becomes one of the most important issues for the national development and social welfare. Our country composed of forests with 65%, this potential value brings us unbonded benefit. The use of land for the graveyard, however, has suggested the very important social problem althought it occupies 2% of the forest land area. In view of this situation this paper was attempted to suggest the improvements for the issues of grave system in Korea. The improvements are following: 1. Reformation of national sene 2. Reduction of large scale of graveyard. 3. Urgent recovery of the effectiveness of the provision of the law which proved a dead letter. 4. The establishment fo park cemetery, and the amendment and supplements of the standard for the facilities. 5. Expulsion of a private graveyard of natural men. 6. Expansion of buring and cremation establishment. In conclusion ,the contents of kind of reform measures have the contents of being able to be practiced at once . and the contents of which requires the establishment of long term planning and practice also exist. Such things are complexly formed and we have to practice them with the continuous interest. and thus the relation between the living person and the dead person is not concerned to the loss which is given to the living person one sidely. but the living person and dead person hereby coexit.

전자상거래를 통한 국내 인터넷 쇼핑몰 업체들의 기대 이득과 경쟁전략

장시영,이정섭 한국경영과학회 2000 經營 科學 Vol.17 No.3

The widespread diffusion of internet has enabled companies to conduct business in quite a different way. Marketing on the internet becomes more important as firms adopt electronic commerce as a means to implement competitive strategies. One hundred and four B2C shopping mall companies responded to an e-mail and web server survey about the anticipated benefits of electronic commerce and related strategies. The survey also asked about improvements in value chain activities and impediments to the implementation of electronic commerce in Korea. The results indicated that Korean shopping mall companies followed differentiation strategy significantly more than the other two strategies. In addition, six benefits factors were drawn from this study - information, productivity, cost savings, customers, management information, and applications. Productivity factor was related to cost leadership strategy, and customers factor was related with cost leadership, differentiation and focus strategies. Several benefits factors were also correlated with value chain activity improvements. The results of this study were compared with those of research conducted in the United States.

山林의 公益的 機能 平價에 관한 考察

麻鎬燮,孫英模,金義庚,鄭永觀 慶尙大學校 1990 論文集 Vol.29 No.1

This study was carried out to estimate and evaluate the public function of forest resoruces, such as soil runoff control, landslide control, head-wsater conservation. purification of air (O? production and CO? purification ), sanitary andoutdoor recreation andwildlife protection for the forest land of 6.500.000 ha in Korea. The results obtaiend were as follows; 1 The function of soil runoff control was estimated to b e1.970million m?.its monetary value was appraised at 3.814.5 billion wons. 2.The function of landslide control was estimated to be 37.876 thousand m?its monetary value was appraised at 73.3 billion wons. 3. The function of head-water conservation was estimated to be 25.507million tons, its monetary value was appraised at 3.571.0 billion wons. 4.The production fo O? in the forest land was estimated to be 78.600 thousand tons,its monetary value was appraised at 3.930.0billion wons. 5.The volume of CO? absorbed in the forest land was estimated to be 94.320 thousand tons,its monetary value appraised at 2.204.3 billion wons. 6.The monetary value of outdoor recreation was appraised at 1.162.5 billion wons. 7.The phytoncide emmited in the forest land was estimated to be 1.954 thousand tons,the function of forest bath using phytoncide was appraised at 1.953.9 billion wons. 8.The monetary value of the functions of wildife protection, control of harmful insect control of tree growth and loss control of timber qality was appraised at 327 1 billion wons. In conclusion, the value of public functions of forest is more 23 times than that of the econmic function. production value of forest products, and comes to 14% of GNP. And also, the function of air purification.and and soil conservation has value than those of others. Particulary, it takes a more great deal of effort achiving the various works such as erosion control, establishment of recreation forest. management of reserved natural forest and afforestation of street tree for increasing of public functions.

