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Lee, Hanbyeol,Park, Jeong-Ran,Kim, Woo Jin,Sundar, Isaac K.,Rahman, Irfan,Park, Sung-Min,Yang, Se-Ran The Federation of American Societies for Experimen 2017 The FASEB Journal Vol.31 No.5
<P>The receptor for advanced glycan end products (RAGE) has been identified as a susceptibility gene for chronic obstructive pulmonary disease (COPD) in genome-wide association studies (GWASs). However, less is known about how RAGE is involved in the pathogenesis of COPD. To determine the molecular mechanism by which RAGE influences COPD in experimental COPD models, we investigated the efficacy of the RAGE-specific antagonist FPS-ZM1 administration in in vivo and in vitro COPD models. We injected elastase intratracheally and the RAGE antagonist FPS-ZM1 in mice, and the infiltrated inflammatory cells and cytokines were assessed by ELISA. Cellular expression of RAGE was determined in protein, serum, and bronchoalveolar lavage fluid of mice and lungs and serum of human donors and patients with COPD. Downstream damage-associated molecular pattern (DAMP) pathway activation in vivo and in vitro and in patients with COPD was assessed by immunofluorescence staining, Western blot analysis, and ELISA. The expression of membrane RAGE in initiating the inflammatory response and of soluble RAGE acting as a decoy were associated with up-regulation of the DAMP-related signaling pathway via Nrf2. FPS-ZM1 administration significantly reversed emphysema in the lung of mice. Moreover, FPS-ZM1 treatment significantly reduced lung inflammation in Nrf2(+/+) , but not in Nrf2(-/-) mice. Thus, our data indicate for the first time that RAGE inhibition has an essential protective role in COPD. Our observation of RAGE inhibition provided novel insight into its potential as a therapeutic target in emphysema/COPD.-Lee, H., Park, J.-R., Kim, W. J., Sundar, I. K., Rahman, I., Park, S.-M., Yang. S.-R. Blockade of RAGE ameliorates elastase-induced emphysema development and progression via RAGE-DAMP signaling.</P>
Sound Analysis in an In Vitro Endotracheal Tube Model
( Young Sik Park ),( Young Wook Kee ),( Kwang Suk Park ),( Jin Woo Lee ),( Sang Min Lee ),( Jae Joon Yim ),( Chul Gyu Yoo ),( Young Whan Kim ),( Sung Koo Han ),( Seok Chul Yang1 ) 대한내과학회 2011 The Korean Journal of Internal Medicine Vol.26 No.4
Background/Aims: Complete endotracheal tube obstruction is a medical emergency, and partial occlusion causes increased breathing rates and failure to wean off mechanical ventilation. Partial occlusion may be underestimated due to the lack of proper detection methods. We tested whether the sound of an endotracheal tube could be used to detect an endotracheal tube obstruction using an in vitro model. Methods: An endotracheal tube was connected to a ventilator on one end and a test lung on the other. Sounds were recorded with a microphone located inside the endotracheal tube via a connector. During mechanical ventilation, we changed the endotracheal tube internal diameter from 5.0 to 8.0 mm and different grades of obstruction at different sites were used along the tube. Sound energy was compared among the different conditions. Results: The energy of endotracheal tube sounds was positively correlated with the internal diameter and negatively correlated with the degree of obstruction. The rate of decline in energy differed with obstruction location. When the obstruction was more distal, the rate of decline in endotracheal sound energy was more rapid. Conclusions: Changes in the sound of an endotracheal tube can be used to detect an obstruction. Further studies are needed for clinical application.
