노인주택의 개념과 유형화 연구

이연숙(Lee, Yeunsook),이성미(Lee, Sungmi),김민수(Kim, Minsoo),이유진(Lee, Yoojin),이선민(Lee, Sunmin) 한국생태환경건축학회 2007 한국생태환경건축학회 논문집 Vol.7 No.1

Comparison of CATA, RATA, Flash Profile, Free listing, and Conventional Profiling for the Sensory Profiling of Ready-To-Drink (RTD) Coffee Beverages

Yoojin Jeong,Gyeonghye Yoon,Daeun Kim,Giho Kim,Soa Lee,Juhee Kim,Woonseo Baik,Youngseung Lee 한국식품영양과학회 2022 한국식품영양과학회 학술대회발표집 Vol.2022 No.10

A multichannel neural probe with embedded microfluidic channels for simultaneous in vivo neural recording and drug delivery.

Lee, Hyunjoo J,Son, Yoojin,Kim, Jeongyeon,Lee, C Justin,Yoon, Eui-Sung,Cho, Il-Joo Royal Society of Chemistry 2015 Lab on a chip Vol.15 No.6

<P>Multi-functional neural probes integrated with various stimulation modalities are becoming essential tools in neuroscience to study the brain more effectively. In this paper, we present a new multi-functional neural probe that allows chemical stimulation through drug delivery and simultaneous recording of individual neuron signals through a microelectrode array. By embedding microchannels in silicon using a proposed glass reflow process, we successfully fabricated 40 μm thick silicon neural probes suitable for small animal experiments. The electrochemical impedance spectroscopy confirms that impedance of iridium microelectrodes is low enough (<1 Mω at 1 kHz) to measure neural signals. Flow rate characterization in a 0.9% w/v agarose gel shows the capability to deliver a small volume of drugs (<1 μl) at a controlled flow rate. We demonstrate the viability and potential of this new probe by conducting in vivo experiments on mice. Because of the proposed compact structure, both action potentials of individual neurons and local field potentials (LFP) at the thalamus region of a mouse brain were successfully detected with a noise level of ~30 μVpp. Furthermore, we successfully induced absence seizure by injecting seizure-inducing drugs (baclofen) at a local target region and observed distinctive changes in neural signal patterns. Specifically, spike-wave discharge (SWD), which is an indicative signal pattern of absence seizure, was successfully recorded. These signals were also directly compared to SWD detected after inducing absence seizure through direct injection of baclofen through the abdomen. This work demonstrates the potential of our multi-functional neural probes for use in effective investigation of brain functions and disorders by using widely available mouse models.</P>

Clinical Validation of a Deep Learning-Based Hybrid (Greulich-Pyle and Modified Tanner-Whitehouse) Method for Bone Age Assessment

Lee Kyu-Chong,Lee Kee-Hyoung,Kang Chang Ho,Ahn Kyung-Sik,Chung Lindsey Yoojin,Lee Jae-Joon,Hong Suk Joo,Kim Baek Hyun,Shim Euddeum 대한영상의학회 2021 Korean Journal of Radiology Vol.22 No.12

Objective: To evaluate the accuracy and clinical efficacy of a hybrid Greulich-Pyle (GP) and modified Tanner-Whitehouse (TW) artificial intelligence (AI) model for bone age assessment. Materials and Methods: A deep learning-based model was trained on an open dataset of multiple ethnicities. A total of 102 hand radiographs (51 male and 51 female; mean age ± standard deviation = 10.95 ± 2.37 years) from a single institution were selected for external validation. Three human experts performed bone age assessments based on the GP atlas to develop a reference standard. Two study radiologists performed bone age assessments with and without AI model assistance in two separate sessions, for which the reading time was recorded. The performance of the AI software was assessed by comparing the mean absolute difference between the AI-calculated bone age and the reference standard. The reading time was compared between reading with and without AI using a paired t test. Furthermore, the reliability between the two study radiologists’ bone age assessments was assessed using intraclass correlation coefficients (ICCs), and the results were compared between reading with and without AI. Results: The bone ages assessed by the experts and the AI model were not significantly different (11.39 ± 2.74 years and 11.35 ± 2.76 years, respectively, p = 0.31). The mean absolute difference was 0.39 years (95% confidence interval, 0.33– 0.45 years) between the automated AI assessment and the reference standard. The mean reading time of the two study radiologists was reduced from 54.29 to 35.37 seconds with AI model assistance (p < 0.001). The ICC of the two study radiologists slightly increased with AI model assistance (from 0.945 to 0.990). Conclusion: The proposed AI model was accurate for assessing bone age. Furthermore, this model appeared to enhance the clinical efficacy by reducing the reading time and improving the inter-observer reliability

