데페록사민 전처치가 토끼 심근경색 크기의 감소에 미치는 효과

양관모,오동렬,박승현,박규남,이원재,김형국,황두영,최승필,채장성 대한응급의학회 1998 대한응급의학회지 Vol.9 No.4

Background: Reperfusion of ischemic myocardium has been postulated to result in a specific oxygen radical mediated tissue injury. Iron may liberate during ischemia and we hypothesized that administration of the iron chelator, deferoxamine during ischemia would result in improved recovery after postischemic reperfusion. Purpose: To test whether iron-catalyzed processes contribute to myocardial necrosis during ischemia and reperfusion, deferoxamine was administered to block iron catalyzed hydroxyl radical formation in rabbits. Methods: Eleven rabbits were divided into two groups : control group (n=5) and deferoxamine pretreatment group (n=6). The left circumflex coronay artery was ligated for 30 minutes and reperfused for 180 minutes. Area at risk (AR) was measured by non-stained area with methylene blue injection into left atrium after left circumflex coronary artery ligation. Infarct size was measured by weighing after triphenyltetrazolium chloride staining. Heart rate was measured using electrocardiographic recording and systemic blood pressure was monitored by pressure transducer connected to the catheter in the left ventricle. Results: 1. There was no significant difference of heart rate and blood pressure in deferoxamine pretreatment group compared with control group. 2. There was significant decrease of serum iron concentration after continuous infusion of deferoxamine compared with serum iron concentration before ligation of coronary artery(P<0.05). 3. There was no significant difference of area at risk between control and deferoxamine pretreatment group. 4. Area at necrosis to area at risk was significantly reduced in deferoxamine pretreatment group compared with control group(P<0.05). The results suggest that deferoxamine infusion prior to coronary artery occlusion has a significant benefit in reducing infarct size in this model.

인체에서 방사되는 생물광자(生物光子)에 대한 소고

이승호,김진수,박하준,양준모,소광섭,임사비나 경희대학교 동서의학연구소 2006 東西醫學硏究所 論文集 Vol.2006 No.-

Objectives : The purpose of this study is to review research papers published by Korean research groups on biophoton of human beings based on experiment subject and methodology. Methods : In order to review human biophoton research executed in Korea, all the papers published in Korean and international journals by Korean research groups were selected. Several key foreign papers were also reviewed for clarification of this study. Based on experiment subjects, experiment methodology, and interpretation of experiment results were analyzed. On each experiment, its original interpretation was directly quoted. Issues on the experiment methodology and interpretation were expressed at the end of each subject. Results and Conclusions : We found that experiments on human biophoton were compelling. However it seemed that mom experiments, especially on their sample sizes, ate needed to demonstrate its clinical application. Interpretations based on Korean traditional medicine also need to be elaborated more. In order to do accomplish clinical application of biophoton, interdisciplinary works are required. Some suggestions on biophoton experiments were made.

Primary malignant melanoma of the small intestine

Kwan Mo Yang,Chan Wook Kim,So-Woon Kim,Jong Lyul Lee,Yong Sik Yoon,In Ja Park,Seok-Byung Lim,Chang Sik Yu,Jin Cheon Kim 대한외과학회 2018 Annals of Surgical Treatment and Research(ASRT) Vol.94 No.5

The majority of malignant melanomas in the small intestine are metastases from primary cutaneous lesions, it can also develop as a primary mucosal tumor in the gastrointestinal tract. In this report, we present rare cases of primary small bowel melanoma and review the current literature. A 78-year-old male presented with abdominal pain and CT enterography identified a ileal mass. A 79-year-old female presented with signs and symptoms of partial small bowel obstruction. Abdominopelvic CT and small bowel series revealed a obstructing mass in the distal jejunum. The masses were confirmed on laparotomy and histologically diagnosed as melanoma. Extensive postoperative clinical examination revealed no cutaneous lesions. A primary small bowel melanoma is an extremely rare neoplasm. A definite diagnosis can only be made after a thorough investigation has been made to exclude the coexistence of a primary lesion. Curative resection of the tumor remains the treatment of choice.