Study of a BALB/c Mouse Model for Allergic Asthma
Yang, Young-Su,Yang, Mi-Jin,Cho, Kyu-Hyuk,Lee, Kyu-Hong,Kim, Yong-Bum,Kim, Jin-Sung,Kang, Myung-Gyun,Song, Chang-Woo Korean Society of ToxicologyKorea Environmental Mu 2008 Toxicological Research Vol.25 No.2
Allergic asthma is a worldwide public health problem and a major socioeconomic burden disease. It is a chronic inflammatory disease marked by airway eosinophilia and goblet cell hyperplasia with mucus hypersecretion. Mouse models have proven as a valuable tool for studying human asthma. In the present report we describe a comparison of mouse asthma models. The experiments were designed as follows: Group I was injected with ovalbumin (OVA, i.p.) on day 1 and challenged with 1% OVA (aerosol exposure) on days $14{\sim}21$. Group II was injected on day 1, 14 and aerosol-immunized on days $14{\sim}21$. Group III was injected on day 1, 14 and immunized by 1% OVA aerosol on days $18{\sim}21$. We assessed asthma induction by determining the total number of white blood cells (WBC) and eosinophils as well as by measuring cytokine levels in bronchoalveolar lavage fluid (BALF). In addition, we evaluated the histopathological changes of the lungs and determined the concentration of immunoglobulin E (IgE) in serum. Total WBC, eosinophils, Th2 cytokines (IL-4, IL-13) and IgE were significantly increased in group I relative to the other groups. Moreover, histopathological studies show that group I mice show an increase in the infiltration of inflammatory cell-in peribronchial and perivascular areas as well as an overall increase in the number of mucus-containing goblet cells relative to other groups. These data suggest that group I can be a useful model for the study of human asthma pathobiology and the evaluation of existing and novel therapeutic agents.
The risk of gastric cancer according to changes in smoking status among Korean men
Sung Keun Park,Min-Ho Kim,Chang-Mo Oh,Eunhee Ha,Eun Hye Yang,Woo Yeon Hwang,Ann Hee You,Jae-Hong Ryoo 한국역학회 2022 Epidemiology and Health Vol.44 No.-
OBJECTIVES Smoking is a risk factor for gastric cancer. Studies have shown that the risk of gastric cancer can vary by smoking status and smoking amount at a single point in time. However, few data have been reported about the effect of changes in smoking status over time on the risk of gastric cancer. METHODS This study collected data from the National Health Insurance Corporation in Korea on 97,700 Korean men without gastric cancer who underwent health check-ups from 2002 to 2013. The smoking status (never smoked, quit smoking, and currently smoking) of study participants was assessed in 2003-2004 and 2009, and the results were categorized into 7 groups: never-never, never-quit, never-current, quit-quit, quit-current, current-quit, and current-current. Participants were followed until 2013 to identify incident gastric cancer. A multivariate Cox proportional hazard model was used to calculate adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for incident gastric cancer according to changes in smoking status and smoking amount (pack-years). RESULTS Compared with group 1 (never-never), participants currently smoking in 2009 (never-current, quit-current, and current-current) had higher HRs for gastric cancer (never-quit: 1.077; 95% CI, 0.887 to 1.306, never-current: 1.347; 95% CI, 0.983 to1.846, quit-quit: 1.086; 95% CI, 0.863 to 1.366, quit-current: 1.538; 95% CI, 1.042 to 2.269, current-quit: 1.339; 95% CI, 1.077 to 1.666, and current-current: 1.589; 95% CI, 1.355 to 1.864, respectively). The risk for gastric cancer was highest in heavy smokers, followed by moderate smokers. CONCLUSIONS In all categories of smoking status, current smoking was associated with the highest risk of gastric cancer. Heavy smoking was associated with an increased risk of gastric cancer, even in former smokers.