Untitle-20-5

YooJin LEE 한국색채학회 2021 International Invitation Exhibition of Color Works Vol.- No.-

A Recombinant Escherichia coli Cell Factory for Production of Single- and Multi-element Nanomaterials

Yoojin CHOI,Tae Jung PARK,Doh Chang LEE,Hanwen XU,Sang Yup LEE 한국생물공학회 2023 한국생물공학회 학술대회 Vol.2023 No.10

Egg phospholipids exert an inhibitory effect on intestinal cholesterol absorption in mice

Yoojin Lee,Catherine Y. Han,Minkyung Bae,Young-Ki Park,Ji-Young Lee 한국영양학회 2019 Nutrition Research and Practice Vol.13 No.4

BACKGROUND/OBJECTIVES: Consumption of cholesterol-rich foods, such as eggs, has a minimal effect on circulating cholesterol levels in healthy humans. To gain insight, we investigated whether phospholipids rich in eggs (EPL) interfere with intestinal cholesterol absorption in vivo. MATERIALS/METHODS: To investigate the acute effect of EPL on intestinal cholesterol absorption, male C57BL/6J mice were orally administered with 6, 11, or 19 mg of EPL for three days. We also tested the effect of chronic EPL consumption on cholesterol metabolism in the small intestine and the liver in mice with diet-induced hypercholesterolemia. Male C57BL/6J mice were fed a high fat/high cholesterol (HF/HC; 35% fat, 0.25% cholesterol, w/w) diet for 4 weeks to induce hypercholesterolemia, and subsequently the mice were either fed 0, 0.4 or 0.8% (w/w) of EPL for 6 weeks. RESULTS: Intestinal cholesterol absorption was significantly decreased by the highest dose of acute EPL administration compared to control. Chronic EPL supplementation did not significantly alter intestinal cholesterol absorption nor plasma levels of total cholesterol and low-density lipoprotein cholesterol. In the small intestine and the liver, EPL supplementation minimally altered the expression of genes which regulate cellular cholesterol levels. CONCLUSION: Although chronic EPL consumption was not able to counteract hypercholesterolemia in HF/HC-fed mice, acute EPL administration decreased intestinal cholesterol absorption. This study provides in vivo evidence that acute administration of PLs in eggs prevent cholesterol absorption in the intestine, suggesting a mechanism for a minimal effect of egg consumption on circulating cholesterol levels.

한국 농장동물 수의사의 항생제 신중사용에 대한 인식과 실천

Yoojin Choi,Seola Joo,Sang-Won Lee,Hong-Jae Lee,Myung-Sun Chun 대한수의학회 2023 大韓獸醫學會誌 Vol.63 No.2

Antimicrobial (AM) resistance is a growing threat in human and veterinary medicine, spreading across species and perceived as One-Health issue. Prudent use of AM products is essential in mitigating this risk in both human and veterinary medicine. Farm veterinarians, responsible for prescribing appropriate AM and offering advice to farmers on their proper usage, are regarded as key players in the livestock industry. An online survey of farm veterinarians (n = 1,531) was conducted to assess their educational experience, beliefs, current status of prescription, practical behavior, and self-efficacy regarding the prudent use of antimicrobials (PUA). The data from 170 respondents were analyzed using descriptive statistics, regression and mediation analysis. Participants chose AM based on their experiences, academic resources, and peer veterinarians. Approximately 77% did not routinely conduct antibiotic-susceptibility-test. Most participants believed in the importance of PUA and the role of veterinarians to reduce AM resistance, but they reported a lack of awareness among farmers and insufficient national support interfere with their practical behavior with regard to PUA. Half of the participants had PUA-education, and 78.6% reported that education had a positive impact on their behavior with PUA. Self-efficacy partly mediates the relationship between belief and behavior for PUA, which accounted for 23.77% of the total effect that beliefs have on behavior for PUA. The findings of the study show that enhancing veterinarians’ abilities to practice and their self-efficacy through education tailored to the current status of farms can contribute to the reduction of AMs in the livestock sector.