The prognostic significance and treatment modality for elevated pre- and postoperative serum CEA in colorectal cancer patients

Kwan Mo Yang,In Ja Park,Chan Wook Kim,Seon Ae Roh,Dong-Hyung Cho,Jin Cheon Kim 대한외과학회 2016 Annals of Surgical Treatment and Research(ASRT) Vol.91 No.4

Purpose: The purpose of this study was to evaluate the prognostic significance of serum CEA (s-CEA) changes in colorectal cancer (CRC) patients with sustained elevated postoperative s-CEA levels. Methods: Between January 1999 and December 2008, 9,380 CRC patients underwent surgery. Curative resection was performed in 1,242 CRC patients with high preoperative s-CEA levels (>6 ng/mL). High s-CEA levels were normalized in 924 patients (74.4%) within 2 weeks from surgery, whereas high s-CEA levels were persistent in 318 patients (25.6%). Patients were divided into 2 groups according to their postoperative s-CEA levels: group 1 (37 patients with a 1-year postoperative s-CEA>6 ng/mL) and group 2 (281 patients with a 1-year postoperative s-CEA≤6 ng/mL). Results: A postoperative recurrence was identified in 24 patients (64.9%) in group 1 and 65 patients (23.1%) in group 2 (P < 0.001). A curative resection after recurrence was performed in 22 patients (33.8%) from group 2, but no patients from group 1 (P = 0.001). The 5-year overall survival and time to recurrence were significantly lower in patients with recurrent cancer in group 1 (P < 0.001). Conclusion: Patients with persistent elevated postoperative s-CEA levels are at high risk for recurrence and a low survival rate. More intensive surveillance of patients with high postoperative s-CEA levels should be mandatory.

Role of Palliative Laparoscopic Bowel Resection in Stage Ⅳ Colorectal Cancer Patients with Unresectable Metastasis

Kwan Mo Yang(양관모),Seok-Byung Lim,Yong Sik Yoon,Chan Wook Kim,In Ja Park,Chang Sik Yu,Jin Cheon Kim 대한종양외과학회 2013 대한임상종양학회 학술대회지 Vol.2013 No.3

Purpose: This study aimed to evaluate short-term and oncologic outcomes of palliative laparoscopic colorectal resection for patients with colorectal cancer with unresectable metastasis compared with open resection.<br/> Methods: From the database for patients who underwent surgery for colorectal cancer in our institution. those with colorectal cancer who underwent palliative bowel resection of tumor during the period from January 2008 to December 2010were included. The outcomes of those with laparoscopic resection were reviewed and was made between patients with laparoscopic and resection.<br/> Results: A total of 248 patients (133 men) were included, and 50 underwent laparoscopic resection. Conversion was required in six patients (12.0%) and the reasons for conversion were fix or bulky tumors. There was no 30-day postoperative mortality in the laparoscopic group. The complication rate after laparoscopic surgery (8.0%) was similar to that after open surgery (13.1%) (p=0.466) The length of postoperative hospital stay in the laparoscopic group was significantly shorter than that in the open group. (6.7 vs 10.3 days; P=0.048). The overall survivals were similar in the two groups.<br/> Conclusions: Compared with open surgery, laparoscopic primary bowel resection for stage Ⅳ colorectal cancer with unresectable metastasis has advantages in the operative outcomes in terms of hospital stay and comparable in the long term oncologic outcomes.

유기용제 흡입중독후 의식소실로 발생한 중증의 저체온증 치유 1례

양관모 ( Kwan Mo Yang ),권태욱 ( Tae Wook Kwon ),김형국 ( Hyung Kook Kim ),박규남 ( Kyu Nam Park ),김세경 ( Se Kyeung Kim ) 대한응급의학회 1997 대한응급의학회지 Vol.8 No.2

A 19-year-old man had a good neurologic recovery from a severe hypothermia(19C) and a prolonged coma following active intemal rewarming. From inhaling hydrocarbons, he was left unconscious on the cold floor for 24 hours. As soon as the patient was brought into the emergency medical center, he was early evaluated and treated aggressively. 'ECG showed Osborn(J) wave on all leads. The temperature of patient was increased by 2-3C per hour through active external rewarming (by heating blankets and warm bag) and active intemal rewarming (by airway rewarming, warmed IV fluids, gastrointestinal tract irrigation, and bladder irrigation). The temperature reached 36C after 6 hours. Active internal rewarming provides rapid core rewarming with the additional benefit of circulatory support during the period of cardiac instability.

절제 불가능한 전이가 동반된 4기 대장암 환자의 고식적 복강경 대장절제

양관모(Kwan Mo Yang),임석병(Seok-Byung Lim),윤용식(Yong Sik Yoon),김찬욱(Chan Wook Kim),박인자(In Ja Park),유창식(Chang Sik Yu),김진천(Jin Cheon Kim) 대한종양외과학회 2013 Korean Journal of Clinical Oncology Vol.9 No.2