Red ginseng extract protects against carbon tetrachloride-induced liver fibrosis
Sung Hwan Ki,Ji Hye Yang,Sae Kwang Ku,Sang Chan Kim,Young Woo Kim,Il Je Cho 고려인삼학회 2013 Journal of Ginseng Research Vol.37 No.1
Korean red ginseng, the processed root of Panax ginseng Meyer, has been frequently used for various therapeutic purposes in oriental medicine. The present study investigated the possible effect of Korean red ginseng extract (RGE) for the treatment of liver fibrosis in mice injected with carbon tetrachloride (CCl4) for 4 wk. Liver injuries were assessed by blood biochemistry and histopathology in mice treated with CCl4 alone or CCl4+ RGE (30, 100, and 300 mg/kg). Concomitant treatment with RGE and CCl4 (three times/wk for 4 wk) effectively inhibited liver fibrosis as evidenced by decreases in plasma alanine and aspartate aminotransferases, as well as by the percentages of degenerative regions, numbers of degenerative hepatocytes, and collagen accumulation in hepatic parenchyma. Treatment with CCl4 for 4 wk increased mRNA levels of transforming growth factor b1 and plasminogen activator inhibitor 1 in fibrogenic liver, whereas RGE (30, 100, and 300 mg/kg) significantly blocked the induction of fibrogenic genes by CCl4. Similarly, RGE also prevented transforming growth factor b1-mediated induction of fibrogenic genes in human hepatic stellate cell lines. More importantly, RGE markedly reduced the number of a-smooth muscle actin-positive cells in liver tissue. This study implies that RGE efficaciously protects against the liver fibrosis induced by chronic CCl4 treatment, and may therefore have potential to treat liver disease.
Yang, C.H.,Song, Y.,Woo, M.S.,Eom, J.H.,Song, G.J.,Kim, J.H.,Kim, J.,Lee, T.H.,Choi, J.Y.,Sung, T.H. Elsevier Sequoia 2017 Sensors and actuators. A Physical Vol.261 No.-
<P>The purpose of this study is designing and examining impact-based piezoelectric road energy harvesters as power sources of a variety of sensors and smart highways. The impact-based piezoelectric road energy harvesters (15 x 15 x 9 cm(3)) developed in this research can convert the input energy efficiently into electrical power. The output power of the proposed harvester is significantly higher than that of the existing harvesters. Moreover, in previous studies, simple experiments were performed for measuring the output power of a road energy harvester, with no consideration for the practical road conditions. In this study, the output power is measured using machines that can simulate the practical road conditions. First, the output power of the harvester is measured using a universal testing machine (UTM) that can apply an axial load with a controlled loading frequency. Then, a third-scale mobile loading simulator (MMLS3) that can simulate practical traffic load on a lab scale is used. As a result, the maximum output power of the road energy harvester is 483 mW(21.47W/m(2)). (C) 2017 Elsevier B.V. All rights reserved.</P>
Systemic lupus erythematosus (SLE) presenting as Stevens-Johnson syndrome
( Sang-jin Cheon ),( Woo-il Kim ),( Min-young Yang ),( Won-ku Lee ),( Tae-wook Kim ),( Sung-min Park ),( Hyun-joo Lee ),( Gun-wook Kim ),( Hoon-soo Kim ),( Byung-soo Kim ),( Moon-bum Kim ),( Hyun-chan 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1
Acute cutaneous lupus erythematosus (ACLE) shows localized eruption like malar rash or generalized form involving diffuse maculopapular erythema. Rarely, ACLE present with Stevens-Johnson syndrome (SJS) / toxic epidermal necrolysis (TEN)-like vesiculobullous eruption in most severe form. A 55-year-old female presented with gradually progressive erythematous maculopatch, blisters, and erosions over face, neck, and trunk for 2 weeks. Erosion and crust were observed in oral mucosa, but ocular and genital mucosa was intact. The patient was diagnosed with SLE 2 months ago and showed gradual improvement of the disease with systemic prednisolone medication. The skin lesion was similar with SJS but no relevant medication had been newly administered. Histopathologic finding showed full thickness epidermal necrosis and dense lymphocytes infiltration in the dermis. Laboratory tests demonstrated thrombocytopenia, low C3 complement, and increased anti-double-stranded DNA that indicated flare up of SLE. Slow progression, sun-exposed distribution with limited mucosal involvement, and laboratory findings indicated that SJS-like skin lesion was not caused by drug, but flare up of SLE in this patient. Herein, we report a rare case of SJS-like SLE and reinforce in a small proportion of SJS patients could be the presentation of flare up of SLE.