Considerably improved water and oil washability of highly conductive stretchable fibers by chemical functionalization with fluorinated silane

Lee, Yoojin,Bae, Seonghyun,Hwang, Byungil,Schroeder, Marc,Lee, Yongwoo,Baik, Seunghyun The Royal Society of Chemistry 2019 Journal of Materials Chemistry C Vol.7 No.39

<P>There have been significant improvements in conductive stretchable fibers and fabrics over the last few decades. However, the durability against washing (<I>i.e.</I>, washability) still remains as a challenging issue hindering practical applications for wearable electronics. In this study, the water and oil washability of conductive stretchable nanocomposite fibers were significantly improved by the covalent functionalization with trichloro(1<I>H</I>,1<I>H</I>,2<I>H</I>,2<I>H</I>-perfluorooctyl)silane (FOTS). The highly conductive (∼14 600 S cm<SUP>−1</SUP>) stretchable AgPU fibers were synthesized by the wet spinning technology using flower-shaped silver nanoparticles and polyurethane (PU). The PU surface of the fiber was firstly treated by Ar plasma to induce reactive hydroxyl groups for the covalent binding with the silane molecules. The vapor-phase FOTS deposition was then carried out to synthesize FOTS-AgPU fibers. Both hydrophobicity and oleophobicity significantly improved after the functionalization. There was negligible change in the electrical conductivity, mechanical strength, and rupture strain of the FOTS-AgPU fiber after 8 thorough detergent water washing cycles, demonstrating almost perfect water washability with laundry detergent. The thermal conductivity slightly decreased by 10% since it was more challenging to maintain the phononic thermal transport than the electrical transport. The oil washability was also improved although perfect passivation could not be achieved. The FOTS layer could also be directly functionalized on the AgPU fabric, instead of the AgPU fibers, demonstrating the possibility of facile up-scale post-functionalization. The conductive stretchable fibers and fabric with improved water and oil washability may find immediate applications for wearable electronics.</P>

Impact of statins on risk of new onset diabetes mellitus: a population-based cohort study using the Korean National Health Insurance claims database

Lee, Jimin,Noh, Yoojin,Shin, Sooyoung,Lim, Hong-Seok,Park, Rae Woong,Bae, Soo Kyung,Oh, Euichaul,Kim, Grace Juyun,Kim, Ju Han,Lee, Sukhyang Dove Medical Press 2016 THERAPEUTICS AND CLINICAL RISK MANAGEMENT Vol.12 No.-

<P>Statin therapy is beneficial in reducing cardiovascular events and mortalities in patients with atherosclerotic cardiovascular diseases. Yet, there have been concerns of increased risk of diabetes with statin use. This study was aimed to evaluate the association between statins and new onset diabetes mellitus (NODM) in patients with ischemic heart disease (IHD) utilizing the Korean Health Insurance Review and Assessment Service claims database. Among adult patients with preexisting IHD, new statin users and matched nonstatin users were identified on a 1:1 ratio using proportionate stratified random sampling by sex and age. They were subsequently propensity score matched further with age and comorbidities to reduce the selection bias. Overall incidence rates, cumulative rates and hazard ratios (HRs) between statin use and occurrence of NODM were estimated. The subgroup analyses were performed according to sex, age groups, and the individual agents and intensities of statins. A total of 156,360 patients (94,370 in the statin users and 61,990 in the nonstatin users) were included in the analysis. The incidence rates of NODM were 7.8% and 4.8% in the statin users and nonstatin users, respectively. The risk of NODM was higher among statin users (crude HR 2.01, 95% confidence interval [CI] 1.93–2.10; adjusted HR 1.84, 95% CI 1.63–2.09). Pravastatin had the lowest risk (adjusted HR 1.54, 95% CI 1.32–1.81) while those who were exposed to more than one statin were at the highest risk of NODM (adjusted HR 2.17, 95% CI 1.93–2.37). It has been concluded that all statins are associated with the risk of NODM in patients with IHD, and it is believed that our study would contribute to a better understanding of statin and NODM association by analyzing statin use in the real-world setting. Periodic screening and monitoring for diabetes are warranted during prolonged statin therapy in patients with IHD.</P>