Purpose: This study aimed to evaluate role of palliative laparoscopic colorectal resection for patients with stage IV colorectal cancer with unresectable metastasis. Methods: We reviewed 248 patients with stage IV colorectal cancer who underwent palliative bowel resection of the primary tumor during the period from January 2008 to December 2010 at Asan Medical Center. The short-term and oncologic outcomes of those with laparoscopic resection were reviewed and comparison was made between patients with laparoscopic and open resection. Results: A total of 248 patients were identified and of these patients, 50 underwent laparoscopic resection and conversion was required in six patients (12.0%). There was no differences in the gender, age, the location of primary tumor. But in the open group, peritoneal seeding was more (31.8% vs. 14.3%) and lung metastasis was less (28.3% vs. 48.0%; P=0.023) than laparoscopic group. The length of postoperative hospital stay in the laparoscopic group was significantly shorter than that in the open group (10.4 days vs. 6.7 days; P=0.048), and the postoperative complications were no significant difference in the both groups (13.1% vs. 8.0%; P=0.466) The overall survivals were similar in the both groups (mean survival, 758 days vs. 851 days; P=0.278). Conclusion: Considering of the patient’s general condition and distant metastasis, laparoscopic palliative bowel resection for stage IV colorectal cancer with unresectable metastasis is effective and safe.

一側 黑質體破壤 白鼠에서 Apomorphine의 回轉運動效果에 미치는 中樞 Opiate 系의 影響

양원모,허광렬,곽용근,김기원,조규박,은홍배 의과학연구소 1991 全北醫大論文集 Vol.15 No.1

To investigate the role of dopamine receptors and possible involvement of brain opiate system in the apomorphine-induced rotational behavior of the substantia nigra-lesioned rats with 6-hydroxydopamine, affects of morphine and naloxone on the action of docpamine agonist or antagonist were examined. Rats were primed with apomorphine after denervation. 1. Apomorphine elicited dose-dependent contralateral cilcling behavior. Maximum development of supersensitivity to apomorphine was observed 4 weeks after denervation in apomorphine-primed rat. The ratatory effect of apomorphine was enhanced by subcutaneous morphine, but diminished by naloxone. 2. A selective D1 agonist, SKF 38393 or a selective D2 agonist LY 171555 induced rotatory behavior of substantia nigra-lesioned rats. Rotatory effect of subcutaneous SKF 38393 was not affected by morphine and naloxone, but the effect of subcutaneous SKF 38393 was potentiated by morphine and dinimished by naloxone. 3. Subcutaneous SCH 23390 or sulpiride decreased the rotatory effect of apomorphine. Naloxone potentiated this effect of SCH 23390, but did not affect the effect of sulpiride. 4. Administration of morphine into ipsilateral caudate nucleus potentiated the rotatory effect of SKF 38393 and LY 171555, while ipsilateral treatment of naloxone did not affect the effect of SKF 38393, but diminished the action of LY 171555. Otherwise, contralateral injection of naloxone did now affect the effect of SKF 38393, but potentiated the action of LY 171555. 5. Chronic administration of naloxone increased the rotatory effects of apormorphine, SKF 38393 and LY 171555. Abrupt withdrawal of the drug potentiated the effect of apomorphine. From the above results, it is suggested that the rotatory effect of apomorphine is due to both the activation of dopamine D1 and D2 receptor, which are party moduated by brain opiate system.

자발적인 식도파열(Boerhaave 증후군) 2례

양관모,박재길,최승필,박규남,김영민,나병호,이원재,김세경 대한응급의학회 1997 대한응급의학회지 Vol.8 No.4

We experienced two cases of Boerhaave syndrome (spontaneous esophageal rupture). The first patient was a 62-year-old male who presented epigastric pain after several violent vomitings associated with alcohol ingestion. Diagnosis was done early and promptly in our emergency center and then definitive treatment was done only after 12hrs from onset of his symptom and he was discharged in relatively good condition 25days after his admission. The second patient was a 44-year-old male who was transfered to our emergency center with chest pain, dyspnea and fever after vomitings associated with autobicycle accident. Diagnosis was delayed due to initial trauma oriented evaluation and incidious development of typical clinical findings and then he was managed conservatively but he died of multiple organ failure due to sepsis. We report these cases with literature review.

Sodium bromate 음독후 비가역적 급성 신부전 및 청력소실과 시력소실이 발생한 1례

양관모,이원재,권태욱,박규남,나병호,유은영,최승필,김세경 대한응급의학회 1997 대한응급의학회지 Vol.8 No.4

A 39-year-old hairdresser developed sodium bromate poisoning after drinking a cup of hair neutralizer in a suicide attempt. This is the first case of visual loss afteringestion of sodlum bromate. Only few cases are as a cause of acute renal failure reported in medical literature. She presented I day later with anuria, required hemodialysis. Sensorineural hearing loss, often a characteristic finding, was developed.