초기계태에서 valproic acid에 의한 신경관 기형 : 입체현미경적 관찰

김동호,조무연,정유남,최영주,이종선,민경수,이무섭 충북대학교 의학연구소 2000 忠北醫大學術誌 Vol.10 No.1

연구목적 ' 항경련제인 valproic acid가 초기계태의 신경관 형성에 영향을 주는 기형유발에 대해 입체현미경하에서 관찰하였다 연구재 료 및 방법 : 백색의 Leghorn의 신선한 수정란을 30-35시간 동안 배양하여 Hamburger & Hamilton 기 5-10기의 초기 계태를 천공 필터를 이용하여 분리하여 6-30시간 동안 CO2 세포 배양기에서 배양하였고 무작위로 대조군과 실험군을 분류하였다. 실험군은 valproic acid 의 RPMI culture media 의 농도에 따라 100 ㎍/㎖, 200 ㎍/㎖, 500 ㎍/㎖, 1000 ㎍/㎖ 네가지 군으로 분리하였다. 각각의 대조군과 valproic acid를 처치한 실험군에서 입체 현미경하에서 초기계태의 신경관 형성의 형태학적인 특징과 기형형성의 빈도를 비교하였다. 결과: valproic acid가 없는 RPMI media에서 배양된 대조군은 24개의 계태는 22(91.7%)개는 정상으로 자랐으며 2(8.3%)개는 비정상으로 자랐다 이에 반하여 valproic acid가 처치된 RPMI media에서 배양된 72개의 계태는 42(58.3%)개가 비정상으로 자랐다. 주로 확인된 이상 형태는 신경주름의 변형. 신경관 폐쇄부전, 체절의 장애 및 발육 정지 등 이었다. 계태의 기형 형성은 valproic acid의 농도에 비례하여 증가하였다. valproic acrid 의 농도가 100 ㎍/㎖인 경우 18개 계태 중 2(11.1%)개에서 경미한 신경관 기형이 나타났으며 200 ㎍/㎖인 경우 18개 계태 중 11(61,1%)개는 정상, 7(38.9%)개는 명백한 신경관 기형이 나타났으며 500 ㎍/㎖인 경우 18개의 계태 중 5(27.8%)개는 정상. 13(72.2%)개는 명백한 신경관 기형을 나타냈다. 1000 ㎍/㎖인 경우 18(100%)개 모두 심한 신경관 기형이 나타났다. 결론: valproic acid는 초기계태에서 신경관 기형을 유발 했는데 저농도에서는 일부 경미한 신경관 이상을 보였고 고농도에서는 대부분 심한 신경관 손상을 동반하고 성장 속도가 둔화되어 약 용량의 증가에 따라 기형이 증가되는 dose-dependent manner 로 그 영향이 나타났다. Purpose : The teratogeruc effects of valproic acid widely used as anticonvulsant on the neurulation of the explanted eraly chick embryos were observed by the stereoscope. Materials and Methods: Fresh fertilized white leghorn hen eggs were incubated for 30-35 hours in an e99 incubator. The Hamburger and Hamilton stage 5-10 chick embryos were explanted using the punched-out filter paper explantation technique and cultured in the CO2 cell culture incubator for 6-30 hours. They were randomly divided into a control group and an experimental group. The experimental group was divided into four subgroups according to the valproic acid concentrations of 100 ㎍/㎖, 200 ㎍/㎖, 500 ㎍/㎖, 1000 ㎍/㎖ with which the RPMI culture media were treated. The morphological characteristics and the incidences of teratogenic effects on the neurulation of early chick embryos in the control and experimental groups were compared with each other using the stereomicroscope. Results : Of the 24 chick embryos cultured in the RPMI media without valproic acrid, 22 embryos(91.7%) developed normally, and 2 embryos (8.3%) developed abnormally, in contrast, among 72 embryos cultured in the valproic acrid-treated media, 42 embryos(58.3%) developed abnormally. The frequent anomalous features were deformities of the neural folds, failure of neural tube closure, derangement of somites, and developmental arrest. Of 18 embryos cultured in the media treated each with 100㎍/㎖ of valproic acid, 2 embryos(11.1%) showed mild abnormality of neural tube defect on stereoscopic examination. Of 18 embryos cultured 7l the media treated each with 200㎍/㎖ of valproic acid, 11 embryos(61.1%) developed normally for 20 hours and 7 embryos (38.9%) showed definite neural tube defect. Of 18 embryos cultured in the media 7reated each with 500㎍/㎖ of vaIprolc acid, 5 embryos(27.8%) developed normally (or 20 hours and 13 embryos (72.2% ) showed definite neural tube defect. Of 18 embryos cultured in the media treated each with 1000㎍/㎖ of valproic acid, 1 embryo developed normally for 4 hours but all embryos (100%) showed severe neural tube defect on whole brain after 8 hours of culture. Conclusion : Valproic acid induced mild neural tube defects in low concentration and in high concentration of valproic acid, most chick embryos developed slowly and showed severe neral tube defects. The frequency and severity of abnormal embryos ulcreased in dose-dependent manner.

동계 난방시 구조체 축열 공조시스템의 축·방열 특성에 관한 연구

임지훈,이시환,차영호,정광섭,이정재 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1

It is the plan that storage gets energy done by in structure with what thermal storage of structure changes only supply air duct among the existing HVAC system, and a basic principle coordinates the damper that it was installed makeup air in supply air duct like former HVAC system to an inside at supply and a night by day, and do makeup air supply with in ceiling space of thermal storage of structure HVAC system. This thermal storage of structure HVAC system uses the existing utility system, and energy saving can get structure of building done with energy storage, before air conditioning and peak load cut getting day heat load done.

Asynchronous Sensor Fusion using Multi-rate Kalman Filter

Young Seop Son(손영섭),Wonhee Kim(김원희),Seung-Hi Lee(이승희),Chung Choo Chung(정정주) 대한전기학회 2014 전기학회논문지 Vol.63 No.11

We propose a multi-rate sensor fusion of vision and radar using Kalman filter to solve problems of asynchronized and multi-rate sampling periods in object vehicle tracking. A model based prediction of object vehicles is performed with a decentralized multi-rate Kalman filter for each sensor (vision and radar sensors.) To obtain the improvement in the performance of position prediction, different weighting is applied to each sensor’s predicted object position from the multi-rate Kalman filter. The proposed method can provide estimated position of the object vehicles at every sampling time of ECU. The Mahalanobis distance is used to make correspondence among the measured and predicted objects. Through the experimental results, we validate that the post-processed fusion data give us improved tracking performance. The proposed method obtained two times improvement in the object tracking performance compared to single sensor method (camera or radar sensor) in the view point of roots mean square error.

Multi-rate Kalman Filter based lane detection method

Young Seop Son(손영섭),Wonhee Kim,Chung Choo Chung(정정주) 한국자동차공학회 2016 한국자동차공학회 부문종합 학술대회 Vol.2016 No.5

Delirium in Patients with Cancer at a Tertiary Hospice Care Unit

( Young Joo Park ),( Young Jin Choi ),( Young Mi Seol ),( Hyo Jeong Kim ),( Ho Jin Shin ),( Joo Seop Chung ) 대한내과학회 2015 대한내과학회 추계학술대회 Vol.2015 No.1

Introduction: Delirium is one of the most common neuropsychiatric complications in patients with terminal cancer and an independent factor of poor prognosis for short-term survival. There were lack of previous studies examining the risk factors, assessment, management, and outcomes of delirium. We investigated the prevalence of delirium, types of delirium, risk factors for delirium, association between delirium occurence and survival, and differences of survival up to delirium types. Methods: We retrospectively reviewed the medical records of 176 cancer patients admitted at a tertiary hospice care unit from Jan. to Dec. 2013. Results: Of the 176 terminal cancer patients, 99 patients (56.2%) experienced delirium. The most common subtype was hypoactive delirium (50.5%). The mortality rate was higher in delirium group than control group (88.9% vs. 62.3%, p 0.001). There were no differences of mean survival time between delirium group and control group (29.58±4.38 vs. 27.12±1.96, p=0.978) and between subtypes of delirium (hyperactive vs. hypoactive vs. mixed type 15.89±2.59 vs. 16.21±2.06 vs. 16.56±2.71, p=0.987). In univariate and multivariate analysis, the use of opioid had independent factor for the development of delirium (HR 4.465, 95% CI 1.039-19.187, p=0.044). Conclusions: Delirium is a frequent complication in terminal cancer and the development of delirium increased the mortality rate. The use of opioid is an independent factor of the development of delirium.